Most Popular
SIMULTANEOUS QUANTITATION AND VALIDATION OF PHENYLEPHRINE HYDRO-CHLORIDE, AMBROXOL HYDROCHLORIDE AND LEVOCITRIZINE HYDROCHLORIDE IN SYRUP FORMULATION BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
A simple, precise and accurate RP-HPLC method was developed and validated for the estimation of Phenylephrine hydrochloride, Ambroxol hydrochloride and Levocetirizine hydrochloride in syrup formulation. This method is based on HPLC separation of the three drugs on Octadecyl Silane C18 column (250 mm × 4.6 mm, 5.0μ), with isocratic conditions and mobile phase containing 0.01M Sodium dihydrogen ph...
4334
1801
ANTIBACTERIAL ACTIVITY OF ETHNOMEDICINAL PLANTS OF IRULARS OF WESTERN GHATS
The present study report deals with the medicinal plants used by the irular tribal people of Coimbatore against pyogenic infections. Five different plants like Abutilon indicum, Datura metel, Lantana Camaro, Tridax procumbens and Leucas aspera were collected and their antimicrobial activity were tested against bacteria such as Staphylococcus aureus, Streptococcus pyogenes, Bacillus anthracis, Ps...
4334
1669
DEVELOPMENT AND VALIDATION OF NOVEL RP-HPLC METHOD FOR THESIMULTANEOUS ESTIMATION OF EZETIMIBE AND BEMPEDOIC ACID IN A TABLETDOSAGE FORM
A simple, novel, precise, and cost-effective reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated to simultaneously estimate ezetimibe and bempedoic acid in the marketed tablet dosage form. The chromatographic separation was carried out on a Prontosil C18 (250 x 4.6 mm, 5 µm) column using a mobile phase of Acetonitrile: water (60:40 v/v). The flow rate...
4334
3273
PRELIMINARY PHYTOCHEMICAL, ANTI-BACTERIAL, ANALGESIC, ANTI-DIARRHOEAL AND CYTOTOXIC ACTIVITY OF METHANOLIC EXTRACT OF POLYALTHIA SUBEROSA LEAVES
The MeOH extract of leaves of Polyalthia suberosa Roxb. (Annonaceae) was screened for its antibacterial, analgesic, Antidiarrhoeal and cytotoxic activities. The extract showed moderate anti-bacterial activity against Vibrio cholerae, Sheigella sonnei, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus saprophyticus. It also produced significant (P<0.01) writhing inhibition in a...
4333
1979
FORMULATION OF DIRECT COMPRESSED VERAMPAMIL SUSTAINED RELEASE FORMULATION USING OPTIMIZED CO PROCESSED EXCIPIENTS
Pharmaceutical excipients when co-processed have improved flow and disintegrant properties in tablet formulations. However, physical mixtures of excipients show limited functions, poor flow properties, and poor functional properties so they cannot be used directly in tablet formulations. Majority of solid dosage forms contain multiple excipients, which provides a wide window of opportunities by co...
4333
2008
ANTIOXIDANT ACTIVITY OF TWO WILD TEUCRIUM SPECIES FROM MOROCCO
The aim of the present study was to investigate antioxidant activity, total polyphenols and total flavonoids contents of extracts from two Moroccan Teucrium species (Teucrium polium and Teucrium aurum). The Antioxidant activity was evaluated in-vitro by three assays namely, free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and t...
4333
1872
SENSITIVE, HIGH-THROUGHPUT AND ENANTIOSELECTIVE QUANTITATION OF ZOPICLONE IN HUMAN PLASMA BY LCMS/MS: APPLICATION TO A HUMAN PHARMACOKINETIC STUDY
Zopiclone (ZPC), a cyclopyrrolone derivative, is a short-acting hypnotic agent. Its pharmacological properties include hypnotic, sedative, anxiolytic, anticonvulsant and muscle-relaxant actions. ZPC has a single chiral centre, and its enantiomers are S-zopiclone (S-ZPC) and R-zopiclone (R-ZPC). S-ZPC was adjudge to possess two- fold enhanced pharmacological activity than racemate (ZPC) while its o...
4331
3062
STUDY OF ENDOPHYTIC FUNGAL COMMUNITY OF MORINGA OLEIFERA FROM OMALUR REGION – SALEM
Endophytic fungi are ubiquitous in nature residing inside all the plant species contributing to their host plants by producing a plenty of substances that provide protection and survival value to the plant. Many researchers have proven that endophytes are a new and potential source of novel natural products for exploitation in modern medicine. This present study is undertaken to isolate and identi...
4331
1690
DESIGN AND EVALUATION OF LAMOTRIGINE ORAL SUSTAINED RELEASE TABLETS
Objective: The objective of the study is to design and evaluate oral sustained release tablet of lamotrigine using polymer such as HPMC K 4M, HPMC K 100M and methocel E50 LV at 15%, 25%, and 35% Concentration range. Methods: All the selected ingredients were weighed and passed through 40# sieve, blended in a Poly Bag except Magnesium Stearate for 10 minutes. The resultant mixture was made in to...
4331
1724
PREVENTIVE EFFECT OF HELIX ASPERSA CRUDE EXTRACT AGAINST CHEMO-INDUCED COLONIC DAMAGES IN RATS
The present work aimed to explore in vivo the effect of Helix Aspersa Crude Extract (HACE) on the chemo-induced damages occurred in rat colon specially on the histology of the crypts foci in liberkhun glands. The toxicity of HACE was evaluated with different HACE concentrations. With the concentration of 160 mg, animals showed the best gain weight, stayed normal and all animals survived. Therefore...
4331
2014