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DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR VENLAFAXINE HYDROCHLORIDE AS BILAYER TABLET
Present research work aims to develop venlafaxine hydrochloride gastro retentive tablets for prolonged release and increased gastric retention time. Venlafaxine is an antidepressant of the serotonin nor- epinephrine reuptake inhibitor (SNRI) class. Bioavailability is 45% following oral administration and half life is 5 hours. To study the effect of formulation variables on drug release and buoyan...
4238
1966
IDENTIFICATION OF AEROTOLERENCE GENE BATA AND BATB IN SUBGINGIVAL MICROFLORA: AGGREGATIBACTER ACTINOMYCETEMCOMITANS, TANNERELLA FORSYTHIA AND PREVOTELLA INTERMEDIA
Subgingival obligate anaerobes present within the biofilm such as Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia and Aggregati bacter actinomycetemcomitans have been implicated in the initiation and progression of periodontal disease. Recent documentation has demonstrated that P.gingivalis is capable of maintaining its viability when exposed to oxidative stress by expressing...
4238
1961
PHYTOCHEMICAL PROFILE OF SEQUOIA SEMPERVIRENS GROWN IN EGYPT
The immunomodulatory and antiulcerogenic activities of the chloroform, ethyl acetate and n-butanol fractions of Sequoia sempervirens (D. Don.) leaves were investigated. The ethyl acetate fraction showed the best results regarding to a high significant increase of RAW 264.7 macrophage cells and reduction of ulcers number and severity compaered with Ranitidine. HPLC technique was used to investiga...
4238
1775
SALINE WATER AS SOURCE OF CANCER DRUGS: ANTI- CANCER METABOLITES FROM MARINE SPONGES
Oceans and its ecosystem comprise an untapped source for many potential drugs. Marine sponges which inhabit mainly in the saline ocean water are considered as one of the oldest form of life. Due to intense concentration of various sponge species and other organisms co- existing in limited extent marine habitats, necessarily makes them highly competitive and complex. Hence most of the sponge specie...
4237
1830
IN VITRO EVALUATION OF ANTIOXIDANT ACTIVITY OF DILLENIA INDICA LINN. LEAF EXTRACT
Reactive oxygen species (ROS) are thought to underline the process of ageing and the pathogenicity of various diseases, such as neurodegenerative disorders and cancer. The use of traditional medicine is widespread and plants still present a large source of natural antioxidants that might serve as leads for the development of novel drugs. In this study, an ethanolic extract of leaves from Dillenia ...
4237
1671
EFFICIENCY OF DIFFERENT SOLVENTS ON PHYTOCHEMISTRY PROFILE OF WATER MELON (CITRULLUS VULGARIS SCHRAD.) SEED EXTRACTS
Citrullus vulgaris Schrad. has occupied a popular place in the indigenous system of folk medicine because of its high nutritional and antioxidant properties. The study aims to elucidate the extractive yield percentage and screen the seed extracts of watermelon using different solvents for its phytochemical profile. The solvents selected were Methanol, Ethanol, Chloroform, Petroleum ether, Ethyl ac...
4237
1770
DEVELOPMENT AND VALIDATION OF A CHROMATOGRAPHIC ASSAY METHOD FOR THE DETERMINATION OF LULICONAZOLE IN CREAMS
A simple and rapid reverse-phase high-performance liquid chromatographic technique was developed and validated for the determination of Luliconazole in the presence of its excipients. Chromatographic elution was performed on a binary gradient HPLC equipped with PDA detector using a Luna-5µ C8(2) 100 Å column (250 × 4.6 mm, 5 µm) with orthophosphoric acid (0.1%) and methanol (20:80% w/v) as mob...
4237
1936
DESIGN OF NEWER ANALOG OF IMATINIB AS ANTICANCER DRUG TARGETING PROTEIN KINASE RECEPTOR
Protein kinases are key players in cellular signal transduction and perturbations in its activity leads to cancer. Targeting these seems to be sufficient to provoke apoptotic response, thus limiting the process of tumorogenesis. Among kinase inhibitors, imatinib has demonstrated magnificent clinical efficacy. But patients with advanced disease harbor faces resistance. Currently there is requisite ...
4235
2067
CRUDE ROOT EXTRACT OF ASPARAGUS RACEMOSUS AMELIORATES ACETAMINOPHEN INDUCED UREMIC RATS.
Now days, herbal medicines are widely used to treat, manage and cure the kidney diseases as well as reduce uremia, acute nephritis & nephritic syndrome. The present study was to evaluate the antiuremic and antioxidative effect of Asparagus racemosus (AR) on acetaminophen induced uremic male rats. The study was designed with 36 male albino rats which were randomly divided into 6 groups. Group I...
4234
1648
PRELIMINARY SCREENING OF ETHNOMEDICINAL PLANTS FOR ANTIBACTERIAL ACTIVITY
Based on the ethno botanical survey and the related literature, 285 solvent extracts from 57 ethno medicinal plants belonging to 55 genera and 34 families were subjected to preliminary screening for antibacterial activity against Escherichia coli and Bacillus subtilis using agar well diffusion method at concentrations of 5 & 2.5 mg/ml. Among 285 plant extracts, some exhibited very effective ac...
4234
1708