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EVALUATION OF JASMINUM GRANDIFLORUM FOR HEPATOPROTECTIVE ACTIVITY IN ISONIAZID INDUCED LIVER DAMAGE
Objectives: The study was designed to evaluate hepatoprotective effect of the ethanolic leaves extract of Jasminum grandiflorum (JG) in Isoniazid (INH) induced hepatotoxicity in wistar albino rats. Materials and methods: Mature leaves of JG were collected, authenticated and subjected to successive ethanolic extraction. Hepatic damage was induced in wistar rats by administering INH (54mg/kg, p.o...
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DEVELOPMENT AND VALIDATION OF DIFFERENT SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE FROM BULK DRUG AND TABLETS
Simple, sensitive and accurate UV- spectrophotometric methods have been developed for the determination of an anti-HIV drug, Tenofovir Disoproxil fumarate (TDF), in raw material and in tablets. The drug shows maximum absorbance at 259 nm in selected four different media namely gastric fluid simulated (HCl) pH 1.5, vaginal fluid simulated (VFS) pH 4.2, phosphate buffer (PB) pH 6.8 and double distil...
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PROTECTIVE EFFICACY OF ALLIUM SATIVUM ON DELTAMETHRIN INDUCED TOXICITY IN REPRODUCTIVE TISSUES OF MALE MICE
Present study was carried out to assess testicular toxicity of pyrethroid insecticide, Deltamethrin (DM) in male Swiss albino mice, Mus musculus and to evaluate protective role of Allium sativum (AS) in alleviating the detrimental effect of DM. Forty male mice were divided into five experimental groups (8 mice per group) and were categorized : Control- Given distilled water and food ad libitum, Ve...
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ION EXCHANGERS: A USEFUL TOOL FOR SEPARATION AND SIMULTANEOUS PURIFICATION OF LYSOSOMAL CYSTEINE PROTEINASES, CATHEPSINS B, H AND L.
Lysosomes of mammalian tissues contain a number of cysteine proteinases such as Cathepsins B, H and L, which participate in intracellular protein degradation and are involved in various pathological disorders. These proteinases have been purified to ~ 1600 fold with ~25% yields from goat liver. These Cathepsins having similar molecular weight (~25,000 Da) were obtained as a single pool after initi...
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1879
NANOCRYSTAL SUSPENSION OF POORLY WATER SOLUBLE ANTIBACTERIAL DRUG BY HIGH PRESSURE HOMOGENIZATION TECHNIQUE USING FULL FACTORIAL DESIGN
Cefixime trihydrate belongs to third generation cephalosporin having poor water solubility. In the present study, nanocrystal suspensions of cefixime trihydrate were prepared with the objective of providing enhanced solubility and stability with reduced particle size and thus improving the bioavailability potential. Nanocrystal suspensions were prepared by high pressure homogenization technique an...
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1884
CORRELATION OF VARIATION IN THE PERCENTAGE OF COMPOUNDS RESPONSIBLE FOR MOSQUITO REPELLENT ACTIVITY IN CITRONELLA OIL OVER TIME WITH MOSQUITO REPELLENT EFFICACY OF COMMERCIAL CITRONELLA OIL SAMPLES AND SPRAYS
The control of mosquitoes, which transmit deadly diseases, has become a significant public health concern globally. Protection against mosquito bites is an important part of preventing mosquito-borne diseases. Citronella oil extracted from two types of citronella grass Cymbopogon winterianus Jowitt (Java type) and Cymbopogon nardus (L.) Rendle (Ceylon type) possess compounds responsible for mosqui...
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FORMULATION AND EVALUATION OF pH TRIGGERED IN-SITU OCULAR GEL OF OFLOXACIN
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled into the eye and undergoes a sol-gel transition in the cul-de-sac. The aim of the present study was to formulate and evaluate pH-triggered in-situ gels for ophthalmic delivery of of...
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1599
BARRIERS TO IMPLEMENTATION OF PERFORMANCE-BASED MANAGEMENT PRACTICES IN PHARMACIES IN A DEVELOPING COUNTRY
The objective of this study was to conduct a survey and determine the barriers to implement performance-based management in pharmacies in Trinidad. PBM is defined as “a systematic approach to performance improvement through an on-going process of establishing strategic performance objectives, measuring performance, collecting, analyzing, reviewing, and reporting performance data, and using that ...
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EXTRACTION EFFICACY, ANTIBACTERIAL POTENTIAL AND VALIDATION OF RP-HPLC COUPLED WITH DIODE ARRAY DETECTION IN HOLARRHENA PUBESCENS
A rapid, simple, sensitive and reproducible RP-HPLC method was developed for the determination of conessine (bioactive steroidal alkaloid) in Holarrhena pubescens, a highly valued medicinal plant extensively used in pharmaceuticals. Separation was achieved on Discovery (R) RP Amide C16 Supelco column (250 µm x 4.6 µm ID) using a mobile phase of acetonitrile: water (95:5 v/v) with flow rate 0.6...
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AMNESIC POTENTIALITY OF DIAZEPAM AT LOW DOSE ON ADMINISTRATION VIA TRANSCRANIAL ROUTE IN RODENTS
The objective of study to evaluate a drug Diazepam applied transcranially to brain targeted drug delivery to screening for its amnesic effects, in different learning and memory paradigms viz., rod walking test, locomotor activity test, elevated plus maze test, water maze test, pole climbing test and pole climbing test on trained animal. Diazepam 4mg/ kg intraperitoneal used as a standard for com...
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