Withania somnifera L. Dunal (Family: Solanaceae) is extensively used in traditional Indian medicine as a nerve tonic and is thought to improve memory. We assessed the acetylcholinesterase (AChE) inhibitory activity and kinetics of an aqueous extract of W. somnifera root, in the context of its potential role in regulating the levels of acetylcholine (ACh) in the brain. The assessment of cholinester...
In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Solanum nigrum (commonly called Makoi) is also a medicinal plant. A dietary intake of Solanum nigrum supplies our body with nutrients that offer protection against numerous diseases. All parts of this...
Oral route is the easiest and most convenient route of drug administration, being non invasive and cost effective, thereby leading worldwide drug delivery market. But major problem encountered in oral formulations (as estimated more than 50 % of oral formulations are found to be poorly aqueous soluble), is low bioavailability, giving rise to further problems like, high inter and intra subject vari...
Tinospora cordifolia (Thunb.) Miers, (Guduchi) is an evergreen perennial climber. This deciduous and dioecious plant belongs to the family Menispermaceae. It is a plant of significant medicinal importance in the Indian system and designated as Rasayana. Its efficacy has been also recognized by the modern system of medicine. The whole plant is used medicinally however; the stem is approved for us...
The manufacture of bi-layer tablets, produced by the sequential compaction of loose powder layers has recently become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. In a bi-layer configuration, the immediate release layer of the bi-layer tablet has worked as the loading dose and the sustained release layer h...
DEVELOPMENT AND VALIDATION OF DERIVATIVE SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND AZITHROMYCIN DIHYDRATE IN COMBINED DOSAGE FORM
A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method was developed and validated for the determination of Azithromycin dihydrate and Cefixime trihydrate in combined dosage form. Second order derivative spectroscopy method is adopted to eliminate spectral interference. The method obeys Beer’s Law in concentration ranges of 10-40 ppm for Cefixime trihydrate and 25-10...
ETHNOMEDICINAL USE OF PTERIDOPHYTES IN REPRODUCTIVE HEALTH OF TRIBAL WOMEN OF PACHMARHI BIOSPHERE RESERVE, MADHYA PRADESH, INDIA
This paper describes the utilization of pteridophytes for the treatment of various gynecological and other related problems by the indigenous women of Pachmarhi Biosphere Reserve in Madhya Pradesh. The present study reveals that 23 species of pteridophytes belonging to 15 families and 18 genera are traditionally used by tribal women of Korku, Gond, Bharia, Bhil, Mauria, Maria, Paria, Bhatara and B...
The present study was undertaken to find out the potential of gum from Almond gum to act as a binder and release retardant in tablet formulations. No significant work has been reported to use it as a tablet binder. The effect of almond gum and pvp on the release of diclofenac sodium was studied. The FT-IR spectroscopic studies of drug, gum and mixture indicated no chemical interaction. Seven formu...
ABSTRACT Study objective: To investigate the use of antihypertensive drugs in hypertensive patients and to identify whether such pattern of prescription is appropriate in accordance with international guidelines for management of hypertension. Methods: This was a prospective analysis. A prescription based survey among patients with established hypertension was conducted at the Me...
SYNTHESIS, SPECTROSCOPIC, THERMAL STUDIES AND BIOLOGICAL ACTIVITY OF A NEW SULFAMETHOXAZOLE SCHIFF BASE AND ITS COPPER COMPLEXES
A new Sulfamethoxazole Schiff base (E)-4-(4-methoxybenzylideneamino)-N-(5-methylis-oxazol-3-yl) benzenesulfonamide (C18H17N3O4S), and its copper complex were synthesized and the structures elucidated on the basis of Physiochemical methods. The studies indicate an octahedral structure for the complexes with the (C22H27N3O10SCu) formula. The IR spectra suggest that the ligand act as tridentate (from...