SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC DETERMINATION OF OXCARBAZEPINE IN PURE FORM AND PHARMACEUTICAL PREPARATION
Simple and sensitive spectrophotometric Method (A) and spectrofluorimetric Method (B) were described for analysis of oxcarbazepine. The proposed methods were based on oxidation of the drug with cerium (IV) ion in acidic medium with subsequent measurement of either the decrease in absorbance at 321 nm or the fluorescence intensity of the produced cerous (III) ion at 363 nm emission after excitation...
IN-VITRO STUDIES ON OIL DEGRADING BACTERIA ISOLATED FROM OIL CONTAMINATED SOIL OF VANIYAMBADI AND AMBUR AREAS OF VELLORE DISTRICT
The oil polluted soil has many hydrocarbons which can be degraded by microbes. These oil degrading microbes were isolated from the oil contaminated soil through plate and dilution technique. The oil contaminated soils were collected from the oil spilled places of Vaniyambadi and Ambur areas of Vellore District, Tamil nadu, India. Through the biochemical tests, the isolated bacterial strains were i...
ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF BRASSICA JUNCEA SEED ON CARRAGEENAN INDUCED PAW EDEMA IN RATS
Inflammation is a primary physiological defence mechanism that helps body to protect itself from infection, toxic chemicals or other noxious stimuli. The methanolic seeds extract of Brassica juncea was evaluated for its anti-inflammatory activity, in-vivo methods. Anti-inflammatory drugs with low toxicity and higher therapeutic values. It is defensive mechanism of the body to remove the injuriou...
Spirulina platensis, planktonic blue-green algae, has been used as a source of protein (60-70%) and vitamin supplement for more than 15 years without any unknown adverse events. Traditionally, Spirulina platensis has been used as an antioxidant agent. However, no pharmacological work has been done to evaluate the anti-anxiety activity. The present study was premeditated for the evaluation of the ...
COMPARATIVE STUDY ON EFFECT OF DIFFERENT CAPPING AGENTS ON THE ANTIMICROBIAL ACTIVITY OF ZNO NANOPARTICLES
The present study focuses on the synthesis of ZnO nanoparticles by chemical method in alcohol base using three different capping agents-Thioglycerol, oleic acid and Triethanol amine (TEA). The effect of concentrations was analyzed for their effectiveness in particle growth and antibacterial activity. The antibacterial activity of ZnO nanoparticles using these capping agents at different concen...
AVAILABILITY AND AFFORDABILITY OF ESSENTIAL ANTIBIOTICS FOR PEDIATRICS IN SEMI-RURAL AREAS IN TANZANIA
In this study, we assessed the availability, cost and affordability of essential antibiotics for paediatrics in a semi-rural region in Tanzania. Data were collected from 1 Medical Stores Department (MSD), 8 public hospitals, 30 Private Pharmacies and 30 Accredited Drug Dispensing Outlets (ADDO`s). The median price of tracer medicines and average stock-out days of per year were used to assess the c...
A STUDY ON PRESCRIBING PATTERN OF DRUGS IN GERIATRICS USING BEERS CRITERIA AT A PRIVATE CORPORATE HOSPITAL
The prevalence of potentially inappropriate medication (PIM) use is high among geriatrics, affecting up to 40% of patients. The objectives of the study are to evaluate the prescription pattern in geriatrics and to identify potentially inappropriate medications using Beers Criteria 2012. The data were collected and recorded in standard data entry format. The prescriptions were analyzed for appropri...
FORMULATION DESIGN, IN-VITRO AND BIOLOGICAL CORRELATION OF SITE SPECIFIC DRUG DELIVERY SYSTEM FOR DISTAL GASTRO-INTESTINAL TRACT
In the present studies was designed to evaluate oral compression coated tablet formulation to achieve time and site specific drug release system to target lower GIT. A pectin based compression coated tablet formulation of different ratios and concentration of ethyl cellulose and cellulose acetate phthalate were designed and evaluated physico chemical parameters and for tinidazole release, compress...
A new simple and rapid reverse phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous estimation of cefpodoxime proxetil in bulk drugs and pharmaceutical dosage form. The separation was accomplished on a sunfire C-18 (250x 4.6 mm, 5 μm) column with a mobile phase consisting of Methanol; Water (70:30 v/v) at a flow rate of 0.8 mL/min. The e...
A NOVEL TANNIC ACID FROM GANODERMA LUCIDUM FRUITING BODIES EXTRACT AMELIORATES EARLY DIABETIC NEPHROPATHY IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Aim: The present study evaluated the anti-diabetic, anti-hyperlipidimeic, antioxidant activities and renal protective effect of aqueous extract from Ganoderma. lucidum fruiting bodies in streptozotocin induced diabetic rats. Material and Results: Qualitative and quantitative phytochemical analysis for G. Lucidum aqueous extract showed the Presence of high concentration of tannins content. Thin lay...