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IN-VIVO ANTICONVULSANT ACTIVITY OF 2-SEMICARBAZONO-1-HYDROXY, 1-[2-CHLOROPHENYL] -2-[4′-METHOXYPHENYL] ETHANE
A benzoin derivative of 2-Semicarbazono-1-hydroxy, 1-[2-chlorophenyl]-2-[4'-methoxyphenyl] ethane (2C4MBS) was synthesized by benzoin condensation followed by addition reaction. The structure elucidation done using single XRD studies. Maximal electroshock seizure (MES) model was used in the present study to evaluate the anticonvulsant activity of the test drugs. MES seizures were induced by an ele...
1903
2345
IN-VITRO AND IN-SILICO STUDIES ON SELECTED PHYTOCONSTITUENTS OF MITRAGYNA PARVIFOLIA (ROXB.) STEM BARK FOR ANTI-CANCER ACTIVITY
Cancer is a dreadful disease all over the world. The death rate had been increasing because of different types of cancers even though several drugs, treatment models and regimens are invented by scientists. Natural drugs have been showing remarkable results in the treatment of different cancers with less or no side effects. Advancements in screening methods using computer aided tools helping the r...
1903
1190
TOPICAL APPLICATION OF BACTERIOPHAGES FOR THE TREATMENT OF WOUND INFECTIONS:
Wound infections persist as a significant and persistent challenge within the realm of healthcare, posing numerous detrimental consequences that extend far beyond the affected individuals. These infections, characterized by the infiltration of harmful microorganisms into wounds, encompass a multifaceted predicament that engenders slower healing periods, heightened morbidity rates, and an onerous f...
1902
1632
FORMULATION AND EVALUATION OF QUINAPRIL EXTENDED-RELEASE TRILAYERED MATRIX TABLETS BY DESIGN OF EXPERIMENT
Objective: The present research was focused on designing, formulate and evaluate the trilayer matrix tablets incorporated with quinapril for extending drug release. Methods: Quinapril trilayer matrix tablets were formulated using response surface methodology wherein initially 27 formulations (QF1-QF27) were designed for active layer from which one best formulation was chosen based on drug content,...
1902
1054
DOCKING ANALYSIS OF SUBSTITUTED 2-PHENYL-1H-INDOL-3YL GLYOXYLAMIDE AS INHIBITORS OF TUBULIN POLYMERIZATION- POTENTIAL NEW ANTICANCER AGENTS
Indibulin (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid; ZIO-301 or D-24851) is a novel synthetic, orally active anti-mitotic agent that binds tubulin, destabilizes microtubulin polymerization, and arrests tumor cell growth at the G2/M phase. Its tubulin binding site is distinct from that of other microtubulin inhibitors such as taxanes, colchicines, and vinca alkaloids. Many resea...
1901
989
3D PRINTING – A NEW TECHNOLOGY FOR THE PHARMACEUTICAL INDUSTRY
Three-dimensional printing (3DP) is an imminent technology used to describe 3D products generated using a digital design platform manufactured layer by layer. This technology appears to be a transformative tool. It has just emerged as a key technological breakthrough, allowing the pharmaceutical sector to develop and generate new pharmaceutical items and equipment. It's a brand-new way to personal...
1901
1039
EXPLORING THE DIVERSITY OF ENTEROPATHOGENS IN NEONATES
Diarrhea alters the movement of ions and water that follows an osmotic gradient and leads to Loose, watery stools, abdominal cramps, abdominal pain, fever, bloating, blood, and mucus in the stool. Numerous critical cases have been observed in both infants and adults. The main objective of this study is based on an exploration of risk factors of diarrheal infection caused in neonates by entering pa...
1900
1092
EFFICACY AND SAFETY PROFILE OF DPP-4 INHIBITORS AS ADD-ON THERAPY IN PATIENTS WITH TYPE 2 DIABETES: A COMPREHENSIVE REVIEW
Aim: This study aimed to evaluate the efficacy and safety profile of DPP-4 inhibitors as add-on therapy in patients with type 2 diabetes. The study is important because DPP-4 inhibitors have been widely prescribed, and understanding their comprehensive effects is essential for better patient outcomes. Methods: An extensive literature search has been conducted using multiple databases, such as PubM...
1900
1069
IN-VITRO ANTI-OXIDANT ACTIVITY OF ELYTRARIA ACAULIS
The overproduction of oxidants in the body leading to different side effects and chronic diseases, including oxidative stress. The oxidative stress is the overproduction of the oxidant's condition in the body, which leads to metabolic imbalance and leading to diseases. It is one of the main diseases around the world, affecting the human lifestyle, either psychologically and physically. The natural...
1900
920
ASSESSMENT OF EPIDEMIOLOGY, PRESCRIBING PATTERNS, MEDICATION ADHERENCE AND IMPACT OF PATIENT EDUCATION ON DIABETICS IN A RURAL COMMUNITY
Background: There is a rise in a number of diabetes mellitus patients globally, but awareness of the disease, symptoms, medication use, associated complications, and comorbidities are low among Indians. The objective of the study was to evaluate the epidemiology of diabetes, prescribing patterns, and medication adherence and the impact of patient education on diabetes in a rural community. Methods...
1899
871