The treatment of cancer up to the saving of life of cancer patient is rare miracle. Cancer is deadly disorder (some cancers are diseases caused by viruses) if diagnosed in second or third stage leads to death, hence it is better to prevent it. The present study emphasizes on prevention of cancer rather than cure. Extraction of garlic was carried out by using maceration process. The liquid extract ...
PHARMACOVIGILANCE STUDY OF PATIENTS RECEIVING TREATMENT AT MEDICAL ICU OF C. U. SHAH MEDICAL COLLEGE & HOSPITAL, SURENDRANAGAR
Background: Medical Intensive Care Unit (ICU) can be a potential place for Pharmacovigilance due to high frequency of Adverse Drug Reactions (ADRs). Regular evaluation can help in understanding the pattern of ADR and reduce the incidence of it. Aims and Objectives: To evaluate incidence of ADRs in patients receiving various modes of treatment at medical ICU of our tertiary care hospital and classi...
STUDY OF THE ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF RHIZOMES OF ZINGIBER OFFICINALE IN EXPERIMENTAL ANIMALS
Objective: To evaluate the anticonvulsant property of Zingiber officinale as well as its interaction with conventional anticonvulsant drug using Maximal electroshock seizures (MES) model and to evaluate possible mechanism involved in its action. Method: The present study was done after getting ethical clearance. The rhizomes of ginger were authenticated and extraction of dried rhizomes was done by...
PREPARATION AND CHARACTERIZATION OF SUPERPOROUS HYDROGELS AS GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR ATENOLOL
Gastro-retentive drug delivery system can retain the drug in the gastric region for several hours which enhances drug release and improves bioavailability. Atenolol, an antihypertensive drug has a short half-life, limited bioavailability, highly unstable at basic pH and is extensively absorbed from the stomach. These features triggered the need for developing the gastro-retentive system. In the pr...
The main objective of the present research was to develop mixed micelles using two biocompatible copolymers, D-α-tocopheryl polyethylene-glycol 1000 succinate (TPGS) and poloxamer 188 (P188) to improve the aqueous solubility and targeting efficacy of Simvastatin (SMV) against a variety of hormone-dependent cancers. A solvent evaporation technique prepared the plain/single copolymer micelles (SCMs...
COMPARATIVE ANALYSIS OF SOCIO-ECONOMIC STATUS IN RHD PATIENTS: A TERTIARY CARE INTERPRETATION AND EXPLORING REASONS TO IMPROVE ADHERENCE
Rheumatic heart disease (RHD) is a major burden in developing countries and leads to heart valve damage resulting from acute rheumatic fever (ARF). RHD and its complications cause more than 1.4 million deaths per year, globally. The mortality in RHD depends on the factors related to socio-economic status and tertiary care, especially in developing countries like India. In this study, a comparative...
EFFECT OF PROBIOTIC LACTOBACILLUS FERMENTUM MCC3216 ON PROGRESSION OF TYPE 2 DIABETES WITH THEIR ANTI-INFLAMMATORY ACTIVITY IN HIGH FRUCTOSE FED DIABETIC RATS
The antidiabetic and anti-inflammatory effects of probiotic Lactobacillus fermentum MCC3216 was investigated in high fructose-fed type 2 diabetic rats. Type 2 diabetes was induced by feeding high fructose diet to male albino Wistar rats. A single daily dose of 2 × 108 CFU/ml of L. fermentum MCC3216 was given to Wistar rats for 8 weeks. The fasting blood glucose, body weight, oral glucose toleranc...
EVALUATION OF α-AMYLASE AND α-GLUCOSIDASE ENZYME INHIBITORY ACTIVITIES OF TRICHURIELLA MONSONIAE BENNET
Diabetes is a noncommunicable chronic metabolic disorder characterized by high blood glucose level in the body. One of the antidiabetic therapeutic strategies is the inhibition of carbohydrate-digesting enzymes such as α-amylase and α-glucosidase. In the present study methanolic extract and its two fractions (Ethyl acetate and n-butanol) of the whole plant of Trichuriella monsoniae were evaluate...
Nowadays, Hospital-acquired infection is one of the significant issues, as the mortality rate is frequently increasing. This may be due to the unhygienic environment of various medical clinics and hospitals, a wide range of antibiotic uses. Nosocomial infections are those which are acquired by the patient within 48-72 h or 3 days of admission in the hospital or medical care unit. The microbes caus...
IMMUNOHISTOCHEMICAL EXPRESSION OF MMP9 IN DIFFERENT GRADES OF ORAL SQUAMOUS CELL CARCINOMA: OUR EXPERIENCE AT TERTIARY CARE CENTRE
Introduction: Oral carcinoma is amongst the leading malignancies worldwide, with squamous cell carcinoma (SCC) as the most common type accounting for over 90% of cases. In OSCC, MMPs, (MMP9) which belongs to gelatinase group, promote tumor progression by new blood vessel formation, disturbing tissue morphology which allows tumor growth breaks the basement membrane and enables metastasis and it's o...