Most Popular
SYNERGISTIC ANTIOXIDANT ACTIVITY OF LIPOIC, FERULIC AND ELLAGIC ACID
Antioxidants prevent the damage done to the cells by free radicals that are released during the normal metabolic process of oxidation. Some of these free radicals include reactive oxygen species, hydroxyl, the superoxide anion, hydrogen peroxide and peroxyl which generate metabolic products that attack lipids in the cell membranes or DNA. These are associated with DNA damage, carcinogenesis and ce...
3110
1222
SCREENING OF UNIQUE BINDING SITE SPECIFIC LIGAND FOR CARBONIC ANHYDRASE IX
Cancer is a common and widespread cause of human death in the world. Treatments like chemotherapy and radiotherapy facilitate in prolonging the patient’s life however in some cases cancer can be prevented. Cancers like breast, prostate, colon, renal cell carcinoma are caused by the overexpression of an enzyme termed Carbonic Anhydrase IX (CAIX). In 2015, 60,290 new cases of breast cancer alone a...
3110
1212
PHARMACOKINETIC STUDY OF ANDROGRAPHIS PANICULATA ETHANOLIC EXTRACT TABLET
Andrographis paniculata (Burm. F) Nees, commonly known as the “king of bitters,” is an herbaceous plant belonging to the Acanthaceae and is found throughout tropical and subtropical Asia, Southeast Asia, and India. Andrographolide, a bitter diterpenoid, is the major active principle present in the plant. Authors have already worked on the phytochemical investigation, analgesic and antipyretic ...
3110
1383
IN-VITRO EVALUATION OF ANTIOXIDANTS ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF CELASTRUS PANICULATUS
Celastrus paniculatus is an important medicinal plant used in India. Traditionally seed oil of this herb is used widely in several medicinal preparations and its bark is used in malaria in folk medicines. It is endangered and vulnerable plant. The investigation used Reducing power assay and Total phenolic content to determine antioxidant potential in the ethanolic extract of the drug. The result s...
3109
1269
AN EXPERIMENTAL STUDY TO EVALUATE THE EFFECTS OF AEGLE MARMELOS AND IT’S COMPARISON WITH PIRACETAM ON LEARNING AND MEMORY IN WISTAR RATS
Present study was done to evaluate the memory enhancing effect of Aegle marmelos and its comparison with the present standard treatment Piracetam in Wistar rats. The learning and memory was assessed using the elevated plus maze. The findings of the present study indicate that, Aegle marmelos extract treated animals at a dose of 100 mg/kg p.o. as well as 200 mg/kg p.o. showed significant decrease...
3109
1174
PREPARATION AND PHYSICAL CHARACTERIZATION OF CISPLATIN CHITOSAN NANOPARTICLES BY ZETA NANOSIZER “PRIME STEP FOR FORMULATION AND DEVELOPMENT”
The ultimate aim of this research work is to develop a cisplatin loaded chitosan nanoparticle system (CCNP) to facilitate the release of cisplatin in a more sustained manner to improve therapeutic efficacy via the reduction of its toxicity. As a step-in formulation studies the work has been limited to studying the various physical characters of CCNP using a zeta nanosizer. The chitosan polymer was...
3109
1063
SELF EMULSIFYING DELIVERY SYSTEM –MOSTLY DISCUSSED BUT STILL REMAINED CHALLENGING ASPECT TO ENHANCE THE ORAL ABSORPTION OF LIPOPHILIC DRUG
Oral route of drug delivery is the simplest and most accepted way of administration of drugs due to greater stability, high patient compliance, accurate dosage, cost effectiveness and high patient compliance of drugs. But with oral formulations bioavailability is the major problem for newly discovered drug because 40 percent are lipophilic compounds. There are several factors responsible for low o...
3108
1053
BIOFILM INHIBITORY EFFECT OF CHLORELLA EXTRACTS ON PSEUDOMONAS AERUGINOSA
Background: Biofilm is a layer like aggregates of bacterial cells which are formed on biotic and abiotic surfaces. Pseudomonas aeruginosa plays an essential role in the aggregation of bacteria on biofilm formation. Quorum sensing and extracellular polysaccharide play a vital role in the biofilm formation in P. aeruginosa. The present study was aimed to investigate the anti-biofilm effect of lyophi...
3108
908
IN – VIVO CONFIRMATION OF A 49.6 KDA PROTEIN PILI OF HELICOBACTER PYLORI TO PREVENT DESTRUCTION OF GASTRIC CELLS AGAINST LIVE HOMOLOGOUS BACTERIA IN MICE
Peptic ulcers is one of the major gastrointestinal disorder in human being that generally associated with the infection of Helicobacter pylori, a gram-negative microaerophilic bacterium in stomach. It is also linked to the development of the stomach cancer. The aim of this study was to investigate the in vivo properties of the sub-unit pili proteins with molecular weight of about 49,6 kDa in m...
3107
1115
SEA BUCKTHORN (H. RHAMNOIDES L.) MEDIATED ACUTE HYPOXIC TOLERANCE IN THE SKELETAL MUSCLE OF RATS BY DIFFERENTIAL ACTIVATION OF ENERGY METABOLISM AND ENHANCED ANTIOXIDANTS
Exposure to hypobaric hypoxia differentially affects physical performance and survival amongst individuals. The present study was designed to investigate the role of metabolic enzymes, antioxidants and bioenergetics molecular markers in the differential hypoxic tolerance of animals exposed to acute hypobaric hypoxia and the effect of herbal supplementation in augmentation of hypoxia tolerance. Adu...
3107
1262