Paracetamol is a well-known drug for its antipyretic, analgesic and anti-inflammatory activity. The drug being an OTC had been used more frequently than required. As a result of this overdosage of the drug caused a hepatotoxic effect. So to overcome this, an approach of PEGylation was chosen. PEG 1500-Paracetamol, PEG 6000-Paracetamol, PEG 1500-Glycine-Paracetamol, and PEG 6000-Glycine- Paracetamo...
Preformulation testing is the first step in the rational development of dosage forms of a drug substance. The preformulation investigations confirm that there are no significant barriers to the compound’s development as a marketed drug. The formulation scientist uses this information to develop an efficacious, stable and safe dosage form. The main objective of the present research work was to do...
DISCOVERY OF NEW ANTI-FUNGAL PHYTOCHEMICAL PDHC (PROPANE-DIYL-BIS-HEXAHYDRO-ISOCHROMENE) ISOLATED FROM ALTERNANTHERA SESSILIS LEAVES
This study reports the potential of Alternanthera sessilis leaves as antioxidant, antimicrobial, anti-inflammatory and anti-diabetic agent and also the characterization of a novel phytochemical from A. sessilis using bio-activity guided extraction. Antimicrobial property was studied against five bacterial pathogens, Escherichia coli (MTCC: 1687), Bacillus cereus (MTCC: 0430), Klebsiella pneumonia ...
Spilanthes acmella (SA) commonly known as “Akarkara” frequently available in most of the areas of India, Sri Lanka, Bangladesh, China, Japan, and Thailand; is well reputed in the indigenous system of medicine for its medicinal use in toothache and rheumatic fever. The present study was aimed to evaluate its traditional use in liver diseases using the in-vivo model of rabbits. The Spilanthes ac...
Traditional medicine is finding more significance and application today, particularly when we are facing difficulty in the management of numerous medical conditions. More effective and palatable drug dosage forms are needed in the modern era. The recent trend in traditional medicine dosage forms is to enhance the solubility, bioavailability, pharmacological activity, stability, reduce the toxicity...
ANTIMICROBIAL RESISTANCE PATTERN OF ENTEROAGGREGATIVE ESCHERICHIA COLI ISOLATED FROM ACUTE DIARRHEA OF PEDIATRIC PATIENT UNDER FIVE IN KANPUR REGION
Enteroaggregative Escherichia coli (EAEC) strains are causal agents of persistent diarrhea in developing countries. Enteroaggregative Escherichia coli strains (EAEC) are an emerging type of diarrheagenic E. coli. We aimed to isolate, identify and characterize the E. coli pathotypes and study their antibiotic resistance in children under five with diarrhea in Kanpur region, India. Children und...
FREQUENCY OF MILD AND SEVERE DEPRESSION CONSIDERING THE GENDER AND BLOOD GROUPS AMONG MEDICAL STUDENTS OF INTERNATIONAL MEDICAL AND TECHNOLOGICAL UNIVERSITY (IMTU), DAR ES SALAAM
Objective: Study to elucidate the relation between depression, gender and blood groups. Methods: The study was prepared on 279 medical students of IMTU, who have spent more than four months in the medical school. A Performa for testing depression scale was given to the students. Blood groups and gender were analyzed. Results: It was evident that few blood groups like A and O shown significan...
PERMEATION ENHANCERS COMPATIBLE WITH TRANSDERMAL DRUG DELIVERY SYSTEMS OVERCOMING THE SKIN BARRIER FUNCTIONS: CURRENT AND FUTURE PROSPECTS
Transdermal drug delivery system (TDDS) provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding the first-pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into the systemic circulat...
Background: Quercetin is one of the important bioflavonoids present in more than twenty plants material and which is known for its anti-inflammatory, antihypertensive, vasodilator effects, antiobesity, antihyper-cholesterolemic and antiatherosclerotic activities. Free-radical is one of the key factors for the development of diseases such as hypertension, vascular disorders, and metabolic syndrome....
COMPARATIVE STUDY ON ANTIBACTERIAL ACTIVITY OF ETHYL ACETATE EXTRACT OF CUSCUTA REFLEXA GROWN ON CASSIA FISTULA AND FICUS BENGHALENSIS
Comparative antibacterial study of ethyl acetate extract of Cuscuta reflexa parasite grown on Cassia fistula and Ficus benghalensis was performed using disc diffusion method. Four different concentrations, 50, 100, 150 and 200 mg/ml of ethyl acetate extract of Cuscuta reflexa grown in two different host plants were prepared and tested against Escherichia coli, Bacillus subtilis, Klebsiella pneumon...