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PROTECTIVE EFFECT OF CINNAMOMUM ZEYLANICUM BARK AGAINST ACETAMINOPHEN INDUCED HEPATOTOXICITY IN ALBINO RATS
The objective of the current study is to investigate the hepatoprotective activity of Cinnamomum zeylanicum bark (CZB) extract on acetaminophen-induced hepatotoxicity in albino rats. Wistar albino rats (150-200 g) of either sex were divided into six groups, and toxicity was induced by acetaminophen (APAP) at a dose of 750 mg/kg, bw, p.o, every 72 h, for two weeks. Silymarin (100 mg/kg, p.o) was gi...
2021
1107
ETHICAL LANDSCAPE OF HERBAL MEDICINES
Remarkable numbers of people have a false belief in naturally obtained herbal medicines as they are safe to use, omitting the fact that herbal medicines have pharmacological action like allopathic medicines. Many plants are poisonous and there is less safety data available for herbal medicines. Adverse drug reactions associated with herbal medicines are overdose and toxicity, herb interactions and...
2020
842
DISSOLUTION ENHANCEMENT OF ROSUVASTATIN CALCIUM BY USING VARIOUS GENERATIONS OF HYDROPHILIC POLYMERS: A COMPARATIVE STUDY
Oral administration is the preferred route of drug administration owing to its convenience, patient compliance, and cost-effectiveness. The study aspired to augment the solubility and dissolution rate of Rosuvastatin calcium (RST) by using the solid dispersion (SD) technique with various generations of hydrophilic polymers. Hot melt and solvent evaporation methods were employed to prepare SD using...
2019
1419
MUCORMYCOSIS (THE BLACK FUNGUS) ASSOCIATED WITH COVID-19 PATIENTS- EPIDEMIOLOGY, PATHOGENESIS, DIAGNOSIS AND TREATMENT REGIMES
Mucormycosis is an opportunistic fungal infection caused by a member of the order Mucorales. It is an angio-invasive fungal infection because of its propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia (restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism), infarct (tissue death that is necrosis) due to inadequate...
2018
878
RADIOTHERAPY AGAINST SARS-COV-2: RISK OR BENEFIT
The noble coronavirus SARS-CoV-2 results in a devastating, multisystem disease among which COVID-19 pneumonia creates serious complications and most of COVID-19 related deaths. COVID-19 patients develop a systemic inflammatory response through interleukin (IL) and tumor necrosis factors. In COVID-19 patients, cytokine storm controlling is the key step for treatment because cytokine attacks own bod...
2018
1069
THE HYDROTROPIC EFFECT: A NOVEL STRATEGY FOR ENHANCED BIOAVAILABILITY
Several techniques were applicable to increase the aqueous solubility’s of poorly water-soluble drugs. Hydrotropy technique is one of them. In the present study, the hydrotropic agent has been used as a Solubilizing agent to solubilize BCS Class-II drugs that is poorly water-soluble drugs. Hydrotropy is an increase in the solubility of a solute in water by adding an agent termed hydrotrope. Incr...
2016
1147
A STUDY ON SERUM UREA AND CREATININE IN DIAGNOSED CASES OF SUBCLINICAL HYPOTHYROIDISM
Hypothyroidism is a progressive disorder characterized by varying degrees of thyroid failure, metabolic consequences, and hemodynamic changes that decrease renal plasma flow and glomerular filtration rate, increasing serum creatinine level. Therefore, the present study aimed to evaluate and analyse the level of serum urea, creatinine and thyroid function tests in cases of subclinical hypothyroidis...
2015
1122
CAPPARIS ZEYLANICA LINN: A COMPREHENSIVE REVIEW
Capparis zeylanica Linn (Capparidaceae), commonly known as “wild caper” is a plant species found in tropical regions. It is known as culinary and medicinal uses. The abstract of a comprehensive study on this plant might discuss traditional uses, phyto-chemical composition. Also, future perspectives about plant: is a computational technique used to study the interaction between small molecules,...
2015
1070
STUDIES ON ANTIMICROBIAL ACTIVITY OF CYMBOPOGON SPECIES OF KARNATAKA AGAINST CLINICAL ISOLATES
Antimicrobial activity of the various species of Cymbopogon plants like Cymbopogon citrates, Cymbopogon martini, Cymbopogon nardus, Cymbopogon flexuosus, Cymbopogon schoenanthus against various pathogens like E. coli, Bacillus subtilis, Streptococcus species, Salmonella typhimurium, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Serratia marcescens were studied with the help ...
2015
1095
THE EFFECT OF CONSTANT LIGHTING ON THE ORGANIZATION OF CIRCADIAN RHYTHMS OF HEMATOLOGICAL PARAMETERS IN WISTAR RATS AT AGE OF 6 MONTHS
The effect of constant lighting on the level of some hematological parameters and their daily dynamics was studied in male Wistar rats at the age of 6 months. It was found that staying in constant light for 3 weeks leads to a rise in hematocrit level, mainly due to an increase in the number of red blood cells, while a decrease in the oxygen-transporting properties of these cells is noted. An analy...
2014
1000