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SIMULTANEOUS EQUATION METHOD AND ABSORPTION CORRECTION METHOD FOR THE ESTIMATION OF PERINDOPRIL ERBUMINE AND AMLODIPINE BESYLATE IN BULK AND IN COMBINED TABLET DOSAGE FORM USING UV SPECTOPHOTOMETRY
In the present work a simple, accurate and precise method has been developed and validated for the simultaneous estimation of Perindopril Erbumine (PDE), Amlodipine Besylate (AMD)and in their combined dosage form by UV Spectrophotometric Methods. The Method A employs estimation of drugs by simultaneous equation method (SEM) using 298.3 nm and 231.9nm i.e. λmax values of PDE and AMD respectively. ...
2077
822
0
EFFECTS OF ALLIUM SATIVUM ON BODY WEIGHT AND BIOCHEMICAL PARAMETERS IN HEALTHY RATS
This case-control study had undertaken to evaluate effect of Allium sativum in normal rats. In this study ethanol extract of Allium sativum had macerated with aqueous gum acacia (2%, w/v) suspension and fed orally (500 mg/kg b w p. o.) to male adult normal rats of charles foster strain for 15 days. Results of this study showing that alcoholic extracts caused no any significant reduction in blood g...
2077
1059
IDENTIFICATION OF POTENTIAL INHIBITOR AGAINST EXFOLIATIVE TOXIN A ASSOCIATED WITH STAPHYLOCOCCUS AUREUS INFECTION – A MOLECULAR DOCKING APPROACH
Staphylococcus aureus is a frequent colonizer of the human body as well as a serious human pathogen. It can cope with stress factors and acquire resistance to antibiotics, thus rendering treatment difficult. Discovering new treatments for this disease is urgently required, especially in view of the emergence of multiple drug resistant organisms and to reduce the total duration of current treatment...
2076
1068
PORTRAYAL EXPLORATION OF PHARMACEUTICAL NANOPARTICLES
Nanotechnology has found its way into most science fields at a tiny scale. Particle of this size and molecules were found to work differently and got diverse applications. Novel drug delivery system leads to the development of Nanocarriers, including Nanoparticles, Nanospheres, Nano capsules, Nano emulsion, liposomes, and Niosomes. The major area for research is to design Nanoparticles that can ef...
2076
1248
A SYSTEMATIC REVIEW ON MUCOADHESION A NOVEL DRUG DELIVERY SYSTEM
The phenomenon known as mucoadhesion is characterized by interfacial molecular attractive forces between a natural or synthetic polymer and the surface of a biological membrane. This allows the polymer to stick to the membrane's surface for a prolonged period of time. The idea of mucoadhesion has garnered significant attention in many pharmaceutics sectors during the past forty years. The mucoadhe...
2075
1084
IMPROVED BIOAVAILABILITY OF LINAGLIPTIN BY RESVERATROL IN RATS- INVOLVEMENT OF PERMEABILITY GLYCOPROTEIN (P-gp) INHIBITION
The maintenance of an appropriate serum concentration of a drug is important to ensure therapeutic efficacy. Functional alterations of drug transporters may influence the serum concentration of drugs through changes in its pharmacokinetics and pharmacodynamics (PK/PD). In this study, we have focused on the influence of functional alterations in the intestinal P-glycoprotein (P-gp) on the PK of lin...
2075
1278
WATER-SOLUBLE VITAMIN IN TEN WILD EDIBLE FRUITS CONSUMED BY THE TRIBAL PEOPLE OF NORTH-EASTERN REGION IN INDIA: SIMULTANEOUS ESTIMATION BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) METHOD
The present study aimed to develop a reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of water-soluble vitamins like ascorbic acid (C), thiamine (B1), riboflavin(B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6) and folic acid (B9) in ten potent wild edible fruits named Artocarpus gomezianus, Baccurea sapida, Cyclanthera pedata, Flacourtia jang...
2073
1113
CYTOTOXICITY OF EXTRACTS FROM THE PHILIPPINE MARINE SPONGES: PARATETILLA SP., STYLISSA SP. AND PETROSIA (STRONGYLOPHORA) NIGRICANS
This paper reports the cytotoxic activities of the hexane, dichloromethane, ethyl acetate, and methanol fractions of the marine sponges: Paratetilla sp., Stylissa sp., and Petrosia (strongylophora) nigricans, collected from the Island waters of Lipata, Surigao del Norte, Philippines, using the enzymatic reduction of a yellow tetrazolium salt, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium...
2073
1094
FORMATION OF INCLUSION COMPLEX OF ANTI-INFLAMMATORY TRITERPENOID CABRALEONE (DN12) WITH HYDROPHILIC BETA CYCLODEXTRIN POLYMER (β-CD-P)
The main objective of this study was to improve the solubility of the triterpenoid cabraleone (DN12) and to investigate the anti-inflammatory activity of the complex. DN12 was stabilized by a complex formation with β-cyclodextrin polymer (β-CD-P) in a molar ratio of 1.0:1.0. The DN12 extract and the cyclodextrin complex have been equilibrated in ethanol at 25°C for approximately 24 h. The β-cy...
2072
945
ANTAGONISTIC MECHANISM OF ANTI-FUNGAL COMPOUNDS FROM ASPERGILLUS GIGANTEUS ON HUMAN FUNGAL PATHOGENS
Cryptococcus neoformans and Candida albicans are the major causative agents for infections, cryptococcosis, and candidiasis in human. Anti-fungal drugs for the treatment of fungal infections may show less effective activity on the pathogens due to the poor absorption or inadequate drug distribution, and some pathogens may evolve anti-fungal drug resistance. The development of anti-fungal drugs fro...
2071
934