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ANTIOXIDANT AND CYTOTOXICITY POTENTIAL OF ALCOHOL AND PETROLEUM ETHER EXTRACT OF BORASSUS FLABELLIFER LINN.
This study was subjected to investigate antioxidant and cytotoxic properties of ethanol and petroleum ether extracts of Borassus flabellifer Linn, expressed as BFA and BFP respectively. DPPH free radical scavenging method, total flavonoid, total phenol, total antioxidants and reducing power of the two extracts were assessed for antioxidant properties and cytotoxicity potentials were assessed by th...
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THE EFFECT OF MUSA SAPIENTUM METHANOLIC FRUIT EXTRACT ON VOLUME OF GASTRIC JUICE AND PEPSIN ACTIVITY IN ASPIRIN INDUCED PEPTIC ULCERS IN ALBINO RATS
The aim of the study was to evaluate the effect of Musa sapientum methanolic fruit extract on volume of gastric juice and pepsin activity in aspirin induced peptic ulcer in albino rats. The extract was prepared by percolation method. Volume of gastric juice was estimated by the method of Deshpande SS et al (2003). Pepsin activity was studied with the methods of Debnath PK et al (1974) and Lowry OH...
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SIMULTANEOUS QUANTIFICATION OF THREE NAPHTHOQUINONES FROM IMPATIENS BALSAMINA L. LEAVES USING VALIDATED RP-HPLC METHOD
Impatiens balsamina belonging to family Balsaminaceae is commonly known as terda. The plant has an extensive range of phyto-constituents like naphthoquinones, coumarins, glycosides, phenolic acids, flavonoids, anthocyanidins and steroids which have effective antimicrobial, anti-anaphylaxis, anti-allergic, antipruritic, and anti-inflammatory activity. Potent naphthoquinones like lawsone, methylene-...
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IN VIVO TOXICOLOGICAL EVALUATION OF CHLORPYRIFOS PESTICIDE ON FEMALE ALBINO MICE: THERAPEUTIC EFFECTS OF CURCUMA LONGA
Chlorpyrifos (CPF) an Organophosphate insecticide was evaluated for its toxicity to produce reproductive disorders in rats following oral exposure. In the present study CPF was given to the mice at the dose levels of 10 and 20mg/kg body weight by Gavage method. A histological alteration of ovary and uterus was examined under light microscope. Its oxidative stress levels were studied by noting lipi...
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EVALUATION OF MIXTURES OF AQUEOUS EXTRACT OF PSEUDOCEDRELA KOTSCHYI AND BOSWELLIA DALZEILII AS INTERACTING PRODUCTS IN REGULATION OF PHAGOCYTOSIS AND LYMPHOCYTES PROLIFERATION
The current study aimed to test the effect of the aqueous extract of Boswellia dalzeilii and Pseudecedrela kotschyi using three different mixing ratios (B. dalzeilii:P. kotschyi) 3:1, 2:2, and 1:3. The assays concerned the study of the interactions in the modulation of phagocytic index, nitric oxide production, lysosomal enzymes and myeloperoxydase activity in macrophages and regulation of lymphoc...
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IDENTIFICATION AND ANALYSIS OF LEAD COMPOUNDS AGAINST HIV-1 INTEGRASE ENZYME USING ADMET PREDICTION AND DOCKING ANALYSIS
Acquired immune deficiency syndrome (AIDS), one of the most challenging diseases world-wide is caused by human immunodeficiency virus (HIV), member of human retrovirus family. Various therapies and treatments of HIV are provided, but these are rapidly drug resistance in recent decades. After the explosion of HIV integrase (enzyme essential for the replication of DNA virus in the host genome), phar...
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STUDY OF ENDOPHYTIC FUNGAL COMMUNITY OF MORINGA OLEIFERA FROM OMALUR REGION – SALEM
Endophytic fungi are ubiquitous in nature residing inside all the plant species contributing to their host plants by producing a plenty of substances that provide protection and survival value to the plant. Many researchers have proven that endophytes are a new and potential source of novel natural products for exploitation in modern medicine. This present study is undertaken to isolate and identi...
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ANTIBIOTIC SUSCEPTIBILITY PATTERN OF METHICILLIN RESISTANCE STAPHYLOCOCCUS AUREUS IN TERTIARY CARE CENTER AT SOUTHERN RAJASTHAN
The objective of this study was to determine antibiotic susceptibility pattern of methicillin resistance Staphylococcus aureus in tertiary care center at Southern Rajasthan. Modified Kirby Baurer disc diffusion method was used for antimicrobial sensitivity testing of all samples. Maximum resistance among Staphylococcus aureus isolates (n=400) was observed against Methicillin (59%), Amikacin (53%...
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ANATOMICAL CHARACTERIZATION AND MICROCHEMISTRY OF VISMIA GUIANENSIS (AUBL.) CHOISY (CLUSIACEAE) BLADE LEAF
Vismia guianensis (Aubl.) Choisy is a tree that belongs to the secondary vegetation in rainforests. This study aimed to perform anatomy analysis by light microscopy; scanning and microchemistry of the leaves of V. guianensis. Tri stratified upper epidermis with intense cutinization and unistratified inferior epidermis was observed. The stomata found are paracytic and the trichomes arranged in rose...
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ESTIMATION OF MANIDIPINE DIHYDROCHLORIDE BY A NEW RP-HPLC METHOD
A rapid reverse phase high performance liquid chromatographic method was developed for the estimation of Manidipine dihydrochloride in its pure form as well as in tablet dosage forms. Chromatography was carried out on an phenomenex C18 column (250´4.6mm, 5 µm), using a mixture of acetonitrile and water (80: 20 v/v) with pH adjusted to 3.5 with ortho phosphoric acid (0.1 % v/v) as the mobile ph...
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