A novel, simple, rapid and sensitive spectrophotometer method has been developed for simultaneous estimation of Lamivudine and Abacavir. The method employs formation and solving of simultaneous equation using 280 nm and 297 nm as two analytical wavelengths. Both the drugs obey Beer’s Law in the concentration ranges employed for this method. Accuracy and reproducibility of the proposed method was...
HYPOGLYCEMIC AND ANTIHYPERGLYCEMIC EFFECT OF ETHANOLIC EXTRACT OF WHOLE PLANT OF LAWSONIA INERMIS (HENNA) IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Diabetes, a global burden, is characterized by fast elevation of blood sugar level. The incidence of diabetes mellitus is rising all over the world, especially in Asia. Many oral hypoglycemic agents, such as biguanides and sulphonylurea are available along with insulin for the treatment of diabetes mellitus but they have significant side effects and sometimes they are found to be ineffective in ch...
PROLONG RELEASE BIOADHESIVE VAGINAL FILM OF ANTI-HIV DRUG (ZIDOVUDINE): FORMULATION AND IN- VITRO EVALUATION
The present study concerned with the development and characterization of bioadhesive vaginal film (VF). Zidovudine containing VF were prepared by solvent casting method using different ratios of Acrycoat S 100 (AC) or Ethyl cellulose (EC) to Hydroxy propyl methyl cellulose (HPMC) and di butyl phthalate(DBP) as a plasticizer. The optimized films were found to be transparent, flexible and soft and e...
EFFECT OF WATER STRESS BY POLYETHYLENE GLYCOL 6000 AND SODIUM CHLORIDE ON SEED GERMINATION AND SEEDLING GROWTH OF CASSIA ANGUSTIFOLIA
The impact of salt stress and water stress on seed germination, root and shoot length, fresh and dry biomass, vigour index was investigated in Senna (Cassia angustifolia) at germination stage (7DAS). Salinity stress was induced by using NaCl and drought stress by using PEG-6000. Different concentration of NaCl (0.1 to 100 mM) and PEG-6000(-0.1 bars to -2.0 bars) were used for seed treatment. The o...
Background: Gouania longipetala Hemsl. (Rhamnaceae), has ethnomedicinal use in the treatment of wounds, gonorrhoea, abdominal pain, lumbago, ophthalmia, conjunctivitis, and rickets. However, no scientific investigation of these effects has been established. Our aim was to verify the antibacterial, antioxidant and anti-inflammatory effects of the stem of Gouania longipetala. Methods: The antibact...
STUDIES ON THE DISINTEGRANT PROPERTIES OF SEED POWDER, HUSK POWDER AND MUCILAGE OF PLANTAGO OVATA BY FORMULATION OF ORALLY DISINTEGRATING TABLET
Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegrating tablets are intended to dissolve or disintegrate rapidly in the mouth for which various natural and synthetic disintegrants are included in the formulation. The present work emphasis on the study of disintegrant property of mucilage, Husk powder and seed powder of Isapghula...
HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF BALANITES AEGYPTIACA (L.) DEL AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS
The various parts of Balanites aegyptiaca (L.) Del (Balanitaceae) is used in Ayurvedic and other folk medicine for the treatment of various ailments such as syphilis, jaundice, liver and spleen problem, epilepsy and yellow fever. This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of aerial part of Balanites aegyptiaca on CCl4 induced hepatotoxicity i...
Comparative and synergistic antioxidant properties of Carica papaya leaf (CPL) and Azadarichta indica leaf (AIL), which are popularly used as medicinal plants were evaluated by analyzing the individual leaves and their 1:1 (mass/mass) homogenous combination (CPL+AIL) concurrently. The antioxidant properties measured were the levels of total phenol, tannin, total flavonoid, total carotenoid, vitami...
FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLETS USING 32 FACTORIAL DESIGN
The main objective of present investigation is to formulate the sustained release tablet of lamotrigine using 32 factorial design. Lamotrigine, a weakly basic and anticonvulsant drug belongs to BCS Class II, having high permeability and poor solubility. The sustained release tablets of lamotrigine were prepared employing different concentrations of HPMC K4M and HPMC K100M in different combinatio...
The present work aim was “Formulation Strategy for Dissolution Enhancement of Simvastatin”. Simvastatin is lipid lowering drug which is known as HMG CoA reductase. The objective of this study was to increase the solubility of poorly water soluble drug, namely simvastatin, by the formation of solid dispersion and complex and also using the microwave induction technique on these formations. For ...