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XANTHOGRANULOMATOUS PYELONEPHRITIS- A RARE CASE REPORT
An unusual type of the long-lasting pyelonephritis demonstrating a long-lasting granulomatous disease resulting in a non-functional kidney in the patient is generally linked with xanthogranulomatous pyelonephritis. The name itself suggests this involves a granulomatous progression that is chronic, due to a chronic or sub-acute infection in the patient inciting a chronic but incomplete immune react...
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FORMULATION DEVELOPMENT OF AMOXICILLIN MICROSPHERE USING NOVEL NATURAL POLYMER
Amoxicillin is an antibiotic beneficial for the treatment of some bacterial infections. When orally administered it is slowly and scarcely absorbed from the gastrointestinal tract. The objective of the present work was to formulate and evaluate microspheres of Amoxicillin and produce sustained drug delivery. Microspheres can be manufactured from various natural and synthetic materials. In these 14...
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EFFECT OF QUERCETIN AND NERVE GROWTH FACTOR ON BIOCHEMICAL PARA-METERS OF THE BRAIN TISSUE IN RATS WITH EXPERIMENTAL NEURO-DEGENERATIVE DISORDER
The work was initiated to induce a toxic model of a neurodegenerative disorder with Alzheimer’s disease symptoms in rats and to study the effect of quercetin, an anti-oxidant, and nerve growth factor on some biochemical parameters and parameters of behavioral performance of the animals. It was established that upon induction of the neurodegenerative disorder by an intranasal administration of al...
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REVIEW: AVAILABLE ANALYTICAL METHODS FOR THE ESTIMATION OF FIRST LINE, SECOND LINE ORAL AND NEWER ANTI-TB DRUGS
Tuberculosis (TB) is one of the top ten causes of death worldwide. Presently, one-quarter of the world's population is thought to be infected with TB. New infections occur in about 1% of the population each year. Tuberculosis is a major global health threat. There is a progressive increase in multidrug-resistant (MDR) and extensively drug-resistant tuberculosis (XDR). Multi drug resistance (MDR)-T...
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IN- VITRO ANTIOXIDANT PROPERTIES, ACUTE AND SUBACUTE TOXICITY STUDIES OF TEPHROSIA CALOPHYLLA ON ALBINO WISTAR RATS
The evaluation of acute oral toxicity of chloroform extract of Tephrosia calophylla (CETC) and methanolic extract of Tephrosia calophylla (METC) and sub-acute toxicity of CETC was done on albino Wistar rats. The animals (female) were divided into four groups containing 3 animals in each group normal control, and 200, 400 and 800 mg/kg of freshly prepared extracts respectively, every 24 h orally fo...
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IN-SILICO MOLECULAR DOCKING ANALYSIS OF ISOLATED HOMOISOFLAVANONES FROM BULBS OF LEDABOURIA REVOLUTA AS GABAA RECEPTOR INHIBITORS
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate central nervous system (CNS); it activates the GABAA receptors that play a role in epilepsy. Targeting GABAA receptors through specific enhancement of neuronal inhibition involving GABA can be a better mechanism for identification of novel antiepileptic drugs. In this report, screening of novel isolated homoisof...
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DEVELOPMENT, OPTIMIZATION AND EVALUATION OF GASTRORETENTIVE TABLETS CONTAINING LOSARTAN POTASSIUM BY USING 32 FULL FACTORIAL DESIGN
Background: The present investigation was aimed at developing, optimize and evaluate gastroretentive floating tablets containing Losartan potassium to retain in the stomach for prolong and predictable period of time for hypertensive patients. In the present study, the effect of HPMC K15M showed prolong release of drug in gastric pH environment. Results: These formulations were evaluated for the pa...
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STUDYING THE EFFECT OF DISPERSED DRUG CRYSTAL IN THE ORGANIC PHASE ON THE ENCAPSULATION BY SOLVENT EVAPORATION TECHNIQUE; (1) EFFECT OF DRUG LOADING EXTENT ON THE PRODUCT SIZE ANALYSIS, MORPHOLOGY AND DRUG CONTENT
Eudragit RS100 microcapsules containing Aspirin as a model drug was prepared using solvent evaporation technique. The drug was dispersed in the organic phase and poured into the aqueous phase with stirring until microcapsules formation. The product was collected by filtration and air dried. The particle size analysis of the products was done and normal distribution curve showed for the same size r...
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COMPARATIVE EVALUATION OF ANTIDEPRESSANT ACTIVITY OF VARIOUS EXTRACTS OF NYCTANTHES ARBOR-TRISTIS
The present study evaluates the antidepressant activity of Nyctanthes arbor-tristis (NT). In the present study antidepressant effects of hydroalcoholic leaf extract (250 & 500 mg/kg) (NTL), flower extract (250 & 500 mg/kg) (NTF) and combination extract (leaf+flower extract in equal ratio) (250 & 500 mg/kg) (NTC) of Nyctanthes arbor-tristis were evaluated by the use of forced swim test....
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ALLELOPATHIC POTENTIAL OF LEAF LEACHATES OF CHROMOLAENA AND LANTANA ON MUNG BEAN (VIGNA RADIATA L. CV. K-851) SEEDS
Chromolaena and Lantana plants were analyzed to evaluate the existence of allelopathic effect using fully viable seeds of mung bean as the bioassay material. The study shows that pretreatment of mung bean seeds with various concentrations [1:1 and 1:2 (w/v)] of Chromolaena and Lantana leaf leachate for 24 h interval reduced the percentage germination. DNA and RNA contents were significantly reduce...
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