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CRUDE ROOT EXTRACT OF ASPARAGUS RACEMOSUS AMELIORATES ACETAMINOPHEN INDUCED UREMIC RATS.
Now days, herbal medicines are widely used to treat, manage and cure the kidney diseases as well as reduce uremia, acute nephritis & nephritic syndrome. The present study was to evaluate the antiuremic and antioxidative effect of Asparagus racemosus (AR) on acetaminophen induced uremic male rats. The study was designed with 36 male albino rats which were randomly divided into 6 groups. Group I...
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1628
PHYTO-CHEMICAL CONSTITUENTS FROM STEM OF TARAXACUM OFFICINALE WEBER
A new flavone glycoside 1 m. p. 223-225ºC, m. f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Taraxacum Officinal weber along with one known compound Taxifolin. A compound 1 was characterized as 6, 4′-dimethoxy-5, 7-dihydroxy-flavone- 7 - O - a - L-rhamnopyranosyl-(1®4) - O – β - D xylopyranosyl-(1®4)-O-β-D-glucopyranoside by various chemical degradations and spectral a...
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1670
DEVELOPMENT OF NEW ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF RACECADOTRIL AS AN ACTIVE PHARMACEUTICAL INGREDIEN BY UV SPECTROPHOTOMETER
A simple and sensitive spectroscopic method was developed for the estimation of Racecadotril in pharmaceutical dosage forms. This method is based on Racecadotril, showing absorbance at 231 nm in methanol. This method obeys Beers law in the concentration range of 8 to100 μg mL-1 respectively. The proposed method is precise, accurate and reproducible and can be extended to the analysis of Racecadot...
4190
2041
DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR VENLAFAXINE HYDROCHLORIDE AS BILAYER TABLET
Present research work aims to develop venlafaxine hydrochloride gastro retentive tablets for prolonged release and increased gastric retention time. Venlafaxine is an antidepressant of the serotonin nor- epinephrine reuptake inhibitor (SNRI) class. Bioavailability is 45% following oral administration and half life is 5 hours. To study the effect of formulation variables on drug release and buoyan...
4190
1939
ANALYSIS OF ANTIMICROBIAL USAGE PATTERN: A RETROSPECTIVE OBSERVATIONAL STUDY
Objective: Antimicrobials have become one of the most misused therapeutic agents resulting in resistance. Present study was carried out to evaluate the antimicrobial drug utilization pattern. Method: A retrospective, observational record based study was done in hospitalized patients from medicine and surgery department of tertiary care hospital of central India over a period of one year. Result: A...
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1554
DESIGN, DEVELOPMENT AND OPTIMIZATION OF VALSARTAN LIQUISOLID TABLETS USING BOX-BEHNKEN DESIGN
The aim of the present study was to investigate the applicability of liquisolid technique in improving the dissolution properties of Valsartan in a solid dosage form. This study was designed to optimize and evaluate the effects of different formulation variables: amount of liquid vehicle (X1), ratio of carrier to coating material(X2) and amount of magnesium oxide(X3) on angle of repose (Y1), har...
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2193
MICRO-COULOMETRIC ESTIMATION OF NITROFURANTOIN
The objective of the present work was to set up micro-coulometric technique in the laboratory and estimate microgram level quantity of nitrofurantoin in the pharmaceutical tablets. A simple, sensitive, and reproducible manually operated microcoulometric technique has been successfully used for the estimation of nitrofurantoin in pharmaceutical tablets. A potentostat and coulometric cell was used i...
4189
2054
FORMULATION AND EVALUATION OF pH TRIGGERED IN-SITU OCULAR GEL OF OFLOXACIN
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled into the eye and undergoes a sol-gel transition in the cul-de-sac. The aim of the present study was to formulate and evaluate pH-triggered in-situ gels for ophthalmic delivery of of...
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1574
CELL PROLIFERATIVE ACTION OF HYDROALCOHOLIC EXTRACT OF TRIGONELLA FOENUM GRAECUM IN RATS
The healing of an adult skin wound is a complex process of different tissues and cell lineages. Understanding wound healing involves understanding of inflammation, proliferation, and maturation phase. The present study was aimed at evaluation of proliferative action of hydroalcoholic extract of Trigonella foenum graecum (HETG) in albino rats using excision and incision wound model. HETG 5% W/W and...
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1639
THE ROLE OF β-ENDORPHIN AND C-PEPTIDE IN STREPTOZOTOCIN INDUCED DIABETIC RATS WITH EFFECT OF ACU-TENS AT ZUSANLI (ST36) ACUPOINTS
Streptozotocin is 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose drug is commonly used to induce diabetes in experimental rats. This study was designed to evaluate the role of β-endorphin and C-peptide in Acu-TENS therapy at Zusanli (ST36) acupoint. Diabetic was induced by Streptozotocin (45mg/kg/body weight) with a single dose of intraperitoneal injection in male albino Wistar rats. The di...
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