Volume 1 (2010) - Issue 8, August
RECENT TRENDS IN TREATMENT AND MANAGEMENT OF FILARIASIS
Filariasis is the name for a group of tropical diseases caused by various thread-like parasitic round worms (nematodes) and their larvae. The larvae transmit the disease to humans through a mosquito bite. Filariasis is characterized by fever, chills, headache, and skin lesions in the early stages and, if untreated, can progress to include gross enlargement of the limbs and genitalia in a condi...
EXPERIMENTAL MODELS FOR ALZHEIMER’S DISEASE: A MECHANISTIC VIEW
Alzheimer’s disease (AD) is a leading cause of morbidity and mortality and its prevalence is continuously increasing. AD is characterized to varying degrees by Amyloid β, neurofibrillary tangles, gliosis, synaptic and neuronal loss leading to a decline in memory & apraxia agnosia and several neuropsychiatric changes like anxiety and depression etc. Increased age, oxidative stress and neuroi...
ROLE OF COMMUNITY PHARMACIST; CARE OF HYPERTENSIVE PATIENTS
The community pharmacist, being an important member of the healthcare team and society, can make successful efforts to counsel the sufferer and guide him about this disease. Pharmacist is now becoming more patient oriented than product oriented and have brought many changes in life of patients. Hypertension or high blood pressure is a condition in which the blood pressure in the arteries is chroni...
NON-PROLIFERATIVE ACTIVITY OF SAPONINS ISOLATED FROM THE LEAVES OF GYMNEMA SYLVESTRE AND ECLIPTA PROSTRATA ON HEPG2 CELLS- IN VITRO STUDY
The non-proliferative activity of isolated saponins, gymnemagenol (C30H50O4) from Gymnema sylvestre and dasyscyphin C (C28H40O8) from Eclipta prostrata leaves were tested under on HepG2 cells under in vitro conditions. Both gymnemagenol and dasyscyphin C exhibited non-proliferative activity on HepG2 cells at 24 h with the IC50 value of 18.5 and 23.5μg/ml respectively. 5-Fluorouracil (5FU) a posit...
A STUDY ON PRESCRIBING PATTERN OF ANTIHYPERTENSIVES AT A TERTIARY CARE HOSPITAL
The retrospective study on prescribing patterns of antihypertensives showed that the prevalence of hypertension was predominantly more with male patients than in female patients. It was also found that the average age of the overall study population was 56 years. The average age of the population clearly indicates the elderly patients were affected more. The results indicates that around 57.6% of ...
COMPARATIVE IN VITRO BIOEQUIVALENCE ANALYSIS OF SOME CIPROFLOXACIN HCl GENERIC TABLETS
Six generic ciprofloxacin HCl 250 mg tablets from different manufacturer have been evaluated to assess their bioequivalence using in vitro tests. Other general quality assessments of these tablets like assay, weight variation, hardness, friability, disintegration time were also determined and all these generic tablets passed compendial specifications. There were no significant differences (p < ...
FORMULATION AND EVALUATION OF MONOLITHIC OSMOTIC TABLETS FOR CONTROLLED DELIVERY OF NIFEDIPINE
An oral monolithic osmotically controlled delivery system for Nifedepine using asymmetric membrane technology was developed and evaluated. Unlike conventional osmotic systems, which require laser drilling, this system releases the drug in a controlled manner from asymmetric membrane coated core tablets. Asymmetric membrane is formed by dry process with phase inversion technology process using cell...
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 2- AMINOTHIAZOLE DERIVATIVES
Novel 2- Aminothiazole derivatives were synthesized by the reaction of 2-aminothiazole (1) with chloroacetylchloride in presence of K2CO3 in chloroform afforded 2- chloro- N- (thiazol - 2- yl) acetamide (2). Compound (2) on condensation with substituted phenols in presence of K2CO3 in acetone afforded the title compound (3a-g). The chemical structures of the synthesized compounds were elucidated o...
PROTECTIVE ACTIVITY OF SEMECARPUS ANACARDIUM FRUIT EXTRACTS AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN WISTAR RATS
The objective of the present investigation of hepatoprotective activity of various Fruit extract of Semecarpus anacardium in paracetamol induced liver damage model in Wistar rats. Liver damage was produced by paracetamol (2gm/kg, p. o.) in 1% CMC. The Plant extracts (200mg/kg, p. o.) were administered every 24 hrs for seven days, while standard group received N-acetyl l- cysteine. At the end of th...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF RANITIDINE HYDROCHLORIDE AND DOMPERIDONE IN COMBINED TABLET DOSAGE FORM
A simple reverse phase HPLC method was developed for the simultaneous estimation of Ranitidine hydrochloride and Domperidone present in combined tablet dosage forms. Efficient chromatographic separation was achieved on Phenomenax C18 stationary phase (250 X 4.6 mm i. d., 5μ particle size) with simple mobile phase combination of phosphate buffer: acetonitrile: methanol 40: 30: 30 (V/V/V) in an iso...
IN VITRO ANTIMICROBIAL ACTIVITY OF THE CRUDE EXTRACTS OF COLOCASIA ESCULENTA LEAVES (ARACEAE)
Colocasia esculenta belonging to family araceae popularly knows as “taro”, is very useful medicinal plant described by Charaka as an anti-inflammatory plant. An experiment was carried out to study the antimicrobial activity of chloroform and methanol extract of Colocasia esculenta plant by agar diffusion method. Zone of inhibition produced by chloroform and methanol extract in dose of 20, 10, ...
ANTI-INFLAMMATORY ACTIVITY OF SOME NEW DIHYDROPYRIMIDINES DERIVATIVES
A series of 6- methyl- 2 - oxo N- (4- oxo- 2- substituted phenyl- 1, 3- thiazolidin- 3- yl)- 4- substituted phenyl- 1, 2, 3, 4- tetrahydropyrimidine- 5- carboxamide have been synthesized and evaluated for their anti-inflammatory activity by carrageenan induced rat paw edema method. The reaction was carried out simply by heating a mixture of three components dissolved in ethanol with a catalytic am...
DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF METFORMIN HYDROCHLORIDE
Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointestina...
MANAGEMENT OF ADVANCED STAGE OF CARCINOMA LARYNX
AIM: The aim of this study was to analyze the efficacy and safety of concurrent chemotherapy with Cisplatin, Paclitaxel and radiotherapy on survival, functional and quality of life outcomes in locally advanced carcinoma of larynx. MATERIALS & METHODS: From June 2004 to Sep 2006, seventy four inoperable, previously untreated, histopathologically proven, locally advanced patients of carcinoma...
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF 3-(5- SUBSTITUTED PHENYL- 1, 3, 4 – OXADIAZOL- 2 – YL) PYRIDINES
A series of 3- (5- substituted phenyl- 1, 3, 4- Oxadiazol- 2- yl) pyridines was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella species and antifungal activity against Candida albicans. Structure-activity relationship led to the conculsion that compound IVb, and IVe exhibited g...
THE MOST RELIABLE APPROCH TO DEFEAT ‘A SILENT KILLER’
Yoga and exercise are an efficient way of declining patients of hypertension in present and in future. However it has been shown that Non-pharmacological intervention prevent the rising blood pressure and reduce it up to maximum extent, near to the normal. This experiment was designed to determine effectiveness of Yoga and exercises therapies to control blood pressure of hypertension patients. The...