A STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS DETERMINATION OF TENELIGLIPTIN HYDROBROMIDE HYDRATE AND METFORMIN HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM
A stability indicating UPLC method was developed and validated for the determination of Teneligliptin hydrobromide and Metformin hydrochloride in bulk and tablet dosage form. The method was carried out using Endoversil column (2.1 × 50 mm, 1.8 mm) with mobile phase consisting of 0.1% v/v ortho-phosphoric acid: acetonitrile (80: 20) under isocratic mode with an injection volume 1 µl and at flow r...
MEDICATION ERRORS IN EGYPTIAN CRITICALLY ILL PATIENTS WITH RENAL INSUFFICIENCY: AN ASSESSMENT OF THE NEED FOR OPTIMIZING CLINICAL PHARMACY SERVICE
Background: The limited evidence of the critical role of clinical pharmacists in Egyptian teaching hospitals led to the fact that critical care pharmacists' responsibilities are still focused on dispensing and drug distribution. Objective: Assess the important role of clinical pharmacy service activities in an Egyptian intensive care unit (ICU) by describing the impact of medication errors on clin...
Objective: The objective of the study is to design and evaluate oral sustained release tablet of lamotrigine using polymer such as HPMC K 4M, HPMC K 100M and methocel E50 LV at 15%, 25%, and 35% Concentration range. Methods: All the selected ingredients were weighed and passed through 40# sieve, blended in a Poly Bag except Magnesium Stearate for 10 minutes. The resultant mixture was made in to...
DEVELOPMENT AND VALIDATION OF A LIQUID CHROMATOGRAPHY-ELECTRO-SPRAY IONIZATION-MASS SPECTROMETRY METHOD FOR THE QUANTITATION OF ERGOCALCIFEROL IN HUMAN PLASMA
A LC-MS method was developed and validated for determination of ergocalciferol in human plasma. n-hexane was used as extraction solvent while kinetex C18 50*2.1 mm, 1.7µm was used as analytical column for chromatographic separation. Mobile phase was acetonitrile: 0.1% formic acid in methanol (90:10). Turbo ion spray with positive polarity was used as an interface with API QTRAP 5500 LC/MS/MS syst...
Paneer has great value in diet because it is a rich source of high quality proteins, fat, and minerals. Paneer has a short life span of 2-3 days of refrigeration storage, but freshness of the product is lost after one day. So, the present study was carried out to know the quality of different brands of paneer sold in Delhi City. A total of 80 packets of eight different brands were analyzed for the...
COMPARATIVE STUDY OF AZADIRACHTA INDICA LEAF POWDER AND ITS DIFFERENT EXTRACTS ON GLYCEMIC, INSULINEMIC AND LIPIDEMIC STATUS OF TYPE 2 DIABETIC MODEL RATS
The present study was carried out to investigate the effect of oral feeding of A. indica leaf (powder, aqueous and 80% ethanol extract) in STZ induced type 2 diabetic rats. Diabetes was induced by single intraperitoneal injection of STZ to 48hrs old pups and experiments were carried out three months later. For chronic experiment type 2 rats were divided into 5 groups: 1) Water control, 2) Glibencl...
SYNTHESIS, CHARACTERIZATION AND ANALGESIC ACTIVITY OF SEVERAL NEW N-SUBSTITUTED PHTHALIMIDE ANALOGUES
The synthesis, characterization and spectroscopic studies of new N-substituted pthalimide analogues 2–7 with analgesic activity were described. The compounds were synthesized using phthalic anhydride with various appropriate amines (Triazolamine, Benzocaine, p-Nitro-aniline, pyrazinamide, Phenazone and glycine) in reflux synthesizer. The purity of the compounds was determined by TLC. With the ph...
Snake venom is cocktail of various enzymes, toxins. Snake venom components have major role as therapeutics application in current drug industry. Snake venom toxins plays vital role as one of the major component in case of bite and most of the toxins are lethal which are of various types such as cardio-toxins, myotoxins and neurotoxins etc. The Indian Cobra neurotoxins sequences were retrieved form...
THE EFFECT OF PHYTIC ACID ON RATE OF STARCH DIGESTIBILITY IN VICIA FABA AND WHITE WHEAT BREAD IN VITRO
ABSTRACT: The effect of the phytic acid on starch digestibility was studied in vitro. Starch digestibility was found to correlate negatively with the phytic acid content of the food tested.When sodium phytate was added (equivalent to 2% of phytic acid based on the starch portion), it was noticed that the rate of Viciafabastarch digestion by human saliva and at human body temperature (37°C) was de...
Diabetic neuropathy is one of the most serious microvascular complications of diabetes, which appears in about 50% of the patients suffering from diabetes. It is a nerve disorder caused by diabetes, characterized usually by numbness, pain or tingling in the feet or legs, which can lead to serious problems. Patients with diabetic neuropathy suffer from various types of pain. The underlying mechanis...