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NEW CO-PROCESSED EXCIPIENTS WITH MICROCRYSTALLINE CELLULOSE AND ISOMALT BY FLUID BED. AN OPTION FOR DIRECT COMPRESSION EXCIPIENTS
Objective: To elaborate and characterize new co-processed excipients for direct compression use. Methods: The new co-processed excipients were obtained with different proportions of microcrystalline cellulose (Avicel® PH101) and Isomalt (galenIQ® 800), using Starch® 1500 and Plasdone® K-25as binding agents in a fluid bed. Rheological characterization was performed; to determine their deformati...
1953
1104
3D PRINTING – A NEW TECHNOLOGY FOR THE PHARMACEUTICAL INDUSTRY
Three-dimensional printing (3DP) is an imminent technology used to describe 3D products generated using a digital design platform manufactured layer by layer. This technology appears to be a transformative tool. It has just emerged as a key technological breakthrough, allowing the pharmaceutical sector to develop and generate new pharmaceutical items and equipment. It's a brand-new way to personal...
1952
1064
CHEMOPREVENTIVE EFFICACY OF ZINGERONE ON MASTOCYTE INFLAMMATION, CELL PRO-LIFERATION AND APOPTOSIS AGAINST DMBA-INCITED MAMMARY CARCINOGENESIS IN FEMALE SPRAGUE-DAWLEY RATS
Zingerone is an active phenolic acid and the least pungent component of Zingiber officinale. It is known to exhibit different pharmacological properties which include anti-inflammatory, antioxidant, anticancer and antimicrobial activities. But, so far there has been no information available on the role of zingerone in experimental breast carcinogenesis. The objective of this experiment is to untwi...
1952
1060
MASS SPECTROMETRIC IDENTIFICATION OF SECONDARY METABOLITES FROM MARINE SEAGRASS – CYMODOCAEA SERRULATA (R. BROWN) ASCHERSON & MAGNUS AND ITS ASSOCIATED BACTERIA BACILLUS CEREUS
A marine sea-grass Cymodocaea serrulata was collected, dried and extracted with a different solvent. The presences of phytochemical constituents were confirmed and the ethyl acetate extraction was considered to be a suitable solvent. In addition, the crude seagrass was serially diluted and spread onto the Zobell Marine Agar plates. Among the eight colonies obtained, the red-pigmented bacterium (CS...
1951
1331
TOTAL PHENOLS, ALKALOIDS, TANNINS AND ANTIOXIDANT ACTIVITY OF WILD PRUNUS ARMENIACA L. SEED COLLECTED FROM GARHWAL REGION OF UTTARAKHAND, INDIA
Plants are the important constituents of folk and traditional medicines and fulfill nutrition and dietary needs from ancient times. The aim of this study to evaluate phytochemicals and antioxidant activity of seed oil of wild apricot (Prunus armeniaca L). Thenon-cultivated seed of wild Prunus armeniaca L. from the Garhwal, Uttarakhand, India was analyzed for its phytochemicals e.g., total phenols,...
1951
1271
IN-VITRO AND IN-SILICO STUDIES ON SELECTED PHYTOCONSTITUENTS OF MITRAGYNA PARVIFOLIA (ROXB.) STEM BARK FOR ANTI-CANCER ACTIVITY
Cancer is a dreadful disease all over the world. The death rate had been increasing because of different types of cancers even though several drugs, treatment models and regimens are invented by scientists. Natural drugs have been showing remarkable results in the treatment of different cancers with less or no side effects. Advancements in screening methods using computer aided tools helping the r...
1951
1218
TASTE MASKING, DESIGN AND EVALUATION OF ORAL DISPERSIBLE TABLET OF ANTICHOLINESTERASE AGENT
This study aimed to determine for taste masking & design of Oro dispersible tablet of an anticholinesterase agent (Donepezil HCl) to achieve the patient compliance. Oral dispersible tablet prepared by compression method. The Anticholinergic activity assure by evaluation, drug dissolution, stability testing and standardize the oral dispersible tablet. On the basis of the preformulating and form...
1951
1247
EVALUATION OF PHYTOCHEMICAL ANALYSIS OF CALLUS TISSUE FROM INTERNODE EXPLANTS OF TRADITIONAL MEDICINAL PLANTS OF JATROPHA GOSSYPIIFOLIA LINN.
Jatropha gossypiifolia Linn. (Euphorbiaceae) is an ornamental shrub extensively used in traditional medicine for various ailments. In view of its potential medicinal properties, an attempt has been undertaken to devise an efficient protocol for in-vitro propagation from the internodes explants of J. gossypiifolia for a rapid and large-scale production as well as to study the phytochemical composit...
1951
1231
HISTOLOGICAL AND PHYTOCHEMICAL ANALYSIS OF FOUR ETHNOMEDICINAL PLANTS USED TO CURE SKIN DISEASES
Natural plant-derived compounds have been an essential resource in the evolution of drug discovery since the dawn of time. Using plants as a source of medicine is a century-long-standing tradition not merely in India but also in the entire world. North-East India is bestowed with incredible biological richness. The current research is focused on the histological and phytochemical analysis of four ...
1951
979
IN VITRO ANTIOXIDANT AND IN VIVO IMMUNOMODULATORY STUDY OF LEMON PEEL EXTRACT (STORG-FA) AND ITS BIOAVAILABILITY ASSESSMENT
Background: Natural bioactive compounds of plant origin have attracted comprehensive attention due to their multiple biological effects, including antioxidant and immunomodulatory activities. However, scientific underpinnings of these health benefits are inadequate. Objective: Present investigation was undertaken to evaluate the bioavailability, antioxidant, and Immunomodulatory activity of the he...
1951
1025