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HEPATOPROTECTIVE ACTIVITY OF STEM BARK EXTRACT OF MANGIFERA INDICA L. ON CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN WISTAR ALBINO RATS
The effects of aqueous stem bark extract of Mangifera indica in Carbon tetrachloride induced liver injury were investigated. In vivo animal models using Wistar albino rats was used in this experimental study. Carbon tetrachloride was successfully induced by significantly (P<0.001) increasing serum parameters AST, ALT, and ALP and decreasing serum total proteins and albumin levels (P<0.05). S...
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ANTIDIABETIC AND ANTI-INFLAMMATORY ACTIVITY OF UTICA DIOICA LEAVES ON STZ INDUCED TYPE 1 DIABETIC MODEL RATS
In the present study we have explored the effect of Urtica dioica, a traditional antidiabetic herb used in India and Bangladesh, on insulinemic and chronic inflammatory status of type 1 diabetic model rats. The mature and fresh leaves of U. dioica was collected from the mountain range of Assam in India and the water extract of the leaves was used at a dose of 1.25g/kg body weight. Adult Long-Evans...
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ANTI-HYPERGLYCEMIC EFFECT OF CARALLUMA LASIANTHA EXTRACT ON HYPERGLYCEMIA INDUCED BY CAFETERIA-DIET IN EXPERIMENTAL MODEL
Caralluma lasiantha is a succulent plant belongs to Ascalpedaceae family. The objective of this study was to evaluate and to compare the anti-hyperglycemic effect of Caralluma lasiantha with Chromium Picolinate on hyperglycemia induced by Cafeteria-Diet in Wistar albino rats. Hyperglycemia was induced in experimental rats by feeding Cafeteria-Diet for a study period of 90 days. Caralluma lasiantha...
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INVESTIGATIONS ON HYPOLIPIDEMIC ACTIVITY OF ASPARAGUS FILICINUS BUCH-HAM EX D. DON
Saponins are the foam producing secondary metabolites of plant. They have been evaluated for a number biological activities like anticancer, anti-inflammatory, hepatoprotective, antimicrobial, antitumor, blood cholesterol lowering properties etc. In the present study we have attempted to check the role of isolated saponins from Asparagus filicinus for its hypolipidemic activity. Saponin rich fract...
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QSAR STUDIES OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS
A QSAR studies on pyrazole derivatives as specific anticancer agents was performed with 37 (32 training + 5 test) compounds. QSAR studies were performed using chemOffice 6.0 software supplied by Cambridge soft. The sketched structures were subjected to energy minimization and then used to calculate the physiochemical properties. The regression analysis was carried out using a computer program call...
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ANATOMICAL AND PHYTOCHEMICAL STUDIES OF ENDEMIC MEDICINAL SPECIES MARTICARIA PUBSCENES (ASTERACEAE) FROM SOUTH ALGERIA
Matricaria pubscens (Asteraceae), with wide distribution area in southern Algeria, is a drug traditionally used in the treatment of certain diseases such as dehydration, cough and sore. The aim of this study was to determine the anatomical features of the root stem and leaves of medicinal species of M. pubscens sections. As a result of the study, it was discovered that in the root the vessels ar...
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AMNESIC POTENTIALITY OF DIAZEPAM AT LOW DOSE ON ADMINISTRATION VIA TRANSCRANIAL ROUTE IN RODENTS
The objective of study to evaluate a drug Diazepam applied transcranially to brain targeted drug delivery to screening for its amnesic effects, in different learning and memory paradigms viz., rod walking test, locomotor activity test, elevated plus maze test, water maze test, pole climbing test and pole climbing test on trained animal. Diazepam 4mg/ kg intraperitoneal used as a standard for com...
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ION EXCHANGERS: A USEFUL TOOL FOR SEPARATION AND SIMULTANEOUS PURIFICATION OF LYSOSOMAL CYSTEINE PROTEINASES, CATHEPSINS B, H AND L.
Lysosomes of mammalian tissues contain a number of cysteine proteinases such as Cathepsins B, H and L, which participate in intracellular protein degradation and are involved in various pathological disorders. These proteinases have been purified to ~ 1600 fold with ~25% yields from goat liver. These Cathepsins having similar molecular weight (~25,000 Da) were obtained as a single pool after initi...
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STUDY OF EFFECT OF ERYTHROMYCIN BASE ON GASTROINTESTINAL SMOOTH MUSCLES IN LABORATORY ANIMALS IN-VITRO
Background - Drugs affecting gastrointestinal motility find place in the treatment of gastrointestinal motility disorders. Objective: To evaluate the effect of erythromycin base on the isolated tissue of rabbit jejunum, guinea pig ileum & rat colon in vitro and also to see whether it alters the contractile responses induced by acetylcholine. Materials and Methods: a) Rabbit jejunum experiment:...
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THE EFFECT OF SUBCHRONIC ADMINISTRATION OF ROSELLA (HIBISCUS SABDARIFFA L.) EXTRACT ON LEVELS OF UREUM, CREATININE, AND RENAL HISTOPATHOLOGY
Rosella (Hibiscus sabdariffa L.) calyx traditionally used to treat various diseases. There is limited evidence based could be found including the efficacy and safety. The present study was aimed to investigate the effects of subchronic administration of Rosella calyx extract on the renal function of female Sprague Dawley (SD) rats. The rosella calyx was extracted by 70% ethanol and evaporated with...
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