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HEPATOPROTECTIVE POTENTIAL OF POLYHERBAL PREPARATION AGAINST CCl4-INDUCED LIVER TOXICITY IN RATS
Hepatoprotective activity of Polyherbal preparation against CCl4 ‑induced hepatic damage in rats was observed. The healthy control (normal), control, and standard drug Silymarin treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALP and total Bilirubin were assessed in all the experimental groups. The changes in liver function parameters were significant...
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ANTIMYCOTICS IN CERTAIN TAXA OF EUPHORBIACEAE
There is a lot of thrust on utilization of bioactive chemicals from plant systems and their significant effect on microorganisms. Ten species of plants of the family Euphorbiaceae have been used for our study they are, Croton bonpandianum, Euphorbia tirucalli, E. hirta, E. heterophylla, Jatropha curcas, J. glandulifera, J. multifida, Phyllanthus amarus, Ricinus cummunis, Pedilanthus tithymal...
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HEMICELLULASE – MEDIATED HYDROLYSIS OF CHITOSAN: AN EFFICIENT METHOD TO SYNTHESIZE WATER SOLUBLE CHITOSAN
Chitosan is a natural biopolymer that has been extensively used traditionally for the treatment of various ailments and as an efficient vehicle or carrier for fabrication, encapsulation and target-specific delivery of a wide range of pharmacological moieties for improved therapeutic efficacy. Despite of numerous characteristic features, the pharmaceutical significance of chitosan is limited due to...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ERTUGLIFLOZIN AND METFORMIN HCl IN BULK AND PHARMACEUTICAL DOSAGE FORM BY HPLC
Analytical method for simultaneous estimation of Ertugliflozin (ERT) and Metformin hydrochloride (MET) was developed and validated by high-performance liquid chromatography (HPLC) as per ICH guidelines. The drugs were injected into the inertsil C18 (250 × 4.6 mm) maintained at room temp and wavelength 220 nm. The mobile phase consists of buffer (potassium dihydrogen pH 4.0) and methanol (65:35 v/...
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL SCHIFF BASES OF CEPHALEXIN
Cephalexin remain as one of the most versatile class of compounds against microbes and therefore, are useful substructures for further molecular exploration. A novel series of Schiff bases of cephalexin were synthesized. Thus condensation of 5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid, 7-[(amino phenyl acetyl) amino]-3-methyl-8-oxo, monohydrate with appropriate aldehydes afforded the S...
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MOLECULAR DOCKING AND 3D-QSAR ANALYSIS STUDIES OF MMP-12 INHIBITORS
Matrix metalloproteinase 12 (MMP-12) inhibitions is an important research topic because of its wide range of associated health implications. The interaction mode of a series of pyridinone compounds with MMP-12 has been studied using molecular docking and 3D-QSAR approaches. Flexible docking was used for the determination of active conformation and molecular alignment. Comparative molecular field a...
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THE EFFECT OF NECA, CGS 21680, PSB 603 ON FATTY ACID TRANSPORT AND OXIDATION IN SKELETAL MUSCLE CELLS
Adenosine is a strong modulator of gene expression, which underpins some of its potential expected effects in skeletal muscle in terms of fatty acid metabolism. Accumulating evidence highlights a critical role for the adenosine system in the regulation of fatty acid metabolism and obesity. However, its molecular signaling role in fatty acid transport and oxidation in skeletal muscle is less clea...
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SERUM HEART TYPE FATTY ACID BINDING PROTEIN (H-FABP) LEVELS IN METABOLIC SYNDROME
Background: Metabolic syndrome (MetS) is a defined cluster of cardiometabolic abnormalities that increases an individual’s risk of type2 diabetes (T2D) and cardiovascular disease (CVD). Heart fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is cl...
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N ACETYL CYSTEINE ALLEVIATES PHENYTOIN INDUCED BEHAVIORAL ABNORMALITIES IN RATS
NAC being an antioxidant combats oxidative stress induced by phenytoin, thereby hypothesized to reduce phenytoin induced behavioral abnormalities. The influence of N acetyl cysteine (NAC) supplementation on phenytoin induced behavioral abnormalities was investigated. Male Wistar rats were divided into 5 groups and each group received vehicle (0.2% CMC), Phenytoin (20mg/Kg), Phenytoin co administer...
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A STUDY ON BIOPOLYMERIC NANOPARTICLES AS AN EFFECTIVE CARRIER FOR ANTIDEPRESSANT DRUG DELIVERY SYSTEM
Drug delivery is the most essential feature in drug administration facility and the design of Nanosystems makes the action more consistent an appropriate. Polymer nano particles bind efficiently to the drug and disperse the drug proficiently into the system. The efficacy of many drugs is often limited by their potential to reach the site of therapeutic action. In most cases (conventional dosage fo...
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