AN INVESTIGATION ON THE TYPE I ANTIDIABETIC ACTIVITY OF METHANOLIC EXTRACT OF MARINE ALGAE, GRACILARIA EDULIS AND SARGASSUM POLYCYSTUM
The objective of this study was to evaluate the antidiabetic activity of methanolic extract of marine algae Sargassum polycystum (MSP) and Gracilaria edulis (MGE) in STZ induced diabetes in rats for Type I diabetic mellitus. The marine algae SP and GE were dried under shade and then powdered, and extracted with methanol. Preliminary phytochemical studies and acute toxicity studies were also carrie...
EVALUATION OF THE EFFICACY OF COMBINATION THERAPY OF AGOMELATINE, DULOXETINE AND SERTRALINE IN THE MANAGEMENT OF STRESS INDUCED DEPRESSION
There is unmet need in the treatment of stress induced depression on suggesting requirement of new therapeutic agent. A combination therapy of antidepressants sertraline (5 mg/kg), duloxetine (10 mg/kg) and agomelatine (8 mg/kg) are used in different combinations of doses by intra-peritoneal route. Swiss albino mice were used as an animal model for stress-induced depression; mice were divided into...
Felodipine is a poorly water soluble drug having 15% oral bioavailability. In the present study Self micro emulsifying drug delivery system of felodipine was developed to improve its solubility and bioavailability. SMEDDS were prepared by phase titration method and ternary phase diagram was constructed using Chemix software. Based on solubility of drug in the excipients, capmul MCM, oleic acid, Tw...
OXONE AND IODOBENZENE ARE USEFUL REACTION SYSTEM FOR SYNTHESIS OF 2-AMINOTHIAZOLE DERIVATIVES FROM EASILY AVAILABLE THIOUREA AND ALKYL / ARYL KETONES
A quick one step, innovative approach for the Synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl / aryl ketones with the help of Oxone and Iodobenzene reaction system has been developed in aqueous acetonitrile solution. The developed procedure is applicable to several types of substituted 2-aminothiazole derivatives to get the corresponding products. The developed me...
EFFECT OF PUTRANJIVA ROXBURGHII WALL. ON PHAGOCYTOSIS AND CHEMOTAXIS BY POLYMORPHONUCLEAR LEUKOCYTE CELLS (IN-VITRO STUDY)
Polymorphonuclear leukocytes or neutrophils are important components of host defense machinery. They are the first line of defense against invading microorganisms. In the present research work, ability of human neutrophils to phagocytose was studied in-vitro by exposing the polymorphonuclear leukocytes to Candida albicans and the phagocytic capacity was evaluated using aqueous extract of leaves po...
Statins exhibit their pharmalogical effects by competitive inhibition trough binding with active sites of enzymes. Rosuvastatin, of all statines, has the most binding interactions with the enzyme, and being the most potent statin, it is presumed that the strength of enzyme binding directly influences its potency. Reduction of derivatives of mevalonic acids results with decreased risk of cardiovasc...
The ancient medicine acupuncture was used to treat the diabetes and its complications. Our study was aimed to find out the hypoglycemic effect of Acu-TENS electrical stimulation at bilateral Zusanli (ST36) acupoint in streptozotocin (45 mg/kg/body weight/IP) induced diabetic rats. Diabetes was induced in male albino wistar rats with the administration of single dose of streptozotocin(45mg/kg/body ...
From time immemorial pharmacologists and researchers have always been in search for novel drug screening methods. One such unique technique that is gripping the world by its leash is “human tissue chip technology”. This study explores the creation of Multiple Sclerosis (MS) using human tissue chip and assessing the ability of Vasicine a quinazoline alkaloid derived from Adhatoda Justiciae plan...
PERFORMANCE IMPLICATIONS OF CLINICAL PHARMACIST INFORMATION ON GESTATIONAL DIABETES MELLITUS AT A TEACHING HOSPITAL IN SOUTHERN INDIA
Context: Gestational diabetes mellitus (GDM) early diagnosis of disease can reduce the morbidity and mortality by prevention of maternal and fetal complications. Aims: To assess the impact of clinical pharmacist knowledge on GDM mothers. Setting Tertiary care teaching hospital of North Karnataka, India. Methods and Materials: A randomized controlled cross-sectional study was carried out for a peri...
A STUDY TO COMPARE EFFICACY OF METFORMIN-GLIMEPIRIDE VERSUS METFORMIN-TENELIGLIPTIN IN TYPE II DIABETIC PATIENTS
Diabetes mellitus relates a metabolic disorder of collective aetiology which is characterized by chronic hyperglycaemia caused due to disturbances of carbohydrate, lipid and protein metabolism due to impaired β cell function of pancreas or insulin resistance or both. Biguanides and Sulphonylureas are the most commonly prescribed drugs due to their efficacy and safety. A total of 60 patients were ...