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ISOLATION AND DEVELOPMENT OF AN HPLC METHOD FOR THE QUANTIFICATION OF A BIOMARKER IN THE ROOTS OF PAULLINIA PINNATA
An RP-HPLC method to be used to quantitate the amount of a biomarker in the roots of Paullinia pinnata was developed. The root bark was milled and extracted and the dry powder obtained taken through column chromatography (CC). The biomarker was then isolated. The melting point of the biomarker was determined and found to be 117-119 oC. A RP-HPLC method was successfully developed and used to quanti...
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1673
SYNTHESIS, CHARECTERIZATION AND ANTIMICROBIAL ACTIVITY OF 5-METHYL -2, 4-DIHYDRO-3H-PYRAZOL-3-ONE-4-(4-SUBTITUTED) BENZYLPIPERAZINE DERIVATIVES
Synthesis of 6-Methyl-2, 4-dihydro-3H-pyrazol-3-one- 4- (4-substituted) Benzylpiperazine derivatives IVP a-e was carried out by bromination of Ethyl aceto acetate (I) with KBr. The reaction was carried out in the presence of Hydrochloric acid and tolune to produce Bromo-ethyl aceto acetate (II), it is further condensed with substituted Benzylpiperazines in presence of ethanol to obtain condensed c...
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1711
NOVEL SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-AMINO PHENYL-5-METHYL PYRAZOLES AND ITS DERIVATIVES
Pyrazoles and fused heterocyclic pyrazoles derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activity in the field of pharmaceutical science, agriculture etc. In the present study, new substituted pyrazoles were prepared by condensation of substituted primary amine and ethyl acetoacetate at 1400C to form analides as ...
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1837
NEW APPROACHES OF 4-ARYL-2-HYDRAZINOTHIAZOLE DERIVATIVES SYNTHESIS, MOLECULAR DOCKING, AND BIOLOGICAL EVALUATIONS
In the field of the preparation of chemotherapeutic agents with new mechanism distinct from currently approved drugs is important. However, the clinically effective approved small inhibitor molecule is still lacking. Previous reports indicated that 4-aryl-2-hydrazinothiazole derivatives provided a useful start point to develop HAT inhibitors (histone acetyltransferase). Consequently, preparation a...
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1949
ANTIOXIDANTS IN THE MANAGEMENT OF FLUORIDE INDUCED NEURAL OXIDATIVE STRESS IN DEVELOPING RATS
Fluoride (F) is highly electronegative anion with cumulative toxic effects, from prolonged ingestion that can lead to the pathogenesis known as fluorosis, a condition especially persistent in third world countries, where populations have little choice as to the main source of F-contaminated drinking. In recent times many neurological problems among children are being addressed in endemic areas. Th...
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1726
BROMELAIN PLUS PEROXIDASE FROM PINEAPPLE INDUCES APOPTOSIS VIA MITOCHONDRIAL DEPENDENT PATHWAY IN LYMPHOMA CELLS
Bromelain is a protease present in pineapple fruit and stem. It is reported that commercially available pure bromelain has anticancer, anti-inflammatory and other therapeutic effects. But there are few reports available on the biological activity of bromelain along with peroxidase which is present in pineapple fruit extract. The aim of the present study was to investigate the effect of bromelain w...
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1628
SUGGESTED VENOUS THROMBOEMBOLISM (VTE) RISK STRATIFICATION SHEET FOR ORTHOPEDIC SURGERIES
Background: Major orthopedic surgeries are divided into 3 major surgeries: total or partial hip replacement (TPHR), total knee replacement (TKR), and hip fracture surgeries (HFS), these surgeries are considered as high-risk surgeries for the development of venous thromboembolism (VTE) which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). In general there are several factors that i...
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1679
CHARACTERIZATION AND STANDARDIZATION OF THE HERBAL DRUG BACCHARIS TRIMERA (LESS.) DC AND ITS LYOPHILIZED EXTRACT
Baccharis trimera is used in traditional medicine in South American countries for treatment of diseases, such as digestive disturbances, rheumatism, diabetes and inflammatory processes. Given its pharmacological potential, the aim was to characterize the vegetal drug B. trimera and attain and standardize its lyophilized extract to use as raw vegetal material in the development of phytotherapeutic ...
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AMPLIFICATION AND SEQUENCING OF MITOCHONDRIAL DNA (HVR-I) EXTRACTED FROM 1200 YEARS OLD HUMAN BONE SPECIMEN
Ancient DNA help in better understanding the evolution and migration pattern of humans throughout the world. The present work is a preliminary effort, to extract and amplify the ancient DNA from human bone samples provided by the Anthropological survey of India collected from the Himalayan region in 1952. Many technical difficulties arise during DNA extraction, PCR amplification and sequencing w...
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PHYTOCHEMICAL SCREENING, IN-VITRO MEMBRANE STABILIZING AND THROMBO-LYTIC ACTIVITIES OF LOPHOPETALUM JAVANICUM
In the present study, different extracts of Lophopetalum javanicum (Zoll) leaves were evaluated for erythrocyte membrane stabilizing and thrombolytic activities. Phytochemical analysis of the plant was also performed to detect presence of different kinds of phytoconstituents. In order to predict anti-inflammatory activity the plant extracts were subjected to check erythrocyte membrane stabilizatio...
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