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A STUDY ON IN VITRO ANTIBACTERIAL ACTIVITY OF FICUS BENGALENSIS LINN. ON DENTAL CARIES PATHOGENS STREPTOCOCCUS MUTANS AND ACTINOMYCES VISCOSUS
The aerial roots of Ficus bengalensis Linn. were collected in and around Chennai, Tamilnadu, India They were washed, shade dried and were ground into powder. The powder was extracted with chloroform, petroleum ether, methanol and hexane. The antibacterial screening of the extracts was carried out by determining the zone of inhibition using disc diffusion method. The strains were grown to logar...
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SPECTROFLUORIMETRIC DETERMINATION OF TOLTERODINE TARTARATE IN PURE FORM AND PHARMACEUTICAL PREPARATION
A Simple, rapid, sensitive, accurate and precise spectrofluorimetric method was developed for the determination of tolterodine tartrate (TOL) in bulk powder and in pharmaceutical preparation. This method is based on measuring the native fluorescence of TOL in methanol at 313 nm after excitation at 285 nm using 1 ml of phosphate buffer pH 6. All variables that affect fluorescence intensity such as ...
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PRELIMINARY PHYTOCHEMICAL, ANTI-BACTERIAL, ANALGESIC, ANTI-DIARRHOEAL AND CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF POLYALTHIA SUBEROSA LEAVES
The MeOH extract of leaves of Polyalthia suberosa Roxb. (Annonaceae) was screened for its antibacterial, analgesic, Antidiarrhoeal and cytotoxic activities. The extract showed moderate anti-bacterial activity against Vibrio cholerae, Sheigella sonnei, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus saprophyticus. It also produced significant (P<0.01) writhing inhibition in a...
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PHYSICOCHEMICAL, ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF A MULTIPURPOSE HERBAL FORMULATION (HB-01)
An herbal formulation composed of Allium cepa (Onion), Zingiber officinale (Ginger), Allium sativum (Garlic), Aloe vera, Andrographis paniculata (King of bitters), Allium ascalonicum (Shallot), reportedly used as anti–inflammatory agent was investigated. This study evaluated the physicochemical, phytochemical properties and in vivo anti–inflammatory effect of the herbal formulation. The herbal...
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STABILITY INDICATING RP-HPLC METHOD FOR COMBINATION OF AMBROXOL HYDROCHLORIDE AND LEVOFLOXACIN HEMIHYDRATE IN PHARMACEUTICAL FORMULATION
Ambroxol hydrochloride (AMB) and Levofloxacin hemihydrate (LVF) in combination were separated using Reverse-Phase - High-Performance Liquid Chromatographic (RP-HPLC) method. Mobile phase acetonitrile and 0.05 M potassium di-hydrogen orthophosphate buffer (pH 7.0 adjusted with sodium hydroxide solution) (50: 50, v/v) was selected for this chromatographic method. The separation was achieved in Zorba...
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EVALUATION OF ANTIMICROBIAL POTENTIAL OF BAUHINIA BLAKEANA FLOWERS
In this study, the phytochemicals and their antimicrobial potential of flowers of Bauhinia blakeana of Fabaceae Family were evaluated. The selected microbes for the antimicrobial study were E. coli, Enterobacter sp., Proteus sp., and Klebsiella sp. Ethanolic extract was prepared by continuous hot percolation method using Soxhlet extractor, and Antimicrobial activity was tested by Agar well diffusi...
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NON-INFERIORITY OF NEBULIZED COLISTIN COMPARED WITH CONVENTIONAL SYSTEMIC ANTIBIOTICS FOR THE TREATMENT OF VENTILATOR-ASSOCIATED PNEUMONIA
Background: In the present study, our objective was to determine whether nebulized colistin as an adjunctive therapy to conventional intravenous antibiotics of Ventilator-associated pneumonia (VAP) caused by multi-drug resistant (MDR) was safe and beneficial in critically ill patients. Methods: A prospective matched case-control study was performed at the ICUs of the University Hospital of Isfahan...
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SYNTHESIS AND ANTI-MYCOBACTERIAL ACTIVITY OF SOME NOVEL ANACARDIC ACID DERIVATIVES FROM CASHEW NUT SHELL LIQUID
Synthesis and anti-mycobacterial activity of some novel derivatives of anacardic acid viz., 2-Ethoxy-6-pentadecyl benzamide (APHK-1), 1-(2-methoxy-6-pentadecylbenzyl)-4-hydroxy ethylpiperazine (APHK-2), 1- (2-hydroxy-6-pentadecyl)- N- (hydroxyl ethylaminoethyl) benzamide (APHK-3) and compounds 20-34 from saturated anacardic acid which was obtained from natural product cashew nut shell liquid (CNSL...
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RECONSTITUTION OF ORAL ANTIMALARIAL SUSPENSIONS: AN UNRECOGNIZED FACTOR IN ANTIMALARIAL DRUG RESISTANCE
Malaria is a foremost universal public health problem, especially in the African region and development of resistance to the older and new generation malaria therapy, has become a persistent health threat requiring urgent solutions. This study intended to assess the ability of human subjects to accurately reconstitute antimalarial dry suspensions according to the manufacturer’s instructions. Two...
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SYNERGISTIC EFFECT OF (S)-CIS-VERBENOL WITH THE ANTIBIOTICS AMOXICILLIN AND GENTAMICIN AGAINST SENSITIVE AND RESISTANT STAPHYLOCOCCUS AUREUS STRAINS
The synergistic activity among the monoterpene (S)-cis-Verbenol and the antibiotics Amoxicillin and Gentamicin were evaluated against a sensitive and a resistant strain of Staphylococcus aureus, is the last one also resistant to methicillin (MRSA). The combinations were evaluated by the checkerboard method. The combinations of both antibiotics with the terpene showed synergic effects for the MRSA ...
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