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CRUDE ROOT EXTRACT OF ASPARAGUS RACEMOSUS AMELIORATES ACETAMINOPHEN INDUCED UREMIC RATS.
Now days, herbal medicines are widely used to treat, manage and cure the kidney diseases as well as reduce uremia, acute nephritis & nephritic syndrome. The present study was to evaluate the antiuremic and antioxidative effect of Asparagus racemosus (AR) on acetaminophen induced uremic male rats. The study was designed with 36 male albino rats which were randomly divided into 6 groups. Group I...
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DEVELOPMENT OF NEW ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF RACECADOTRIL AS AN ACTIVE PHARMACEUTICAL INGREDIEN BY UV SPECTROPHOTOMETER
A simple and sensitive spectroscopic method was developed for the estimation of Racecadotril in pharmaceutical dosage forms. This method is based on Racecadotril, showing absorbance at 231 nm in methanol. This method obeys Beers law in the concentration range of 8 to100 μg mL-1 respectively. The proposed method is precise, accurate and reproducible and can be extended to the analysis of Racecadot...
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BIOCHEMICAL STUDIES ON THE ANTI-ULCEROGENIC POTENTIAL OF CARDIOSPERMUM HALICACABUM L. SEEDS
Cardiospermum halicacabum L. var. microcarpum (Kunth) Blume and var. luridum (Blume) Adelb. (Sapindaceae) are used for various ailments in Indian traditional medicines. The present study evaluated the antiulcerogenic property of seed oils (Petroleum ether extracts) in animal model. Ethanol induced gastric ulcers was used for this study and analysed for gastric volume, ulcer score pH, free and tota...
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PHYTO-CHEMICAL CONSTITUENTS FROM STEM OF TARAXACUM OFFICINALE WEBER
A new flavone glycoside 1 m. p. 223-225ºC, m. f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Taraxacum Officinal weber along with one known compound Taxifolin. A compound 1 was characterized as 6, 4′-dimethoxy-5, 7-dihydroxy-flavone- 7 - O - a - L-rhamnopyranosyl-(1®4) - O – β - D xylopyranosyl-(1®4)-O-β-D-glucopyranoside by various chemical degradations and spectral a...
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INVESTIGATION OF EFFECT OF MURRAYA KOENIGII ON BIOPHYSICAL AND BIOCHEMICAL PARAMETERS OF WOUND IN DIABETIC HYPERLIPIDEMIC WISTAR RATS
Plants have been used in traditional medicine for several thousand years. India is perhaps the largest producer of medicinal herbs and is rightly called the “Botanical garden of the World”. Murraya koenigii Linn. commonly known as Meethi neem, belongs to the family Rutaceae. The curry tree is native to India and it is found almost everywhere in the Indian subcontinent excluding the higher leve...
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DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR VENLAFAXINE HYDROCHLORIDE AS BILAYER TABLET
Present research work aims to develop venlafaxine hydrochloride gastro retentive tablets for prolonged release and increased gastric retention time. Venlafaxine is an antidepressant of the serotonin nor- epinephrine reuptake inhibitor (SNRI) class. Bioavailability is 45% following oral administration and half life is 5 hours. To study the effect of formulation variables on drug release and buoyan...
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DOCKING STUDIES OF GANODERMA LUCIDUM
Ganoderma is a miracle edible mushroom with unique composition and miraculous health benefits. The investigation aimed to elucidate interactions for the active compounds of Ganoderma lucidum namely Ganoderol A, Ganoderol B, Ganoderal A and Ganoderic Acid Y with Lanosterol 14 alpha demethylase enzyme using molecular docking software Arguslab. The effect of ganomycin1 and 2 as an inhibitor against H...
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TOXICOLOGICAL EFFECT OF MALLASINDURA (MSL) ON LIVER FUNCTION PARAMETERS OF RAT PLASMA AFTER CHRONIC ADMINISTRATION
Mallasindura (MSL), a widely used ayurvedic preparation is used for the treatment of bronchial asthma. It contains rasa –mercury, Rasakarpura -mercurial compound, Bali –purified and processed sulphur and Malla-purified arsenic oxide with herbal juices. The liver function parameters of rat plasma were studied after chronic administration of MSL. The animals used to conduct this experiment wer...
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CELL PROLIFERATIVE ACTION OF HYDROALCOHOLIC EXTRACT OF TRIGONELLA FOENUM GRAECUM IN RATS
The healing of an adult skin wound is a complex process of different tissues and cell lineages. Understanding wound healing involves understanding of inflammation, proliferation, and maturation phase. The present study was aimed at evaluation of proliferative action of hydroalcoholic extract of Trigonella foenum graecum (HETG) in albino rats using excision and incision wound model. HETG 5% W/W and...
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FORMULATION AND EVALUATION OF pH TRIGGERED IN-SITU OCULAR GEL OF OFLOXACIN
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled into the eye and undergoes a sol-gel transition in the cul-de-sac. The aim of the present study was to formulate and evaluate pH-triggered in-situ gels for ophthalmic delivery of of...
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