Bi-layer tablets have been developed to achieve controlled delivery of different drugs with pre-defined release profiles. In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bilayer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bilayer tablets can be a primary ...
HYPOLIPIDEMIC AND HEPATOPROTECTIVE EFFECTS OF DIFFERENT FRACTIONS OF ETHANOLIC EXTRACT OF IMMATURE LEAVES OF MANGIFERA INDICA (LINN.) IN ALLOXAN INDUCED DIABETIC RATS
The study was undertaken to investigate the hypolipidemic and hepatoprotective effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of immature leaves of Mangifera indica. The different fractions of extract were administered intraperitonially as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduce blood lipid...
Pelletization process first came into existence way back during the 1950s, when the first product was introduced to the market. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sustai...
In recent time, scientific investigations of medicinal plants using indigenous medical systems has attracted a lot of attention globally. Nature has bestowed our planet with an enormous wealth of medicinal plants have been known for millennia and are highly esteemed all over the world as a rich source of therapeutic agents for the prevention and cure of diseases and ailments. Inflammation is compl...
Antioxidants have become a vital part of our lives today. Antioxidants help neutralize or destroy “Reactive Oxygen Species” (ROS) or free radicals before they can damage cells. This paper focuses on types of damaging free radicals generated in metabolic processes and also gives an insight of mechanistic aspect of various in-vitro methods for evaluation of antioxidant capacity of plant metaboli...
Nanotechnology is science of matter and material that deal with particle size in nanometers. Nanotechnology has received a lot of attention with never-seen-before enthusiasm because of its future potential. It has provided fine lined diagnosis and focus treatment of disease at molecular level. This technology offers the advantage of protecting drugs from degradation; reduce the number of doses req...
RP-HPLC METHOD FOR SIMULTATANEOUS DETERMINATION OF AMLODIPINE BESYLATE, VALSARTAN, TELMISARTAN, HYDROCHLOROTHIAZIDE AND CHLORTHALIDONE: APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS
A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Amlodipine Besylate, Valsartan, Telmisartan and diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Cosmosil PAQ (150 mm × 4.6 mm) 5 μm column with gradient flow. The mobile phase at a flow rate of 1.0 mL min−1 cons...
Biosynthesis of nanoparticles is reviewed in detail in this study. Comparison of different synthesis methods, namely physical, chemical and green methods giving emphasis to biological synthesis is documented here. This study also details limitations of the present techniques and envisages the future scope of nanoparticle biosynthesis. Important applications of nanoparticles are also discussed brie...
Oral mucosal drug delivery system is widely applicable as novel site for administration of drug for immediate and controlled release action by preventing first pass metabolism and enzymatic degradation due to GI microbial flora. Oral mucosal drug delivery system provides local and systemic action. In this review, attention is focused to give regarding physiology of oral mucosal including tissue pe...
ANTIOXIDANT, ORGAN PROTECTIVE AND AMELIORATIVE PROPERTIES OF METHANOL EXTRACT OF ANOGEISSUS LEIOCARPUS STEM BARK AGAINST CARBON TETRACHLORIDE- INDUCED LIVER INJURY
The methanol extract of the stem bark of Anogeissus leiocarpus was evaluated in vivo at 2.5mg/kg for antioxidant, hepatoprotective and ameliorative effect on hepatocellular injury following pre-treatment or post-treatment with carbon tetrachloride (CCl4). Levels of the lipid peroxidation product, malondialdehyde (MDA) or thiobarbituric reactive substances (TBARS) were taken as a measure of oxidati...