SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY EVALUATION OF SOME NEW 2-(3-FLUOROBIPHENYL-4-YL) PROPANOIC ACID DERIVATIVES
Different new compounds derived from 2-(3-flourobiphenyl-4-yl) propanohydrazide  as starting material were synthesized. Reaction  with maleic anhydride, succinic anhydride and phthalic anhydride gave the corresponding cyclicimides [3a-c]. The hydrazone derivatives [4a-d] were obtained by condensation of compound  with 2,4-dimethoxybenzaldehyde, 4-(N,N-dimethylamino)benzaldehyde, 3-hydroxy...
Adverse drug reactions in the form of toxic epidermal necrolysis is a rare but potentially fatal disorder. The pathophysiology of such reactions are not properly understood. There are many drugs which are very often implicated for causing such severe reactions. Allopurinol is a common drug used in chronic gout but also notorious for causing Steven - Johnson syndrome and rarely toxic epidermal necr...
Phosphodiesterase PDE10A is an enzyme that has established connection earlier with schizophrenic condition, schizophrenia is well known severely chronic and disabling disease worldwide today. Unfortunately, there is no concrete evidence till day to point out as a single cause of this disease. However, in a recent work a research team of Merck Research Group recognized earlier pyp-1 as an effective...
Tea has been considered as a health promoting drink & stimulant. Globally 4842.1 thousand tons tea consume annually. But due to change in soil characteristics, indiscriminate use of pesticide & fertilizer lead to accumulation of toxic heavy metal like Lead(Pb), Arsenic(As), Copper(Cu), Nickel(Ni) & Cadmium(Cd) in tea leafs & bud. Tea market in India is not well regulated, an abunda...
EFFICACY OF GRIFFITHSIA PACIFICA KYLIN ON IN VIVO ANTI DIABETIC AND ALTERATIONS IN ENZYMATIC ACTIVITIES OF STZ INDUCED RATS
In recent years there is more research work taken in Marine sources for its pharmaceutically valuable compounds and active medicines for anticancer, anti diabetic, anti oxidant, antimicrobial, and anti-inflammatory. The present study investigated for the medicinal value of red algae Griffithsia pacifica Kylin (GPK) and its alterations in enzymatic activity of STZ induced diabetic rats. The resul...
ACID AMINE COUPLING OF (1H-INDOLE-6-YL)PPIPERAZIN-1-YL)METHANONE WITH SUBSTITUTED ACIDS USING HATU COUPLING REAGENT AND THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY
Acid amine coupling of 1H-indol-6-yl(piperazin-1-yl) methanone with different acids has been synthesized in presence of HATU reagent, DIPEA base with DMF solvent at 45 °C 30 mins to yield Indole piperzine derivatives 3a-j. The structures of all the synthesized compounds have been characterised by elemental analysis and spectral studies like 1H-NMR and LCMS. Some selected Indole piperazine derivat...
In the present study, the hypolipidemic activity of Piper longum (Family: Piperaceae) fruit extract was studied in two experimental models of hyperlipidemia. In an acute model of hyperlipidemia, induced by injecting a single dose of triton WR-1339 (400 mg/kg, b.w.) intraperitonially in rats, administration of Piper longum extract at the dose of 500 mg/ kg, b.w. resulted in significant lipid loweri...
Helminthiasis is infestation with one or more intestinal parasitic worms roundworms, whipworms , or hookworms in humans and animals. Presently, many synthetic drugs are available to treat Helminthiasis infection effectively, but suffer from number of side effects like abdominal pain, dizziness, headache, fever, nausea, vomiting, or temporary hair loss. Moreover, drug resistance is also another fac...
The threats and risks of the invalid drugs as expired, counterfeit (cheated drugs), Substandard, spurious, falsely labeled, falsified) .The risks and threats of the invalid drugs are many and wide vary, and the countries are trying to prevent these threats by some efforts as the regulatory institution's efforts and the recorded expire date on the drug container, but that are not enough to prevent ...
DRUG DESIGN OF CORTICOTROPHIN RELEASING FACTOR RECEPTOR-1 ANTAGONIST FROM DERIVATIVES OF α ASARONE BY MOLECULAR DOCKING
Stress is one of the most significant health problem in modern society. This paves way for the researchers to focus and investigate into the biological pathways linking stress and health. Hence the goal of the present study is to discover novel drug derivatives from the active principle α asarone of the plant Acorus calamus Linn. (ACL) which was found to have antioxidant &antidepressor effect...