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DESIGN, DEVELOPMENT AND OPTIMIZATION OF VALSARTAN LIQUISOLID TABLETS USING BOX-BEHNKEN DESIGN
The aim of the present study was to investigate the applicability of liquisolid technique in improving the dissolution properties of Valsartan in a solid dosage form. This study was designed to optimize and evaluate the effects of different formulation variables: amount of liquid vehicle (X1), ratio of carrier to coating material(X2) and amount of magnesium oxide(X3) on angle of repose (Y1), har...
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INVESTIGATION ON REGIONAL VARIATION IN TOTAL PHENOLIC, ALKALOID CONTENT AND IN-VITRO ANTIOXIDANT ACTIVITY OF LEUCAS ASPERA
In this study, we investigated and compared the total phenolic, alkaloid content and in-vitro antioxidant activity of Leucas aspera collected from four different regions; Tirupathi (Southern zone), Lam (Krishna river region), Jagityala (Northern Telangana) and Hyderabad (Southern Telangana) of Andhra Pradesh, India. Quantitative regional variation was observed in total phenolic content, and alka...
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1751
SALINE WATER AS SOURCE OF CANCER DRUGS: ANTI- CANCER METABOLITES FROM MARINE SPONGES
Oceans and its ecosystem comprise an untapped source for many potential drugs. Marine sponges which inhabit mainly in the saline ocean water are considered as one of the oldest form of life. Due to intense concentration of various sponge species and other organisms co- existing in limited extent marine habitats, necessarily makes them highly competitive and complex. Hence most of the sponge specie...
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1808
IN-VITRO EVALUATION OF ANTIOXIDANTS ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF CELASTRUS PANICULATUS
Celastrus paniculatus is an important medicinal plant used in India. Traditionally seed oil of this herb is used widely in several medicinal preparations and its bark is used in malaria in folk medicines. It is endangered and vulnerable plant. The investigation used Reducing power assay and Total phenolic content to determine antioxidant potential in the ethanolic extract of the drug. The result s...
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1822
TOXICOLOGICAL EFFECT OF MALLASINDURA (MSL) ON LIVER FUNCTION PARAMETERS OF RAT PLASMA AFTER CHRONIC ADMINISTRATION
Mallasindura (MSL), a widely used ayurvedic preparation is used for the treatment of bronchial asthma. It contains rasa –mercury, Rasakarpura -mercurial compound, Bali –purified and processed sulphur and Malla-purified arsenic oxide with herbal juices. The liver function parameters of rat plasma were studied after chronic administration of MSL. The animals used to conduct this experiment wer...
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PHYTOCHEMICAL PROFILE OF SEQUOIA SEMPERVIRENS GROWN IN EGYPT
The immunomodulatory and antiulcerogenic activities of the chloroform, ethyl acetate and n-butanol fractions of Sequoia sempervirens (D. Don.) leaves were investigated. The ethyl acetate fraction showed the best results regarding to a high significant increase of RAW 264.7 macrophage cells and reduction of ulcers number and severity compaered with Ranitidine. HPLC technique was used to investiga...
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1748
DOCKING STUDIES OF GANODERMA LUCIDUM
Ganoderma is a miracle edible mushroom with unique composition and miraculous health benefits. The investigation aimed to elucidate interactions for the active compounds of Ganoderma lucidum namely Ganoderol A, Ganoderol B, Ganoderal A and Ganoderic Acid Y with Lanosterol 14 alpha demethylase enzyme using molecular docking software Arguslab. The effect of ganomycin1 and 2 as an inhibitor against H...
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1626
FORMULATION, CHARACTERIZATION AND IN-VIVO APPLICATION OF ORAL INSULIN NANOTECHNOLOGY USING DIFFERENT BIODEGRADABLE POLYMERS: ADVANCED DRUG DELIVERY SYSTEM
The overall objective of this research is to improve the oral bioavailability of insulin through encapsulation in nanoparticles formulated by "ionotropic pre-gelation followed by polyelectrolyte complexation technique". The preparation variables such as initial drug concentration, polymer: polymer ratios, crosslinker concentration, stirring speed, stirring time, pH of drug / polymer mixture were i...
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1628
IN VITRO EVALUATION OF ANTIOXIDANT ACTIVITY OF DILLENIA INDICA LINN. LEAF EXTRACT
Reactive oxygen species (ROS) are thought to underline the process of ageing and the pathogenicity of various diseases, such as neurodegenerative disorders and cancer. The use of traditional medicine is widespread and plants still present a large source of natural antioxidants that might serve as leads for the development of novel drugs. In this study, an ethanolic extract of leaves from Dillenia ...
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1651
DEVELOPMENT AND VALIDATION OF A CHROMATOGRAPHIC ASSAY METHOD FOR THE DETERMINATION OF LULICONAZOLE IN CREAMS
A simple and rapid reverse-phase high-performance liquid chromatographic technique was developed and validated for the determination of Luliconazole in the presence of its excipients. Chromatographic elution was performed on a binary gradient HPLC equipped with PDA detector using a Luna-5µ C8(2) 100 Å column (250 × 4.6 mm, 5 µm) with orthophosphoric acid (0.1%) and methanol (20:80% w/v) as mob...
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1915