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HISTORY, MANIFESTATION AND PREVENTIVE MEASURES FOR RUBELLA IN INDIA: A REVIEW
Rubella is an eradicable illness on the grounds of immunization against it produces solid protection. The name rubella comes from the Latin language, and it means “little red”. In olden times people thought that rubella was a variant of measles. German literature first described it as a separate disease, and hence it was also called “German Measles”. People are the main reservoir of the in...
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PHYSICAL-CHEMICAL CHARACTERIZATION, ANATOMICAL AND SEASONAL EVALUATION OF THUJA OCCIDENTALIS L. (CUPRESSACEAE)
Thuja occidentalis L. is a plant widely used therapeutically. Having seen the necessity to standardize the vegetal drug and to evaluate the interference of certain environmental and seasonal factors on the synthesis of metabolites, notably flavonoids, this work considered anatomical and physical-chemical characterization assays for the aforesaid vegetal drug, in addition to phytochemical prospecti...
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FORMULATION OF DIRECT COMPRESSED VERAMPAMIL SUSTAINED RELEASE FORMULATION USING OPTIMIZED CO PROCESSED EXCIPIENTS
Pharmaceutical excipients when co-processed have improved flow and disintegrant properties in tablet formulations. However, physical mixtures of excipients show limited functions, poor flow properties, and poor functional properties so they cannot be used directly in tablet formulations. Majority of solid dosage forms contain multiple excipients, which provides a wide window of opportunities by co...
4291
1991
EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-PYRETIC ACTIVITY OF AERVA PSEUDOTOMENTOSA LEAVES AQUEOUS EXTRACT
Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae) is arid region plant commonly known as Bui. It is used in ethno medicinal practices for the treatment of pain and inflammatory hyperalgesic disorders such as rheumatic pain, fever, inflammation, wounds and urinary disorders. This study was conducted to evaluate the anti-nociceptive, antipyretic effects of A. pseudotomentosa leaves aqueous e...
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1583
NOVEL SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-AMINO PHENYL-5-METHYL PYRAZOLES AND ITS DERIVATIVES
Pyrazoles and fused heterocyclic pyrazoles derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activity in the field of pharmaceutical science, agriculture etc. In the present study, new substituted pyrazoles were prepared by condensation of substituted primary amine and ethyl acetoacetate at 1400C to form analides as ...
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1822
SENSITIVE, HIGH-THROUGHPUT AND ENANTIOSELECTIVE QUANTITATION OF ZOPICLONE IN HUMAN PLASMA BY LCMS/MS: APPLICATION TO A HUMAN PHARMACOKINETIC STUDY
Zopiclone (ZPC), a cyclopyrrolone derivative, is a short-acting hypnotic agent. Its pharmacological properties include hypnotic, sedative, anxiolytic, anticonvulsant and muscle-relaxant actions. ZPC has a single chiral centre, and its enantiomers are S-zopiclone (S-ZPC) and R-zopiclone (R-ZPC). S-ZPC was adjudge to possess two- fold enhanced pharmacological activity than racemate (ZPC) while its o...
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ANATOMICAL CHARACTERIZATION AND MICROCHEMISTRY OF VISMIA GUIANENSIS (AUBL.) CHOISY (CLUSIACEAE) BLADE LEAF
Vismia guianensis (Aubl.) Choisy is a tree that belongs to the secondary vegetation in rainforests. This study aimed to perform anatomy analysis by light microscopy; scanning and microchemistry of the leaves of V. guianensis. Tri stratified upper epidermis with intense cutinization and unistratified inferior epidermis was observed. The stomata found are paracytic and the trichomes arranged in rose...
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CHOLESTEROL ESTERASE ENZYME INHIBITORY AND ANTIOXIDANT ACTIVITIES OF LEAVES OF CAMELLIA SINENSIS (L.) KUNTZE. USING IN VITRO MODELS
The present study was to evaluate the in vitro cholesterol esterase enzyme inhibitory and in vitro antioxidant activity of the methanol extract of the leaves of Camellia sinensis (L.). Phytochemical screening of the extract shows the presence of flavonoids, phenolics and terpenoids. The extract shows ability to inhibit the enzyme with IC50 (82.46±0.74µg/ml) whereas that of standard, Orlistat (...
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SYNTHESIS AND EVALUATION OF MESOPOROUS SILICA NANOPARTICLES (MSN) LOADED COX-II INHIBITOR – MELOXICAM FOR TARGETED COLORECTAL CANCER TREATMENT
Polymer functionalised mesoporous silica nanoparticles hold great promise to enhance drug targeting and cell internalisation for cancer cells. Since the presence of abundant folate receptors on cancer cells, folic acid functionalised mesoporous silica nanoparticles (MSN) were used as folate marker and polyethyleneimine was used to improve cell internalisation. Meloxicam was loaded into the pores o...
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1743
ACRIDINE A VERSATILE HETEROCYCLIC MOIETY AS ANTICANCER AGENT
Acridine is a heterocyclic nucleus consisting of three fused rings heterocyclic moiety and a presence of Nitrogen in the ring structure. It is used in a large number of therapeutically agents for curing ailments like antimalarial, antiseptics, abortifacient, anticancer, and so on because of its adjuvant molecule attached to it. It possesses high pharmacological properties mainly with respect to ca...
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