Volume 1 (2010) - Issue 9, September
Review Articles
NANOSUSPENSION: AN ATTEMPT TO ENHANCE BIOAVAILABILITY OF POORLY SOLUBLE DRUGS
Most of the new chemical entities coming out from High-throughput screening in drug discovery process are failing due to their poor solubility in the water. Poorly water-soluble drugs show many problems in formulating them in conventional dosage forms. One of the critical problems associated with poorly soluble drugs is too low bioavailability. The problem is even more complex for drugs belonging ...
4877
1909
TRANSGENIC ANIMALS: PRODUCTION AND APPLICATION
Organisms containing integrated sequences of cloned DNA (transgenes), transferred using techniques of genetic engineering (to include those of gene transfer and gene substitution) are called transgenic animals. The development of transgenic animals has been part of biotechnology research which has been expanding rapidly. Transgenic animals produced with the purpose of producing better and good qua...
134511
20223
A REVIEW ON ETHANOMEDICINAL USES AND PHYTO-PHARMACOLOGY OF ANTI-INFLAMMATORY HERB VITEX NEGUNDO
Vitex negundo is an important medicinal plant with potent anti-inflammatory activity. The major constituents of this plant are flavonoids, casticin, chryso-splenol and vitexin, Chrysophenol D, nishindine and hydrocotylene. It also contains monoterpenes agnuside, eurostoside, and aucubin. These constituents contribute various pharmacological activities as anti-inflammatory, antioxidant, antinocicep...
11786
1996
PHARMACOLOGICAL SCREENING OF ANTIULCER AGENTS: A REVIEW
Gastric hyperacidity and gastro duodenal ulcer is a very common global problem today. Among various causes of gastric ulceration lesions caused by stress, alcohol consumption, H.pylori infection and use of NSAIDs have been shown to be mediated largely through the generation of reactive oxygen species (ROS), especially hydroxyl radical (*OH). Hyper secretion of gastric acid is a pathological condit...
8363
2043
Research Articles
FORMULATION AND IN VITRO EVALUATION OF RAPIDLY DISINTEGRATING TABLETS OF LORATADINE
The aim of the present research work is to evaluate the impact of superdisintegrants in the formulation and evaluation of rapidly disintegrating tablets. In the present study, Loratadine is the model drug. Rapidly disintegrating tablets of Loratadine was prepared by direct compression method. In this method the different excipients used were Calcium Silicate (FM1000), Pharmattose DCl-21 (anhydrous...
4301
1671
ANTI-ALLERGIC AND ANTICATALEPTIC ACTIVITY OF AQUEOUS EXTRACT OF LEAVES OF AILANTHUS EXCELSA ROXB.
The anti-allergic of an aqueous extract of the leaves of Ailanthus excelsa Roxb.(AELAq) was evaluated by using milk induced leucocytosis and eosinophilia in mice, passive paw anaphylaxis in rats models while the anticataleptic properties was evaluated by Clonidine induced catalepsy in mice mode. The extract significantly (*p<0.05, **p< 0.01) decreased the leucocytosis and eosinophilia along ...
2919
1194
MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA-CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS
Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are ...
2864
1339
PHARMACOGNOSTIC STUDIES OF POTENTIAL HERB – TRIDAX PROCUMBENS LINN.
The study is aimed at development of physicochemical parameters and to investigate the active principle present in Tridax Procumbens Linn. Tridax Procumbens Linn. (Asteraceae) commonly known as Coat Buttons is an important plant used against various disorders in indigenous system of medicine such as Wound-Healing, Hepatoprotective, Anti-Inflammatory, Anti-diabetic and Immunomodulatory activities. ...
4186
1394
SYNTHESIS AND EVALUATION OF SOME ALDEHYDE DERIVATIVES OF 1, 4 DI-HYDRO PYRIDINE AND THEIR BIOLOGICAL EVALUVATION
Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, P...
2861
1252
EFFECT OF TRIDAX PROCUMBENS ON PROTEIN CONTENTS OF VARIOUS ORGANS IN FEMALE ALBINO RATS
The optimization of this study is biochemical effect of protein in Liver, Kidney, Uterus and Ovary of albino rats (Sprague-dawley strain) weighing about 200-250gm treated orally of ethanolic extract of plant Tridax procumbens at 300mg/kg body weight concentration for 3 and 5 days chronically. The result showed that both treated groups of rats are not showing very significant changes in protein con...
4279
1366
EVALUATION OF ANTIDIABETIC ACTIVITY OF A POLYHERBAL FORMULATION IN ALLOXAN INDUCED DIABETIC RATS
Objective of the study was to assess the antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats. Methods: The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan β- cytotoxin induced chemical diabetes in a wide variety of wister albino rats. Result: The polyherbal formulation contain the following plants l...
3312
1269
EVALUATION OF ANTIFUNGAL ACTIVITY OF CALOTROPIS GIGANTEA LATEX EXTRACT: AN IN VITRO STUDY
Medicinal plants are important source of potentially useful structures for the development of novel chemotherapeutic agents. The present study was aimed to evaluate the antifungal effect of partially purified C. gigantea latex extract on some human pathogenic fungi. Ethanolic extract of the latex were tested in vitro against fungi strains. The inhibitory effect was assessed by disc diffusion metho...
7275
2218
PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF SOLANUM NIGRUM ON THE BLOOD SUGAR OF ALBINO RATS
In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Solanum nigrum (commonly called Makoi) is also a medicinal plant. A dietary intake of Solanum nigrum supplies our body with nutrients that offer protection against numerous diseases. All parts of this...
3772
1392
PHARMACOGNOSTIC AND PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS ON PTEROSPERMUM ACERIFOLIUM LEAVES
Keywords: Pterospermum acerifolium, Pharmacognosy, Sterculiaceae, Drug StandardizationPterospermum acerifolium plant is considered to be laxative, anthelmintic, stomachic and used in inflammation, blood disorders, ulcers and leprosy. The leaf was studied for pharmaconostic evaluations, including examination of morphological and microscopic characters, determination of leaf const...
3179
1267
SYNTHESIS, ANTI-VIRAL AND CYTOTOXICITY STUDIES OF SOME NOVEL N-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES
A series of novel N-substituted benzimidazole derivatives were synthesized and screened anti-viral activity against a HIV -1 and -2 in MT-4 cells. New compounds were synthesized through modifying the N-1 hydrogen of benzimidazole moiety with the substitution of sulphanilamide, sulphadimidine, sulphamethoxazole, 2-aminopyridine, pthalamide, benzamide, nicotinamide, anthranilic acid and 2- marcapto-...
2978
1490
TISSUE CHLOROQUINE LEVELS IN DIABETIC RATS
Diabetes mellitus is a disorder of metabolism resulting from insulin abnormality. Tissue levels of chloroquine in diabetes were investigated. Few diseases have such plural effects in the body as diabetes mellitus. Chloroquine distribution in the tissue and blood was investigated in diabetic rats to a certain how diabetes mellitus affects the levels of chloroquine in tissues and blood. This may pro...
2766
1055
ANALYTICAL METHOD DEVELOPMENT AND ITS VALIDATION FOR THE ESTIMATIONOF THYMOL IN TACHYSPERMUM AMMI MILL FRUIT BY GAS LIQUID CHROMATOGRAPHY
Thymol is the main volatile compound extracted from dried fruits of Tachyspermum ammi Mill. The compound serves as a biological marker because of its interesting biological activities and is used in traditional medicine, as a bactericide, fungicide, Gastro-intestinal disorders, Bronchitis and asthma, and others. A GC method for the determination of thymol was developed. Chromatographic analysis wa...
3235
1301
IN VITRO ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACT OF VETIVERIA ZIZANIOIDES ROOT
Objective: To evaluate the antibacterial activity of ethanolic extract of roots of Vetiveria zizanioides. Method: Ethanolic extract of roots of Vetiveria Zizanioides was prepared. Standard cultures of Escherichia coli NCIM 2118; Bacillus subtilis NCIM 2063, P. aeurogenosa NCIM 2036 and Staphylococcus aureus NCIM 2079 were used for the study. The antibacterial tests used were the agar well plate...
5236
1518