ANTIBACTERIAL, RADICAL- SCAVENGING ACTIVITIES AND CYTOTOXICITY PROPERTIES OF PHALERIA MACROCARPA (SCHEFF.) BOERL. LEAVES IN HEPG2 CELL LINES
Antibacterial, and radical scavenging activities of four crude extracts of Phaleria macrocarpa (Scheff) Boerl.) leaves extracts and its active crude cytotoxic properties in HepG2 cells were investigated. The susceptibility bacteria tests were performed by the Mueller Hinton agar well diffusion method. The Radical scavenging activity was measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method...
Biosynthesis of nanoparticles is reviewed in detail in this study. Comparison of different synthesis methods, namely physical, chemical and green methods giving emphasis to biological synthesis is documented here. This study also details limitations of the present techniques and envisages the future scope of nanoparticle biosynthesis. Important applications of nanoparticles are also discussed brie...
PHYTOCHEMICAL INVESTIGATION AND CHROMATOGRAPHIC EVALUATION OF THE ETHANOLIC EXTRACT OF WHOLE PLANT EXTRACT OF DENDROPHTHOE FALCATA (L.F) ETTINGSH
The present study was aimed to investigate phytochemicals present in the whole plant extract of Dendrophthoe falcata and development of new solvent system for thin layer chromatography of ethanolic (whole plant) extract of medicinal plant Dendrophthoe falcata. The extract showed presence of Carbohydrates, Sterols, Glycosides, Flavonoids and Phenolic compounds. For TLC, new solvent system developed...
Niosomes are self assembled vesicles composed primarily of synthetic surfactants and cholesterol. They are analogous in structure to the more widely studied liposomes formed from biologically derived phospholipids. Niosomes represent an emerging class of novel vesicular systems. Niosome formation requires the presence of a particular class of amphiphile and aqueous solvent. In recent years a compr...
Incorporation of drugs into non-ionic surfactant vesicles (niosomes) during their manufacture affords a possible method of achieving controlled release. The aim of this study is to formulate niosomes as carriers for delivery of diclofenac sodium (DCS). Niosomes are prepared with a series of sorbitan monoesters (Span 20, 40, 60, and 80) and sorbitan tri-oleate (Span 85) and co-surfactants of polyox...
The objective of this review is to form a short compilation of phytochemical screening, pharmacological activity and some analytical methods available for Sapindus mukorossi plant. Although the plant is of importance in Ayurvedic system of medicine mainly as cleansing agent, a review article based on the phytochemical and pharmacological screening of Sapindus mukorossi is not so far reported. The ...
Astaxanthin, a member of the carotenoid family, is a dark-red pigment which is the main carotenoid found in the marine world of algae and aquatic animals. Astaxanthin, is present in many types of seafood, including salmon, trout, red sea bream, shrimp and lobster, as well as in birds such as flamingo and quail. Synthetic Astaxanthin dominates the world market but recent interest in natural sources...
Nanotechnology is science of matter and material that deal with particle size in nanometers. Nanotechnology has received a lot of attention with never-seen-before enthusiasm because of its future potential. It has provided fine lined diagnosis and focus treatment of disease at molecular level. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses req...
A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FEBUXOSTAT IN BULK AND PHARMACEUTICAL FORMULATIONS
A simple and cost effective spectrophotometric method is described for the determination of febuxostat in pure form and in pharmaceutical formulations. The drug was highly soluble in methanol so it was selected as the solvent system for the drug. This ensured adequate drug solubility and maximum assay sensitivity. The linearity range for febuxostat at its wavelength of detection of 315 nm was obta...
HYPOLIPIDEMIC AND HEPATOPROTECTIVE EFFECTS OF DIFFERENT FRACTIONS OF ETHANOLIC EXTRACT OF IMMATURE LEAVES OF MANGIFERA INDICA (LINN.) IN ALLOXAN INDUCED DIABETIC RATS
The study was undertaken to investigate the hypolipidemic and hepatoprotective effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of immature leaves of Mangifera indica. The different fractions of extract were administered intraperitonially as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduce blood lipid...