Most Popular
FORMULATION DEVELOPMENT AND IN VITRO – IN VIVO CHARACTERIZATION OF ORAL FAST DISINTEGRATING FILMS OF A DRUG MEANT FOR CHRONIC DISEASE
The objective of the work was to design oral FDFs of a drug meant for management of chronic disease like type-2 diabetes mellitus which affects mostly elderly population. Glimepiride was the drug of choice because of its low dose. Since in vitro dissolution rate is the rate limiting step in drug absorption for class II drugs, in the present work,it was also proposed to make a complex of the drug...
4189
2419
HEMATOLOGICAL AND HISTOPATHOLOGICAL STUDIES OF ENDOSPERM-RICH FRACTION OF FLAXSEED IN CHICKS
Flaxseed is being consumed as an ingredient in various food formulations as it plays a major role in the field of diet and disease research due to its potential health benefits associated with a- linolenic acid (57%) and its rich phytoestrogens or lignans. Hence, presently, it is in great demand by food industries and in nutraceutical applications. The present study was carried out using 80, 3...
4188
1819
SYNTHESIS AND SCREENING N-(2, 4′-DIOXO-1, 2-DIHYDRO-3’H-SPIRO [INDOLE-3, 2′-[1,3]THIAZOLIDIN]-3′-YL)-2-HYDROXYBENZAMIDES FOR ANTI-BACTERIAL ACTIVITY
A novel synthesis of N-(2, 4'-dioxo-1, 2-dihydro-3'H-spiro [indole-3, 2'-[1, 3] thiazolidin]-3'-yl)-2 -hydroxybenzamide derivatives were synthesized by cyclization of isatin hydrazones with thioglycolic acid. The synthesized compounds were characterized by spectral data (IR, 1H-NMR, Mass) and evaluated for antibacterial activity against various strains of bacteria at the concentrations of 200 µg/...
4188
1396
POTENTIAL PROTECTIVE EFFECT OF GUM ARABIC AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY IN WISTAR ALBINO RATS
Gum Arabic (GA) is a water-soluble polysaccharide, obtained from stems of Acacia senegal trees as gummy exudates. It is a beneficial adjunct to the low-protein diet for chronic renal failure patient because it reduces serum urea nitrogen level. It is also have a good protective activity against CCl4 and acetaminophen-induced hepatotoxicity in rats but it failed protect kidney from gentamicin-induc...
4187
1589
PRELIMINARY SCREENING OF ETHNOMEDICINAL PLANTS FOR ANTIBACTERIAL ACTIVITY
Based on the ethno botanical survey and the related literature, 285 solvent extracts from 57 ethno medicinal plants belonging to 55 genera and 34 families were subjected to preliminary screening for antibacterial activity against Escherichia coli and Bacillus subtilis using agar well diffusion method at concentrations of 5 & 2.5 mg/ml. Among 285 plant extracts, some exhibited very effective ac...
4186
1686
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF LEAF EXTRACT PREPARED BY SOXHLET EXTRACTION OF SELECTED MEMBERS OF APOCYNACEAE
The present study aimed to understand, phytochemistry and antioxidant property of five members belonging to Apocynaceae, Catharanthus roseus (L) G. Don; Plumeria alba L.; Pentalinon luteum (L) B. F. Hanson & Wunderlin; Rauvolfia tetraphylla L and Nerium oleander L. The preliminary phytochemical analysis was carried out using the methanolic extract for protein, carbohydrate, alkaloids, phenol, ...
4186
1980
CARDIOPROTECTIVE EFFECT OF MORUS ALBA L. LEAVES IN ISOPRENALINE INDUCED RATS
The study was designed to evaluate the cardioprotective effect of methanolic extract of Morus alba L. leaves against isoprenaline- induced myocardial infarction and was investigated by an in vivo method in rats. Male Wistar albino rats were divided into four groups (n=6). Group I rats served as normal control. Group II rats served as isoprenaline induced toxic control (110 mg/kg body weight) which...
4185
1630
STUDY OF ANTIBIOTIC SUSCEPTIBILITY TEST OF MODERN GENERATION OF DRUGS AGAINST UPPER RESPIRATORY TRACT PATHOGENS
Nasal infection or sinusitis is an inflammation of nasal passages caused by both viral and bacteriological pathogens. Antimicrobial resistance has universally recognized as growing problem concern about suitable therapy for nasal infection. The study was aimed at determining the prevalence and antimicrobial susceptibility against nasal infecting microorganisms. 50 clinical samples were taken from ...
4185
1649
TO INVESTIGATE THE EFFECTS OF GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) ON AMPHETAMINE-INDUCED LOCOMOTOR ACTIVITY IN RAT
To investigate the effects of ginger-juice (Zingiber officinale roscoe) on amphetamine-induced locomotor activity in rat. Methods: (A) Albino rats (n=6-12) were administered G.J at the single doses (4 ml/rat, p.o) as single administration (acute) and chronic treatment over period of 7 days. Following this assessment was done. Effect of treatment with G.J acutely and chronically (7days) administere...
4185
2118
ANTI-DIABETIC, HYPOLIPIDEMIC AND HEPATO-RENAL PROTECTIVE EFFECT OF A NOVEL FERMENTED BEVERAGE FROM SYZYGIUM CUMINI STEM
In view of therapeutic values associated with Syzygium cumini and increasing consumer demand for functional foods, a non-conventional alcoholic beverage prepared from the stem of Syzygium cumini was evaluated for its efficacy against streptozotocin-induced diabetes mellitus in male wistar rats. The beverage was observed to be safe for consumption as it did not produce any anomalies in the biochemi...
4185
1398