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DRUG DESIGN OF CORTICOTROPHIN RELEASING FACTOR RECEPTOR-1 ANTAGONIST FROM DERIVATIVES OF α ASARONE BY MOLECULAR DOCKING
Stress is one of the most significant health problem in modern society. This paves way for the researchers to focus and investigate into the biological pathways linking stress and health. Hence the goal of the present study is to discover novel drug derivatives from the active principle α asarone of the plant Acorus calamus Linn. (ACL) which was found to have antioxidant &antidepressor effect...
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POTENTIAL HERBAL HEPATOPROTECTIVE PLANTS: AN OVERVIEW
Hepatic diseases (Liver diseases) are a major worldwide health problem, with high endemicity in developing countries. Hepatic disease is a term for a collection of conditions, diseases, and infections that affect the cells, tissues structures, or functions of the liver. Liver has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for dig...
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DEVELOPMENT AND CHARACTERIZATION OF POLY (ε-CAPROLACTONE) MICROSPHERES CONTAINING ACETAZOLAMIDE
The aim of this study was to prepare and evaluate poly(ε-caprolactone) (PCL) microspheres containing acetazolamide. Microspheres were prepared by solvent evaporation method. The influence of formulation factors (polymer: drug ratio, aqueous: oil phase ratio, concentration of aqueous phase, stirring speed and stirring time) on morphology, particle size, encapsulation and recovery efficiency were i...
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FORMULATION DEVELOPMENT USING MAIZE STARCH & AVICEL PH101 AS DISINTEGRATING AGENTS AND THEIR EFFECT ON PHYSICAL CHARACTERISTICS & IN VITRO RELEASE PROFILE
The present study was undertaken to formulate directly compressible tablets to investigate the effect of different disintegrating agents such as maize starch and avicel PH101 on disintegration time, in vitro drug dissolution and their release properties. Tablets of paracetamol and the combination of paracetamol and diclofenac using maize starch and avicel PH 101 were prepared separately by direct ...
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QUALITY ASSESSMENT OF SOME BRANDS OF CLARITHROMYCIN AND AZITHROMYCIN TABLETS USING THE CONCEPT OF DISSOLUTION EFFICIENCY AND SIMILARITY FACTOR
Counterfeit and substandard pharmaceutical products circulate widely in developing countries, yet adequate techniques to monitor quality is lacking. We report herein a quick and reliable approach to predict the in-vitro bioequivalence and interchangeability of common antibiotics using nine model drugs; four brands of azithromycin and five brands of clarithromycin tablets marketed in Nigeria. Pharm...
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STUDY OF DISSOLUTION CHARACTERISTICS OF IBUPROFEN BY DIFFERENT POLYMERS AND SOLID DISPERSION TECHNIQUES
Poor water solubility is characterized by low dissolution rate and consequently reduced bioavailability. Formulation of solid dispersion has attracted considerable interest where dispersing a poorly water soluble drug in a water soluble polymer matrix improves the dissolution characteristics and bioavailability of the drug. The aim of the present study was to enhance the dissolution rate and bioav...
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PENETRATION OF DICLOFENAC FROM NOVEL QUICK PENETRATING SOLUTION. A COMPARATIVE SCINTIGRAPHY STUDY WITH GEL
Topical NSAIDs do not effectively cross the skin due to barrier of stratum corneum. The aim of the study was to evaluate penetration of diclofenac from a novel quick penetrating solution (QPS) and conventional gel prepared using Tc-99 m labeled diclofenac. The study was conducted in 16 healthy subjects, divided in 4 groups, each with 4 subjects. In first three groups, the applications were made on...
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METHOD DEVELOPMENT AND VALIDATION OF KETOROLAC TROMETHAMINE IN TABLET FORMULATION BY RP-HPLC METHOD
In the present study, a simple, precise, and accurate method was developed and validated for analysis of Ketorolac Tromethamine in Tablet formulation. A gradient HPLC analysis was performed on Grace C18 column (250 cm × 4.6 mm × 5 µ). The compound was separated with a solvent mixture of Methanol and water in a ratio of 65:35 v/v with 0.1% O-phosphoric acid as the mobile phase at a flow rate of ...
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STUDY OF NEUTRALIZATION OF ENZYMATIC ACTIVITY OF DABOIA RUSSELII VENOM BY VARIOUS PLANT EXTRACTS AND THEIR COMBINATIONS USING IN VITRO METHODS
Snakebite is an important cause of morbidity and mortality and is one of the major health problems in India. Russell’s viper (Daboia russelli) appears to be the commonest cause of fatal snakebite in many Asian countries and especially in the Indian subcontinent. Intravenous administration of anti venom serum neutralizes the systemic actions, but it is of little effect on the reversal of local sy...
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VIROSOMES: A NOVEL VACCINATION TECHNOLOGY
Vaccine development has continuously shifted away from live attenuated or inactivated whole organisms. Although this approach having good efficacy but for improvement on comparison of risk/benefit ratio which needs improvement due to their highly complex compositions which result in safety concerns. As a consequence, a number of indications remained unadressed. The next generation vaccines represe...
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