Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
EVALUATION OF EFFICACY AND SAFETY OF GEMIFLOXACIN IN CHRONIC BRONCHITIS PATIENTS
The study aimed to assess the efficacy and safety of Amoxicillin/Clavulanate 625 mg and Amoxicillin/Clavulanate 1 gram in chronic bronchitis patients. Chronic bronchitis, a type of COPD defined by a productive cough that lasts for 3 months or more for at least 2 years, other symptoms include wheezing and breathlessness, upon exertion. It is caused by recurring irritation to the epithelium of bronc...
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1571
HISTOPATHOLOGICAL EFFECT OF ETHANOLIC EXTRACT OF TRIDAX PROCUMBENS ON KIDNEY OF ALBINO RATS
Herbal drugs are emerging as a leading area for new drug discovery and development, and are being looked at seriously for health problem. Plants, especially used in Ayurvedic can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and or reduced toxicity. Exposure of toxicants manifests variety of pathological lesions in vari...
5036
1685
DEVELOPMENT AND OPTIMIZATION OF LIPOSOMAL KETOTIFEN FUMARATE DRY POWDER USING RESPONSE SURFACE METHODOLOGY
The aim of this study was to develop and optimize nano-liposomally entrapped ketotifen fumarate (KTF) loaded dry powder inhalation (DPI) formulation using response surface methodology (RSM). Based on the 33 full factorial design (33FFD), the mass ratio of KTF solution to soybean phosphatidylcholine (SPC94), KTF/ SPC94 to 0.5 M lactose solution that after lyophilization produce lyophilized liposoma...
4469
1909
DEVELOPMENTS OF CARCINOGENESIS INDUCED BY ABNORMALITIES OF WNT GENES
In cancers, many signals were involved in self-renewal, differentiation and proliferation. Especially, Wnt signaling pathway plays crucial impact in stem cells and cancer development. Wnt genes were involved in the stimulation of Wt signaling pathway in stem cells development. Despite, mutation and overexpression of Wnt genes induced regulation of carcinogenesis. Out of 19 Wnt genes, each Wnt gene...
5768
1587
THE EFFECT OF VALERIAN ON THE PHARMACOKINETICS OF CARBAMAZEPINE IN HEALTHY RABBITS
This article aimed to evaluate the effect of valerian on a single dose kinetic of carbamazepine in rabbits. Five healthy male rabbits in a randomized, two-crossover design were enrolled in this study. Rabbits were divided into two groups; the first received a single dose of 100 mg carbamazepine (CBZ) suspension. The second group received CBZ 100 mg suspension concurrently with valerian (VAL) 25 mg...
5719
2300
BIOEFFICACY OF PREMNA CORYMBOSA ROTTL. (VERBANACEAE) WITH SPECIAL REFERENCE TO ITS ANTIOXIDANT ACTIVITY
In the present investigation, the bioefficacy of an indigenous plant was investigated with special reference to its antioxidant potential. Antioxidant effects of Methanolic, Chloroform and Ethyl acetate extracts of the leaves of Premna corymbosa Rottl. (family Verbenaceae) were tested based on DPPH (1, 1-diphenyl-2-picryl-hydrazyl), phosphomolybdenium assay, superoxide radical scavenging activity,...
3974
1845
ENHANCEMENT OF BIOAVAILABILITY OF ATORVASTATIN AND FENOFIBRATE COMBINATION USING SOLID DISPERSION TECHNIQUE
The present investigation aimed to design and evaluate solid dispersions of Atorvastatin and Fenofibrate combination, to enhance the solubility and bioavailability. When used in combination, these drugs show additive beneficial effect and comparatively fewer side effects, in the treatment of Hyperlipidemia. Being members of BCS Class-II, these drugs exhibit low aqueous solubility and high permeabi...
4912
1874
EFFERVESCENT BIOADHESIVE VAGINAL TABLET OF METRONIDAZOLE FOR BACTERIAL VAGINOSIS – DESIGN AND IN-VITRO EVALUATION
In the present study, the effort has been made to formulate the effervescent bioadhesive vaginal tablet of Metronidazole for localized treatment of Bacterial vaginosis. Among various bioadhesive polymers carbopol 934P, hydroxyl propyl methylcellulose K4M, methylcellulose, and sodium carboxymethyl cellulose were selected. Eight different formulations were made using a single polymer as well as a co...
5560
1801
ANOVULATORY FOLLICLE DEVELOPMENT IN ADULT ALBINO MICE DUE TO PROLONGED EXPOSURES TO GENISTEIN
Genistein is a soy phytoestrogen that mediates its functions by interacting with the endogenous estrogen receptor β. To investigate the effect of 10mg/kg body weight/ day genistein administration up to 90 days on the ovarian folliculogenesis and its correlation with serum gonadotropins and estrogen, adult Mus musculus were either administered with 1:4 DMSO : PBS (vehicle) or with 10mg genistein/k...
3957
1692
STUDY OF STRUCTURE BASED DESIGN FOR SULFONES AS ENOYL-ACP REDUCTASE INHIBITORS
Mycobacterium leprae, the causative agent of the disease, leprosy develops resistance against most of the drugs, so novel drug targets are required to design new drugs. Present work is aimed at understanding the inhibition of enoyl-acyl carrier protein reductase (Enoyl-ACP reductase), which is one of the receptor proteins used in drug discovery for screening anti-leprosy agents by virtually design...
3707
1627