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COW URINE- A PANACEA
Cow urine is considered a Sanjeevani–a medicine capable of curing any disease according to ancient manuscripts from Vedic times. The present study was conducted to validate the medicinal properties of cow urine in a scientific manner. The cow urine sample was procured from Indian indigenous cow Bos indicus from Bombay Panjrapole, Bhuleshwar, Mumbai, and commercial gaumutra from the local market....
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ANIMAL MODELS OF CHEMICAL-INDUCED ALZHEIMER’S DISEASE: AN OVERVIEW
Characteristics like dementia, behavioural and cognitive dysfunction, and memory decline may characterize Alzheimer's disease (AD). A deterioration of short-term memory, inability to acknowledge new information, mood swings, difficulty recognizing words, forgetting names, and losing things are demonstrated by early disease. Popular emotional characteristics displayed by patients with AD are anger,...
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UPLC STABILITY INDICATING METHOD FOR SIMULTANEOUS ESTIMATION OF GLECAPREVIR AND PIBRENTASVIR
A forced stability-indicating method for simultaneous estimation of glecaprevir and pibrentasvir by Ultra Performance Liquid Chromatography (UPLC) was developed and validated. The separation was done on column BEH C18 50 × 2.1mm 1.7m which was maintained at 30 °C, eluted with isocratic mobile phase and eluents were detected at 260nm. Mobile phase containing Buffer 0.01NKH2PO4: Acetonitrile taken...
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INFLUENCE OF PIOGLITAZONE ON IMMUNOMODULATORY ACTIVITY OF AZATHIOPRINE IN RODENT MODELS
The present study was designed to investigate the antioxidant and immunomodulatory activity of Azathioprine-Pioglitazone combination therapy to check whether it has added on benefit over monotherapy with Azathioprine or Pioglitazone in rodent models. The test drugs in combination showed better inhibition of free radicals in both H2O2 radical scavenging assay and nitric oxide scavenging assay than ...
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AMELIORATION OF DEXTRAN SULPHATE SODIUM INDUCED ULCERATIVE COLITIS IN MICE BY STEM BARK EXTRACT OF TERMINALIA TOMENTOSA
A plethora of herbs have been tested for their activity against ulcerative colitis, a debilitating disease in the group of IBDs. However, a promising adjuvant to conventional therapy remains still at large. Ellagic acid, a polyphenol widely available in berries have shown efficacy against ulcerative colitis in preclinical models. Owing to its high content of ellagic acid and its analogs, the stem ...
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QSAR STUDIES, SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS: AN APPROACH TO DESIGN ANTICANCER AGENTS
A series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(4-Amino-phenyl)-5-(3-nitro-phenyl)-4, 5-dihydro-pyrazole-1-carbothioic acid amide (AP-2) displayed the most potent EGFR inhibitory activity. The QSAR analysis of a set of these compounds tested for growth inhibitory activity ...
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DESIGN AND CHARACTERIZATION OF SOME NEW NON-SYMMETRIC SUBSTITUTED TRIAZINES AND TRIAZINE DERIVATIVES
Attempts were made to carry out the laboratory synthesis of non-symmetric mono-, di- and tri- substituted 1, 3, 5-triazines by the action of the electron-donating substituent on 2, 4, 6-trichloro-1, 3, 5-triazines by aromatic nucleophilic substitution reaction mechanism (SNAr reaction) by temperature controlled. The introduction of the amino group (-NH-), ether (-O-) and thiol (-S-) Linker Bridge ...
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DIURETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF FRAGARIA ANANASSA FRUIT IN WISTAR ALBINO RATS
Fragaria ananassa fruit are small shrubs belonging to family rosaceae. Fragaria ananassa mainly contains anti-oxidants such as tocopherols, ascorbic acid and b-carotene which are effective against cancer, heart disease and cataracts. The focus of the study was toanalyze the diuretic activity of hydro alcoholic extract of Fragaria ananassa fruit in albino rats. Diuretic activity of hydroalcoholic (...
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EVALUATING THE EFFECTS OF COMMIPHORA MOLMOL (MYRRH) AGAINST OXIDATIVE DNA DAMAGE IN HUMAN LYMPHOCYTES
Oxidative stress is a condition that might predispose individuals to diseases, including cancer. The 8- hydroxydeoxyguanosine (8-OHdG) is an index that reflects DNA damage caused by oxidative stress in the body. In this study, Commiphora molmol (Myrrh) (C. molmol) (Myrrh) that belongs to the family Burseraceae were investigated for its potential favorable properties to blunt DNA damage induced by ...
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SYNTHESIS, CHARACTERIZATION AND ANTITUBERCULAR ACTIVITY OF 6-(ARYL)-2-(SUBSTITUTED METHYL)-4,5-DIHYDRO(2H)PYRIDAZIN-3-ONE DERIVATIVES AGAINST MYCOBACTERIUM TUBERCULOSIS H37RV
Two series of pyridazinone derivatives, 6-(aryl)-2-(substituted methyl)-4,5-dihydro (2H) pyridazin-3-one derivatives (3a-8a and 3b-8b) were synthesized by reacting 6-phenyl substituted 2,3,4,5-Tetrahydro pyridazin-3-one (2a and 2b) with cyclic secondary amine under Mannich reaction conditions. These final compounds (3a-8a and 3b-8b) were characterized by spectral analysis (IR, 1HNMR and mass spect...
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