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ISOLATION AND ANTIMICROBIAL AND DEGRADATIVE POTENTIAL OF ACTINOMYCETES
Problem Statement: Do the soil Actinomycetes do have Antimicrobial and Petrol degradation potential? An intriguing question. Actinomycetes are continues to be a subject of study with reference to their Antimicrobial and degradative potential. However studies have been done is limited. Our object was to study its Antimicrobial activity in wide spectrum and to study its degradation potential on Petr...
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ESTIMATION OF QUERCETIN BY HIGH PERFORMANCE CHROMATOGRAPHY AND ANTIFUNGAL ACTIVITY OF MOSS PHILONOTIS REVOLUTA
Bryophytes- the small, slow growing group of plants is stockroom of naturally occurring materials. They contain a high number of biologically active compounds, however their use as a natural fungicides is negligible. In the recent years bryophytes has emerged as a potential biopharming tool for production of complex biopharmaceutiticals. In order to evaluate potential use of bryophytes as an antif...
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SYNTHESIS AND CHARACTERIZATION OF 3-[(5-(2-NITROPHENYL)-1, 3, 4-OXADIAZOL-2-YL) METHYL AMINO]-2-METHYL QUINAZOLIN-4(3H)-ONE
Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. The present survey aims to achieve the synthesis of quinazolinones and their derivatives of specific pharmacological properties. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting ...
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HOMOLOGY MODELING AND DOCKING STUDIES ON HIV REVERSE TRANSRIPTASE INHIBITORS
The usefulness of computational methods in drug design process is no longer a point of debate. The contributions from this evolving field have become apparent to both pharmaceutical scientists and academic biomedical researchers. As all the computational drug design are based on statistical and mathematical calculations there is strong evidences present for each and every step, thus research by ch...
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ALLIUM SATIVUM REGULATES LIPID METABOLISM IN ALLOXAN INDUCED DIABETIC RATS
Allium sativum (A. sativum), commonly known as garlic, is a species in the onion genus, Allium. The hypolipidemic activity of A. Sativum (Family: Amaryllidaceae) extract have been studied in alloxan-induced diabetic rats. In this model oral administration of extract (500mg/kg bw., p.o.) for 15 days in diabetic-dyslipidemic rats exerted significant lipid lowering effect as assessed by the reversal ...
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A SURVEY ON LINE OF MANAGEMENT OF HYPERTENSION BY PRIMARY HEALTH CARE PHYSICIANS IN PUDUDCHERRY
Hypertension is one of the most important public health problems globally. If the blood pressure is effectively controlled, many of the disastrous complications of hypertension such as myocardial infarction, stroke, kidney failure, heart failure, and death can be prevented or delayed. Patients usually attend the family physicians first for any illness they are suffering, including hypertension. He...
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EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF BAUHINIA PURPUREA IN GENTAMICIN INDUCED NEPHROTOXICITY IN RATS
Objective: To study the nephroprotective activity of Bauhinia purpurea unripe pods and bark against gentamicin-induced nephrotoxicity. Materials and Methods: Twenty four healthy adult albino rats of either sex (150-200 g) were randomly divided into four groups of six animals each. Group, I served as vehicle control and Group II as the negative control (gentamicin 80 mg/kg/d, i.p). Groups III and I...
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LIQUID CHROMATOGRAPHIC SEPARATION AND ANALYSIS OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN PHARMACEUTICAL FORMULATIONS
An accurate, simple and precise RP-HPLC method for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical formulations was developed and validated. Chromatographic separation of two drugs was achieved on a Kromasil C18, (250x4.6nm, 5µm) column by using the mobile phase consisted of methanol, tetrahydrofuran and water in the ratio 55:05:40 at a flow rate of 1mL/min...
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EVALUATION OF ANTI- HYPERGLYCAEMIC ACTIVITY OF MAYTENUS EMARGINATUS WILLD LEAVES EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETES IN WISTAR RATS
Maytenus emarginatus Willd. Celeastraceae, popularly known as “Kankeri or kankero”, is a Thorny staff evergreen tree that is rich in various chemical constituents that determine the medicinal potential of this species. Diabetes mellitus is a disease that is affecting major population of the world. This study aimed to evaluate the antihyperglycaemic activity of the hydroalcoholic extract of the...
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IN VITRO EVALUATION OF ANTIBACTERIAL ACTIVITY OF LEAF EXTRACTS OF BALLOTA NIGRA AGAINST FIVE BACTERIAL PATHOGENS
Ballota nigra (Lamiaceae) has been widely used as traditional medicine in many countries for the treatment of neuro-sedative, antidepressant, antioxidant, antibacterial, insecticidal, anticholinesterase and antifeedant effects. The main objective of this study is to evaluate the antibacterial activity of leaf extracts of Ballota nigra Linn. against five bacterial pathogens. The leaves were extract...
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