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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 13 (2022) - Issue 2, February

Review Articles

 
Title
Views
PDF
Cited
01.

A REVIEW ON SUSCEPTIBILITY OF HYPERTENSIVE PATIENTS TOWARDS COVID-19: LIFESTYLE MODIFICATION FOR BETTERMENT AND CONTROL

Hypertension is a major global health challenge due to its prevalence and increased risk of cardiovascular disorder. Non-pharmacological intervention or lifestyle modification is a safer option to control blood pressure and shows effective results in regulating high blood pressure. In this review, we have described the pathophysiology of a hypertensive patient infected with severe acute respirator...

Vivek Kumar, Umeshwar Pandey, Anuj K. Singh, Shashi Alok, Pranay Wal and Amita Verma *

Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).484-92

484-492

494

483

02.

A REVIEW ON TRADITIONAL MEDICINAL PLANTS USED AGAINST COMMON NEURO-MUSCULO-SKELETAL DISORDERS IN KARNATAKA STATE, INDIA

Karnataka is a southern state of India with richer diversity of plants and nearly 20% of its land area occupied by forest. Geographically Karnataka state is divided into three major zones, Western Ghats (Sahyadri), Coastal region and the Eastern plains which harbor a diversity of medicinal plants that have been used in traditional medicine by tribes and various ethnic groups for their primary heal...

A Yogeesha and Krishna G. Kumar *

Department of Applied Botany, Mangalore University, Mangalagangothri, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).493-09

493-509

349

286

03.

A REVIEW ON HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND RETROVIRUSES

Human Immunodeficiency Virus or HIV is generally known, is a unique type of virus (retrovirus). HIV is a slow virus that causes acquired immunodeficiency syndrome, a human condition in which the progressive failure of the immune system allows opportunistic infections and life-threatening cancers to spread. Retroviruses are a single positive susceptible RNA virus with a DNA mediator and binding par...

Ganta Suhasin * and Ramisetti Sai Krishna

Department of Pharmacology, GITAM Institute of Pharmacy, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).510-19

510-519

418

219

04.

GENERAL AWARENESS TO COMMON MEDICINAL HERBS, “THE NATURAL, DOESN’T MEANS SAFE” – A REVIEW

The term "Naturals are the safer" is quite trendy, but the incomplete knowledge of the natural herbs interaction may result in several allergies and unwanted effects that may even take life and sometimes be critical to a life-threatening extent. The responsibility of the FDA is to ensure that the safety and efficacy of the drug consumed by humans and veterinary should be worthful and should cause ...

M. S. Prajapati, K. R. Shahir and P. K. Kulkarni *

Pharmaceutical Science, Gahlot Institute of Pharmacy, Koparkhairane, Navi-Mumbai, University of Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).520-30

520-530

315

182

05.

IMPACT OF FLAX ON METABOLIC SYNDROME AND RELATED ENVIRONMENTAL FACTORS

Flax (Linum usitatissimum) is an annual herb with a huge source of essential fatty acids, amino acids, vitamin E, organic acids, and cyanogenetic glycosides. Flax is primarily observed with antioxidative and cell rejuvenating properties. Due to the major ups and downs of lifestyle, metabolic syndrome is the most common terminology associated with humans. Metabolic syndrome is amplified by unhealth...

Supriyo Saha and Dilipkumar Pal *

Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).531-42

531-542

275

134

06.

THERAPEUTIC CARRIERS FOR THE VAGINAL DELIVERY OF ANTI-HIV DRUG

HIV is a pandemic disease that is rapidly spreading across the world. The current review's objective is to present how comprehensive various advanced anti-HIV drug delivery systems are. The use of a new drug delivery system helps in overcoming the challenges of dosage form growth, such as drug instability, insolubility, and restricted entrapment. Several delivery routes for ARV therapy have been i...

Nitin Martandrao Mehetre * and Inderbir Singh

Formulation Research and Development, Hetero Labs Limited, Village: Kalyanpur, Chakkan Road, Baddi, Tehsil Baddi, District Solan, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).543-58

543-558

168

110

07.

A COMPREHENSIVE REVIEW OF MEDICINAL HERBS USED AS ANTI-DEPRESSANT

Depression is a significant contributor to the global burden of disease and affects people in all communities across the world. Today, depression is estimated to affect 350 million people. The World Mental Health Survey conducted in 17 countries found that, on average, about 1 in 20 people reported having an episode of depression in the previous year. Depressive disorders often start at a young ag...

Rasika Dnyandeo Bhalke *, Mahendra Ashok Giri, Yash S. Lodha, Komal A. Pawar and Yogesh S. Kulkarni

Sanjivani College of Pharmaceutical, Education and Research Kopargaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).559-68

559-568

312

141

08.

A STUDY ON THE NOSE TO BRAIN DRUG DELIVERY SYSTEM

Drugs have been controlled by the nasal route for remedial & therapeutic use since ancient times. Enthusiasm & importance for the basic impacts of drugs directed via the nasal route has developed to last decades. Intra-nasal drug organization provides an attractive substitute for achieving the important beneficial impacts of drugs virtually similar to the parenteral route, that may be impr...

Mrugendra B. Potdar *, Neetesh K. Jain, Sumit S. Rathod and Kiran D. Patil

Faculty of Pharmacy, Oriental University, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).569-78

569-578

200

95

09.

A REVIEW ON CUBOSOME: A NOVEL APPROACH FOR DRUG DELIVERY

Cubosomes are very stable nanoparticles, which consist of cavernous or honeycombed structures. Cubosomes are formed from some amphiphilic lipids and stabilized by a polymer. They are known as bicontinuous cubic phase liquid crystals. The bicontinuous word refers to the two continuous but non-intersecting aqueous regions by a lipid bilayer. Cubosomes are self-assembled liquid crystalline particles ...

A. R. Tekade * and G. D. Avhad

Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy (MMCOP), Thergaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).579-588

579-588

272

170

10.

REVIEW OF ANALYTICAL METHODS FOR IDENTIFICATION AND QUANTIFICATION OF ZOLMITRIPTAN

Zolmitriptan is a selective serotonin receptor agonist of 1B and 1D receptors belonging to the triptan class. Zolmitriptan binds to the serotonin (5-HT) 1B receptors, receptor binding leads to inhibition of nociceptive transmission, constriction of cranial vessels, and reduction of vessel pulsation, thereby providing relief of migraine headaches, as Zolmitriptan holds great importance in migraine...

S. Venkata Sai Kumar *, K. Srinivasa Rao and R. N. Bhushan

Department of Pharmaceutical Analysis and Quality Assurance, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).589-97

589-597

168

102

11.

RUTIN – A POTENTIAL BIOFLAVONOID WITH VARIOUS PHARMACOLOGICAL ACTIONS

Rutin or quercetin-3-O-rutinose (C27H30O16) is an essential member of the flavonoid family, a classification of total components of plant phenolic compounds. Rutin is typically located in buck herb seeds. Broccoli fruits, especially citrus fruits, red apples, and berries and drinks such as beer, tea, and coffee. This bioflavonoid is accountable for imparting color and flavor to fruits and vegetabl...

Pathivada Manasa and Ganta Suhasin *

Department of Pharmacology, GITAM Institute of Pharmacy, GITAM, Deemed to be University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).598-02

598-602

180

103

12.

FERULIC ACID: A NATURAL ESSENTIAL COMPOUND HAVING POTENTIAL INDUSTRIAL AND MEDICINAL PROPERTIES

The ubiquitous compound 4-Hydroxy-3-methoxy cinnamic acid, also known as ferulic acid, constitute. A bioactive ingredient of many food that may offer a potential therapeutic effects useful in the treatment of cancer, diabetes, lung and cardiovascular disease. It is also effective against the disorders relative to oxidative stress, including certain neurodegenerative diseases. Ferulic acid is widel...

Meghna Diarsa and Akshaya Gupte *

Natubhai V. Patel College of Pure and Applied Sciences, Vallabh Vidyanagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).603-11

603-611

175

112

13.

ANIMAL MODELS USED IN THE SCREENING OF ANTIEPILEPTIC DRUGS

Epilepsy is a disorder of episodic brain dysfunction characterized by recurrent unprovoked spontaneous seizures. Epilepsy is the second most common neurological disorder after stroke. Antiepileptic drug discovery in animal models starts with the assumption that the experimental seizure model mimics human seizure. The identification of potential therapeutic agents for the treatment of epilepsy requ...

Chitra Phalak and Smeeta Sadar *

Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).612-20

612-620

182

81

14.

OVERVIEW OF MATERIALS AND TECHNIQUES FOR ENCAPSULATION OF NATURAL PRODUCTS: A MINI-REVIEW

In the recent advancement of the food and pharmaceutical industry, the encapsulation process has gained interest in the production of functional food and the sustained release of drugs to the target site. The designing and the fabrication of micro or nanocapsule has become the active field of research over the few decades. Encapsulation increases the shelf life of the bioactive materials, increase...

Archana Borah

Department of Zoology, B. Borooah College, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).621-27

621-627

166

87

15.

A COMPREHENSIVE REVIEW ON LIPOSOMES: A NOVEL DRUG DELIVERY SYSTEM

Liposome was derived from two Greek words “Lipos” meaning fat, and “Soma” meaning body. Liposome, where spherical-shaped vesicles consist of phospholipids and cholesterol vesicles which are under extensive investigation as drug carriers for improving the bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome-based drug d...

R. Divyasree *, K. Divya, S. Aarti, K. Bhavani, M. Vamsidhar, S. B. Bhanja, M. Sudhakar and B. B. Panigrahi

Department of Pharmaceutics, Malla Reddy College of Pharmacy, (Affiliated to Osmania University), Maisammaguda, Hyderabad, Telangana State, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).628-44

628-644

330

197

16.

BIOLOGICAL ACTIVITIES AND THERAPEUTIC POTENTIAL OF PERILLA FRUTESCENS (PURPLE MINT): A REVIEW

Perilla frutescens (Linn.) is an annual herbal medicinal, aromatic, vitamins-rich food and ornamental plant that belongs to the mint family, Lamiaceae. It is distributed throughout India, extending to China, Japan, Korea, Taiwan, Vietnam, and other Asian countries. Perilla frutescens seeds, leaves and stems contain fixed oil which is useful edible oil. It is an alternative source of polyunsaturate...

Seema Singh, Sunita Singh *, Santosh Kumar and S. K. Verma

Department of Microbiology, King Georges Medical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).645-53

645-653

189

114

17.

MICRONEEDLES: AN EMERGING TECHNOLOGY FOR THE EFFECTIVE TRANSDERMAL DRUG DELIVERY

Topical drug delivery is the conventional route of drug administration to the surface of the skin. Barrier present in the various layers of skin hinders the permeability of drug molecules, specifically large size of drug substance into the systemic circulation. A small-sized needle in micron range is found to be a promising approach to penetrate the uppermost layer of the skin i.e., epidermis to t...

Ritika Puri * and Vimal Arora

University Institute of Pharma Sciences, Chandigarh University, Gharuan, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).654-61

654-661

165

86

18.

A CRITICAL REVIEW ON THIRATCHAI KUDINEER -A SIDDHA DECOCTION FOR LIVER DISEASES

Pollution and overgrowing populations cause many problems such as environmental degradation, climate change, disease, etc. Among all the problems, the disease is an important factor that may affect the normal day-to-day activities of human beings, and it may be fatal sometime. Hence many researchers, government and private sectors are involved in the process of formulating new drugs to the existin...

D. Mantela *, J. Anbujebasunilson, V. Velpandian and S. Ramalingam

Department of Siddha Medicine, Tamil University, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).662-68

662-668

176

81

19.

CARBON NANOTUBES AS AN EFFECTIVE METHOD FOR ANTI-CANCER DRUG DELIVERY: A REVIEW

Cancer is a diverse category of diseases involving the growth of unchecked cells. Cancer cells uncontrollably divide and expand, creating malignant tumours that can invade surrounded parts of the body. Carbon nanotubes (CNTs) consist solely of a carbon atom organized into a tubular form in a sequence of condensed benzene rings. These sheets are rolled at a particular and distinct angle and the pro...

H. Yadav, K. Singh, M. Rana, D. P. Ghosh and Ashu Mittal *

KIET Group of Institutions (KIET School of Pharmacy), Delhi-NCR, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).669-87

669-687

159

90

20.

COMPREHENSIVE REVIEW ON ORPHAN DRUG REGULATIONS IN THE USA, EU, JAPAN, AND AUSTRALIA: POSSIBLE RECOMMENDATIONS TO SPECIFIC CHALLENGES

Orphan drugs are medicinal products intended to diagnose, prevent, or treat life-threatening or debilitating rare diseases. In some parts of the world, a rare disease is also addressed as an orphan disease due to its poor diagnosis mechanism, low prevalence, and limited treatment options. The United States, Japan, Australia, and the European Union have adopted policies promoting orphan drugs devel...

Manasa Tadepalli *, Sri Sowmya Veeravalli and Ravi Kumar Reddy Juturi

Department of Pharmaceutical Regulatory Affairs, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).688-06

688-706

141

93

21.

A SYSTEMATIC REVIEW ON THE EFFECTIVENESS OF PUNICA GRANATUM EXTRACT FOR THE TREATMENT OF RECURRENT APHTHOUS STOMATITIS

Recurrent aphthous Stomatitis (RAS) is a painful ulcerous condition that was conservatively treated using topical corticosteroids, immuno-suppressants, thalidomide with some potential risks and reactions. Considering this, herbal extracts are found to be a better alternative with very minimum side effects. Punica granatum (pomegranate) extract is one such flavonoid-containing food supplement with ...

R. Pavithra, Lubna Fathima *, D. Prabu, Sindhu, Raj Mohan and Bharathwaj

Master of Dental Surgery, Senior lecturer, Department of Public Health Dentistry, SRM Dental College and Hospital, Ramapuram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).707-12

707-712

153

100

22.

IS HOARDING A NORMAL PHENOMENON, PERSONALITY DEFORMITY, OR A MENTAL DISORDER

Hoarding behavior is a normal phenomenon commonly observed in all corners of the world to prevent future scarcity of resources and overcome challenges of survival. Hoarding signs typically develop in childhood or early adolescence, which may become a serious disorder in the late phase of life. At present, hoarding disorder has been covered under the chapter of ‘Obsessive-Compulsive and Related D...

Milind Parle *, Sapna Rani and Priya Joon

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).713-27

713-727

180

85

23.

POTENTIAL ROLE OF PHYTOMEDICINAL AGENTS IN OCULAR MANIFESTATION OF MICROBIAL INFECTION

Although the human eye has multiple physical and chemical barriers to save itself from foreign materials, there are certain times when an attack on the ocular surface may lead to trauma and/or growth of microbial flora, which can be proved lethal if left untreated. However, certain allopathic treatments and therapies are available; still, there is an increased need for herbal medicines because the...

Rashmi Rawal and U. K. Patil *

Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalay, Sagar, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).728-38

728-738

154

82

24.

BIOACTIVE COMPOUNDS FROM MARINE INVERTEBRATES AND THEIR PHARMACEUTICAL POTENTIAL

Marine environment is an exceptional storehouse of novel bioactive natural products that are mainly found in invertebrates such as sponges, arthropods, annelids, molluscs, etc. This diversity has been the source of unique chemical compounds. A large portion of these natural compounds has been extracted from marine invertebrates. Marine invertebrates are rich sources of bioactive compounds and thei...

V. Priya Senan * and M. Karthika

Post Graduate Department of Biotechnology, SAS SNDP Yogam College, Konni, Pathanamthitta, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).739-46

739-746

152

120

25.

EVOLVING SAFETY CONCERNS ASSOCIATED WITH ANTI-DIABETIC DRUGS

Diabetes Mellitus, a chronic metabolic disorder, is prevalent all over the world nowadays. As a result, it is estimated that it can become an epidemic in some parts of the world soon. The number of affected people could be as double as that of the currently affected patients till the next decade. In order to fulfill the increasing demands of newer, safer, and more effective medications for treatme...

Roma Ghai, Kiran Sharma *, Manisha Prajapati, Ishani Verma, Jaskaran Singh, Harsh Bansal and K. Nagarajan

KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).747-54

747-754

197

123

Research Articles

 
Title
Views
PDF
Cited
26.

VALIDATION STUDY FOR PARACETAMOL DETERMINATION IN LIQUID PRODUCTS (PARACEROL) USING RAMAN SPECTROSCOPY

In this study, Raman spectroscopy was used as an analytical quality control methodology to evaluate the paracetamol (PCT) quantity in a commercially available formulation in the pharmaceutical industry. The Raman Spectroscopy has been established for the validation and the quantification of PCT in a commercial product called Paracerol (Prc) Solution for I.V. Infusion containing 10.0 mg.mL-1 PCT. T...

T. Kocaağa, F. Yıldırım, U. Kumrulu, E. Kumrulu, N. Mutlu, E. Sopacı, B. Demirdoğan and D. Giray Dilgin *

Secondary Science and Mathematics Education Department, Faculty of Education, University of Çanakkale Onsekiz Mart, Çanakkale, Turkey.

DOI: 10.13040/IJPSR.0975-8232.13(2).755-62

755-762

313

172

27.

A SIMPLE METHOD FOR SYNTHESIS OF AMANTADINE HYDROCHLORIDE

Amantadine hydrochloride (1) is an antiviral drug currently used to treat certain influenza infections (type A). It is also used as an anti-dyskinetic agent to treat Parkinson’s disease. Several methods for the preparation of amantadine hydrochloride (1) were reported, these procedures started from adamantane (2), using procedure four reaction steps to obtain amantadine hydrochloride with an ove...

Binh Duong Vu, Thi Phuong Dung Phan *, Thi Van Tran, Anh Tuan Dang, Phuong Linh Nguyen and Dinh Chau Phan *

School of Chemical Engineering, Hanoi University of Science and Technology, No.1, Dai Co Viet str, Bach Khoa ward, Hai Ba Trung district, Hanoi, Vietnam.

DOI: 10.13040/IJPSR.0975-8232.13(2).763-75

763-775

348

182

28.

PREFORMULATION, FORMULATION DEVELOPMENT AND DRUG RELEASE STUDIES OF CLOPIDOGREL BISULPHATE FLOATING MICROBALLOONS

Multi particulate systems are of greater importance than the single unit dosage forms in oral drug delivery. Floating micro balloons are among the best methods to increase gastric retention among all the multi particulate drug delivery systems. They offer more reproducible drug absorption, reduce the risk of local irritation and improve the bioavailability of the drug. In the current research work...

S. Ramya Krishna *, A. Ramu, S. Vidyadhara and A. Prameela Rani

Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).776-85

776-785

371

160

29.

SYNTHESIS AND IN-VIVO ACTIVITY OF SOME ANTIHYPERTENSIVE AGENT BASED ON PYRIDAZINE SCAFFOLD DESIGN

The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives. To study the different synthesized derivatives by using different analytical parameters like IR, Mass, and NMR analysis. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wid...

Vikash Jakhmola

Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).786-92

786-792

277

144

30.

QUALITATIVE PHARMACOGNOSTIC AND PHYTOCHEMICAL EVALUATION ON ACHYRANTHES ASPERA LINN. LEAF

Medicinal plants and their investigation towards the phytoconstituents is much interested in today’s research. The plant Achyranthes aspera Linn.  is one of the most use full drugs in Siddha and Ayurvedha medicines for treating various diseases in different formulations. Here the aim of this study is to evaluate the pharmacognostic parameters and identify the phytoconstituents. A preliminary ph...

V. E. Ida Christi *, M. Khadar Bhatcha and N. I. Blesson Sha Fogarty

PSG College of Pharmacy, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).793-02

793-802

354

181

31.

SCREENING OF NATURAL PIGMENTS FROM SEAWEED KAPPAPHYCUS ALVAREZII AND ITS EFFICACY IN PHARMACEUTICAL PRODUCTS

This paper focused on research on seaweed contains good nutritional source of protein, carbohydrate, pigments, vitamins, and antioxidants and has low lipid content. The source of natural substances has considered more efficient bio-molecules in building immunity and improving resistance to cancer development, prevent infections were analyzed. Classical biochemical methods were applied for extracti...

R. Nithyaa and G. Renuga *

Department of Biotechnology, Sri Adi Chunchanagiri Women’s College, Cumbum, Theni (Dt.), Affiliated to Mother Teresa Women’s University, Kodaikanal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).803-09

803-809

175

88

32.

FORMULATION AND EVALUATION OF SUSTAINED-RELEASE TABLET HAVING GENISTEIN

Genistein is phytoestrogens that function on estrogen receptors through a receptor-dependent mechanism. Genistein is commonly used to alleviate menopause symptoms, lower breast cancer risk, protect against prostate problems, improve bone health and lower the risk of heart disease. This research aims to create Genistein oral tablets with a long release time. In a rotary tableting machine, tablets w...

Heena Farooqui * and Prashant Upadhyay

School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).810-20

810-820

230

135

33.

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 1, 2, 3-TRIAZOLE-CHALCONE HYBRIDS AS ANTI-PROLIFERATIVE AGENTS AGAINST HT29 COLON CANCER CELLS

Independent studies have shown that chalcones and 123 triazole exhibited cytotoxic effects on human cancer cell lines. In the present study, we prepared a series of novel 1,2,3-triazole-chalcone hybrid compounds and evaluated the cytotoxic effect and probable mode of action in HT29 colon cancer cell line. Among the 10 evaluated compounds, compounds 4 (3-nitro) and 8 (3-chloro) were the only compou...

G. A. Kurian

Vascular Biology Lab, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).821-27

821-827

161

93

34.

FORMULATION AND EVALUATION OF QUINAPRIL EXTENDED-RELEASE TRILAYERED MATRIX TABLETS BY DESIGN OF EXPERIMENT

Objective: The present research was focused on designing, formulate and evaluate the trilayer matrix tablets incorporated with quinapril for extending drug release. Methods: Quinapril trilayer matrix tablets were formulated using response surface methodology wherein initially 27 formulations (QF1-QF27) were designed for active layer from which one best formulation was chosen based on drug content,...

K. Ashwin * and T. Rama Mohan Reddy

Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).828-40

828-840

187

120

35.

ISOLATION AND CHEMICAL CHARACTERIZATION OF POTENTIAL BIOACTIVE COMPOUNDS FROM ALBIZIA STIPULATA BARK

The present research effort was undertaken to isolate phytoconstituents from pharmacologically active extracts of stem bark of Albizia stipulata based on in-vitro pharmacological screening and their subsequent characterization. Methods: Crude extracts of bark of Albizia stipulata were prepared using various solvents such as methanol, hydro alcohol, and water. These extracts were screened for in-vi...

Jadi Sujatha, Gorantla Nagamallika *, Yelamanchi Ravi Shankar Babu, Manduva Deepthi, Vejendlaravi Kumar and Gonepally Surekha

Department of Pharmaceutical Chemistry, Sarada Collge of Pharmaceutical Sciences, Kondakavur, Guravaya Palem, Narsaraopet, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).841-52

841-852

171

113

36.

OCULAR EFFECTS OF WATER EXTRACT OF OCIMUM GRATISSIMUM IN RABBITS

The water extract of Ocimum gratissimum, L Lamiaceae, used in traditional medicine and local food spice, was evaluated for its ocular effect using three ocular parameters, pupil diameter (PD), corneal reflex (CR) and pupillary light reflex (PLR). The phytochemical tests were performed on the pulverized leaves, which were used to ascertain the distribution pattern of some possible bioactive agents ...

S. A. Igwe *, M. N. Ezenwaeze, S. O. Nweze and D. J. Ogbonna

Department of Pharmacology and Therapeutics, ESUT College of Medicine, Parklane, GRA, Enugu.

DOI: 10.13040/IJPSR.0975-8232.13(2).853-57

853-857

154

75

37.

IN-VITRO SENSITIVITY OF SALMONELLA TYPHI ISOLATES FROM POULTRY FARMS TO SELECTED BRANDS OF CIPROFLOXACIN ON THE GHANAIAN MARKET

Poultry products are a major source of animal protein in Ghana. However, disease outbreaks have constantly threatened increased poultry production in some regions of the country. The most common source of human salmonellosis is food of poultry origin. The evolution of resistant strains of Salmonella in natural environments and animal houses presents a serious public health concern. Fluoroquinolone...

Hayford Odoi *, Vivian Etsiapa Boamah and Yaa B. O. Asubonteng

Department of Pharmaceutical Microbiology, School of Pharmacy, University of Health and Allied Sciences, Ho, Volta region, Ghana.

DOI: 10.13040/IJPSR.0975-8232.13(2).858-63

858-863

158

84

38.

ANTI-BACTERIAL EFFICACY OF PHYTO-SYNTHESIZED ZINC OXIDE NANOPARTICLES USING MURRAYA PANICULATA L. LEAF EXTRACT

Human beings always tried to protect their body from pathogenic microbes, whereas these pathogens always mimic and mutate themselves to infect humans. Nanotechnology is new and upgrading itself as well as enhancing its applicability in pharmaceuticals. Due to their nano-size structure, property drastically changes from their parent elements. Nanoparticles are used widely in biomedical sciences. Fo...

Ajay Kumar Tiwari, Saket Jha *, Rahul Agrawal, Sheo Kumar Mishra, Ashok Kumar Pathak, Abhimanyu Kumar Singh, Anupam Dikshit and Ram Rashile Awasthi

Department of Botany, Institute of Professional Studies, University of Allahabad Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).864-71

864-871

173

133

39.

DEVELOPMENT AND VALIDATION OF RP-HPLC FOR SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN PHARMACEUTICAL TABLET DOSAGE FORM

A simple, precise, rapid, linear and economical RP-HPLC method was developed and validated for simultaneous estimation of Pregabalin and Etoricoxib in pharmaceutical tablet dosage form. The determination was performed on Phenomenex C18 (250 mm × 4.6 mm, ID, 5µ) column at 30 ºC temperature using a mobile phase Acetonitrile: Water (55:45 %v/v) at a flow rate of 0.8 ml/min was employed. The RP-HPL...

M. B. Karanjkar

Department of Quality Assurance Techniques, S.V.P.M. College of Pharmacy Malegaon (BK), Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).872-79

872-879

261

125

40.

GREENER SYNTHESIS OF CUO NANOCRYSTALS USING RAMBUTAN NEPHELIUM LAPPACEUM L. PEEL EXTRACT AND ITS ANTIBACTERIAL APPLICATIONS

Green synthesis of copper oxide nanocrystals was carried out via hydroxide precipitation using rambutan peel wastes. The successful formation of copper oxide nanocrystals was confirmed by X-Ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM) analysis. XRD analysis confirms the calculated average crystallite size of hig...

Joghee Suresh *, Lingaraj Ragunath and Viswanath Bellie

Department of Chemistry, Sri Ramakrishna Engineering College, N.G.G.O Colony, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).880-90

880-890

162

85

41.

DEVELOPMENT OF NATEGLINIDE MODIFIED RELEASE DOSAGE FORM USING ELEMENTARY OSMOTIC PUMP (EOP) AND PUSH-PULL OSMOTIC PUMP (PPOP) METHODS

Objective: The aim of the study was to develop osmotic tablets of nateglinide by two methods, namely elementary osmotic pump (EOP) and push-pull osmotic pump (PPOP) method for controlled drug release. Methods: Initially, pre-compression parameters were studies for the tablet blend in both EOP and PPOP methods. The tablets were prepared by the wet granulation method in both methods. The prepared t...

Fatima Shireen, M. Ajitha and S. Roshan *

Deccan School of Pharmacy, Darussalam, Aghapura, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).891-01

891-901

143

80

42.

PHYTOCHEMICAL INVESTIGATION AND ANTIOXIDANT POTENTIAL OF TWO AMARANTHACEAE PLANTS: ACHYRANTHES ASPERA LINN AND CHENOPODIUM ALBUM LINN

Antioxidants are renowned protective molecules that are significant in the management of many chronic diseases. They can support the free radical mechanism to quench the cellular stress to prevent oxidative damage and improve existing therapy by playing a vital role in protection through antioxidant activities. The family Amaranthaceae is a well-known family for various health benefits. The select...

T. Rajeshwari *, R. Suresh and M. Sudhakar

Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).902-11

902-911

153

105

43.

ACUTE AND SUB-ACUTE TOXICITY STUDIES OF THE SIDDHA PREPARATION MV KASHAYAMIN WISTAR RATS

The acute and sub-acute toxicity analysis of Siddha preparation MV kashayam was carried out with Wistar rats as per the guidelines 423 and 407of the Organization for Economic Co‐operation and Development (OECD), respectively. In the acute toxicity study, a single dose of MV kashayam (1000 and 2000 mg/kg body weight) was administered orally to the rats and monitored for 14 days. In the sub-acute ...

S. P. Malarkannan *, P Dharumarajan and Mkhariyohesh

Department of Rural Development Science, Arul Anandar College, Karumathur, Madurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).912-20

912-920

175

106

44.

IN-VITRO AND IN-VIVO ANTIOXIDANT PROPERTIES OF STEM EXTRACTS OF CROTON MEMBRANACEUS

Croton membranaceus is a tropical plant that grows wildly in some West African countries. Though several parts of this plant are used for the treatment of diverse disease conditions, its root extracts are traditionally used mainly in Ghana for the management of prostate diseases. This present study aimed to investigate the in-vitro and in-vivo antioxidant activities of the stem extracts of C. memb...

D. K. Afriyie *, E. Ofori-Ameyaw, D. O. Acheampong, I. Tuffour and Regina Appiah-Opong

Department of Biomedical Sciences, University of Cape Coast, Ghana, College of Health Sciences, University of Ghana.

DOI: 10.13040/IJPSR.0975-8232.13(2).921-29

921-929

156

88

45.

FORMULATION AND CHARACTERIZATION OF IBRUTINIB LOADED CYCLODEXTRIN NANOSPONGES

The aim of this study was to explore the feasibility of complexing the poorly water-soluble drug ibrutinib with β-cyclodextrin (β-CD) based nanosponges (NS), which offer advantages of improving dissolution rate and eventually oral bioavailability. Blank NS were fabricated by reacting β-CD with the cross-linker carbonyldiimidazole at different molar ratios (1:2, 1:4 and 1:8). The effect of formu...

G. Surendar * and B. Ramesh

Department of Pharmacy, Career Point University, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).930-41

930-941

192

133

46.

PATTERN OF ANTIDEPRESSANT PRESCRIPTION IN PATIENTS SUFFERING FROM DEPRESSIVE DISORDER IN A TERTIARY CARE HOSPITAL

Background: Depression is becoming an important health problem worldwide because of its relatively high lifetime prevalence, significant disability, suffering, dysfunction, and economic burden caused by it. Objectives: The present study was conducted with the objective to determine the prescribing pattern of antidepressant drugs in patients suffering from depression disorder in the psychiatric out...

Prosenjit Ghosh *, Sarajita Barman, Dolly Roy and Shirsendu Roy

Department of Psychiatry, Silchar Medical College & Hospital, Silchar, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).942-47

942-947

153

90

47.

DOSE APPROPRIATENESS AND ADJUSTMENT OF DRUGS IN CHRONIC KIDNEY FAILURE PATIENTS IN A TERTIARY CARE HOSPITAL OF TELANGANA

Background: Dose appropriateness in Chronic Kidney Disease patients is crucial to avert toxicity since several drugs are eliminated through kidneys. The present study was taken up to identify the degree of appropriateness in the dosage regimen of patients with chronic kidney disease (CKD) patients. Methods: The study was a prospective observational study carried out in the Department of Nephrology...

Veena Gadicherla *, Sujatha Palatheeya, Varun Dasari, Nagalatha Dhulipalla, Srikanth Reddy Singaram, Sabitha Ramavath, Sowmya Macharla, Hima Bindu Erram and Ramakrishna Prudhvi

Department of Pharmacy Practice, Sri Ind Institute of Pharmacy, Sheriguda (V), Ibrahimpatnam (M), R.R. District Sheriguda, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).948-55

948-955

159

91

48.

PERSISTENCE OF CANDIDA AURIS ON ELEMENTS USED FOR PERSONAL PROTECTION (LATEX GLOVES AND DISPOSABLE GOWN)

Candida sp. is currently associated with nosocomial infection; in this study, we aimed to determine the persistence of Candida auris on inanimate surfaces. Two test surfaces (latex gloves and disposable gown) were inoculated with two strains of Candida auris (clinical Ca1 and environmental H005913). The initial concentration of the inoculum was 108 UFC / mL, sampling was performed by rubbing a ste...

Edith Sihomara Bohorquez, Janeth Arias Palacios and Claudia Marcela Parra *

Laboratory of Human and Proteomic Mycoses, Pontificia Universidad Javeriana, Faculty of Sciences, Department of Microbiology Bogota Colombia.

DOI: 10.13040/IJPSR.0975-8232.13(2).956-61

956-961

138

74

49.

DEVELOPMENT AND STANDARDIZATION OF STABILITY INDICATING UV-SPECTROPHOTOMETRIC METHOD FOR ASSESSMENT OF BILASTINE IN BULK AND PHARMACEUTICAL DOSAGE FORMULATION

The objective of the present work is to develop and standardize the UV-Spectrophotometric method for the assessment of Bilastine in bulk and pharmaceutical dosage forms.  On account of not much work being reported on the drug Bilastine and also it is a new second-generation anti-histamine molecule. Hence it is necessary in this context to relook into the older methods and further research for new...

O. S. Supe, M. M. Maste *, S. S. Suryawanshi and R. K. Yadav

Department of Pharmaceutical Chemistry, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).962-68

962-968

178

134

50.

ESTIMATION OF SECONDARY METABOLITES AND TOXICITY TO ARTEMIA SALINA L. OF SELECTED PLANTS OF FAMILY COMBRETACEAE: AN APPROACH FOR SCREENING OF HERBAL PREVENTIVE AGENTS

Objective: Combretaceae, a large family, includes more valuable species that are used against many diseases and disorders along with cancer therapy. Cancer is a very common lethal disease throughout the world. Keeping this in view, two species are Combretum roxburghii Spreng and Terminalia catappa L. selected for present studies to provide baseline data for future formulation. Methods: Phytochemic...

Hrudaya Ballava Dash, Sanjeet Kumar, Moumita Saha *, Rajkumari Supriya Devi and Susanta Kumar Biswal

Shri Gnanambica Degree College, Madanapalle, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).969-76

969-976

158

103

51.

DNA BINDING AND ANTIBACTERIAL ACTIVITY OF TRANSITION METAL COMPLEXES WITH PREORGANIZED HEXADENTATE LIGAND

A new preorganized ligand, benzil bis [2-(2-amino-ethylamino) ethanol)] (H2BAE) has been synthesized and characterized for the first time. Copper (II) and cobalt (II) complexes of H2BAE have been synthesized and characterized based on molar conductivity data IR, UV-Vis spectroscopy.  The complexes are found to have general formula M(BAE)2 (where, M = Cu (II) and Co (II).  IR spectral data indica...

K. Anuja, K. Hussain Reddy *, D. Dhanalakshmi, K. Srinivasulu and Y. B. Nagamani

Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).977-86

977-986

160

88

52.

RP-UPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF LEVOCETIRIZINE IN LEVOCETIRIZINE DIHYDROCHLORIDE TABLETS

Current analytical research and experiments provide the development of a simple, sensitive, accurate, rapid, and stability indicative RP-UPLC method for estimation of Levocetirizine in Levocetirizine dihydrochloride tablets. This development was achieved using a Waters Acquity UPLC with BEH, C18 column of dimensions of 100 mm × 2.1 mm, 1.7 µm column at 0.3 mL/min flow rate and Acquity TUV detect...

S. S. Shetgar *, D. Ramadevi, B. M Rao, K. Basavaiah

Department of Inorganic and Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).987-95

987-995

154

81

53.

IN-VITRO ANTHELMINTIC EFFECT OF CAPPARIS DECIDUA (KAIR) ON TEGUMENT OF GASTROTHYLAX CRUMENIFER IN GOAT BY LIGHT MICROSCOPY

Paramphistomiasis is the major problems in the yield of goat and human health. This disease causes loss of life of goat, reduce meat and milk production. The medicinal plant Capparis decidua has been used in the treatment of asthma, cough and inflammation. This plant also shows anthelmintic activity. Live amphistome Gastrothylax crumenifer were collected from the rumen of the freshly slaughtered g...

Gayatri Swarnakar * and Babita Jogpal

Department of Zoology, Government P. G. Meera Girls College, M. L. S. University, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).996-02

996-1002

162

90

54.

STRUCTURAL TRANSFORMATION OF LUPEOL AND EVALUATION THEIR IN-VITRO ANTIOXIDANT ACTIVITY

Lupeol (I) is a naturally occurring triterpene that has been isolated from the stem bark of Crataeva nurvala in appreciable amount. Due to the presence of a single hydroxyl group and a large, apolar skeleton, lupeol acts as an amphiphile. The two possible sites for chemical modification present in lupeol are ring-A and isopropenyl side chain. We modified it in three naturally occurring analogous d...

Tek Chand Sharma, Anil Kumar Sharma * and Jai B. S. Kachhawa

Department of Chemistry, Jagan Nath University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).1003-11

1003-1011

163

77

55.

TIME COURSE OF SYSTEMIC AND BRAIN CYTOKINE EXPRESSION BY ENDOTOXIN AND ROLE OF DEXAMETHASONE

Literature evidence suggests that neuroinflammation plays a key role that activates and propagates the neurodegenerative process associated with many neurological diseases. Different stimuli, such as lipopolysaccharide (LPS) are the endotoxin that activates the immune system to create neuroinflammation associated with neurodegeneration. The peak expression of different cytokines (TNF-α, IL-1β &a...

Shuvranshu Praharaj *, V. K. Kalaichelvan, V. Murugan and Ishtiyaque Ahmad

Jubilant Biosys Ltd, Bangalore, College of Pharmaceutical Sciences, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(2).1012-18

1012-1018

165

103