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A STUDY ON BIOPOLYMERIC NANOPARTICLES AS AN EFFECTIVE CARRIER FOR ANTIDEPRESSANT DRUG DELIVERY SYSTEM
Drug delivery is the most essential feature in drug administration facility and the design of Nanosystems makes the action more consistent an appropriate. Polymer nano particles bind efficiently to the drug and disperse the drug proficiently into the system. The efficacy of many drugs is often limited by their potential to reach the site of therapeutic action. In most cases (conventional dosage fo...
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1583
AMELIORATED ACTIVITY OF MURRAYA KOENIGII LEAVES CHLOROFORM EXTRACT (MKCE) AGAINST LEAD INDUCED HEPATIC DYSFUNCTIONS IN MICE
Lead is a well-known hepatotoxic and all-pervading heavy metal. Ingestion of lead induces structural dysfunctions, physiological distortion and biochemical impairment in the liver. The present study was aimed to ascertain the ameliorated effect of chloroform extract of Murraya leaves against the deleterious effects of lead on hepatic function parameters. Murraya koenigii Chloroform Extract (MKCE) ...
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1435
DEVELOPMENT OF A POLYHERBAL CAPSULE FOR THE TREATMENT OF ASTHMA
A drug dosage form is very important in delivering the drug in proper dose in most appropriate form. The capsule shell is an excellent barrier to air, and it also has some other advantages such as being easy to swallow and tasteless, flexibility of formulation etc. The use of the hard gelatin capsule dosage form may perhaps be an alternative to overcome the problem, which the hygroscopicity of the...
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1690
QUALITY OF LIFE IN PATEINTS WITH PSORIASIS IN OSMANABAD REGION OF INDIA: A SINGLE CENTRE STUDY
The prevalence of psoriasis has a deep negative impact on Quality of life (QoL) daily. It has been classified under psychophysiological disorders. The prime objective of the present study is to evaluate and assess the Quality of Life (QoL) of psoriasis patients in Osmanabad region of India. A retrospective analyzing study was carried out on 52 psoriatic patients attending outpatient and inpatient ...
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1513
DESIGN UTILIZING BILE SALT SURFACTANTAND IN VITRO EVALUATION: IMIDAZOLE CLASS DRUG NASAL SPRAY FOR TREATMENT OF NASAL CONGESTION
The objective of the present work is to develop the meter dose nasal formulation of xylometazoline hydrochloride with a view to improve the effectiveness as nasal decongestion. The 32 factorial experimental design was employed for optimization of sodium cholate (X1) and PEG 400 concentration (X2) in the formulation. All the possible experimental trials were carried out according to design layout. ...
4297
1934
EVALUATION OF ANTIOXIDANT AND HYPOLIPIDEMIC ACTIVITY OF VEDIC GUARD, A POLYHERBAL FORMULATION
The present study was undertaken to evaluate antioxidant and hypolipidemic activity of Vedic guard, a polyherbal formulation comprising of Terminalia arjuna, Withania sominefera, Bacopa monnierii, Tinosporia cardifolia, Commiphora mukul and many other plant extracts, all of which are classifieds in Ayurveda as Rasaayanas which are reported to promote antioxidant and hypolipidemic activity. Antioxi...
4296
1925
EXTRACTION, MOLECULAR DOCKING, HPTLC ESTIMATION AND IN VITRO EVALUATION OF UREASE INHIBITION POTENTIAL OF STEM BARK OF TERMINALIA ARJUNA
The extraction of stem bark of Terminalia arjuna using different extraction methods viz. room temperature extraction (RTE), soxhlet extraction (SE), Ultrasound assisted extraction (USAE) and microwave assisted extraction (MAE), estimation of the percentage yield of marker compounds arjunic acid and arjunolic acid present and in vitro evaluation of urease inhibitory activity of the extracts has bee...
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2687
SIMULTANEOUS QUANTITATION AND VALIDATION OF PHENYLEPHRINE HYDRO-CHLORIDE, AMBROXOL HYDROCHLORIDE AND LEVOCITRIZINE HYDROCHLORIDE IN SYRUP FORMULATION BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
A simple, precise and accurate RP-HPLC method was developed and validated for the estimation of Phenylephrine hydrochloride, Ambroxol hydrochloride and Levocetirizine hydrochloride in syrup formulation. This method is based on HPLC separation of the three drugs on Octadecyl Silane C18 column (250 mm × 4.6 mm, 5.0μ), with isocratic conditions and mobile phase containing 0.01M Sodium dihydrogen ph...
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1778
ANTIOXIDANT PROPERTIES OF POLYGALA CHINENSIS L. WHOLE PLANT ON ALLOXAN INDUCED DIABETIC RATS
Administration of ethanol extract of Polygala chinensis whole plant (100 mg/kg and 200 mg/kg body weight) to alloxan induced diabetic rats for 14 days reduced the elevated level of lipid peroxidation (LPO). The treatment also resulted in significant increase in reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) in serum, liver and kidney. The res...
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1635
PROPRANOLOL HYDROCHLORIDE LOADED NANOSPHERES: DEVELOPMENT AND CHARACTERIZATION
Nanotechnology is widely used for delivery of various drugs to the body for increasing the bioavailability, reducing toxicity and controlled release.Nanospheres are the solid particles which are spherical in shape, having the particle size range between 1-1000 nm and having better bioavailability. In nanospheres, the drug is physically and uniformly dispersed in the matrix system of the polymer. N...
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