The present study was undertaken to find out the potential of gum from Almond gum to act as a binder and release retardant in tablet formulations. No significant work has been reported to use it as a tablet binder. The effect of almond gum and pvp on the release of diclofenac sodium was studied. The FT-IR spectroscopic studies of drug, gum and mixture indicated no chemical interaction. Seven formu...
Transdermal drug delivery is proving to be superior to the conventional oral delivery of drugs owing to its distinct virtues. But it has got its own limitations as well- inability to transport large molecules, inability to overcome the barrier properties of stratum corneum and many more. Using this route of drug delivery along with novel approaches can help to solve these problems. Formulating the...
Clinacanthus nutans Lindau (Family: Acanthaceae) has attracted public interest recently due to its high medicinal values for the treatment of cancer, inflammation and various skin problems. This study was aimed to determine the oral LD50 value of the methanol leaves extract of C. nutans and identify the targeted organs in mice. This acute oral toxicity study was conducted in accordance to OECD 423...
Medicinal plants are important source of potentially useful structures for the development of novel chemotherapeutic agents. The present study was aimed to evaluate the antifungal effect of partially purified C. gigantea latex extract on some human pathogenic fungi. Ethanolic extract of the latex were tested in vitro against fungi strains. The inhibitory effect was assessed by disc diffusion metho...
ANTIBACTERIAL PROPERTIES OF TRADITIONALLY USED MEDICINAL PLANTS FOR ENTERIC INFECTIONS BY ADIVASI’s (BHUMKA) IN MELGHAT FOREST (AMRAVATI DISTRICT)
Medicinal plants are a major source of therapeutic agents since time immemorial. Tribal and rural community from their parents on folklore medicines acquires incredible knowledge of phytomedicine in non-coded form. With the repeated discussions and consultations with Tribal and Bhumkas, we selected 36 different medicinal plants of 30 families used against enteric infections form Melghat forest (Am...
Heliotropium indicum Linn., commonly known as ‘Indian heliotrope’ is very common in India with a long history of traditional medicinal uses in many countries in the world. The plant is reported to possess antibacterial, antitumor, uterine stimulant effect, antifertility, wound healing, anti-inflammatory, antinociceptive and diuretic activities. Several pyrrolizidine alkaloids have been isolate...
DEVELOPMENT OF A SELF MICRO-EMULSIFYING TABLET OF CYCLOSPORINE- A BY THE LIQUISOLID COMPACT TECHNIQUE
Purpose: The aim of this study was to enhance the dissolution rate of Cyclosporine A, a poorly water-soluble drug by developing a self micro-emulsifying (SME) tablet formulation by using the liquisolid compact technique. A liquisolid system is formed by converting a liquid formulation into a dry, free-flowing and compressible powder mixture with selected carrier material and coating material. This...
PREVALENCE OF DEPRESSION AND ASSOCIATED FACTORS AMONG PEOPLE LIVING WITH HIV/AIDS IN TIGRAY, NORTH ETHIOPIA: A CROSS SECTIONAL HOSPITAL BASED STUDY
Objective: The aim of this study was to determine the prevalence of depression and associated factors among people attending ART clinics in Tigray, Ethiopia. Method: Institution based cross-sectional study was conducted on patients attending ART clinics for persons living with HIV/AIDS (PLWHA) at Adigrat, Mekelle and Maichew Hospitals in Tigray region. Sample size was calculated using Epi info ...
Methanolic extracts of the tuber of Amorphophallus paeoniifolius were investigated for its antihelmintic activity against Pheretima posthuma and Tubifex tubifex. The extract with the concentrations of 25, 50 and 100 mg/ml were tested in the bioassay, which involved determination of time of paralysis and time of death of the worms. The extract exhibited significant antihelmintic activity at highest...
RP-HPLC METHOD FOR SIMULTATANEOUS DETERMINATION OF IRBESARTAN, LOSARTAN, HYDRO-CHLOROTHIAZIDE AND CHLORTHALIDONE–APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS
A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Irbesartan, Losartan, diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Hypersil BDS (Length 250 mm × Diameter 4.6 mm Particle size 5 μm) column with gradient flow. The mobile phase at a flow rate of 1.0 mL min−1 ...