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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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11.

POTENTIAL HERBAL HEPATOPROTECTIVE PLANTS: AN OVERVIEW

Hepatic diseases (Liver diseases) are a major worldwide health problem, with high endemicity in developing countries. Hepatic disease is a term for a collection of conditions, diseases, and infections that affect the cells, tissues structures, or functions of the liver. Liver has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for dig...

Rajesh Kumar Soni*, Vihangesh Dixit, Raghuveer Irchhaiya and Shashi Alok

Department of Pharmacognosy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).774-89

774-789

8073

3200

23.

DEVELOPMENT AND CHARACTERIZATION OF POLY (ε-CAPROLACTONE) MICROSPHERES CONTAINING ACETAZOLAMIDE

The aim of this study was to prepare and evaluate poly(ε-caprolactone) (PCL) microspheres containing acetazolamide. Microspheres were prepared by solvent evaporation method. The influence of formulation factors (polymer: drug ratio, aqueous: oil phase ratio, concentration of aqueous phase, stirring speed and stirring time) on morphology, particle size, encapsulation and recovery efficiency were i...

N. Singh*, J. Gagoria, S. C. Arora, A. Khatkar and S. A. Saraf

RKSD College of Pharmacy, Kaihal-136027, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(8).2080-90

2080-2090

8070

1550

31.

SIMULTANEOUS ESTIMATION OF NORFLOXACIN AND TINIDAZOLE IN COMBINED TABLET DOSAGE FORM BY USING RP- HPLC METHOD

Simultaneous estimation method for Norfloxacin and Tinidazole in tablet dosage form had been developed by RP- HPLC. Both the drugs come under the category of antimicrobials and prescribed frequently in combination. The developed method is a gradient method which gives retention time of Norfloxacin and Tinidazole as 3.8min and 4.8min respectively. The separation was carried out on Supelco C18 (25cm...

Mrunal Bulbule and Deepali Gangrade *

Vivekanand Education Society’s College of Pharmacy, Mumbai University, Chembur (E), Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(1).236-43

236-243

8069

2436

8.

VIROSOMES: A NOVEL VACCINATION TECHNOLOGY

Vaccine development has continuously shifted away from live attenuated or inactivated whole organisms. Although this approach having good efficacy but for improvement on comparison of risk/benefit ratio which needs improvement due to their highly complex compositions which result in safety concerns. As a consequence, a number of indications remained unadressed. The next generation vaccines represe...

Priyanka Rathore* and Gaurav Swami

Department of Pharmaceutical Sciences, C.T. Group of Institutes, Shahpur campus, Jalandhar, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3591-97

3591-3597

8064

2130

28.

ANTI-ULCER EFFICACY AND SAFETY OF ANDA LEGHYAM A POLYHERBAL SIDDHA FORMULATION

Anda leghyam (AL) a herbo-animal Siddha formulation is administered for Gunmam (Acid peptic diseases) by many Siddha physicians popularly. Anti ulcerogenic activity of the AL has been studied using Aspirin-Pylorus ligation induced gastric ulcer methods (four groups/method, n=6, Aspirin 400mg/kg, Omeprazole 10mg/kg, AL 250,500mg/kg) in wistar albino rat models. Animals were sacrificed and their sto...

G.J. Christian*1, H. Mubarak , K. Yamini , T. Onesimus , S. Elansekaran , K. Vennila and L. Janani

National Institute of Siddha, Autonomous Institution under Dept. of AYUSH, Ministry of Health & Family Welfare, Govt. of India,Tambaram Sanatorium, Chennai - 47, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1837-42

1837-1842

8061

2288

2.

AN OVERVIEW ON MICROBIAL FIBRINOLYTIC PROTEASES

Microbial fibrinolytic proteases are of considerable interest in view of their specific activity and stability at biological pH. This review describes different isolation methods which enable the screening and selection of promising organisms for industrial production. Further, strain improvement using mutagenesis and/or recombinant DNA technology can be applied to augment the efficiency of the pr...

E. Venkata Naga Raju*and G. Divakar

Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522 510, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).643-56

643-656

8060

2172

37.

A STUDY OF PREGABALIN, TRAMADOL, THEIR COMBINATION AND NIGELLA SATIVA IN NEUROPATHIC PAIN IN RATS

Nigella sativa (NS) is a commonly used herb in Asian and African countries. Extensive experimental studies have been done to shed light on its hepatoprotective, immunumodulator, antioxidant, antimicrobial and several other useful pharmacological properties. However, there is dearth of evidence to evaluate the effect of Nigella sativa extract in neuropathic pain. In this study we have used neuropat...

S. N. Tewari *, M. T. Salman, S. Thadani, S. Singh, A. Ahmad

Department of Pharmacology, Era’s Lucknow Medical College, Sarfarazganj, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.6(10).4406-14

4406-14

8049

1903

4.

THE NEWER DIMENSION OF INHALATION AEROSOLS IN THE PROSPECTIVE OF VALIDATION

Aerosol drug delivery systems are much more importance in present days and have much advantage over other route of administration. Meter dose inhaler was used to deliver asthma medication in easy way and reliable multi dose preparation. The importance of the MDIs device play important role in determining drug delivery to the lungs. The word validation means,” Impose of validation or action of pr...

Sunil Kumar G. and M. P. Gowrav

Department of Pharmaceutics (Unit of Quality Assurance), J.S.S College of Pharmacy, J.S.S University, Sri Shivarathreeshwara Nagar, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).401-10

401-410

8048

3195

17.

METHOD DEVELOPMENT AND VALIDATION OF KETOROLAC TROMETHAMINE IN TABLET FORMULATION BY RP-HPLC METHOD

In the present study, a simple, precise, and accurate method was developed and validated for analysis of Ketorolac Tromethamine in Tablet formulation. A gradient HPLC analysis was performed on Grace C18 column (250 cm × 4.6 mm × 5 µ). The compound was separated with a solvent mixture of Methanol and water in a ratio of 65:35 v/v with 0.1% O-phosphoric acid as the mobile phase at a flow rate of ...

D. A. Khairnar *, C. S. Chaudhari and S. P. Anantwar

Department of Pharmaceutics, M.V.P. Samaj’s College of Pharmacy, Nasik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.5(9).3696-03

3696-3703

8046

3891

24.

STUDY OF DISSOLUTION CHARACTERISTICS OF IBUPROFEN BY DIFFERENT POLYMERS AND SOLID DISPERSION TECHNIQUES

Poor water solubility is characterized by low dissolution rate and consequently reduced bioavailability. Formulation of solid dispersion has attracted considerable interest where dispersing a poorly water soluble drug in a water soluble polymer matrix improves the dissolution characteristics and bioavailability of the drug. The aim of the present study was to enhance the dissolution rate and bioav...

Farhana Akter , Mukta Saha *, Johura Ansary , Arnab Debnath and Tahiatul Shams

Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.6(4).1528-37

1528-1537

8046

2782