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SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME NEW 2, 3-DIHYDRO-1, 5-BENZODIAZEPINE DERIVATIVES
A series of some New 2, 3-dihydro-1, 5-benzodiazepines has been synthesized using condensation reaction of o-phenylenediamine and various substituted chalcones in presence of DMF as solvent and screening of antibacterial and antifungal activities of synthesized compounds....
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ELEMENTAL ANALYSIS, DITERMINATION OF ALKALOID, SAPONIN AND FLAVONOID OF THREE SELECTED SPECIES OF ZINZIBERACEAE FAMILY
The present study reveals the chemical composition and mineral analysis of Curcuma amada, Alpinia nigra, Amomum gracile. They are belongs to the same family zingiberaceae. The result reveals; (a) alkaloid contains in Alpinia nigra (6.0mg/100gm), amomum gracile (0.6mg/100gm), Curcuma amada (4.280mg/100gm); (b) saponin contain in Alpinia nigra burtt(18.960mg/100gm), Amomum gracile (18.1mg/100gm) and...
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QUALITY BY DESIGN: THE TOOL FOR REGULATORY COMPLIANCE
QbD decrees the definition of a goal for the method and accentuates thorough evaluation and scouting of alternative methods systematically to obtain ideal method performance. QbD tools like risk assessment and design of the experiment, empowers better quality to be instilled into the analytical method and facilitate prior understanding and identification of variables affecting the method performan...
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PHARMACOLOGICAL ACTIVITIES OF MUNTINGIA CALABURA: AN OVERVIEW OF THE LAST LUSTRUM
Background: In honor of a dutch botanist, Abraham Munting, the tree was named Muntigia calabura L. The Jamaica cherry, M. calabura is a shrub or tree which is native to Jamaica, Brazil, Mexico, and North America. M. calabura is a well-known, fast-growing tree clasped with different medicinal and health benefits. Different parts of the tree are being used for various ailments in different parts of ...
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STATUS OF SERUM FRUCTOSAMINE IN HYPERTHYROID SUBJECTS IN UDAIPUR, RAJASTHAN
Introduction: Measurement of glycated hemoglobin (HbA1c) and fructosamine has a growing role in the assessment of glycemic control but their use for screening purpose is questionable. Material and methods: The study was carried out on 50 controls and 50 patients suffering from hyperthyroidism from October 2014 to March 2015 at Geetanjali Medical College & Hospital, Udaipur (Rajasthan). Results...
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GC-MS ANALYSIS OF CALLUS AND LEAF EXTRACTS OF IN VITRO PROPAGATED PLANTS OF JUSTICIA WYNAADENSIS (NEES) T. ANDERSON
The present study was aimed at induction of callus, micropropagation of Justicia wynaadensis (Nees) T. Anderson in vitro by using different explants and study of the phytocomponents present in the aqueous and methanol extracts of callus and leaf of in vitro propagated plants through GC-MS analysis. Callus was induced using MS basal medium supplemented with combinations of 2, 4-D, IAA and NAA growt...
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SYNTHESIS OF SOME 2, 3-DIARYL-6-ISOXAZYL-QUINOLINE-4-CARBOXYLIC ACID DERIVETIVES
A series of some new substituted quinolines were synthesized by Doebner reaction, a three component coupling of various aromatic amines with two aldehydes and phenyl pyruvic acid, the intermediate 2, 3-diary-6-acetyl-quinoline-4-carboxylic acids were reacted with various aromatic aldehydes in the presence of basic medium using Claisen-Schmidt condensation in order to afford the corresponding chalc...
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CHARACTERIZATION AND STANDARDIZATION OF THE HERBAL DRUG BACCHARIS TRIMERA (LESS.) DC AND ITS LYOPHILIZED EXTRACT
Baccharis trimera is used in traditional medicine in South American countries for treatment of diseases, such as digestive disturbances, rheumatism, diabetes and inflammatory processes. Given its pharmacological potential, the aim was to characterize the vegetal drug B. trimera and attain and standardize its lyophilized extract to use as raw vegetal material in the development of phytotherapeutic ...
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PHARMACOGNOSTIC AND PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS ON PTEROSPERMUM ACERIFOLIUM LEAVES
Keywords: Pterospermum acerifolium, Pharmacognosy, Sterculiaceae, Drug StandardizationPterospermum acerifolium plant is considered to be laxative, anthelmintic, stomachic and used in inflammation, blood disorders, ulcers and leprosy. The leaf was studied for pharmaconostic evaluations, including examination of morphological and microscopic characters, determination of leaf const...
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SYNERGISTIC EFFECT OF (S)-CIS-VERBENOL WITH THE ANTIBIOTICS AMOXICILLIN AND GENTAMICIN AGAINST SENSITIVE AND RESISTANT STAPHYLOCOCCUS AUREUS STRAINS
The synergistic activity among the monoterpene (S)-cis-Verbenol and the antibiotics Amoxicillin and Gentamicin were evaluated against a sensitive and a resistant strain of Staphylococcus aureus, is the last one also resistant to methicillin (MRSA). The combinations were evaluated by the checkerboard method. The combinations of both antibiotics with the terpene showed synergic effects for the MRSA ...
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