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IMPACT OF ALCOHOL ON RAT HEART AND AORTIC TISSUE ACETYLCHOLINE CONTENT LEVELS IN VITRO AND IN VIVO
Acetylcholine satisfies all criteria for a transmitter substance. Its most widely recognized action sites are the endings of vertebrate motor nerves, the endings of the automatic pre ganglionics and the parasympathetic post ganglionics. It appears also to be the transmitter of motor nerves in all advanced invertebrate animals except the arthropods where it seems to separate at the endings of senso...
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HEPATOPROTECTIVE ACTIVITY OF FICUS DALHOUSIAE MIQ LEAVES ETHANOLIC EXTRACT ON CARBON TETRACHLORIDE AND PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS
Leaves and bark preparations of Ficus dalhousiae Miq (Moraceae) are used in folklore and Siddha system of medicine for liver and skin ailments. So the intent of the present study was to evaluate the Hepatoprotective effect of Ficus dalhousiae Miq leaves ethanolic extract (FDLEE) by means of Carbon tetrachloride and Paracetamol induced hepatotoxicity model in Albino rats. Administration of carbon t...
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THE EFFECT OF NECA, CGS 21680, PSB 603 ON FATTY ACID TRANSPORT AND OXIDATION IN SKELETAL MUSCLE CELLS
Adenosine is a strong modulator of gene expression, which underpins some of its potential expected effects in skeletal muscle in terms of fatty acid metabolism. Accumulating evidence highlights a critical role for the adenosine system in the regulation of fatty acid metabolism and obesity. However, its molecular signaling role in fatty acid transport and oxidation in skeletal muscle is less clea...
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HEPATOPROTECTIVE POTENTIAL OF POLYHERBAL PREPARATION AGAINST CCl4-INDUCED LIVER TOXICITY IN RATS
Hepatoprotective activity of Polyherbal preparation against CCl4 ‑induced hepatic damage in rats was observed. The healthy control (normal), control, and standard drug Silymarin treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALP and total Bilirubin were assessed in all the experimental groups. The changes in liver function parameters were significant...
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CHARACTERIZATION OF BACTERIOCIN FROM PROBIOTIC LACTOBACILLUS PLANTARUM
In our study, the sample (cheese) was selected for isolation and identification of Lactobacillus species as local probiotic isolate. The strain was subjected to microscopic and macroscopic investigations for probiotic selection. The world health organization criteria (WHO) were applied to all Lactobacillus species against E. coli, P. areoginosa, S. aerus, Chromobacterium, Serratia and A. flavus, a...
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MOLECULAR DOCKING AND 3D-QSAR ANALYSIS STUDIES OF MMP-12 INHIBITORS
Matrix metalloproteinase 12 (MMP-12) inhibitions is an important research topic because of its wide range of associated health implications. The interaction mode of a series of pyridinone compounds with MMP-12 has been studied using molecular docking and 3D-QSAR approaches. Flexible docking was used for the determination of active conformation and molecular alignment. Comparative molecular field a...
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SERUM HEART TYPE FATTY ACID BINDING PROTEIN (H-FABP) LEVELS IN METABOLIC SYNDROME
Background: Metabolic syndrome (MetS) is a defined cluster of cardiometabolic abnormalities that increases an individual’s risk of type2 diabetes (T2D) and cardiovascular disease (CVD). Heart fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is cl...
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N ACETYL CYSTEINE ALLEVIATES PHENYTOIN INDUCED BEHAVIORAL ABNORMALITIES IN RATS
NAC being an antioxidant combats oxidative stress induced by phenytoin, thereby hypothesized to reduce phenytoin induced behavioral abnormalities. The influence of N acetyl cysteine (NAC) supplementation on phenytoin induced behavioral abnormalities was investigated. Male Wistar rats were divided into 5 groups and each group received vehicle (0.2% CMC), Phenytoin (20mg/Kg), Phenytoin co administer...
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A STUDY ON BIOPOLYMERIC NANOPARTICLES AS AN EFFECTIVE CARRIER FOR ANTIDEPRESSANT DRUG DELIVERY SYSTEM
Drug delivery is the most essential feature in drug administration facility and the design of Nanosystems makes the action more consistent an appropriate. Polymer nano particles bind efficiently to the drug and disperse the drug proficiently into the system. The efficacy of many drugs is often limited by their potential to reach the site of therapeutic action. In most cases (conventional dosage fo...
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IN-SILICO ANALYSIS AND HOMOLOGY MODELING OF TARGET PROTEINS FOR CLOSTRIDIUM BOTULINUM
The completion of genome sequences of pathogenic bacteria and the completion of human genome project has provided lot amount of data that can be utilized to design vaccines and drug targets. Recently adopting strategies for drug designing is based on comparative genomics approach, it gives a set of genes that are likely to be essential to the pathogen but absent in the host. By performing homology...
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