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HEMICELLULASE – MEDIATED HYDROLYSIS OF CHITOSAN: AN EFFICIENT METHOD TO SYNTHESIZE WATER SOLUBLE CHITOSAN
Chitosan is a natural biopolymer that has been extensively used traditionally for the treatment of various ailments and as an efficient vehicle or carrier for fabrication, encapsulation and target-specific delivery of a wide range of pharmacological moieties for improved therapeutic efficacy. Despite of numerous characteristic features, the pharmaceutical significance of chitosan is limited due to...
4344
1977
SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR PROPERTIES PREDICTION OF 1, 3, 5-TRISUBSTITUTED 2-PYRAZOLINE DERIVATIVES
A number of trisubstituted 2-pyrazolines which are known for their biological importance like antimicrobial, anti-inflammatory, antitubercular, analgesic, anticancer, antimalarial, anti-viral, antihelmentic activities are prepared by reacting chalcones with phenyl hydrazine in absolute ethanol in presence of pyridine. In the present investigation an attempt has been made for the synthesis of 2-pyr...
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2322
HEPATOPROTECTIVE ACTIVITY OF FICUS DALHOUSIAE MIQ LEAVES ETHANOLIC EXTRACT ON CARBON TETRACHLORIDE AND PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR ALBINO RATS
Leaves and bark preparations of Ficus dalhousiae Miq (Moraceae) are used in folklore and Siddha system of medicine for liver and skin ailments. So the intent of the present study was to evaluate the Hepatoprotective effect of Ficus dalhousiae Miq leaves ethanolic extract (FDLEE) by means of Carbon tetrachloride and Paracetamol induced hepatotoxicity model in Albino rats. Administration of carbon t...
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1483
VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAUNORUBICIN AND CYTARABINE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
This paper describes a new validated Reverse-Phase High-Performance Liquid Chromatography (HPLC) method for the simultaneous determination of two anti-cancer drugs, Daunorubicin and Cytarabine (Ara-C). A simultaneous determination method saves cost and time as both drugs can be injected into a single HPLC system without the need to change or re-equilibrate with a new mobile phase. The objective of...
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1862
MEDICATED TATTOOS: A RECENT DRUG DELIVERY APPROACH IN MEDICAL SCIENCE
Trandermal drug delivery systems are potential sources of administrating drugs through and have certain advantages as delivering a therapeutically effective amount of drug across a patient's skin. Medicated Tattoos is one of the upcoming approaches in transdermal drug delivery. Researches reveal that humans from the generations have used tattoos for various reasons like symbol of rank, religious/s...
4343
1920
SOME EXPERIMENTALLY PROVED HERBS IN PEPTIC ULCER DISEASE
Peptic ulcer is a worldwide health problem because of its high morbidity, mortality and enormous financial implication. An estimated 15,000 deaths per year occur as a consequence of complicated PUD.A large number of drugs for peptic ulcer disease are available in mainstream medicine but they are associated with numerous side effects like arrhythmias, impotence, gynaecomastia and haematopoietic cha...
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1647
PHARMACOLOGICAL STUDY OF THE PELTOPHORUM PTEROCARPUM FLOWER
The present study was designed to investigate in vivo analgesic and cytotoxicity as well as in vitro antibacterial activities of the methanol: ethylacetate (1: 9) extract of the flowers of Peltophorum pterocarpum. Analgesic activity was assayed by acetic acid induced assay method wherein the extract showed moderate activity in a dose dependent manner. In respect of in vivo cytotoxicity, the flower...
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1518
CURATIVE EFFECTS OF MALOTILATE ON ETHANOL – INDUCED HEPATIC DYSFUNCTION IN RATS
In chronic alcoholics, continuous heavy drinking leads to progression of alcoholic liver disease (ALD) from alcoholic fatty liver, hepatitis to cirrhosis. Strict abstinence from alcohol has its own limitations and there is paucity of promising drugs available to treat ALD. Malotilate showed promising hepatocyte regenerating capacity and ability to prevent such damage. Aims: The objective of this...
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1445
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF MORUS INDICA LINN. AGAINST TOXICITY INDUCED BY CARBON TETRACHLORIDE IN RATS
Morus indica- MI-S36 is a potential source of phytochemicals and is well explored for its medicinal properties such as antidiabetic and antioxidant activity. In the present study, Mous indica aqueous (MAq) and dechlorophyllised (MDc) extracts efficacy to protect against the carbon tetrachloride (CCl4) induced hepatotoxicity was studied in rats in comparison with standard drug Liv52. The experiment...
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1691
ANTIMYCOTICS IN CERTAIN TAXA OF EUPHORBIACEAE
There is a lot of thrust on utilization of bioactive chemicals from plant systems and their significant effect on microorganisms. Ten species of plants of the family Euphorbiaceae have been used for our study they are, Croton bonpandianum, Euphorbia tirucalli, E. hirta, E. heterophylla, Jatropha curcas, J. glandulifera, J. multifida, Phyllanthus amarus, Ricinus cummunis, Pedilanthus tithymal...
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1552