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IN VIVO STABILIZATION STUDIES ON INDIAN COBRA (NAJA NAJA) VENOM FOR ITS TOXICOLOGICAL ACTIVITY (LD50) IN MICE
Biological/Toxicological activity of Cobra venom (CV) is usually estimated in terms of LD50 which varies at each time of test, when stored in liquid condition at non-native environment, as the CV contains most unstable complex proteins in it. Prepared & stored working solution of cobra venom at 5±3ºC in liquid condition for experimentation without any stabilizing agent, it becomes unstable a...
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UROPATHOGEN RESISTANT ESSENTIAL OILS OF COLEUS AROMATICUS AND OCIMUM SANCTUM
Urinary tract infections are common type of pathogenic infections in body. Essential oils of Coleus aromaticus and two varieties of Ocimum sanctum (Rama Tulasi and Shyama Tulasi) were compared for antibacterial activity against urinary tract infection (UTI) causing bacteria; Staphylococcus aureus, Klebsiella oxytoca, Proteus vulgaris, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa...
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DIAGNOSIS OF NON-POLIO ENTEROVIRAL INFECTIONS IN SEPTIC NEONATES BY POLYMERASE CHAIN REACTION ASSAYS
Objective: The purpose of this study was to investigate the prevalence of non-polio enteroviral infections by quantitative and qualitative PCR assays in neonates 3-30 days old with clinical diagnosis of sepsis. Methods: The patients included all the neonates aged 3-30 days admitted with diagnosis of neonatal sepsis. Blood specimens, throat swabs, and in 60 cases CSF specimens were tested for Enter...
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FORMULATION, CHARACTERIZATION AND IN-VITRO / EX-VIVO EVALUATION OF TROLAMINE SALICYLATE – LOADED TRANSFERSOMES AS TRANSDERMAL DRUG DELIVERY CARRIERS
The percutaneous delivery of salicylates to muscle and joints via the application of trolamine salicylate including transfersomes is the goal of this study and is beneficial for the treatment of inflammatory muscle, tendon and joint diseases. In this study, Trolamine salicylate permeability parameters through rat skin were evaluated with different trasfersome formulations in comparison with contro...
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EVALUATION OF GASTRIC ANTIULCEROGENIC ACTION OF VEGETABLE PLANTAIN BANANA (MUSA SAPIENTUM VAR. PARADISIACA) IN ASPIRIN PLUS PYLORUS LIGATED ALBINO RATS
Objectives: To assess the effect of unripe dried banana powder in experimentally induced gastric ulcers and effect on gastric acid secretion. To evaluate the antiulcerogenic effect of plantain banana of Gujarat as a part of evaluation of impact of biological variables on this activity. Results: Orally administered banana powder in the dose of 2gm/kg caused a statistically significant decrease...
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IDENTIFICATION AND ANALYSIS OF LEAD COMPOUNDS AGAINST HIV-1 INTEGRASE ENZYME USING ADMET PREDICTION AND DOCKING ANALYSIS
Acquired immune deficiency syndrome (AIDS), one of the most challenging diseases world-wide is caused by human immunodeficiency virus (HIV), member of human retrovirus family. Various therapies and treatments of HIV are provided, but these are rapidly drug resistance in recent decades. After the explosion of HIV integrase (enzyme essential for the replication of DNA virus in the host genome), phar...
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HEPATITIS C VIRUS: AN OUTLINED REVIEW
Chronic hepatitis C (CHC) is a big cause of liver-related fibrosis and cirrhosis. The level of fibrosis is usually in the past (established by histology). The prognosis is estimated using fibrosis progression rates (FPRs; the annual probability of progressing across histological stages). However, new non-invasive options are quickly replacing biopsy. As the rates of HCV cirrhosis go on increasing ...
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THE REAL-WORLD STUDY OF SHENMAI INJECTION AND ITS ADVERSE REACTIONS ASSOCIATED TO PATIENTS IN CHINESE HOSPITALS: A PROSPECTIVE RESEARCH
Shenmai injection (SMI) is the Traditional Chinese Medicine Injection (TCMI) prepared by Red Ginseng and Radix Ophiopogonis extract. The aim of this study is to reveal the real-word of SMI, to evaluate its use and its adverse reactions associated to patients.A prospective, observational combined nested case-control clinical research carried out in two tertiary care teaching hospitals and two secon...
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HEPARIN IN HIT: EFFECTIVENESS AS AN ANTICOAGULANT
Heparin-induced thrombocytopenia (HIT), a devastating immune mediated adverse drug reaction, is triggered by the development of antibodies that stimulates the platelet activation in presence of heparin. Bleeding is infrequent in HIT patients regardless of thrombocytopenia; however, HIT is strongly associated with thromboembolic complications involving both venous and arterial systems. Numerous nov...
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IN-VITRO EVALUATION OF SHEA BUTTER-BASED NYSTATIN MICROPARTICLES
Nystatin, an antifungal drug for mucosal infections has a large dosing frequency and is rapidly inactivated by acids. In order to increase drug stability and reduce dosing frequency and reduce dosing frequency and gastric irritation, formulation into inert lipid matrices as solid lipid microparticles may be utilized. The formulations were done from Shea butter extract using either Tween 20 or Twee...
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