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EVALUATION OF MIXTURES OF AQUEOUS EXTRACT OF PSEUDOCEDRELA KOTSCHYI AND BOSWELLIA DALZEILII AS INTERACTING PRODUCTS IN REGULATION OF PHAGOCYTOSIS AND LYMPHOCYTES PROLIFERATION
The current study aimed to test the effect of the aqueous extract of Boswellia dalzeilii and Pseudecedrela kotschyi using three different mixing ratios (B. dalzeilii:P. kotschyi) 3:1, 2:2, and 1:3. The assays concerned the study of the interactions in the modulation of phagocytic index, nitric oxide production, lysosomal enzymes and myeloperoxydase activity in macrophages and regulation of lymphoc...
4292
1820
PHYSICAL-CHEMICAL CHARACTERIZATION, ANATOMICAL AND SEASONAL EVALUATION OF THUJA OCCIDENTALIS L. (CUPRESSACEAE)
Thuja occidentalis L. is a plant widely used therapeutically. Having seen the necessity to standardize the vegetal drug and to evaluate the interference of certain environmental and seasonal factors on the synthesis of metabolites, notably flavonoids, this work considered anatomical and physical-chemical characterization assays for the aforesaid vegetal drug, in addition to phytochemical prospecti...
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2480
EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-PYRETIC ACTIVITY OF AERVA PSEUDOTOMENTOSA LEAVES AQUEOUS EXTRACT
Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae) is arid region plant commonly known as Bui. It is used in ethno medicinal practices for the treatment of pain and inflammatory hyperalgesic disorders such as rheumatic pain, fever, inflammation, wounds and urinary disorders. This study was conducted to evaluate the anti-nociceptive, antipyretic effects of A. pseudotomentosa leaves aqueous e...
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1583
SENSITIVE, HIGH-THROUGHPUT AND ENANTIOSELECTIVE QUANTITATION OF ZOPICLONE IN HUMAN PLASMA BY LCMS/MS: APPLICATION TO A HUMAN PHARMACOKINETIC STUDY
Zopiclone (ZPC), a cyclopyrrolone derivative, is a short-acting hypnotic agent. Its pharmacological properties include hypnotic, sedative, anxiolytic, anticonvulsant and muscle-relaxant actions. ZPC has a single chiral centre, and its enantiomers are S-zopiclone (S-ZPC) and R-zopiclone (R-ZPC). S-ZPC was adjudge to possess two- fold enhanced pharmacological activity than racemate (ZPC) while its o...
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3006
ANATOMICAL CHARACTERIZATION AND MICROCHEMISTRY OF VISMIA GUIANENSIS (AUBL.) CHOISY (CLUSIACEAE) BLADE LEAF
Vismia guianensis (Aubl.) Choisy is a tree that belongs to the secondary vegetation in rainforests. This study aimed to perform anatomy analysis by light microscopy; scanning and microchemistry of the leaves of V. guianensis. Tri stratified upper epidermis with intense cutinization and unistratified inferior epidermis was observed. The stomata found are paracytic and the trichomes arranged in rose...
4290
1559
CHOLESTEROL ESTERASE ENZYME INHIBITORY AND ANTIOXIDANT ACTIVITIES OF LEAVES OF CAMELLIA SINENSIS (L.) KUNTZE. USING IN VITRO MODELS
The present study was to evaluate the in vitro cholesterol esterase enzyme inhibitory and in vitro antioxidant activity of the methanol extract of the leaves of Camellia sinensis (L.). Phytochemical screening of the extract shows the presence of flavonoids, phenolics and terpenoids. The extract shows ability to inhibit the enzyme with IC50 (82.46±0.74µg/ml) whereas that of standard, Orlistat (...
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2129
FORMULATION OF DIRECT COMPRESSED VERAMPAMIL SUSTAINED RELEASE FORMULATION USING OPTIMIZED CO PROCESSED EXCIPIENTS
Pharmaceutical excipients when co-processed have improved flow and disintegrant properties in tablet formulations. However, physical mixtures of excipients show limited functions, poor flow properties, and poor functional properties so they cannot be used directly in tablet formulations. Majority of solid dosage forms contain multiple excipients, which provides a wide window of opportunities by co...
4290
1991
NOVEL SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-AMINO PHENYL-5-METHYL PYRAZOLES AND ITS DERIVATIVES
Pyrazoles and fused heterocyclic pyrazoles derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activity in the field of pharmaceutical science, agriculture etc. In the present study, new substituted pyrazoles were prepared by condensation of substituted primary amine and ethyl acetoacetate at 1400C to form analides as ...
4290
1822
SYNTHESIS AND EVALUATION OF MESOPOROUS SILICA NANOPARTICLES (MSN) LOADED COX-II INHIBITOR – MELOXICAM FOR TARGETED COLORECTAL CANCER TREATMENT
Polymer functionalised mesoporous silica nanoparticles hold great promise to enhance drug targeting and cell internalisation for cancer cells. Since the presence of abundant folate receptors on cancer cells, folic acid functionalised mesoporous silica nanoparticles (MSN) were used as folate marker and polyethyleneimine was used to improve cell internalisation. Meloxicam was loaded into the pores o...
4290
1743
ACRIDINE A VERSATILE HETEROCYCLIC MOIETY AS ANTICANCER AGENT
Acridine is a heterocyclic nucleus consisting of three fused rings heterocyclic moiety and a presence of Nitrogen in the ring structure. It is used in a large number of therapeutically agents for curing ailments like antimalarial, antiseptics, abortifacient, anticancer, and so on because of its adjuvant molecule attached to it. It possesses high pharmacological properties mainly with respect to ca...
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