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HOMOLOGY MODELLING, SECONDARY STRUCTURE PREDICTION AND PHYLOGENETIC COMPARATIVE ANALYSIS OF PHOSPHOLIPASE A2FROM DIFFERENT ORGANISMS
Phospholipase A2 is the enzyme that catalyzes the hydrolysis of the sn-2 fatty acyl bond of phospholipids, liberating free fatty acids and lysophospholipids. These enzymes are found in mammalian tissues, insects, reptiles, urochordates, invertebrates and echinoderms. Some of the PLA2 are toxic in nature. Venom from snakes and insects is largely composed of melittin, which is a stimulant of PLA2...
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SEA BUCKTHORN (H. RHAMNOIDES L.) MEDIATED ACUTE HYPOXIC TOLERANCE IN THE SKELETAL MUSCLE OF RATS BY DIFFERENTIAL ACTIVATION OF ENERGY METABOLISM AND ENHANCED ANTIOXIDANTS
Exposure to hypobaric hypoxia differentially affects physical performance and survival amongst individuals. The present study was designed to investigate the role of metabolic enzymes, antioxidants and bioenergetics molecular markers in the differential hypoxic tolerance of animals exposed to acute hypobaric hypoxia and the effect of herbal supplementation in augmentation of hypoxia tolerance. Adu...
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CRISPR-Cas9 MEDIATED GENOME EDITING IN ESCHERICHIA COLI
Clustered regularly interspaced palindromic repeats are the centerpiece of a robust adaptive bacterial immune system that forms the basis for the CRISPR-Cas9 genetic engineering technology. CRISPR-associated protein-9 (Cas9) is part of this immune system that seeks out, cuts, and degrades viral DNA. By taking advantage of the CRISPR-Cas9 system, a tool has been developed to delete or insert DNA in...
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ANTIOXIDANT STUDIES, ERYTHROCYTE MEMBRANE STABILIZATION AND THROMBOLYTIC POTENTIAL OF DIALLYL DISULPHIDE
Diallyl Disulphide is an essential component of garlic which has numerous medicinal applications. Thus it was evaluated for its free radical scavenging potential. The compound was assayed for its ability to stabilize the erythrocyte membrane by osmotic fragility test and heat induced hemolysis assay. The thrombolytic potential was evaluated by the ability of the compound to dissolve the clot forme...
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PROCESS VALIDATION OF SOTALOL HYDROCHLORIDE TABLETS
Process Validation is a very common term in the pharmaceutical industry. But it involves series of activities carried out in order to have the assurance that the desired quality products are manufactured. The manufacturing process need to be controlled and for this one should have sound knowledge and understanding regarding the process as well as the product. Each and every step should be scientif...
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AN UPDATE ON NOVEL TECHNOLOGIES, IN-VITRO AND IN-VIVO MODELS FOR TUBERCULOSIS AND TUBERCULOUS MENINGITIS
Tuberculosis is a bacterial infection which is caused by the bacteria Mycobacterium tuberculosis. It is next to AIDS and causes morbidity and mortality. These bacteria can stay in the host’s body for decades. In this article we have mentioned about the pathogenesis of pulmonary tuberculosis followed by the pathogenesis of tuberculous meningitis wherein the bacteria first enter to the lungs which...
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SYNTHESIS, CHARACTERIZATION OF SOME 2-AZETIDINONE DERIVATIVES FROM 4- NITRO ETHYL BENZOATE BY MICROWAVE METHOD AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY
Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2-azetidinones is developed. This method has been assessed as greener methodology. In our present study, series of five novel azetidinones are synthesi...
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EFFECT OF ADMINISTRATION OF ETIZOLAM ON THE DEVELOPMENT OF THE CHICK EMBRYO
There are various drugs used in daily life. Some of them show hazardous effect on various organs and some of them shows even lethal effect. Such drugs are required to banned. One of them is Etizolam (marketed under the brand name Sedekopan, Pasaden or Depas) is a drug which is a thiebenzothiodiazepines analog. The aim of this work is done to compare the effect of administrati...
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AUTHENTICATION OF MORPHOLOGICALLY SIMILAR RHIZOME DRUGS BASED ON TLC FINGERPRINT PROFILES AND VALERENIC ACID CONTENT
Objective: Present study involved comparison of thin layer chromatograms and quantification of valerenic acid (VA) in four morphologically similar rhizome drugs – Valeriana jatamansi, Nordostachys jatamansi, Selinum vaginatum and Ferula sumbul. Materials and methods: Ethanol extract of the four drugs were prepared under standard conditions and VA content was determined using TLC densitometry. Re...
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HEPATOPROTECTIVE ACTIVITY OF BERRY EXTRACTS OF DIOSPYROS KAKI LINN. AGAINST CARBON TETRACHLORIDE INDUCED LIVER DAMAGE MODEL
Currently, nutrition and health linkages focused on the emerging strategy of diet based regimen to combat various physiological threats including cardiovascular disorders, oxidative stress, diabetes mellitus, etc. Berry / Fruit part of Diospyros kaki Linn. was extracted using petroleum ether, chloroform, ethanol consecutively and the obtained extracts were screened for hepatoprotective activity us...
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