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ASSESSMENT OF PHYTOCHEMICAL AND ANTIOXIDANT POTENTIAL OF UNDERUTILIZED PEAR (PYRUS PYRIFOLIA) AND PLUM (PRUNUS DOMESTICA) FROM INDIGENOUS HIMALAYAN REGION OF HIMACHAL PRADESH
The present investigation revealed the phytochemical constituent, antioxidant potential and correlation between antioxidant activities with total phenol and flavonoid contents of fruit extracts of Pyrus pyrifolia and Prunus domestica from local Himalayan region of Himachal Pradesh, India. The total phenolic content was estimated by using Folin-Ciocalteu reagent method, whereas, flavonoid content w...
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ANALYSIS OF ANTIMICROBIAL USAGE PATTERN: A RETROSPECTIVE OBSERVATIONAL STUDY
Objective: Antimicrobials have become one of the most misused therapeutic agents resulting in resistance. Present study was carried out to evaluate the antimicrobial drug utilization pattern. Method: A retrospective, observational record based study was done in hospitalized patients from medicine and surgery department of tertiary care hospital of central India over a period of one year. Result: A...
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ANTINOCICEPTIVE EFFECTS OF METHANOLIC EXTRACTS OF POTENTILLA ANSERINA IN ANIMAL MODELS
Potentilla anserina (Rosaceae) is a traditional medicinal plant in India, and it is available throughout the Northern hemisphere. This study was intended to evaluate the antinociceptive activity of methanolic extract of Potentilla anserina in acetic acid-induced writhing test in mice and Eddy’s Hot Plate method in Albino rats at the dose level of 75, 150 and 300 mg/kg p.o and the study was compa...
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DEVELOPMENT AND VALIDATION OF DIFFERENT SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE FROM BULK DRUG AND TABLETS
Simple, sensitive and accurate UV- spectrophotometric methods have been developed for the determination of an anti-HIV drug, Tenofovir Disoproxil fumarate (TDF), in raw material and in tablets. The drug shows maximum absorbance at 259 nm in selected four different media namely gastric fluid simulated (HCl) pH 1.5, vaginal fluid simulated (VFS) pH 4.2, phosphate buffer (PB) pH 6.8 and double distil...
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HISTORY, MANIFESTATION AND PREVENTIVE MEASURES FOR RUBELLA IN INDIA: A REVIEW
Rubella is an eradicable illness on the grounds of immunization against it produces solid protection. The name rubella comes from the Latin language, and it means “little red”. In olden times people thought that rubella was a variant of measles. German literature first described it as a separate disease, and hence it was also called “German Measles”. People are the main reservoir of the in...
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IN-VITRO ANTHELMINTIC ACTIVITY OF ENICOSTEMMA LITTORALE BLUME
The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with a resultant economic impact. Despite this prevalence of parasitic infections, the research on antihelmentic drug is poor. As per WHO, only few drugs are frequently used in the treatment of helminthes in human ...
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ANTIHELMINTIC ACTIVITY OF ETHANOLIC EXTRACT OF BARK OF MYRICA ESCULENTA
Myrica esculenta (Myricaceae), commonly known as ‘Katphala’, is an evergreen, sun-temperate tree. Phytochemical constituents reported in the bark are tannins mainly epigallocatechin-3-o-gallate, gallic acid, myricanone, myricanol and a yellow dye. The edible portion of the fruit is its pulp which contains reducing sugars, tannins and vit C. Myrica esculenta (M. esculenta) is known traditionall...
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PRENYLATED BENZOIC ACID DERIVATIVES FROM PIPER SPECIES AS SOURCE OF ANTI-INFECTIVE AGENTS
A number of prenylated benzoic acids derivatives with interesting biological activities have been previously isolated and characterized from different species of piperaceae family. Several Piper species contained structurally similar compounds with diverse biological activities such as anti-bacterial, anti-fungal, insecticidal as well as anti-parasitic all of which produces compounds that can be c...
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ANTI-INFLAMMATORY, ANTI-ARTHRITIC AND ANALGESIC ACTIVITY OF THE ALCOHOLIC EXTRACT OF THE PLANT URGINEA INDICA KUNTH.
This study was designed to present the observation of the pharmacological properties to the bulb of the plant. The extract of the bulb of Urginea indica Kunth were collected by using of alcoholic extraction. The anti-inflammatory action of the alcoholic Extract of the bulb of the plant Urginea indica was evaluated in rats (female) against carrageenan induced edema i.e., using plethysmographic meth...
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SOLID SUPPORTED MICROWAVE ASSISTED RAPID SYNTHESIS OF 1, 3, 4 OXADIAZOLES
We have carried out solid supported ,solvent free condition, microwave assisted rapid synthesis of 1- (2,5- substituted diphenyl)-1, 3, 4- oxadiazol -3(2H) - yl) ethanone (3a-3k) by cyclization of N'- (substituted phenyl methylidene) substituted benzohydrazide (2a-2k) in the presence of acetic anhydride and silica gel ( solid support) for 3-4 minutes by microwave irradiation giving excellent...
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