ENHANCEMENT OF BIOAVAILABILITY OF NORFLOXACIN MUCOADHESIVE SUSPENSION BY USING DIFFERENT GRADES OF CARBOPOL
Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone. Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability an...
PREVALENCE AND ASSOCIATED FACTORS OF MENTAL DISTRESS AMONG LEPROSY PATIENTS AT ALERT HOSPITAL OUT PATIENT CLINIC ADDIS ABABA, ETHIOPIA, 2011
Background: Leprosy is one of the infectious diseases of public health importance; it is the leading cause of permanent physical disability as aresult of nerve damage. Individuals with leprosy have emotional stress and anxiety, which may lead to both psychological and psychiatric co-morbidity. Objective: This study was conducted to estimate the prevalence of mental distress among leprosy patien...
PREPARATION OF TERMINALIA CHEBULA LOADED CELLULOSE/CHITOSAN COMPOSITE FILMS AND THE EVALUATION OF DRUG RELEASE AND ANTIMICROBIAL CHARACTERISTICS
Diabetic foot ulcer (DFU) is one of the major problems encountered by nearly 15 % of diabetic patients. Combinations of different antibiotics are used to treat the infection which makes the microorganism multi drug resistant. Among various types of drug delivery system, transdermal drug delivery is preferred in treating DFU because it delivers the drug directly to the wound site, which increases t...
This experimental work aimed at formulating and systemically characterizing mucoadhesive amoxicillin microspheres for the eradication of H.pylori and its associated diseases. The microsphere batches were prepared by emulsion-solvent evaporation technique with the use of carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier polymer. Initially 27 formulations were prepared using 33 ...
Bioequivalence studies should be conducted for two products marketed by different licensees, containing same active ingredient(s), must be shown to be therapeutically equivalent to one another order to be considered interchangeable. The bioequivalence of two formulations of the same drug can be determined based on the absence of significant differences in primary pharmacokinetic properties of bioa...
ROLE OF DEFERASIROX, AN ORAL IRON CHELATOR IN PREVENTION OF ISCHEMIC REPERFUSION MYOCARDIAL INJURY IN ALBINO RABBITS
An experimental study was carried out after getting approval from institustional animal ethical committee to study the role of oral iron chelator, deferasirox in prevention of myocardial ischemic reperfusion injury in albino rabbits. Albino Rabbits of either sex were divided into two groups control (n=5) and test group (n=5), receiving deferasirox. Experiments were done using isolated heart perf...
COMPARATIVE PHARMACEUTICAL QUALITY CONTROL TESTING OF DIFFERENT BRANDS OF PARACETAMOL TABLETS AVAILABLE IN THE TRINIDAD & TOBAGO, WEST INDIES
Paracetamol tablets are popular over the counter (OTC) products among the patients as a good analgesics and antipyretics. The objective of this study was to compare the quality of the paracetamol tablet formulations those are locally available in Trinidad & Tobago pharmaceutical market manufactured by various pharmaceutical companies with pharmacopoeia standards. The four popular brands (A, B,...
DESIGN, FORMATION AND EVALUATION OF A CO-DRIED DIRECTLY COMPRESSIBLE EXCIPIENT “TSAG-15” AND ITS UTILIZATION IN THE FORMULATION OF A RAPID RELEASE-MOUTH DISINTEGRATING ASCORBIC ACID TABLETS
A research was conducted to design a directly compressible filler binder characterized with rapid release and mouth disintegrating. Acacia gum was obtained from local source and was purified using a standard method. Tapioca starch was also extracted from cassava tuber using a standard method. Both primary excipients were evaluated for power properties and coprocessed at varying concentration using...
Urolithiasis is a relevant clinical problem in every day practice with a subsequent burden for the health system. Animal models of disease most closely replicate the sum of physiological conditions present in humans. Rats and mice are however, the two most commonly used experimental animals in medical research including stone disease. The oxalate metabolism in the rat is nearly identical to that i...
The main objective of this study is to evaluate the antibacterial activity and phytochemical analysis of Lemon (Citrus limon L.) and Orange (Citrus sinensis L.) Increasing resistance of microorganisms to present day antibiotics arose a way to focus on antimicrobial activity and future prophylactic potential of the lemon and orange peels. In the present study, a total of two extract each of Methano...