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EVALUATION OF ANTIOXIDANT AND HYPOLIPIDEMIC ACTIVITY OF VEDIC GUARD, A POLYHERBAL FORMULATION
The present study was undertaken to evaluate antioxidant and hypolipidemic activity of Vedic guard, a polyherbal formulation comprising of Terminalia arjuna, Withania sominefera, Bacopa monnierii, Tinosporia cardifolia, Commiphora mukul and many other plant extracts, all of which are classifieds in Ayurveda as Rasaayanas which are reported to promote antioxidant and hypolipidemic activity. Antioxi...
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1931
PROPRANOLOL HYDROCHLORIDE LOADED NANOSPHERES: DEVELOPMENT AND CHARACTERIZATION
Nanotechnology is widely used for delivery of various drugs to the body for increasing the bioavailability, reducing toxicity and controlled release.Nanospheres are the solid particles which are spherical in shape, having the particle size range between 1-1000 nm and having better bioavailability. In nanospheres, the drug is physically and uniformly dispersed in the matrix system of the polymer. N...
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1697
PHARMACOLOGICAL STUDY OF THE PELTOPHORUM PTEROCARPUM FLOWER
The present study was designed to investigate in vivo analgesic and cytotoxicity as well as in vitro antibacterial activities of the methanol: ethylacetate (1: 9) extract of the flowers of Peltophorum pterocarpum. Analgesic activity was assayed by acetic acid induced assay method wherein the extract showed moderate activity in a dose dependent manner. In respect of in vivo cytotoxicity, the flower...
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BIOACTIVE COMPOUNDS IDENTIFICATION FROM MARINE MACRO ALGAE PADINA AUSTRALIS USING METHANOL EXTRACT
The investigation was carried out to determine the possible bioactive compounds marine macro algae Padina australis using methanol extract. The GC-MS analysis of methanol extract was performed using perkin Elmer GC clarus. Six compounds were identified from Padina australis showed highest peak area Pentadecanoic acid 14-methyl ester [100%] followed by 1, 2 Benzenedi carboxylic acid, butyl octyl es...
4299
1925
SIMULTANEOUS QUANTITATION AND VALIDATION OF PHENYLEPHRINE HYDRO-CHLORIDE, AMBROXOL HYDROCHLORIDE AND LEVOCITRIZINE HYDROCHLORIDE IN SYRUP FORMULATION BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
A simple, precise and accurate RP-HPLC method was developed and validated for the estimation of Phenylephrine hydrochloride, Ambroxol hydrochloride and Levocetirizine hydrochloride in syrup formulation. This method is based on HPLC separation of the three drugs on Octadecyl Silane C18 column (250 mm × 4.6 mm, 5.0μ), with isocratic conditions and mobile phase containing 0.01M Sodium dihydrogen ph...
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1785
ZYGOPHYLLUM GAETULUM AQUEOUS EXTRACT PROTECTS AGAINST DIABETIC DYSLIPIDEMIA AND ATTENUATES LIVER AND KIDNEY OXIDATIVE DAMAGE IN STREPTOZOTOCIN INDUCED-DIABETIC RATS
Zygophyllum gaetulum is one of several traditional remedies used for diabetes treatment in Algeria. The purpose of this study is to investigate the effects of this plant on hyperglycemia, insulin sensitivity indexes, lipid profiles, lecithin: cholesterol acyltransferase (LCAT) and paraoxonase (PON1) activities and liver and kidney antioxidant status, in streptozotocin-induced diabetic rat. Diabete...
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1674
ANTIBACTERIAL ACTIVITY OF ETHNOMEDICINAL PLANTS OF IRULARS OF WESTERN GHATS
The present study report deals with the medicinal plants used by the irular tribal people of Coimbatore against pyogenic infections. Five different plants like Abutilon indicum, Datura metel, Lantana Camaro, Tridax procumbens and Leucas aspera were collected and their antimicrobial activity were tested against bacteria such as Staphylococcus aureus, Streptococcus pyogenes, Bacillus anthracis, Ps...
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1654
ANTIOXIDANT AND CYTOTOXICITY POTENTIAL OF ALCOHOL AND PETROLEUM ETHER EXTRACT OF BORASSUS FLABELLIFER LINN.
This study was subjected to investigate antioxidant and cytotoxic properties of ethanol and petroleum ether extracts of Borassus flabellifer Linn, expressed as BFA and BFP respectively. DPPH free radical scavenging method, total flavonoid, total phenol, total antioxidants and reducing power of the two extracts were assessed for antioxidant properties and cytotoxicity potentials were assessed by th...
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DESIGN AND EVALUATION OF LAMOTRIGINE ORAL SUSTAINED RELEASE TABLETS
Objective: The objective of the study is to design and evaluate oral sustained release tablet of lamotrigine using polymer such as HPMC K 4M, HPMC K 100M and methocel E50 LV at 15%, 25%, and 35% Concentration range. Methods: All the selected ingredients were weighed and passed through 40# sieve, blended in a Poly Bag except Magnesium Stearate for 10 minutes. The resultant mixture was made in to...
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SYNTHESIS, CHARACTERIZATION & BIOLOGICAL STUDIES OF NEWER CLASS OF QUNINOLONE DERIVATIVES
Background: Antimicrobials are used for bacterial infections & has a great benefits in health related problems of human life. The main objectives of medicinal chemistry is synthesising and producing newer molecules having a valuable significant therapeutic action. Quinolones has a considerable scientific and clinical interest since their discovery. Objective: Quinolones class of drugs are usef...
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