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BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CANDESARTAN BY DERIVATIVE SPECTROSCOPY (FIRST ORDER)
Candesartan cilexetil, a prodrug is a racemic mixture containing one chiral center at the cyclohexyloxy-carbonyloxy- ethyl ester group. It is soluble in dimethyl formamide, acetone, methanol, 0.1 N sodium hydroxide solution and insoluble in water. Objective of the present study was to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric bioanalytical method for th...
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IN VITRO ANTIOXIDANT ACTIVITY OF CURCUMA AMADA ROXB.
A study was undertaken to evaluate the antioxidant potential of rhizomes of Curcuma amada (Zingiberaceae). Aqueous and ethanolic extracts were subjected to in vitro antioxidant activity screening models such as DPPH, ABTS, nitric oxide and inhibition of lipid peroxidation activity. Ascorbic acid was used as the standard. In all the models studied, both the extracts showed nearly equal activities...
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1818
ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF LAWSONIA INERMIS
The leaf of the plant Lawsonia inermis was examined for analgesic and anti-diarrhoeal properties. From the study of analgesic activity it was found that ethanol extract at a dose of 500 mg/kg exhibited no significant (p<0.3) inhibition of writhing reflex (28.45 % inhibition) while the inhibition of standard drug diclofenac sodium showed 82.7 % inhibition at a dose of 25 mg/kg body weight. The f...
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INVESTIGATION OF IN-VITRO THROMBOLYTIC AND IN-VIVO ANTIPYRETIC, ANTIDEPRESSANT POTENTIALITY AND ANALGESIC ACTIVITY WITH PHYTO-CHEMICAL NATURE OF METHANOLIC EXTRACT OF NYMPHOIDES HYDROPHYLLA
Nymphoides hydrophylla (NH) is mainly an aquatic herb of Menynthaceae family and traditionally used to treat fever, insect bites, different ulcers, and also to wash skin, where parasitic affection occurs. In this study, methanolic extract of Nymphoides hydrophylla (NH) plant was examined for the determination of thrombolytic, antipyretic, Central Nervous System (CNS) and analgesic activities. The ...
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1361
HEPATOPROTECTIVE ACTIVITY OF STEM BARK EXTRACT OF MANGIFERA INDICA L. ON CARBON TETRACHLORIDE-INDUCED HEPATIC INJURY IN WISTAR ALBINO RATS
The effects of aqueous stem bark extract of Mangifera indica in Carbon tetrachloride induced liver injury were investigated. In vivo animal models using Wistar albino rats was used in this experimental study. Carbon tetrachloride was successfully induced by significantly (P<0.001) increasing serum parameters AST, ALT, and ALP and decreasing serum total proteins and albumin levels (P<0.05). S...
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ANTIOXIDANT ACTIVITY OF THE ENDOPHYTIC FUNGI ISOLATED FROM MANGROVE ENVIRONMENT OF KARANKADU, RAMANATHAPURAM DISTRICT
Antioxidant property of Phomopsis amygdali culture filtrate extracted with ethanol, was evaluated in vitro. ABTS and DPPH radicals were used to evaluate their antioxidant activity. Antioxidant components like total phenol and flavonoid were also determined. The ethanolic extract of Phomopsis amygdali showed potent antioxidant activity against both ABTS and DPPH radicals with the EC50 value of 58...
4249
1816
COMPARISON OF BLUMEA DENSIFLORA AND SALVINIA CUCULLATA LEAVES FOR THEIR ANTHELMENTIC ACTIVITY BY USING PHERETIMA POSTHUMA
Plant derived drug molecules are frequently showing their role in treating the disease conditions with minimal side effects comparing to the synthetic molecules. Forest and trees are natural assets that provide a variety of benefits to the mankind. Currently available anthelmintic drugs require improved management, high cost and also worms developing resistance to these drugs. So, there is a need ...
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1714
SCREENING OF INDIGENOUS MEDICINAL PLANTS FOR THEIR ACARICIDAL ACTIVITY AGAINST CATTLE TICKS UNDER IN VIVO CONDITION
The acaricidal activity of leaf extracts of Annona squamosa, Azadirachta indica and Calotropis procera were tested against the cattle ticks under in vivo condition. Plants were extracted with methanol and water and the extracts were tested against the cattle ticks under in vivo condition. The aqueous and alcoholic extracts of A. indica showed maximum mortality rate of ticks followed by A. squamo...
4249
1914
ANALYSIS OF ANTIMICROBIAL USAGE PATTERN: A RETROSPECTIVE OBSERVATIONAL STUDY
Objective: Antimicrobials have become one of the most misused therapeutic agents resulting in resistance. Present study was carried out to evaluate the antimicrobial drug utilization pattern. Method: A retrospective, observational record based study was done in hospitalized patients from medicine and surgery department of tertiary care hospital of central India over a period of one year. Result: A...
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GENOMIC STRUCTURAL IDENTIFICATION AND IMMUNOINFORMATICS STUDIES FOR SARS‐COV‐2
Coronaviruses are a group of viruses that belongs to the Coronaviridae family. These viruses have helical symmetry, enveloped, positive-sense, single-stranded RNA genome with nucleocapsid that causes diseases in birds and mammals. SARS-CoV 2 complete genome has genome size of 29,903 bp, having nine genes identified as Orf1a Polyprotein, Orf1ab Polyprotein, ORF3a Protein, ORF7a Protein, ORF8 Protei...
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