The oral route is considered to be the most preferred route for administration of drugs for systemic effect, but the oral route is not suitable to the administration of drug for lower gastrointestinal (GI) diseases, this happened due to their release at upper GI tract (stomach, small intestine), which further minimizes the accessibility of drugs at the lower GI tract. To overcome this difficulty, ...
EFFICIENT USE OF TRADITIONAL MEDICINE TO DETOXIFY UPPER REPRODUCTIVE ORGANS TOXICITY THAT MAY LEAD TO INFERTILITY
This study aims at investigating the use of herbal medicine (F. vogelii) as a natural antioxidant to detoxify reproductive toxicity. Twenty-five (25) female Wistar rats used in this research were divided into five groups of five (5) rats per group. Group A served as negative control and received feed and water ad libitum. It also received formal saline. B and C served as the low (100 mg/kg) and hi...
Fluoride becomes toxic at higher doses which leads to Fluorosis. In addition to dental and skeletal fluorosis, it also affects soft tissues including liver, heart, kidney, muscle, brain, etc. The aim of this study to examine the fluoride-induced oxidative stress and the protective role of Allium sativum ethanolic extract (ASEE) against underlying fluoride induced neurotoxic effects in the brain of...
A COMPARISON OF MENTAL HEALTH, QUALITY OF LIFE, AND HAPPINESS IN MOTHERS OF CHILDREN WITH AUTISM SPECTRUM DISORDERS VERSUS MOTHERS WITH HEALTHY CHILDREN
Introduction: Autism spectrum disorders (ASD) are a group of mental problems that interfere with social interaction skills, and behavioral spectrum. ASDs are one of the most prevalent developmental disorders among children. The purpose of this study was to examine the mental health, quality of life, and happiness in mothers who had ASDs children and compare them with mothers having healthy childre...
This study reports the potential of a marine mollusk, Chicoreus sp., as a producer of peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand that activate the scavenger receptor class B type 1 (SR-B1) for anti-atherosclerotic activity. The objective of this study is to determine the cytotoxicity of the obtained compound C35, with a molecular weight of 270.1 and the level of SR-B1 expres...
Nanotechnology is an advancing technology expected to bring revolutionary changes in the field of life sciences including drug delivery. The advance in nanotechnology helps in the preparation of new pharmaceutical formulations with high benefits. One of its approaches is to stabilize the niosomal drug delivery system without affecting its properties have resulted in the development of proniosomes,...
ELECTROCHEMICAL STUDY OF INTERACTION OF THE HEAVY METAL IONS IN HYDROXYLATION REACTION OF SALICYLIC ACID ON GLASSY CARBON ELECTRODE
The formation of free hydroxyl radical (˙OH) in oxygen transfers at GCE and the reaction between the electrochemically produced ˙OH and salicylic acid (SA) is studied by cyclic voltammetry method. Experiments showed that ˙OH is formed in the potential range of 1.0-1.4V corresponding to the anodic discharge of H2O at the GCE. The interaction of Cu2+, Hg2+, Cd2+, Mn2+ ions on the hydroxylation re...
SHORT-TERM TREATMENT OF ELASTASE-LPS INDUCED EXACERBATION MODEL OF EMPHYSEMA IN MICE WITH DOCOSAHEXAENOIC ACID, A PRECURSOR OF ANTI-INFLAMMATORY AUTACOIDS
An essential pathological phenotype of chronic obstructive pulmonary disease is emphysema or lung tissue destruction. The study aims to assess docosahexaenoic acid (DHA), a precursor for specialized pro-resolving mediators, as a treatment of emphysema. Albino mice were challenged with porcine pancreatic elastase on day 1 and bacterial lipopolysaccharide on day 21 to induce emphysema. The pathologi...
Zidovudine is the first approved compound for the treatment of HIV; however the main limitation to therapeutic effectiveness of Zidovudine is its dose dependent toxicity, short biological half-life and poor bioavailability. Thus, to overcome the problem the gastroretentive floating drug delivery system is developed. Floating drug delivery system is a low density system which have capacity to remai...
Neurodegeneration accounts for diseases like Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, etc. that come under neurodegenerative diseases. Parkinson’s disease is the second most common neurodegenerative disease. The main hallmarks of Parkinson’s disease are progressive loss of motor control and cognitive dysfunction. Current treatments are of reducing the symptoms, do ...