Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
HAEMATOLOGICAL AMELIORATION BY ZIZYPHUS MAURITIANA IN SILICA INDUCED TOXICITY IN WISTAR ALBINO RATS
This study was aimed to investigate the biochemical influence of aqueous extracts of roots, stem and leaves of Zizyphus mauritiana (ZM) on silica induced toxicity in rats, with changes in inflammatory markers in liver and kidney. To test the preventive effect of extracts of Zizyphus mauritiana on development of silica induced toxicity in wistar albino rats, animals were treated simultaneously with...
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FORMULATION DEVELOPMENT AND EVALUATION OF CLOPIDOGREL BISULFATE TRANSDERMAL PATCHES
Clopidogrel bisulphate is a drug used in inhibiting the platelet aggregation and also used in the treatment of cardiovascular disorders. It acts by inhibiting the adenosine diphosphate and is almost absorbed (98%) after oral administration. Approximately 50 % of drug is excreted in urine and 40% in feces. The plasma half life of drug is about 8 hours which makes frequent dosing necessary to mainta...
6152
2021
SCOPE AND EVALUATION OF SAPODILLA PECTIN IN PHARMACEUTICAL SOLID AND LIQUID ORALS WITH ESPECIAL REFERENCE TO ITS EFFECT ON VARIOUS PHYSICO-MECHANICAL PROPERTIES UPON BOTH SOLID AND LIQUID DOSAGE FORM
The aim of this study was to understand and study the role and effect of different concentration of sapodilla pectin as a binding agent in tablet formulations and also its on the effect on physical evaluation of suspension. For this purpose two model drugs paracetamol and ibuprofen were selected and granules were made by wet granulation using different concentration of pectin. The tablets were fir...
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RP-HPLC METHOD FOR THE SIMULTANEOUS ASSAY OF METFORMIN AND BENFOTIAMINE: DEVELOPMENT AND VALIDATION
A sensitive, precise and accurate reverse phase high performance liquid chromatographic method (RP-HPLC) using an isocratic elution of 0.1 M NaH2PO4 (pH 3.0) and acetonitrile (80:20 v/v) with a flow rate of 1.0 mL/min, a column temperature of 30 °C and UV detection at 254 nm was developed for the estimation of metformin and benfotiamine simultaneously. The method was validated following guideline...
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MITOCHONDRIA – TARGETED ANTIOXIDANT: AGING
The mitochondrion, the “power house of cell”, plays a central role in energy-generating processes so called as ‘‘master of life and death’’. A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders. With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to accumulation of mutations and ...
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BISPHENOL A ENHANCES GROWTH OF Hep-G2 CANCER CELLS BY UPREGULATING EXPRESSION OF PRO – INFLAMMATORY AND PRO – ANGIOGENESIS PROTEINS
Bisphenol A (BPA) is primarily used in the manufacture of plastics and resins. There are many scientific reports that point to the adverse effects of this chemical to different animal models. There has been an increase in use of plastic during the last couple of decades and this has increased human exposure to plasticizers like Bisphenol A. But since little is known on how these endocrine disrupto...
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AN EFFICIENT, GREENER MICROWAVE ASSISTED MULTI-COMPONENT ONE POT SYNTHESIS OF [1, 3, 4] THIADIAZIN-2-YL-THIAZOLIDIN-4-ONES
This work involves synthesis of [1, 3, 4] thiadiazin-2-ylamine 3(a-c) derivatives from various substituted acetophenone derivatives 1(a-c), and thiosemicarbazide 2 mixed in ethanol and irradiation with microwaves which were directly used for next step. [1, 3, 4]Thiadiazin-2-yl)-thiazolidin-4-one 6(a-f) were synthesized in the second step from substituted-6H-[1, 3, 4] thiadiazin-2-ylamine 3(a-c), s...
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NEUROPROTECTIVE PROPERITY OF CENTELLA ASIATICA AGAINST PENTYLENE- TETRAZOLE INDUCED EPILEPSY IN RAT BRAIN WITH PARTICULAR REFERENCE TO LIPID METABOLISM
This study evaluated the anticonvulsant effect of different extracts of Centella asiatica (CA) with particular reference to lipid metabolism in different regions of rat brain. The rats were randomly divided into 4 groups having 6 in each group: i.e. Control group received saline, PTZ-induced epileptic group (60mg/kg b.w op/ 1 day), epileptic group pretreated with chloroform extract (CE),...
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COMPARATIVE ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACETONE / WATER EXTRACTS OF GRAINS AND BRANS OF GRANIFEROUS SORGHUM [SORGHUM BICOLOR (L.) MOENCH] HYBRID GUANIPA 71 IN VITRO
Sorghum is an important food source with substantial nutritional value. An in vitro antioxidant evaluation of different extractions of graniferous sorghum [Sorghum bicolor (L.) Moench] hybrid Guanipa 71 was proposed here. Acetone / water extracts of both grains and brans revealed strong antioxidant properties by reducing Fe3+ (22.9% and 42.3%) and chelating Fe2+ (47.3% and 32.4%), respectively. Mo...
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CHARACTERISTICS OF DIGESTION IN HIGH-PRODUCING COWS: DEPENDENCE ON THE FAT CONСENTRATION IN THE RATION DRY MATTER
Lipid metabolism in animals has recently gained growing interest among researchers. Among organic compounds, it is only protein and nucleic acids that for a long time have remained in primary focus of research, though lipids are now known to be essential for the origin of life and development of organic forms. Metabolic processes are very active in the bodies of high-producing cows. Large amounts ...
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