Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF NOVEL 1-(PYRIDINE-2YL)-1H-PYRAZOLE-5-CARBOXAMIDE DERIVATIVES
Introduction: Bacterial infections are associated with significant morbidity and mortality globally. This scenario is further complicated by the development of antibiotic resistance, which has an adverse impact on the world economy by increasing the treatment cost and prolonging the hospital stay. It also requires use of reserve antibiotics which have higher toxicity. Hence, new antibacterial drug...
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ANTIBIOTIC DE-ESCALATION IN BACTEREMIC UTI & ITS IMPACT ON COST AND LENGTH OF STAY-A PROSPECTIVE OBSERVATIONAL STUDY IN A TERTIARY CARE TEACHING HOSPITAL IN SOUTH KERALA
Urinary tract infection (UTI) is one of the most common infections affecting humans and is one of the leading causes of both community-acquired and nosocomial infections. The study's objective was to assess the rate of de-escalation and the impact of de-escalation on cost and length of stay, antibiotics utilization pattern, and adverse effects of antibiotics in bacteremic UTI. A prospective observ...
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FORMULATION, OPTIMIZATION AND EVALUATION OF NORFLOXACIN TRANSDERMAL PATCH FOR ANTI-BACTERIAL ACTIVITY
Objective: This investigation aimed to formulate, optimize and evaluate the matrix-type transdermal patch of norfloxacin for antibacterial activity by incorporating different polymer concentrations and penetration enhancers. Methods: Nine formulations were prepared by a solvent evaporation method using ethyl cellulose dibutyl phthalate, tea tree oil, and tulsi oil at concentrations (0.25%, 0.5%, 1...
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ANTIULCER ACTIVITY OF THE METHANOLIC AZADIRACHTA INDICA (NEEM) LEAVES EXTRACT ON INDUCED GASTRIC ULCERS
Gastric inflammation and ulceration are directly associated with accumulating reactive oxygen species, interleukins, TNF-α, and depletion of antioxidants. In addition to the frequent use of non-steroidal anti-inflammatory drugs, gastric lesions are also provoked by stress, alcohol consumption and Helicobacter pylori. Among other NSAIDs, Indomethacin has been very effective compound to generate a ...
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ATTENUATION OF INFLAMMATION AND MEDIATORS’ MODULATION BY PIPER PEDICELLATUM C. DC. LEAF CHLOROFORM EXTRACT IN GRANULOMA-INDUCED RATS
Objective: The study aims to evaluate the granuloma and associated inflammatory mediators inhibition potential of the chloroform extract of Piper pedicellatum C. DC. Leaves, as plant leaves, are being used traditionally in the mitigation of various inflammatory conditions; however, there is an insufficiency of scientific evidence about the relevant bioactivity of the plant. Method: The cotton pell...
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STRUCTURE-BASED VIRTUAL SCREENING AND IDENTIFICATION OF POTENTIAL INHIBITORS OF MYCOLIC ACID BIOSYNTHESIS ENZYMES (KASA, INHA, PKS13) FOR THE TREATMENT OF TUBERCULOSIS
Tuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis, identified as a global health emergency by the world health organization. The development of drug-resistance stains due to spontaneous gene mutation has been a major boost to research in the pathogenicity and biochemistry of Mtb. To combat drug resistance to tuberculosis, new drugs and methodologies are emerging. Since,...
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PAN-GENOMIC ANALYSIS OF HUMAN INFECTING SEROTYPES OF LISTERIA MONOCYTOGENES: IDENTIFICATION OF PUTATIVE DRUG TARGETS
Pan-genome analysis can identify the core genome, which is the total number of genes present in all strains of a bacterial species. Further essential genes can be identified in this core set of genes which gives us a minimal number of genes required for the survival of the bacteria. This set of genes can be analyzed to develop new antimicrobial agents against pathogenic, multidrug-resistant bacter...
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EVALUATION OF PHYTOCHEMICAL, ANTIBACTERIAL AND ANTIOXIDANT ANALYSIS OF LINUM USITATISSIMUM L. SEED EXTRACT
Plants have been widely adopted as the source of all drugs; this field has gradually broadened in developing countries where traditional medicine is essential in health care. Flaxseed is the seed from the plant Linum usitatissimum, which is an annual plant. This plant has attracted man’s attention for its advantages for human health. Plant materials contain a lot of bioactive phenolics, which de...
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SILVER NANOPARTICLES POSSESS ANTI-BIOFILM ACTIVITY AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS SAPROPHYTICUS ATCC 15305
An example of the human microbiota is Staphylococcus saprophyticus, a gram-positive, non-hemolytic pathogenic bacterium. It's a prevalent culprit behind simple infections associated with the urinary tract, especially among sexually active young women. It has a high colonization rate in the perineum, rectum, urethra, cervix, and gastrointestinal system and is also quite lethal. Because of their abi...
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GREEN SYNTHESIS OF SILVER NANOPARTICLES USING MILLETS, ITS CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY
The development of Nanotechnology has paved the way to study various nanomaterials. Nanoparticles are structures that measure the size from 1-100nm. Widely used nanoparticles are usually prepared using noble metals, that is, gold, silver, palladium, and platinum. At the same time, they find their way into a wide range of applications in medicine, electronics, energy saving, environment, textile, c...
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