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CHARACTERISATION OF ISOELEUTHERINE IN AQUEOUS EXTRACT OF ELEUTHERINE PLICATA HERB, IRIDACEAE, ACTIVE AGAINST ENTAMOEBA HYSTOLITICA/ ENTAMOEBA DISPAR IN-VITRO
Eleutherine plicata Herb., Iridaceae, is an herbaceous Iridaceae, vernacular marupazinho, largely used as tea, in the Amazonian popular phytotherapy, to treat diarrhoea alleged to amoeba infestation. To investigate the form of use of this medicinal plant andits alleged activity, and to perform a phytochemical analysis and an anti-amoebaean assay. Bulbs of the plant were dried, grinded and extracte...
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SYNTHESIS OF NEW SERIES OF THIENYL ACRYLATE DERIVATIVES VIA BAYLIS-HILLMAN REACTION AND EVALUATION OF ANTIMICROBIAL ACTIVITY
A series of new Thienyl acrylate compounds were synthesized via Baylis-Hillman reaction and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a very good activity against Gram positive strains. The structure of these newly synthesized compounds were conformed by 1H NMR, IR, Mass and Elemental analysis, some of them were also confirmed by 13C NMR....
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IN VITRO ANTIOXIDANT ACTIVITY OF CURCUMA AMADA ROXB.
A study was undertaken to evaluate the antioxidant potential of rhizomes of Curcuma amada (Zingiberaceae). Aqueous and ethanolic extracts were subjected to in vitro antioxidant activity screening models such as DPPH, ABTS, nitric oxide and inhibition of lipid peroxidation activity. Ascorbic acid was used as the standard. In all the models studied, both the extracts showed nearly equal activities...
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LIPOSOMAL GEL AS OCULAR DELIVERY SYSTEM FOR DICLOFENAC SODIUM: IN- VITRO AND IN-VIVO STUDIES
The aim of this work is to formulate topically effective controlled release ophthalmic liposomal gel for targeting diclofenac sodium to the eye in an attempt to heal the inflamed tissue of ocular ulcerative area. Large unilamellar vesicles (LUVs) and multilamellar vesicles (MLVs) gel formulations composing of phosphatidylcholine (PC) and cholesterol (CH) in the molar ratios of (7:2; 7:4 and 7:7)...
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SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM FOR COMBINATION OF HYDROPHILIC AND LIPOPHILIC DRUGS
Improvement in the bioavailability of poorly soluble drugs is one of the challenges faced in the formulation development of the drugs. One of the most admirable and viable formulation approaches for this is self micro emulsifying drug delivery system (SMEDDS). A combination of clarithromycin and amoxicillin has been proved effective for treatment of H. pylori which are available only in tablet dos...
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EVALUATION OF ANTIDIABETIC ACTIVITY OF A POLYHERBAL FORMULATION IN ALLOXAN INDUCED DIABETIC RATS
Objective of the study was to assess the antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats. Methods: The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan β- cytotoxin induced chemical diabetes in a wide variety of wister albino rats. Result: The polyherbal formulation contain the following plants l...
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PHYTOCHEMICAL SCREENING AND BIOLOGICAL STUDIES ON THE LEAVES OF TINOSPORA CORDIFOLIA
Helminthiasis is also known as worm infection and a endoparasitic disease of humans and other animals in which a part of a body is infected with parasitic worms. Tinospora cordifolia is a well known medicinal plant and widely used in folk medicine ayurvedic system. The objective of this work is to carry out phytochemical screening and in vitro anthelmintic activity of methanolic, petroleum ether a...
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PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT ACTIVITY OF KNEMA ATTENUATA (HOOK. F. & THOMSON) WARB STEM BARK EXTRACT
The plant Knema attenuata or Myristica attenuata (Myristicaceae) is an endemic tree species found in the Western Ghats. Traditionally, the stem bark of K. attenuata is used in folk medicine without any scientific information available for the same. Phytochemical screening was carried out for ethanolic stem bark extract of K. attenuata to investigate the antioxidant potential of the extract. The an...
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THE ANTI-INFLAMMATORY ACTIVITY OF PLANT DERIVED INGREDIENTS: AN ANALYTICAL REVIEW
Inflammation, a protective response, can be dangerous if left untreated. The current synthetic anti-inflammatory drugs available in the market are coupled with various side effects. Plant-derived products can serve as a better alternative being cheap, easily available and having very few side effects. A sizable number of plants having anti-inflammatory activity have been studied. The crude extract...
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IN VIVO STABILIZATION STUDIES ON INDIAN COBRA (NAJA NAJA) VENOM FOR ITS TOXICOLOGICAL ACTIVITY (LD50) IN MICE
Biological/Toxicological activity of Cobra venom (CV) is usually estimated in terms of LD50 which varies at each time of test, when stored in liquid condition at non-native environment, as the CV contains most unstable complex proteins in it. Prepared & stored working solution of cobra venom at 5±3ºC in liquid condition for experimentation without any stabilizing agent, it becomes unstable a...
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