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EFFECT OF HYDROALCOHOLIC EXTRACT OF SIDA SPINOSA L. ON 2,4,6-TRINITRO-BENZENESULFONIC ACID INDUCED ULCERATIVE COLITIS IN RATS
The present study aimed to evaluate the effect of hydroalcoholic extract of Sida spinosa L. (HYSS) in colitis induced in rats by intrarectal administration of TNBS by clinical, morphological and biochemical alterations. The HYSS administered at three different concentrations 100, 200 and 400 mg/kg, p.o. and sulfasalazine (50 mg/kg, p.o) as reference standard for 10 days in colitis induced rats. TN...
2025
1168
SAFETY AND EFFICACY OF FORMOTEROL/TIOTROPIUM BROMIDE AND FORMOTEROL/GLYCOPYRRONIUM COMBINATION IN COPD WITH GOLD GRADE 3 PATIENTS
An increasing airflow limitation that is not entirely reversible is a hallmark of chronic obstructive pulmonary disease (COPD). In patients with COPD, the present study investigated the effectiveness and safety of formoterol/tiotropium bromide vs formoterol/glycopyrronium in fixed combinations. In conjunction with formoterol, the long-acting anti-muscarinic drug glycopyrrolate has recently receive...
2025
759
FORMULATION AND EVALUATION OF POLY-HERBAL ANTI-DIABETIC FAST-DISSOLVING TABLET FROM HOME REMEDY AND COMPARISON WITH MARKETED METFORMIN TABLET
The current study's purpose was to develop and test a multi-herbal anti-diabetic quick-dissolving tablet compared to a commercially available metformin tablet. The multi-herbal anti-diabetic tablet contains natural medicines with anti-diabetic properties, such as Curcuma longa, Cinnamomum zeylanicum, Zingiber officinale, and Trigonella foenumgraecum. This mixture contains the botanical extracts Cu...
2024
1326
SHORT TERM (21 DAYS) TOXIC IMPLICATIONS OF PERMETHRIN ON REPRODUCTIVE TISSUES OF MALE SWISS ALBINO MICE
Permethrin, a member of one of the newest class of insecticides, the synthetic type-I pyrethroids, is very much in use nowadays. Due to its relatively low mammalian toxicity and high photostability, it has earned great popularity. Several reports suggest its endocrine disrupting activity, damaging effect on nervous system, its receptors, and other adverse effects. However, very limited information...
2024
1143
REVIEW STUDIES ON THE FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF SOME ANTINEOPLASTIC DRUGS
Cancer refers to a group of diseases characterized by abnormal, unchecked cell growth that spreads to other body parts. Breast, liver, colorectal, kidney, stomach, lungs, and cervical cancer are the most common tumours, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percent of the cases). Surgery, chemotherapy, and other traditional medical methods have several...
2023
1912
WATER-SOLUBLE VITAMIN IN TEN WILD EDIBLE FRUITS CONSUMED BY THE TRIBAL PEOPLE OF NORTH-EASTERN REGION IN INDIA: SIMULTANEOUS ESTIMATION BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) METHOD
The present study aimed to develop a reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of water-soluble vitamins like ascorbic acid (C), thiamine (B1), riboflavin(B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6) and folic acid (B9) in ten potent wild edible fruits named Artocarpus gomezianus, Baccurea sapida, Cyclanthera pedata, Flacourtia jang...
2022
1091
SOLID DISPERSION EXTENDED-RELEASE SYSTEM: A REVIEW
Solid dispersion extended-release system involves amorphization of drug material that leads to creating an alternative pathway for poorly water-soluble drugs. The drug increases solubility due to an increase in apparent solubility of the particular drug. Crystalline lattices of the drug are disturbed during its manufacture, which minimizes the crystal packing energy for solubilization. Along with ...
2021
866
QUALITY STANDARDIZATION OF AYURVEDIC FORMULATIONS – SANSHAMANI VATI AND MAHALAXMIVILAS RASA
Purpose: Sanshamani Vati (SHV) is useful in all types of Jwara, and Mahalaxmivilas Rasa (MLVR) is the best drug in various cardiovascular and respiratory disorders. To maintain the enormous trust in Ayurveda, it’s necessary to ascertain the quality, efficacy & safety of Ayurvedic formulations on scientific lines using modern techniques. Present work attempts have been made to standardize the...
2021
1082
SOLID DISPERSION: STRATEGIES TO ENHANCE SOLUBILITY AND DISSOLUTION RATE OF POORLY WATER-SOLUBLE DRUG
The solubility problem of drugs is always one of the most challenging aspects in formulation and development of dosage forms. In fact, most of new chemical entities are poorly water soluble and not well-absorbed after oral administration resulting in low bioavailability. The current challenges of the pharmaceutical industries are related to techniques that improve the water...
2020
1676
DEVELOPMENT AND VALIDATION OF THE METHOD FOR THE SIMULTANEOUS ESTIMATION OF ACECLOFENAC AND PANTOPRAZOLE
In the present research work, a new UV spectroscopic and RP-HPLC method was described for simultaneous estimation of Aceclofenac (ACL) and Pantoprazole (PNT). Simultaneous Equation method was applied for the spectrophotometric determination of ACL and PNT. Statistical calculations were done by use of 276 nm and 289 nm wavelengths. In RP-HPLC method, the estimation of ACL and PNT carried out by ACN...
2019
848