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REVIEW ON THE FIXED DOSE COMBINATION DRUGS AND THEIR INCOMPATIBILITIES
Incompatibility is an undesirable reaction that occurs between drugs, excipients, or with container. This may be therapeutic, chemical and physical incompatibility. Fixed dose combination provides challenge in product development due to incompatibility of two drugs. So severe degradation of drug in presence of each other. Formulation and stability difficulties arise with incompatible combination. ...
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3856
STUDY THE EFFECT OF PROCESS VARIABLES IN FLUID BED GRANULATION ON THE PHYSICO-CHEMICAL PROPERTIES OF GRANULES
The purpose of this research was to improve the granulation efficiency and the final granule characteristics for the any kind of the material that is to be granulated via FBG process. The fluid bed granulation process is an influenced by various processing parameters like atomization pressure, binder addition rate, in let temperature etc. These process variables largely affect the granulation effi...
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1524
A STUDY ON ANTIMICROBIAL POTENTIAL OF TRIDAX PROCUMBENS (L.) AGAINST CLINICAL ISOLATES
In-vitro antibacterial and antifungal activity of Tridax procumbens plant parts (leaf and stem) were investigated by agar well diffusion method. The petroleum ether, methanol and aqueous extracts of the plant parts were tested against two bacterial strains i.e., Bacillus subtilis and Escherichia coli and two fungal strains i.e., Trichoderma reesei and Fusarium oxysporium. The results of antibacter...
6230
1779
FORMULATION AND EVALUATION OF SOLID DISPERSION OF OLANZEPINE
The poor dissolution rate of water-insoluble drugs is still a major problem conforming the pharmaceutical industry. The most common method for improving the solubility is by increasing the surface area of the drug through micronization. But, in practice the effect of micronization is often disappointing, especially when the drugs are encapsulated or tablet. It is generally recognized that low solu...
6228
1931
EFFECTIVENESS OF TENDER COCONUT WATER (COCOS NUCIFERA L) AGAINTS PARASITEMIA INDEX AND HEMOGLOBIN LEVELS IN MALARIA INFECTION
Red blood cells (RBCs) is the primary target of human Plasmodium. Species. Occurs oxidative stress on uninfected and infected RBC and lead to hemoglobin (Hb) level decreased. The mechanism of decreased hemoglobin level are reduced survival time, diserythropoiesis and increased erythrolysis. Ascorbic acid and phenolics of TCW effectives to prevent RBCs from oxidative damage. Methods: The post test ...
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1212
ANTIMICROBIAL AND CELLULAR METABOLIC INHIBITORY PROPERTIES OF THE ETHANOLIC EXTRACT FROM THE BARK OF ‘LUNAS-BAGON’ (LUNASIA SP.)
This study was conducted to evaluate the antimicrobial and cellular metabolic inhibitory properties of the ethanolic extract from the bark of ‘Lunas-bagon’, Lunasia sp. Extracts were evaluated using the agar well diffusion method for antimicrobial assay. The standard phytochemical screening was done for the determination of compounds that can be considered toxic and MTT assay for the effects o...
6224
2009
BIOSENSORS: WAY OF DIAGNOSIS
Biosensors have revolutionized the way of diagnosis by allowing detection of diseases at earlier stage & detection of altered amount of biomarkers in the body. All biosensors usually involve minimal sample preparation as the biological sensing component is highly selective for the analyte concerned. There are numerous biosensors available now-a-days such as electrochemical biosensors, optical ...
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1381
REVIEW ON 2-SUBSTITUTED BENZOTHIAZOLES: DIVERSITY OF SYNTHETIC METHODS AND BIOLOGICAL ACTIVITIES
In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Benzothiazole is a privileged bicyclic ring system with diverse applications. The small and simple benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess biological activities, such as...
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2513
DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LEVOFLOXACIN BOTH IN BULK AND PHARMACEUTICAL FORMULATION
The present study was undertaken to develop and validate a simple, accurate, precise, reproducible and cost effective UV-Visible spectrophotometric method for the estimation of levofloxacin in bulk and pharmaceutical formulation. The solvent used throughout the experiment was 0.1N NaOH. Absorption maximum (λmax) of the drug was found to be 288 nm. The quantitative determination of the drug was ca...
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1683
CARBON NANOTUBES: THE FUTURE OF CANCER TREATMENT
Graphite is made up of layers of carbon atoms arranged in a hexagonal lattice, like chicken wire (see fi the term nanotube is normally used to refer to the carbon nanotube, which has received enormous attention from researchers over the last few years and promises, along with close relatives such as the nanohorn, a host of interesting applications. The theoretical minimum diameter of a carbon nano...
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