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SALINE WATER AS SOURCE OF CANCER DRUGS: ANTI- CANCER METABOLITES FROM MARINE SPONGES
Oceans and its ecosystem comprise an untapped source for many potential drugs. Marine sponges which inhabit mainly in the saline ocean water are considered as one of the oldest form of life. Due to intense concentration of various sponge species and other organisms co- existing in limited extent marine habitats, necessarily makes them highly competitive and complex. Hence most of the sponge specie...
4193
1813
HEMATOLOGICAL AND HISTOPATHOLOGICAL STUDIES OF ENDOSPERM-RICH FRACTION OF FLAXSEED IN CHICKS
Flaxseed is being consumed as an ingredient in various food formulations as it plays a major role in the field of diet and disease research due to its potential health benefits associated with a- linolenic acid (57%) and its rich phytoestrogens or lignans. Hence, presently, it is in great demand by food industries and in nutraceutical applications. The present study was carried out using 80, 3...
4193
1823
FORMULATION AND EVALUATION OF NIOSOMES ENCAPSULATED WITH KT2 AND RT2: ANTIMICROBIAL AND ANTICANCER PEPTIDES DERIVED FROM CROCODILE LEUKOCYTE EXTRACT
Niosome is one of the synthetic nanoparticles which often is used for drug delivery and cosmetic industry. The aim of this study was to prepare niosomes encapsulated with KT2 and RT2. KT2 and RT2 are antimicrobial and anticancer peptides derived from crocodile leukocyte extract. Niosomes encapsulated with KT2 and RT2 were prepared by thin-film hydration technique, and peptide encapsulation efficie...
4193
1941
CARDIOPROTECTIVE EFFECT OF MORUS ALBA L. LEAVES IN ISOPRENALINE INDUCED RATS
The study was designed to evaluate the cardioprotective effect of methanolic extract of Morus alba L. leaves against isoprenaline- induced myocardial infarction and was investigated by an in vivo method in rats. Male Wistar albino rats were divided into four groups (n=6). Group I rats served as normal control. Group II rats served as isoprenaline induced toxic control (110 mg/kg body weight) which...
4192
1633
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF LEAF EXTRACT PREPARED BY SOXHLET EXTRACTION OF SELECTED MEMBERS OF APOCYNACEAE
The present study aimed to understand, phytochemistry and antioxidant property of five members belonging to Apocynaceae, Catharanthus roseus (L) G. Don; Plumeria alba L.; Pentalinon luteum (L) B. F. Hanson & Wunderlin; Rauvolfia tetraphylla L and Nerium oleander L. The preliminary phytochemical analysis was carried out using the methanolic extract for protein, carbohydrate, alkaloids, phenol, ...
4192
1986
POTENTIAL PROTECTIVE EFFECT OF GUM ARABIC AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY IN WISTAR ALBINO RATS
Gum Arabic (GA) is a water-soluble polysaccharide, obtained from stems of Acacia senegal trees as gummy exudates. It is a beneficial adjunct to the low-protein diet for chronic renal failure patient because it reduces serum urea nitrogen level. It is also have a good protective activity against CCl4 and acetaminophen-induced hepatotoxicity in rats but it failed protect kidney from gentamicin-induc...
4191
1591
SOFT MALLEABLE VESICLES TAILORED FOR ENHANCED DELIVERY OF ACTIVE AGENTS THROUGH THE SKIN: AN UPDATE
Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. These are soft, malleable vesicles tailored for enhanced delivery of active agents. They are composed mainly of phospholipids, high concentration of ethanol and water. The high concentration of ethanol makes the ethosomes unique, as ...
4190
1984
PRELIMINARY SCREENING OF ETHNOMEDICINAL PLANTS FOR ANTIBACTERIAL ACTIVITY
Based on the ethno botanical survey and the related literature, 285 solvent extracts from 57 ethno medicinal plants belonging to 55 genera and 34 families were subjected to preliminary screening for antibacterial activity against Escherichia coli and Bacillus subtilis using agar well diffusion method at concentrations of 5 & 2.5 mg/ml. Among 285 plant extracts, some exhibited very effective ac...
4190
1687
SYNTHESIS AND SCREENING N-(2, 4′-DIOXO-1, 2-DIHYDRO-3’H-SPIRO [INDOLE-3, 2′-[1,3]THIAZOLIDIN]-3′-YL)-2-HYDROXYBENZAMIDES FOR ANTI-BACTERIAL ACTIVITY
A novel synthesis of N-(2, 4'-dioxo-1, 2-dihydro-3'H-spiro [indole-3, 2'-[1, 3] thiazolidin]-3'-yl)-2 -hydroxybenzamide derivatives were synthesized by cyclization of isatin hydrazones with thioglycolic acid. The synthesized compounds were characterized by spectral data (IR, 1H-NMR, Mass) and evaluated for antibacterial activity against various strains of bacteria at the concentrations of 200 µg/...
4190
1397
ANTIMICROBIAL ACTIVITY OF STEM BARK OF COMBRETUM ALBIDUM G. DON; A TRADITIONAL MEDICINAL LIANA
Traditional knowledge and ethno-botanical use of plants have been widely acknowledged all over the world. In the present scenario, emergence of multiple drug resistance to human pathogenic organisms, this has necessitated a search for new antimicrobial substances from other sources including plants. Combretum albidum, a traditional medicinal liana, used by rural peoples, villagers and tribals resi...
4189
1867