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ANGIOGENESIS IN CARDIOVASCULAR DISEASE: A REVIEW
Angiogenesis is process of new blood vessel formation that occurs under both normal and pathological conditions. In the normal state, two distinct processes can be seen. One utilizes endothelial progenitor cells (EPC) and the second utilizes existing vasculature to generate new vessels. The healthy body controls angiogenesis through a series of "on" (angiogenesis-stimulating growth factors) and "o...
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DESIGN AND EVALUATION OF CHITOSAN-BASED MICROPARTICLES AS MODELS OF PROTEIN DELIVERY SYSTEMS
Controlled release systems for protein and peptide vaccines based polymers have been considered for many applications in medical therapies. Chitosan is non-toxic and easily absorbed biopolymers and is often used in many researches to sustained release drugs and proteic vaccines. This study investigates the kinetics of release in vitro of bovine serum albumin (BSA) from chitosan microparticles and ...
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PHYTOCHEMICAL SCREENING AND BIOLOGICAL STUDIES ON THE LEAVES OF TINOSPORA CORDIFOLIA
Helminthiasis is also known as worm infection and a endoparasitic disease of humans and other animals in which a part of a body is infected with parasitic worms. Tinospora cordifolia is a well known medicinal plant and widely used in folk medicine ayurvedic system. The objective of this work is to carry out phytochemical screening and in vitro anthelmintic activity of methanolic, petroleum ether a...
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ANTIOXIDANT ACTIVITY OF TWO WILD TEUCRIUM SPECIES FROM MOROCCO
The aim of the present study was to investigate antioxidant activity, total polyphenols and total flavonoids contents of extracts from two Moroccan Teucrium species (Teucrium polium and Teucrium aurum). The Antioxidant activity was evaluated in-vitro by three assays namely, free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and t...
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ANTHROPOMETRIC AND BIOCHEMICAL ANALYSIS OF NORMAL AND OBESE SUBJECTS ON AN INDIAN POPULATION
Obesity is a very serious health problem worldwide. Obesity depends on several physical and bio-chemicals parameters that are discussed in this work, i.e., BMI, cholesterol level that includes Total cholesterol (TC), High density lipoprotein concentration (HDL-c), Low density lipoprotein (LDL-c), Triglycerides level (TG), Glucose level, Postprandial glucose level. The present study throws light on...
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ANTIPYRETIC ACTIVITY OF CRUDE AND AQUEOUS EXTRACT OF GULE GHAAFIS (GENTIANA OLIVIERI GRISEB) ON YEAST INDUCED PYREXIA IN ANIMAL MODEL
Ghaafis (Gentiana olivieri Griseb) has been recommended in Classical Unani literature as an important ingredient of many antipyretic formulations. Singularly, it is advocated in both crude and extract form. The present study was conducted to investigate the antipyretic activity of crude and aqueous extract of Gule Ghaafis on yeast induced pyrexia in animal model. The study was carried out by the m...
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DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR DETERMINATION OF CERITINIB IN RABBIT PLASMA USING PDA DETECTOR
A rapid, sensitive and reproducible HPLC method was developed and validated for the quantification of Ceritinib in rabbit plasma using PDA detector at wave length 264 nm. The method was developed using Dasatinib as internal standard (IS). Ceritinib is a selective and potent inhibitor of anaplastic lymphoma kinase (ALK) indicated in the treatment of non-small cell lung cancer (NSCLC). The Ceritinib...
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ACUTE AND 28-DAY REPEATED DOSE TOXICITY OF AVERRHOA CARAMBOLA LEAVES ETHANOLIC EXTRACT IN RODENTS
Averrhoa carambola -L. (Oxalidaceae) has great importance in the Indian traditional system of medicine for controlling diabetes and piles: the combined extracts of leaves as well as fruits of A. carambola are used for the treatment of jaundice, gastric problems and other chronic conditions as well as in food supplements.The objective underlying this experiment is to determine the safety profile of...
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INVITRO ANTIOXIDANT STUDY AND SEARCH FOR A NOVEL BIOACTIVE COMPOUND FROM LEAVE FRACTIONS OF CANTHIUM COROMANDELICUM (BURM.F.) ALSTON
Background: Plants are enriched with various types of phytoconstituents present in the form of secondary metabolites that ensure its medicinal value. Keeping this in view, the present investigation was carried out focusing on its antioxidant property that may mainstay of exploring other therapeutic potency. Hence, phytochemical investigation followed with antioxidant property was evaluated in the ...
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VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAUNORUBICIN AND CYTARABINE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
This paper describes a new validated Reverse-Phase High-Performance Liquid Chromatography (HPLC) method for the simultaneous determination of two anti-cancer drugs, Daunorubicin and Cytarabine (Ara-C). A simultaneous determination method saves cost and time as both drugs can be injected into a single HPLC system without the need to change or re-equilibrate with a new mobile phase. The objective of...
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