Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
EXPLORING SOME ANTIMALARIAL PLANTS SOLD IN THE MARKET IN LIBREVILLE GABON
The increasing microorganism resistance to common antimicrobial drugs constitutes a major public health issue worldwide and particularly in Gabon. The objective of this study was to conduct an ethnobotanical survey among merchants of Peyrie market in Libreville (Gabon) to identify plants or a combination of plants used to treat malaria in traditional medicine. Information was collected by intervi...
708
313
HPTLC METHOD DEVELOPMENT AND VALIDATION FOR THE IN-VITRO INTERACTION STUDY OF MEBENDAZOLE WITH ATORVASTATIN
By HPTLC method, a mobile phase system comprising of Ethyl acetate: Toluene: Methanol (5:4:1v/v/v) was selected, and the detection was carried out at 280nm. The Rf values were found to be 0.65 ± 0.03 and 0.27 ±0.03 for Mebendazole and Atorvastatin, respectively, which showed a good separation. The method was validated as per ICH guidelines. The percentage RSD values of repeatability, intraday, a...
646
241
IN-VITRO DRUG RELEASE KINETICS FROM CONTROLLED-RELEASE GLIPIZIDE MATRIX TABLETS AND THE INFLUENCE OF TWO DIFFERENT DILUENTS ON DRUG RELEASE PATTERNS
The objective of the study was to formulate and evaluate controlled release glipizide matrix tablets for the release rate, release patterns, and the mechanism involved in the release process of the drug. Formulations with hydrophobic and hydrophilic polymer in several drug-to-polymer ratios and using water-soluble and water-insoluble diluents were compressed into tablets using the direct compressi...
727
266
LCMS/MS QUANTITATION OF CATECHOLAMINES AND THEIR PREDECESSORS FROM PORTULACA OLERACEA AND GOMPHRENA GLOBOSA
The plants Portulaca oleracea and Gomphrena globosa belong to the order Caryophyllales, and their flowers are known to produce betalains. The biosynthesis of betalains involves various intermediate molecules such as catecholamines or biogenic amines. Catecholamines include dopamine, adrena-line (epinephrine), and noradrenaline (norepinephrine) and are normally believed to be released in response t...
638
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EVALUATION OF DETRIMENTAL FACTORS OF DRINKING WATER AND THE EFFECT OF BLOOD GLUCOSE LEVELS AND ANXIETY STATUS: AN EXPERIMENTAL STUDY IN WISTAR ALBINO RATS USING ELEVATED PLUS MAZE
This study is focused on evaluating the detrimental factors of drinking water and its relation to blood glucose level and anxiety status of non-stressed experimental rats. The study was conducted on 30 adult Wistar albino rats. The control group was treated with filtered water by reverse osmosis unit, and test 1, test 2, test 3, and test 4 groups were treated with well water from rural area 1, r...
655
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ENHANCEMENT OF BIOACTIVE CRUDE COMPOUND PRODUCTION BY STATISTICAL OPTIMIZATION OF FERMENTATION PARAMETERS FROM STREPTOMYCES SP. NLKPB45 ISOLATED FROM MARINE SOIL SEDIMENT
Actino bacterium Streptomyces sp. NLKPB45, which was isolated from mangrove soil sediments of Nellore coastal regions of Andhra Pradesh, India, was used in shake-flask fermentation to explore the different carbon and nitrogen substrates for antimicrobial crude compound. Careful experimentation of ranging each variable in the fermentation medium found that glucose and peptone as preferred carbon an...
641
335
PHARMACOPHORE BASED MODELLING OF PYRIDINE-PYRIMIDINE ANALOGS AS MER TYROSINE KINASES INHIBITORS IN ANTICANCER THERAPY
MER kinase is an important tyrosine-kinase receptor that is associated with a variety of cancers, including mantle cell lymphomas, pituitary adenomas and T-cell acute lymphoblastic leukemia. Identification of new MERTK inhibitors assumes crucial importance. Only one ligand-based pharmacophore model is reported to date for MERTK inhibitors. There are many more molecules with improved enzyme inhibit...
635
275
FORMULATION AND EVALUATION OF PROPRANOLOL HYDROCHLORIDE ORAL DISINTEGRATING TABLETS
Background and purpose of the study: Propranolol hydro-chloride beta-adrenergic receptor antagonist utilized in the treatment of high blood pressure, atrial fibrillation, myocardial infarction, angina and migraine headaches. The pharmacokinetic parameters make Propranolol hydrochloride an appropriate candidate for oral disintegrating tablets. This work aims to develop orally disintegrating tablets...
1445
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STUDIES ON ANTIMICROBIAL ACTIVITY OF HIBISCUS SPECIES OF KARNATAKA AGAINST CLINICAL ISOLATES
Antimicrobial activity of the various species of Hibiscus like Hibiscus sabdariff, Hibiscus rosa-sinensis, Hibiscus trionum, Hibiscus cannabinus, Hibiscus mutabilis against various pathogens like Staphylococcus aureus, E. coli, Bacillus subtilis, Streptococcus species, Salmonella typhimurium, Klebsiella pneumonia, Pseudomonas aeruginosa, Serratia marcescens, were studied with the help of agar well...
724
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AN OPTIMIZED HERBAL FORMULA DIMINISHES CCL4-INDUCED HEPATOTOXICITY IN RATS BY INHIBITION OF LIPID PEROXIDATION AND P53-MEDIATED APOPTOSIS
Introduction: In this present study, the heaptoprotective effect of an optimized herbal formula (HF) was evaluated against carbon tetrachloride (CCl4)-induced liver injuries in rats. Methods: In-vitro antioxidant activity of the HF was evaluated by reducing power, lipid peroxidation, and DPPH scavenging assays. Hepatoprotective activity of HF (100, 200 and 400 mg/kg b.w) was evaluated against CCl4...
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