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PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF AZADIRACHTA INDICA A. JUSS (MELIACEAE) (CÔTE D’IVOIRE)
The purposes assigned to this work are the phytochemical screening of certain phytoconstituents, the estimation of the antioxidant and antibacterial activities of extracts of Azadirachta indica A. Juss. The selective extracts obtained from the aqueous decocts were used to establish the chromatographic profile of the various extracts. As for the crude aqueous extracts, they were used to carry out t...
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FORMULATION AND IN-VITRO EVALUATION OF SOLID LIPID NANOPARTICLES CONTAINING NADOLOL
The solid lipid nanoparticles are sub-micron colloidal carriers (50-100 nm) that are composed of physiological lipid dispersed in water or in aqueous surfactant solution. Nadolol-loaded SLNs were prepared by modified high shear homogenization. It was observed that all formulations contain a good product yield. The highest drug content was found in formulation F5 98.37%. Entrapment efficiency for f...
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BIOLOGICAL ASPECTS OF NOVEL BENZOTHIAZOLE DERIVATIVES
The heterocyclic compounds are formed by the hetero atoms (O, S, N, etc.) in the cyclic ring system. These are mainly started from 3- membered to 10- membered heterocyclic rings. The compound containing heterocyclic molecules shows potent activity in various pharmacological targets. Benzothiazole is a fusion of a benzene ring with a 5-membered thiazole ring which is widely used in heterocyclic com...
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DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING HPTLC ASSAY METHOD OF REMOGLIFLOZIN ETABONATE IN BULK AND MARKETED FORMULATION
Remogliflozin Etabonate (RE) is the latest addition to the sodium-glucose transport proteins 2 inhibitor class of drugs recently approved in India to manage type 2 Diabetes Mellitus. Literature survey revealed that no high-performance thin-layer chromatographic (HPTLC) method had been reported to date for this drug. The present work describes the development and validation of an HPTLC method for R...
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A COMPREHENSIVE REVIEW ON PSIDIUM GUAJAVA LINN: AS AN HERBAL REMEDY
Psidium guajava Linn is an herbal remedy used in Ayurveda as a traditional system of medicine in ethnomedicine. It is a tropical evergreen plant that grows in tropical and subtropical climates. It has a wide variety of nutritional components. The whole plant and various parts of the plants possess different types of therapeutic activity, such as Tannin, phenols, triterpenes, flavonoids, essential ...
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BIOACTIVE COMPOUNDS FROM MARINE INVERTEBRATES AND THEIR PHARMACEUTICAL POTENTIAL
Marine environment is an exceptional storehouse of novel bioactive natural products that are mainly found in invertebrates such as sponges, arthropods, annelids, molluscs, etc. This diversity has been the source of unique chemical compounds. A large portion of these natural compounds has been extracted from marine invertebrates. Marine invertebrates are rich sources of bioactive compounds and thei...
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A NEW ASSAY METHOD DEVELOPMENT AND VALIDATION OF TWO ANTI-CANCER DRUGS BY USING EFFECTIVE LIQUID CHROMATOGRAPHIC METHOD
A simple, sensitive and rapid chromatographic method was developed and validated for quantification of Mitomycin and Fluorouracil in bulk and pharmaceutical dosage form using Symmetry C18 (4.6 × 150 mm, 3.5 µ) column. The mobile phase consists of buffer, 0.1% Ortho Phosphoric acid (OPA), and acetonitrile in the ratio of 50:50 v/v. The flow rate is maintained as at 1.0 ml/min; detection was carri...
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APPLICATION OF THE INFORMATION TECHNOLOGIES IN EARLY PREDICTING THE SEVERITY OF ATOPIC DERMATITIS IN CHILDREN
The application of mathematically based prognostic software is a rational and promising approach to determining disease prognoses. In our research, we identified indicators as prognostic criteria for the development of atopic dermatitis (AD). Our research involved 260 healthy children and 268 newborns with AD. To select the risk factors for predicting the formation of AD, initially, variation and ...
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NOVEL IN-SITU GEL TO PROVIDE SUSTAIN RELEASE DRUG DELIVERY FOR OCULAR FUNGAL KERATITIS
Ocular deliveries possess a challenging pharmaceutical approach due to poor absorption index through the corneal appendages and washing away of the drug through tears and lachrymal secretion. The ocular appendages lead to provide lesser bioavailability of conventional dosage forms; hence, frequent dosing is advised to get the optimum effect of the medicine. Therefore, in-situ gel offers a promisin...
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RECENT RECOMMENDATIONS IN THERAPEUTIC APPROACHES FOR DIABETES AND ITS COMORBIDITIES
Diabetes Mellitus (DM) is a persistent metabolic cluster of diseases that involves erroneously excessive blood glucose levels. The polygenic disorder cluster of diseases includes Type I, Type II, Physiological state polygenic disorder (Gestational diabetes), Infant polygenic disorder (Neonatal diabetes), Maturity Onset Diabetes of the Young (MODY), and secondary causes because of endocrinopathies,...
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