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ANTIMICROBIAL ACTIVITY OF SOME SPECIES OF PHELLINUS AND GANODERMA SAMPLE FROM WESTERN GHATS OF INDIA
Phellinus and Ganoderma are a folk medicinal, wood inhabiting fungus, recently been studied for its pharmacological activities. In the current study, Acetone, Methanol and ethyl acetate extracts were prepared from species of Phellinus and Ganoderma. The active compounds of acetone and methanol extracts have the same polarity but they show different activity. The antimicrobial assay showed zone of ...
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QSAR STUDIES OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS
A QSAR studies on pyrazole derivatives as specific anticancer agents was performed with 37 (32 training + 5 test) compounds. QSAR studies were performed using chemOffice 6.0 software supplied by Cambridge soft. The sketched structures were subjected to energy minimization and then used to calculate the physiochemical properties. The regression analysis was carried out using a computer program call...
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A COMPARATIVE STUDY OF THE IN VITRO ANTIBACTERIAL ACTIVITY OF ENDOCARP, DATE PALM TISSUE AND DATE PALM TISSUE WITH ENDOCARP TOGETHER AGAINST SOME GRAM NEGATIVE AND GRAM POSITIVE PATHOGENIC BACTERIA
The antibacterial activities of water extracts of the three major parts of the date palm fruit were compared against Eschereshia coli; Klebsiella pneumonia; Salmonella enteritidis; Pseudomonas aeruginosa; Staphylococcus aureus using the agar well diffusion method. Endocarp extract showed a wide range of activity against all Gram negative bacteria while it exhibited a low activity against Gram posi...
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COMBINED EFFECTS OF ATORVASTATIN AND NICOTINE ON TESTICULAR EXPRESSION OF STEROIDOGENIC ENZYMES IN EXPERIMENTAL RATS
Nicotine and atorvastatin have indirect effects on reproductive function. So this study focused on changes in testosterone biosynthesis in rats co administered nicotine and atorvastatin. Rats were divided into 4 groups.(1) Control, (2) Atorvastatin (10 mg/Kg b.wt), (3) Nicotine (0.6 mg/Kg b.wt)and (4) Atorvastatin (10 mg/Kg b.wt) + nicotine (0.6 mg/Kg b.wt). After sixty days of treatment testicu...
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STUDY OF DIFFERENT PROCESSING PARAMETERS FOR POLYLACTIC ACID MICROSPHERES FORMULATIONS
To evaluate the effects of different processing parameters on drug-loaded microspheres, the solvent evaporation technique was chosen as the formulation method. Indomethacin-loaded Polylactic acid microspheres were prepared by varying drug masses, then by changing the stirring speed. They were analyzed for their drug content, physical morphology, size, polymer-drug physicochemical compatibility, an...
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INVESTIGATION ON REGIONAL VARIATION IN TOTAL PHENOLIC, ALKALOID CONTENT AND IN-VITRO ANTIOXIDANT ACTIVITY OF LEUCAS ASPERA
In this study, we investigated and compared the total phenolic, alkaloid content and in-vitro antioxidant activity of Leucas aspera collected from four different regions; Tirupathi (Southern zone), Lam (Krishna river region), Jagityala (Northern Telangana) and Hyderabad (Southern Telangana) of Andhra Pradesh, India. Quantitative regional variation was observed in total phenolic content, and alka...
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DOCKING STUDIES OF GANODERMA LUCIDUM
Ganoderma is a miracle edible mushroom with unique composition and miraculous health benefits. The investigation aimed to elucidate interactions for the active compounds of Ganoderma lucidum namely Ganoderol A, Ganoderol B, Ganoderal A and Ganoderic Acid Y with Lanosterol 14 alpha demethylase enzyme using molecular docking software Arguslab. The effect of ganomycin1 and 2 as an inhibitor against H...
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ANTIMICROBIAL ACTIVITY OF STEM BARK OF COMBRETUM ALBIDUM G. DON; A TRADITIONAL MEDICINAL LIANA
Traditional knowledge and ethno-botanical use of plants have been widely acknowledged all over the world. In the present scenario, emergence of multiple drug resistance to human pathogenic organisms, this has necessitated a search for new antimicrobial substances from other sources including plants. Combretum albidum, a traditional medicinal liana, used by rural peoples, villagers and tribals resi...
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STABILITY INDICATING RP-HPLC METHOD FOR COMBINATION OF AMBROXOL HYDROCHLORIDE AND LEVOFLOXACIN HEMIHYDRATE IN PHARMACEUTICAL FORMULATION
Ambroxol hydrochloride (AMB) and Levofloxacin hemihydrate (LVF) in combination were separated using Reverse-Phase - High-Performance Liquid Chromatographic (RP-HPLC) method. Mobile phase acetonitrile and 0.05 M potassium di-hydrogen orthophosphate buffer (pH 7.0 adjusted with sodium hydroxide solution) (50: 50, v/v) was selected for this chromatographic method. The separation was achieved in Zorba...
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COMPARISON OF SURGICAL SITE INFECTION RATE BETWEEN ANTIBACTERIAL COATED SURGICAL SUTURE AND CONVENTIONAL SUTURE: A RANDOMIZED CONTROLLED SINGLE CENTRE STUDY FOR PREVENTIVE MEASURE OF POSTOPERATIVE INFECTION
The main objective of this study is to compare the reduction rate of surgical site infection (SSI) between Triclosan coated (TC) and conventional surgical (CS) suture postoperatively. Surgical site infection (SSI) can be presented as a major challenge for people in the sense of mortality and morbidity mostly in developing countries. The result of SSI with antibacterial suture in developed countrie...
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