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STUDY OF EFFECT OF ERYTHROMYCIN BASE ON GASTROINTESTINAL SMOOTH MUSCLES IN LABORATORY ANIMALS IN-VITRO
Background - Drugs affecting gastrointestinal motility find place in the treatment of gastrointestinal motility disorders. Objective: To evaluate the effect of erythromycin base on the isolated tissue of rabbit jejunum, guinea pig ileum & rat colon in vitro and also to see whether it alters the contractile responses induced by acetylcholine. Materials and Methods: a) Rabbit jejunum experiment:...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF 3-SUBSTITUTED SCHIFF BASES OF QUINAZOLINE2,4-DIONES
Objective: 3-Substituted Schiff bases of Quinazolne-2,4-diones belongs to the N-containing heterocyclic compounds. The aim of the present study is to synthesis and characterization of ten novel derivatives of 3-Substituted Schiff bases of Quinazoline2,4-diones and their pharmacological study. In the current course of work the novel Schiff bases of Quinazolne-2,4-diones which are synthesized ar...
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2221
A NOVEL RP- HPLC METHOD FOR THE QUANTIFICATION OF CABOZANTINIB IN ACTIVE PHARMACEUTICAL INGREDIENTS AND PHARMACEUTICAL DOSAGE FORMS
A simple, specific, accurate reversed-phase high performance liquid chromatographic method was developed for the quantification of Cabozantinib. Although extensive studies on Cabozantinib have been developed for determining Cabozantinib in human place and urine by LC-MS, studies on the pharmaceutically active ingredient and formulation are scarce. The effective separation was achieved through BDS ...
4197
2015
DEVELOPMENT AND VALIDATION OF DIFFERENT SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE FROM BULK DRUG AND TABLETS
Simple, sensitive and accurate UV- spectrophotometric methods have been developed for the determination of an anti-HIV drug, Tenofovir Disoproxil fumarate (TDF), in raw material and in tablets. The drug shows maximum absorbance at 259 nm in selected four different media namely gastric fluid simulated (HCl) pH 1.5, vaginal fluid simulated (VFS) pH 4.2, phosphate buffer (PB) pH 6.8 and double distil...
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ANTIMICROBIAL ACTIVITY OF SOME SPECIES OF PHELLINUS AND GANODERMA SAMPLE FROM WESTERN GHATS OF INDIA
Phellinus and Ganoderma are a folk medicinal, wood inhabiting fungus, recently been studied for its pharmacological activities. In the current study, Acetone, Methanol and ethyl acetate extracts were prepared from species of Phellinus and Ganoderma. The active compounds of acetone and methanol extracts have the same polarity but they show different activity. The antimicrobial assay showed zone of ...
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ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF LAWSONIA INERMIS
The leaf of the plant Lawsonia inermis was examined for analgesic and anti-diarrhoeal properties. From the study of analgesic activity it was found that ethanol extract at a dose of 500 mg/kg exhibited no significant (p<0.3) inhibition of writhing reflex (28.45 % inhibition) while the inhibition of standard drug diclofenac sodium showed 82.7 % inhibition at a dose of 25 mg/kg body weight. The f...
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PREPARATION AND EVALUATION OF CONTROLLED RELEASE OF BETAXOLOL HYDROCHLORIDE OCULAR INSERTS
The present work focuses on treatment of glaucoma by formulating ocular inserts of different polymeric combination and Betaxolol to enhance therapeutic effect through prolonging contact time with corneal surface, Betaxolol is a cardio selective (β1 adrenergic) receptor blocking agent. Ophthalmic betaxolol may be especially useful in the treatment of glaucoma in patient with pulmonary disease. Sus...
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1784
NANOCRYSTAL SUSPENSION OF POORLY WATER SOLUBLE ANTIBACTERIAL DRUG BY HIGH PRESSURE HOMOGENIZATION TECHNIQUE USING FULL FACTORIAL DESIGN
Cefixime trihydrate belongs to third generation cephalosporin having poor water solubility. In the present study, nanocrystal suspensions of cefixime trihydrate were prepared with the objective of providing enhanced solubility and stability with reduced particle size and thus improving the bioavailability potential. Nanocrystal suspensions were prepared by high pressure homogenization technique an...
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1856
ELECTROCHEMICAL BEHAVIOR AND ANALYSIS OF KETAMINE IN PHARMACEUTICAL FORMULATIONS BY VOLTAMMETRIC TECHNIQUES
The electrochemical behavior of Ketamine is studied by employing D.C. Polorography (DCP), Cyclic Voltammetry (CV) and Differential Pulse Polarography (DPP) in universal buffers of pH ranging from 2.0-12.0. The kinetic parameters, such as transfer coefficients, diffusion coefficients and heterogeneous forward rate constant values were evaluated by employing these techniques. Differential Pulse Pola...
4195
1935
EXTRACTION EFFICACY, ANTIBACTERIAL POTENTIAL AND VALIDATION OF RP-HPLC COUPLED WITH DIODE ARRAY DETECTION IN HOLARRHENA PUBESCENS
A rapid, simple, sensitive and reproducible RP-HPLC method was developed for the determination of conessine (bioactive steroidal alkaloid) in Holarrhena pubescens, a highly valued medicinal plant extensively used in pharmaceuticals. Separation was achieved on Discovery (R) RP Amide C16 Supelco column (250 µm x 4.6 µm ID) using a mobile phase of acetonitrile: water (95:5 v/v) with flow rate 0.6...
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