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IMPACT OF ALCOHOL ON RAT HEART AND AORTIC TISSUE ACETYLCHOLINE CONTENT LEVELS IN VITRO AND IN VIVO
Acetylcholine satisfies all criteria for a transmitter substance. Its most widely recognized action sites are the endings of vertebrate motor nerves, the endings of the automatic pre ganglionics and the parasympathetic post ganglionics. It appears also to be the transmitter of motor nerves in all advanced invertebrate animals except the arthropods where it seems to separate at the endings of senso...
4347
1506
ROLE OF SESAMUM ALATUM L. ON NEPHROPATHY IN DIABETIC RATS
Background: Type 2 Diabetes is a metabolic disorder, characterized by chronic hyperglycemia. It results from insulin resistance, a condition in which the body cells fail to use insulin properly. In Ayurveda Sesamum alatum L. (Pedaliaceae) has been used for the treatment of Diabetes. In this study, the antidiabetic activity of the Methanolic leaf extract of S. alatum was investigated, and the ren...
4347
1718
ANTIBIOTIC SUSCEPTIBILITY PATTERN OF METHICILLIN RESISTANCE STAPHYLOCOCCUS AUREUS IN TERTIARY CARE CENTER AT SOUTHERN RAJASTHAN
The objective of this study was to determine antibiotic susceptibility pattern of methicillin resistance Staphylococcus aureus in tertiary care center at Southern Rajasthan. Modified Kirby Baurer disc diffusion method was used for antimicrobial sensitivity testing of all samples. Maximum resistance among Staphylococcus aureus isolates (n=400) was observed against Methicillin (59%), Amikacin (53%...
4346
1574
QUALITY IMPROVEMENT OF FRESH-CUT-FRUITS BY GAMMA RADIATION FOR IMMUNE-COMPROMISED PATIENTS
Objective: Immune-compromised patients are vulnerable to microbes, which are usually safe and sound for healthy individuals. The aim of this study is to provide a quality fresh fruits such as apple, grape, guava, pear and plum for immune-compromised personnel sing different doses of gamma radiation. Methods: Irradiation impacts on microbial number, in treated fruits were assessed and compared to s...
4346
1709
ANTHROPOMETRIC AND BIOCHEMICAL ANALYSIS OF NORMAL AND OBESE SUBJECTS ON AN INDIAN POPULATION
Obesity is a very serious health problem worldwide. Obesity depends on several physical and bio-chemicals parameters that are discussed in this work, i.e., BMI, cholesterol level that includes Total cholesterol (TC), High density lipoprotein concentration (HDL-c), Low density lipoprotein (LDL-c), Triglycerides level (TG), Glucose level, Postprandial glucose level. The present study throws light on...
4346
1227
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF METFORMIN HCl FOR THE TREATMENT OF TYPE-2 DIABETES MELLITUS
Floating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. The tablets were formulated by using central composite design having two independent variables at three levels. Ind...
4345
1935
EVALUATION OF ANTIOXIDANT AND HYPOLIPIDEMIC ACTIVITY OF VEDIC GUARD, A POLYHERBAL FORMULATION
The present study was undertaken to evaluate antioxidant and hypolipidemic activity of Vedic guard, a polyherbal formulation comprising of Terminalia arjuna, Withania sominefera, Bacopa monnierii, Tinosporia cardifolia, Commiphora mukul and many other plant extracts, all of which are classifieds in Ayurveda as Rasaayanas which are reported to promote antioxidant and hypolipidemic activity. Antioxi...
4345
1948
MOLECULAR DOCKING AND 3D-QSAR ANALYSIS STUDIES OF MMP-12 INHIBITORS
Matrix metalloproteinase 12 (MMP-12) inhibitions is an important research topic because of its wide range of associated health implications. The interaction mode of a series of pyridinone compounds with MMP-12 has been studied using molecular docking and 3D-QSAR approaches. Flexible docking was used for the determination of active conformation and molecular alignment. Comparative molecular field a...
4345
1675
IN VIVO TOXICOLOGICAL EVALUATION OF CHLORPYRIFOS PESTICIDE ON FEMALE ALBINO MICE: THERAPEUTIC EFFECTS OF CURCUMA LONGA
Chlorpyrifos (CPF) an Organophosphate insecticide was evaluated for its toxicity to produce reproductive disorders in rats following oral exposure. In the present study CPF was given to the mice at the dose levels of 10 and 20mg/kg body weight by Gavage method. A histological alteration of ovary and uterus was examined under light microscope. Its oxidative stress levels were studied by noting lipi...
4344
1490
MICRO-ELECTROPHORETIC MOBILITY STUDY OF THE INFLUENCE OF CHLORPROMAZINE HYDROCHLORIDE ON DIMYRSTOYLPHOSPHATIDYLCHOLINE LIPOSOMES IN DIFFERENT MEDIA
In this study, the possible influence of the model, cationic drug chlorpromazine hydrochloride (CPZ-HCl) concentration on the micro-electrophoretic mobility of neutral large multi-lamellar dimyrstoylphosphatidylcholine (DMPC) liposomes was investigated in various media at both 25oC and 37oC. In addition the effect CPZ-HCl concentration on the micro-electrophoretic mobility of both positively charg...
4344
1906