CATHARANTHUS ROSEUS AND PROSPECTS OF ITS ENDOPHYTES: A NEW AVENUE FOR PRODUCTION OF BIOACTIVE METABOLITES
Catharanthus roseus is a medicinal herb found in many tropical and subtropical regions around the world. This plant produces a diverse array of secondary metabolites that are pharmaceutically important like vinblastine and vincristine used as chemotherapeutic agents in the treatment of several types of cancers. Low yield of these vinca alkaloids from the plant in vivo and the challenges to meet th...
The phytochemical analysis of the medicinal plant Kalonchoe pinnata was carried out to evaluate the antioxidant potential. Alcoholic extracts of the leaves was subjected to in vitro antioxidant activity screening models such as inhibition of lipid peroxidation, nitric oxide ,superoxide radical and hydroxyl radical scavenging activity. Ascorbic acid was used as the standard for superoxide anion rad...
SIMULTANEOUS ESTIMATION OF MOXIFLOXACIN HCl AND BROMFENAC SODIUM IN EYE DROPS BY SPECTROPHOTOMETRIC METHODS
Moxifloxacin Hydrochloride is a fluorinated quinolone antibacterial and Bromfenac Sodium is a non-steroidal anti-inflammatory. The combination formulation is used for the treatment of the reduction of post operative inflammatory conditions of the eye. Three new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Moxifl...
EFFECT OF WATER STRESS BY POLYETHYLENE GLYCOL 6000 AND SODIUM CHLORIDE ON SEED GERMINATION AND SEEDLING GROWTH OF CASSIA ANGUSTIFOLIA
The impact of salt stress and water stress on seed germination, root and shoot length, fresh and dry biomass, vigour index was investigated in Senna (Cassia angustifolia) at germination stage (7DAS). Salinity stress was induced by using NaCl and drought stress by using PEG-6000. Different concentration of NaCl (0.1 to 100 mM) and PEG-6000(-0.1 bars to -2.0 bars) were used for seed treatment. The o...
Air pollution tolerance index was assessed with plant species located at ChinnaTirupathi, Salem, Tamil Nadu, India. This study was conducted during March, 2013. Since, all the lands are converted to buildings, it is essential to know more about plants and its benefits offered to the environment and the dangers, risks caused by cutting trees. In this study, our aim is to evaluate, whether the plant...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF PREDNISOLONE ACETATE AND OFLOXACIN IN EYE-DROP
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of prednisolone acetate and ofloxacin in combined eye drop dosage form. The method is based on the simultaneous equations method for analysis of both the drugs using methanol as solvent. Prednisolone acetate has absorbance maxima at 243 nm and ofl...
INFUSIBLE PLATELET MEMBRANES IMPROVE HEMOSTASIS IN THROMBOCYTOPENIC RABBITS: STUDIES WITH TWO DIFFERENT INJECTION DOSES
Due to the limited life span of platelets during regular storage in blood banks, we were interested to investigate the both potential hemostatic effect and dose-dependent response properties of non-viable platelet preparations with injection of two high and low doses in experimental animal model. Infusible platelet membrane (IPM) was prepared from outdated platelet concentrates. Platelet concentra...
The bioavailability of some orally administered botanical extracts is erratic and poor due to limited gastro-intestinal absorption. Bioavailability can be improved by using new delivery systems which can enhance the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids based drug delivery system have been found promising for bett...
Background: Gouania longipetala Hemsl. (Rhamnaceae), has ethnomedicinal use in the treatment of wounds, gonorrhoea, abdominal pain, lumbago, ophthalmia, conjunctivitis, and rickets. However, no scientific investigation of these effects has been established. Our aim was to verify the antibacterial, antioxidant and anti-inflammatory effects of the stem of Gouania longipetala. Methods: The antibact...
STUDIES ON THE DISINTEGRANT PROPERTIES OF SEED POWDER, HUSK POWDER AND MUCILAGE OF PLANTAGO OVATA BY FORMULATION OF ORALLY DISINTEGRATING TABLET
Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegrating tablets are intended to dissolve or disintegrate rapidly in the mouth for which various natural and synthetic disintegrants are included in the formulation. The present work emphasis on the study of disintegrant property of mucilage, Husk powder and seed powder of Isapghula...