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IN-SILICO DESIGN AND DOCKING STUDY OF SOME 4-(10-ACETYL-10H-PHENO-THIAZINES-3-YL)-1-PHENYLAZETIDIN-2-ONE DERIVATIVES
Background: The current study used computational approaches to investigate the molecular, physicochemical and drug-like properties of some 4-(10-acetyl-10H-phenothiazines-3-yl)-1-phenylazetidin-2-one derivatives. Methods: The structures of the compounds were drawn using Chemdraw ultra12 and smiles were generated using ACD chem sketch software. The physicochemical and molecular properties were calc...
2005
1051
CHEMICAL PROFILE OF THE ANTIBACTERIAL COMPONENT FROM LEPTOLYNGBYA SP. HNBGU 002 ISOLATED FROM A HOT SPRING OF GARHWAL HIMALAYA
Cyanobacteria are a well-established source of antibacterial compounds. However, the hot spring cyanobacterial strains are not properly explored for the purpose. The study investigates the antibacterial potential of the thermophilic oscillatoriales isolated from a hot spring of Garhwal Himalaya. Out of 48 endo-metabolite pools, extracted from 16 thermophilic cyanobacterial strains, tested for anti...
2005
993
TO STUDY THE EFFECT OF NATURAL POLYMER ON THE RELEASE OF OSMOTIC TABLET FOR COLON SPECIFIC DRUG DELIVERY SYSTEM
Controlled and targeted drug delivery system is more advantages than conventional dosage in various aspects. In the case of treating colonic disorders such as inflammatory bowel disease, the drugs do not reach the site of action in appropriate concentration. Thus there is a need to develop effective and safe therapy for the treatment of these colonic disorders, using site-specific drug delivery ap...
2005
950
A SENSITIVE LC-MS/MS ASSAY FOR THE DETERMINATION OF NAFTOPIDIL IN HUMAN PLASMA AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
A specific, rapid, and sensitive LC-MS/MS assay was developed and validated for the determination of Naftopidil in human plasma. Naftopidil d7 was used as an internal standard (IS). A faster and one-step protein precipitation (PP) technique was employed for sample preparation. The processed samples were chromatographed on a C18 column using ammonium formate (5mM) buffer in combination with acetoni...
2003
1298
PHARMACOGNOSTICAL STANDARDIZATION AND HPTLC FINGERPRINT PROFILE OF ORIGANUM VULGARE L. (LAMIACEAE)
India is a great source of naturally occurring plant drugs which are having potential pharmacological activities. Origanum vulgare L. (Lamiaceae) is one of the most important medicinal plants in India, consisting of aromatic and medicinal properties which is used to cure many ailments. In spite of its plethora of uses as medicine and food additives since ancient times, it has reaped very little sc...
2003
1323
DEVELOPMENT AND VALIDATION OF STABILITY-INDICATING HPTLC METHOD FOR ESTIMATION OF CELECOXIB AND AMLODIPINE BESYLATE FROM SYNTHETIC MIXTURE
The current research paper describes a highly specific, reproducible, and efficient stability-indicating HPTLC method for estimation of Celecoxib and Amlodipine Besylate from its synthetic mixture. Chromatographic separation and quantification carried out on Merck HPTLC aluminum sheets of silica gel 60 F254 using Chloroform: Acetone: Toluene: Methanol in the ratio of 5:3:2:0.5 v/v/v/v as solvent s...
2003
1293
HERBAL DRUG LOADED NANOGEL FOR EFFECTIVE TREATMENT OF SKIN DISORDERS
Since ancient times, plants have been used for medicinal purposes for their various therapeutic potentials and safest to modern allopathic medicines. Regularly phytochemicals are proving to be modern medicine with novel drug delivery systems by treating different diseases and disorders. Phytochemical compounds need improvement of efficacy and patient's compatibility to deliver in various diseases,...
2001
1520
METHOD DEVELOPMENT, VALIDATION AND FORCED DEGRADATION STUDIES OF NEW RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF REMOGLIFLOZIN AND TENELIGLIPTIN IN PURE AND TABLET DOSAGE FORM
According to ICH guidelines, an easy, cost-effective, accurate, and precise RP-HPLC method for simultaneously determining Remogliflzin and Teneligliptin was developed and validated. The drug's quantity was determined using a photodiode array (PDA) detector. The column was run in isocratic mode with mobile phase acetonitrile and ammonium phosphate buffer at a 40:60 ratio. The flow rate was one mill...
2001
1201
NANOCURCUMIN SELECTIVELY ACTIVATES ENDOTHELIAL NITRIC OXIDE IN MIDDLE UTERINE ARTERY OF GOAT (CAPRA HIRCUS)
Objective: The present study is designed to investigate vasorelaxation mechanisms of Nanocurcumin in the middle uterine artery (MUA) of both non-pregnant (NP) and pregnant (P) Capra hircus (Ch). Methods: MUA rings were mounted in an automatic organ bath and the contractile response was recorded isometrically by highly sensitive force transducer connected to a power lab data acquisition system. Nan...
2001
1137
APPLICATION OF BIOANALYTICAL METHOD IN PHARMACOKINETIC STUDIES OF DIKAMALI GUM BASED MICROSPHERES OF FLURBIPROFEN FROM RABBIT BLOOD SAMPLES
Preparation and evaluation of dikamali gum-based microspheres of Flurbiprofen, needed a suitable bioanalytical method. In this direction, we report the development of a simple RP-HPLC method for the determination of Flurbiprofen in rabbit plasma samples by using the standard internal method. The method was carried out on RP C18 column, with a mixture of the buffer: acetonitrile (60:40) as the mobi...
2000
1191