Amino acid chelated complexes were synthesized and characterized to determine their purity. The purity of the complexes was found to be ranging from 42-75%. The HPLC method for determination of free amino acid content in the complexes was developed and validated and found to be linear, precise and accurate within concentration range of 0.157 mg/mL to 20.14 mg/mL. The method was used to estimate ...
PREVALENCE OF FOOD INSECURITY AND ITS ASSOCIATION WITH MUSCLE MASS, HAND GRIP STRENGTH AND GAIT SPEED AMONG ELDERLY IN TEHRAN
Background: Human muscle mass undergoes constant changes as one getting older. This change can be accelerated by inadequate nutrition. The aim of the study is to investigate the association between food insecurity and its association with muscle mass strength. Methods: The cross-sectional and case-control study was conducted among 310 men and 334 women (60 and over) from August 2014−July 2015 in...
The aim of this research work was to formulate and optimize a floating drug delivery system of famotidine. In the present study, preparation of famotidine floating beads, in-vitro evaluation of Floating Drug Delivery System (FDDS), prediction of the release, and optimization of polymers ratio to match target release profile was investigated. An attempt was made to prepare oil entrapped floating be...
Streptozotocin (STZ) induced neurotoxicity causes development of diabetic neuropathy in rodent models and oxidative stress is the main culprit in development of diabetic neuropathy. In the present study we aimed to evaluate the neuroprotective and antioxidant role of Pregabalin in STZ induced neurotoxicity. After 8 weeks, STZ induced diabetic rats showed sciatic nerve damage which was evident from...
Arterial thrombus formation are due to mainly platelet activation and aggregation which are considered to be central to pathological changes occurring in the vessel leading to the various complications and mortality . Antiplatelet drugs are used to prevent and help in the reversal of platelet aggregation in arterial thrombosis which was the major culprit in the pathology of myocardial infarcti...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MARAVIROC IN BULK AND PHARMACEUTICAL FORMULATION BY UV SPECTROSCOPY
The aim of present work is to develop and validate simple, sensitive, economical and accurate Spectrophotometric methodhas been developed for determination of Maraviroc in pure form and in pharmaceutical formulations. Maraviroc in Phosphate buffer pH 7.4 shows maximum absorbance at 210 nm. Beer’s law was obeyed in the concentration range of 5-25 µg/mL, The LOD and LOQ were found to ...
A COMPARATIVE ANTIMICROBIAL EVALUATION OF EMBELIARIBES BURM. F. AND EMBELIAROBUSTA AUCT. NONROXB. FRUITS
Background: Vidang (Embelia ribes Burm. f.) is a very famous plant for its anthelmintic activity. In Ayurveda, it is a first choice of drug for its krimighna action or to kill foreign pathogens. Embeliaro busta auct. Nonroxb., the other species of vidang is adulterated in Embelia ribes Burm. f. Therefore shastrokta or original vidang and its adulterant species were selected for the comparative stu...
ANTI-DIABETIC ACTIVITY OF ETHANOL EXTRACT OF PRAECITRULLUS FISTULOSUS LEAVES ON STREPTOZOTOCIN INDUCED DIABETIC RATS
Objective: The present study was designed to evaluate the anti-diabetic activity of ethanol extract of Praecitrullus fistulosus leaves on streptozotocin induced diabetic rats. Materials and Methods: The anti-diabetic activity of plant leaves was investigated in streptozotocin induced diabetes model. Effect of ethanol extract of Praecitrullus fistulosus (EPF) leaves on normal blood glucose levels a...
AEG-1 expression is known to elevate in diverse cancers, where it plays a primary role in activating multiple signaling pathways that drives copious oncogenic properties. The versatile role of AEG-1 in mediating oncogenesis was found to be cognate with numerous signaling cascades such as the activation of NF-κB/p65, Ha‑Ras, PI3K/Akt, ERK/MAPK, Wnt/β-catenin, AURKA and RNAi pathways. In additio...
The studies on tree biomass for assessing carbon density in tropical forest ecosystem of central India was undertaken during 2009-11 in forest area of eight districts [Jabalpur, Seoni, Balaghat, Narsinghpur, Mandla, Dindori, Shahdol and Umaria] at 30 adopted representative sites at varying latitudes and longitudes. The annual rainfall of their study area was 1000-1600 mm. The soils of the study si...