Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
STUDY OF THE ENZYME-SUBSTRATE BY MOLECULAR MODELING INTERACTION; CASES OF THE DISEASE OF CANCER
This study was carried out with goal to predict the inhibition of Aurora Kinase B by a series of Oleocanthal by molecular modeling. During last year’s Kinases Aurora were emerged like one of the important targets of drug in several pharmaceutical companies and industries of research and it plays a main function in the regulation of the mitosis and the cytocinèse 1 and for this reason one inhibi...
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PREVALENCE AND RISK FACTORS OF METABOLIC SYNDROME IN ADULT TUNISIAN PATIENTS
Background: Metabolic syndrome (MetS) is a cluster of diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. We therefore aimed to estimate MetS prevalence and to determine risk factors for MetS. Methods: In the present study, we recruited 209 adult Tunisian MetS patients (57 males and 152 females, mean age 58.9±10.7 years) matched by gender and ethnic origin to 193 healthy i...
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THERMAL AND STRUCTURAL PROPERTIES OF IRRADIATED SILVER/POLY (VINYL ALCOHOL) (Ag/PVA) NANOCOMPOSITES USING ARGON ION BEAM
Structural and thermal properties of silver/poly(vinyl alcohol) (Ag/PVA) nanocomposites has been investigated as a function of Argon ion beam fluence. The XRD patterns (X-ray diffraction) showed the formation of the Ag/PVA in polymer structure and phase analysis with different sizes as a function of either ion beam fluence or Ag+ ion molar concentrations. The kinetic parameters for the thermal s...
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MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY IONOTROPIC GELATION TECHNIQUE
Diltiazem hydrochloride is a calcium channel blocker used in various cardiac diseases. It is associated with problem of short biological half life leading to high dosage frequency. Therefore, to ensure the controlled drug delivery systems of diltiazem the alginate-chitosan microspheres were prepared by Ionotropic gelation technique and characterized. The diltiazem hydrochloride SR microspheres w...
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QSAR STUDIES OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS
A QSAR studies on pyrazole derivatives as specific anticancer agents was performed with 37 (32 training + 5 test) compounds. QSAR studies were performed using chemOffice 6.0 software supplied by Cambridge soft. The sketched structures were subjected to energy minimization and then used to calculate the physiochemical properties. The regression analysis was carried out using a computer program call...
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CHEMICAL OXIDATION OF PHENYLEPHRINE BY USING CHLORAMINE-T IN ACID MEDIA: A KINETIC AND MECHANISTIC STUDY
The kinetics and mechanism of oxidation of Phenylephrine (PHE) by Chloramine-T (CAT) in acid media have been investigated by spectroscopic technique at the temperature of 298 K. It is found that the reaction is of first order with respect to PHE, fractional order with respect to CAT & inverse order with respect to H+. The reaction rate remained unchanged with the variation of ionic strength of...
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MITIGATING POTENTIAL OF ALLLIUM SATIVUM ON ARTESUNATE INDUCED RENAL TOXICITY IN MALE MICE
In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antim...
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EMBRYOTOXICITY IN DANIO RERIO USING FOENICULUM VULGARE AND ITS ABORTIFACIENT ACTIVITY
Danio rerio is one of the best model organisms to study various kinds of disorders. Their genome is fully sequenced and they possess easily detectable developmental properties. The development of their embryo is quite rapid. This is important as the embryos are formed by external fertilization, are large and transparent. Abortifacient is a substance that induces abortion. It can be used in the for...
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RESOLVIN AND LIPOXINS ENDUE UNVEILING ROLE IN MOA OF ASPIRIN: A REVIEW
Resolvins and lipoxins endue a novel way of approaching aspirin mechanism of action by developing models. Recent advances in research of aspirin from starting point Willow bark (Salix alba) to resolvins and lipoxins along with their repurposing network. Therefore, aspirin have a big impact on most interesting areas of research. Aspirin and there interaction with several targets molecules (Magic sh...
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IMPROVING SOLUBILITY OF CURCUMIN IN AQUEOUS SYSTEM BY THE SELF-ASSEMBLY OF HYPERBRANCHED POLY(AMIDE-ESTER) AND CURCUMIN
In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. Flu...
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