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SCREENING OF NATURAL PIGMENTS FROM SEAWEED KAPPAPHYCUS ALVAREZII AND ITS EFFICACY IN PHARMACEUTICAL PRODUCTS
This paper focused on research on seaweed contains good nutritional source of protein, carbohydrate, pigments, vitamins, and antioxidants and has low lipid content. The source of natural substances has considered more efficient bio-molecules in building immunity and improving resistance to cancer development, prevent infections were analyzed. Classical biochemical methods were applied for extracti...
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IDENTIFICATION AND QUANTIZATION OF OLEANOLIC ACID IN STEM AND ROOTS OF ACHYRANTHES ASPERA USING VALIDATED HPTLC METHOD
Objective: Active chemical constituent in plants exhibits pharmacological action. Hence this research work aimed to identify and quantitate oleanolic acid. Methods: A simple, high-performance thin-layer chromatography (HPTLC) is developed and validated to identify and quantify oleanolic acid. The extracts were spotted as bands on aluminum TLC plates which were pre-coated with silica gel. Different...
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PORTRAYAL EXPLORATION OF PHARMACEUTICAL NANOPARTICLES
Nanotechnology has found its way into most science fields at a tiny scale. Particle of this size and molecules were found to work differently and got diverse applications. Novel drug delivery system leads to the development of Nanocarriers, including Nanoparticles, Nanospheres, Nano capsules, Nano emulsion, liposomes, and Niosomes. The major area for research is to design Nanoparticles that can ef...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL QUINAZOLINE DERIVATIVES AS ACID PUMP ANTAGONISTS
Gastric acid hypersecretion is a major cause of gastric complications like hypergastrinemia, hyperhistaminemia and Zollinger-Ellison syndrome. Out of various drug treatments used, H2-receptor antagonists possess some limitations, such as the development of tolerance when used for a long period, having a short duration of action, and no complete inhibition of acid secretion in response to a meal. I...
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SYNTHESIS AND ANTI-CONVULSANT ACTIVITY OF NOVEL BENZHYDRYL PIPERAZINE DERIVATIVES
A series of 1 - (4 -Benzhydryl piperazin-1-yl) -3-(mono -substituted) propan-1-one (7c-i) and N - (substituted) - 2 - (4 –benz-hydrylpiperazin – 1 - yl) acetamide (7a, 7d) were designed, synthesized and evaluated for their anticonvulsant and neurotoxicity activity. The chemical structure of the synthesized compounds was elucidated by spectral and elemental analysis. Compounds like 7d, 7c, and ...
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IN-VIVO EVALUATION OF GLICLAZIDE SOLID DISPERSIONS INCORPORATED TABLETS FOR CONTROLLED DRUG RELEASE
Gliclazide is an anti-diabetic medication used to treat diabetes mellitus type 2.It suffers from deprived solubility, reduced drug dissolution, and bioavailability. The current paper is aimed to formulate and evaluate gliclazide solid dispersion with HP β Cyclodextrin for enhanced solubility and incorporate into controlled-release tablet formulation. Gliclazide solid dispersion (SD) was prepared ...
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EVALUATION OF HEPATOPROTECTIVE POTENTIAL OF ALSTONIA SCHOLARIS STEM BARK AGAINST CCL4 INDUCED HEPATOTOXICITY – AN IN-VIVO SCREENING
The hepatoprotective potential of ethanolic extract of stem bark of Alstonia scholaris belonging to the family Apocynaceae and commonly known as Devil’s tree or Saptaparni was assessed against carbon tetrachloride-induced hepatotoxicity in Wistar rats. It is an evergreen tropical tree native to the Indian sub-continent and Southeast Asia and contains various phytoconstituents like alkaloids, tri...
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DOSE APPROPRIATENESS AND ADJUSTMENT OF DRUGS IN CHRONIC KIDNEY FAILURE PATIENTS IN A TERTIARY CARE HOSPITAL OF TELANGANA
Background: Dose appropriateness in Chronic Kidney Disease patients is crucial to avert toxicity since several drugs are eliminated through kidneys. The present study was taken up to identify the degree of appropriateness in the dosage regimen of patients with chronic kidney disease (CKD) patients. Methods: The study was a prospective observational study carried out in the Department of Nephrology...
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STRUCTURAL TRANSFORMATION OF LUPEOL AND EVALUATION THEIR IN-VITRO ANTIOXIDANT ACTIVITY
Lupeol (I) is a naturally occurring triterpene that has been isolated from the stem bark of Crataeva nurvala in appreciable amount. Due to the presence of a single hydroxyl group and a large, apolar skeleton, lupeol acts as an amphiphile. The two possible sites for chemical modification present in lupeol are ring-A and isopropenyl side chain. We modified it in three naturally occurring analogous d...
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AMINO ACID PROFILING AND PROTEIN CONTENT DETERMINATION OF BOVINE MILK COLLECTED FROM DIFFERENT TEHSIL OF SINGRAULI DISTRICT
Milk and milk products are nutritious food items containing numerous essential nutrients. This study was carried out to determine the influence of variable season on profiling of amino acid and protein content from 90 bovine milk collected (March 2018 to February 2019) samples belongs to four tehsils of Singrauli district. The most abundant amino acid was glutamic acid, followed by proline and leu...
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