Posted by admin on Dec 31, 2021 in |
Background: Cardiometabolic syndromes are the co-occurrence of metabolic abnormalities such as obesity, insulin resistance, atherogenic dyslipidemia, and hypertension. Cardiometabolic disorders includes type2 diabetes mellitus, metabolic syndrome, and cardiovascular diseases. The prevalence of cardiometabolic disorders are growing in epidemic proportions all over the world; hence cardiometabolic disorders are a major health problem in developing as well as in developed countries. It has been observed in the previously reported clinical studies that deficiency of vitamin D is a highly prevalent risk factor in the patients with cardiometabolic disorders and it has been suggested that deficiency of vitamin D has a crucial role in the pathogenesis of cardiometabolic disorders. Aim: To reveal the role of vitamin D deficiency in cardiometabolic disorders and the opportunity of vitamin D supplementation as vital therapy in cardiometabolic disorders. Methods: We performed a systematic review based on available literature of vitamin D deficiency in cardiometabolic disorders using PubMed, Google Scholar, Science Direct, and Willey online library databases up to November 2020. Conclusion: Vitamin D deficiency has a...
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Posted by admin on Dec 31, 2021 in |
Chronotherapeutic systems are meant for the treatment of most of the diseases that occurred and found till date, which are proved to be in association with the biological/circadian rhythms of our body with respect to disease symptoms and their severity. Such diseases use this treatment as it involves in-vivo drug availability with distinctive release patterns so as to match the rhythms of disease and achieve optimized therapeutic outcomes with minimized side effects. The specific time at which patients take their medications is taken into consideration as it is the main reason for the treatment success. There is a synchronization of pharmacodynamics and pharmacologic activity of drugs with that of the biological clock, so variations in disease state and plasma drug concentration are taken into consideration during the development of this drug delivery system. Various novel technologies are employed in developing Chronotherapeutic devices and dosage forms, some are available in the market already, and many others are yet to arrive. The main objective of this review is to explore the...
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Posted by admin on Dec 31, 2021 in |
Hugonia mystax is a woody evergreen plant that grows in the dry forest areas of India and Sri Lanka. Often found in the forests of Kerala and Tamil Nadu in southern India. It is locally known as modirakanni (tamil) and kamsamaraha and tribals from Tamil Nadu, India, have used it in primary health care. The plant parts are used ethnobotanically to treat rheumatism, skin diseases and inflammations, snake bites, fever, and worm infestation. Hugonia mystax is an antibiotic, anthelmintic, febrifuge, astringent, peptic ulcer and verminosis remedy. Hugonia mystax has been practising herbal medicine for a long time. This plant is a member of the linaceae family and is an essential medicinal plant in Indian medicine. To evaluate the extractive values, powdered materials were subjected to successive extractions with ethanol using the Soxhlet process. The existence of several compounds such as flavonoids, phenolic elements, steroids, tannins, saponins, terpenoids, and carbohydrates was revealed by qualitative phytochemical screening of the ethanolic extracts of the leaves, as well as GC-MS analysis to examine...
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Posted by admin on Dec 31, 2021 in |
Patients with psychotic disorders often require long-term and intensive treatment. Several drug utilization studies have been carried out using WHO (World Health Organization) prescribing indicators, but these studies are deficient for psychiatry patients in India. To analyze antipsychotic prescriptions according to WHO core prescribing indicators and identify various techniques used for switching over from one antipsychotic to another, a cross-sectional, observational study was conducted with one year and six months duration. 128 patients were enrolled who fulfilled the inclusion criteria and gave written informed consent. This study revealed male (53.91%) predominance over female patients (46.09%). The average number of drugs prescribed per encounter was 4.56. The percentage of drugs prescribed by generic name was 48.79%, and 52.06% of drugs were prescribed from the essential drug list. Atypical antipsychotics (53.28%) were prescribed more than typical antipsychotics (46.71%). 56.25% of patients were treated with monotherapy, and 43.75% patients were treated with polytherapy. Switching over of antipsychotics was seen in 33 (25.78%) patients. The most commonly used technique for switching was immediate/abrupt...
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Posted by admin on Dec 31, 2021 in |
Micro sponges are patented polymeric drug delivery systems consisting of porous microspheres. The physical appearance of microsponges is tiny spherical sponge-like with the surface with large spores. Micro sponges are typically used and nowadays used as the oral dosage form. The inert and indestructible tiny spherical particles do not pass through the skin. But, it collects in the tiny nooks and crannies of skin. Thus slowly release the drug for a prolonged period. It prevents the excess accumulation of drugs within the epidermis and dermis. They have a modified drug release pattern with lesser side effects. Micro sponges are biologically safe and provide a selective advantage of programmable drug release. Micro sponges Drug Delivery System provides entrapment of ingredients because of its porous nature and is believed to contribute lesser side effects, improve drug stability, increase elegance, and enhance formulation flexibility. One of the best features of microsponges is their self- sterilizing property. Several studies have confirmed that Micro sponges are non-mutagenic, non-allergic, non-irritant, and non-toxic. This review focused...
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