STUDY OF ANTIDIABETIC EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS) AQUEOUS ROOTS AND FLOWER EXTRACTS ON ALBINO MICE
Dexamethasone drug induced the hyperglycemia in the Albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of dexamethasone raised the level of blood sugar in the mice. Administration of aqueous extract of C. citratus root and flower extract reduced the fasting and postprandial blood sugar levels, bringing them towards normal. We were observed anti-diabetic effect...
The purpose of present study was to formulate the gastro-retentive floating microspheres of atazanavir sulfate to be retentive in the stomach for prolonged period of time. The gastro-retentive floating microspheres were prepared by double emulsion w1/o/w2 solvent evaporation technique and characterization for particle size, SEM, floating time, FTIR, DSC, and entrapment efficiency. The in-vitro dru...
The present study deals with the Pharmacognostical and preliminary phytochemical studies of fruit pulp of Aegle marmelos. Macroscopy, organoleptic characters, microscopic features, physiochemical standardization parameters such as total ash, acid insoluble ash, water soluble ash, alcohol, water and other organic solvent extractives, preliminary phytochemical assay, fluorescence analysis and microb...
IMPAIRMENT OF OVARIAN BIOCHEMICAL CONTENTS AND ENZYMES ACTIVITIES DURING POTASSIUM BROMATE (KBRO3-) INTOXICATION IN ALBINO MICE MUS MUSCULUS
Potassium bromate (KBrO3-) is a chemical compound commonly used as a oxidizing agent that has been used as a food additive for baking of white bread, bun, pav and pizza bread. Potassium bromate (KBrO3-) is mainly known to generate free radicals, which cause oxidative damage to essential cellular macro molecules, leading to cause nephrotoxicity in experimental animals. In this part of experiment bi...
Prostaglandin endoperoxide synthases, usually known as cyclooxygenases (cyclooxygenase-1 and cyclooxygenase-2), catalyze a key step in the formation of biologically effective prostaglandins. In recent times, a cyclooxygenase-1 variant protein, called cyclooxygenase-3 used to be found and characterized. COX-3 is studied recent along with significant margin for the formation of anti-inflammatory, an...
MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEWLY SYNTHESIZED 1, 3, 4-THIADIAZOLE DERIVATIVE OF GUAR GUM
A new derivative of Guar gum, incorporated with 1, 3, 4-thiadiazole nucleus was synthesized by using a new green and efficient synthetic approach. Guar gum is a biodegradable polymer having numerous applications in various industries. Thiadiazole compounds are well known in the therapeutic world due to their pharmacological importance. The newly synthesized derivative was characterized by IR, H1 N...
A NOVEL RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DICYCLOMINE AND ETHYL MORPHINE IN BULK AND PHARMACEUTICAL FORMULATION
The present study was designed to develop and validate a simple, sensitive, precise and accurate RP-HPLC method for simultaneous estimation of dicyclomine and ethylmorphine in bulk and tablet dosage form. The chromatographic separation was achieved on Discovery C18 column (250 × 4.6 mm, 5 µm) as stationary phase with a mobile phase of water (pH 5.4 adjusted with orthophosphoric acid): acetonitri...
ENHANCED MECHANISM OF METAL NANOPARTICLES USING SYZYGIUM CUMINI AS A POTENTIAL SYNTHESIZER AND ITS INHIBITORY EFFECT
In recent years metallic nanoparticles, represent one of the most comprehensively studied materials because of their application in biology The synthesis of silver nanoparticles using biological entities has received immense attention in the area of research. Medicinal plants have attracted interest over antibiotics due to a rapid increase in the rate of infections, development of antibiotic resis...
ANTIOBESITY, ANTIHYPERLIPIDEMIC AND ANTIDIABETIC AGENTS OF PROTO-CATECHUIC ACID IN HIGH FATTY DIET ALONG WITH ALLOXAN INDUCED DIABETES
Aim: The present investigation was carried out by evaluating the effect of protocatechuic acid (PCA) on a high-fat diet (HFD) along with a low dose of alloxan-induced hyperglycemia in male Wistar rats. Methods: In the present study, administration of high fatty diet (HFD) for 45 days along with low dose of alloxan (80 mg/kg) in rats on 30 days produced significant high fatty diet in the, body we...
PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ETHANOLIC EXTRACT OF THE ARTOCARPUS HIRSUTUS LAM. LEAVES
Artocarpus hirsutus Lam. is a common plant with a variety of folk medicinal value. The present study was conducted to evaluate the phytochemical and pharmacological properties of the ethanolic extract of Artocarpus hirsutus. The screening for various phytochemicals was conducted by using various standard procedures. Acute toxicity of the extract was determined by using OECD guidelines 423. The ant...