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COMPARATIVE STUDY OF HYPOGLYCEMIC EFFECT OF ETHANOLIC AND HOT WATER EXTRACTS OF ANDROGRAPHIS PANICULATA IN ALLOXAN INDUCED RAT
The aim of present study was to investigate the potential roles of ethanolic and hot water extracts of Andrographis paniculata on reducing the blood sugar level (BSL) in alloxan- induced rats. Oral administration of ethanolic (2 g/kg b. w.) and hot water (0.8 g/kg b. w.) extracts of Andrographis paniculata showed the antidiabetic properties and decreased the blood glucose level by 33.71% (p<0.0...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME NEW 2, 3-DIHYDRO-1, 5-BENZODIAZEPINE DERIVATIVES
A series of some New 2, 3-dihydro-1, 5-benzodiazepines has been synthesized using condensation reaction of o-phenylenediamine and various substituted chalcones in presence of DMF as solvent and screening of antibacterial and antifungal activities of synthesized compounds....
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DEVELOPMENT OF A NOVEL ENTERIC COATED EXTENDED RELEASE PELLETS USING MODEL NSAID FLURBIPROFEN
The aim of this study was to develop a pH responsive enteric coated extended release pellets containing a model drug flurbiprofen, a non-steroidal anti-inflammatory drug used for rheumatoid arthritis. The drug loaded pellets were prepared by using extrusion/ spheronization method. Core pellets were coated with polymer Eudragit RS30D in a coating pan to achieve a sustainable release for 12 hours. A...
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SALVIA VIRGATA JACQ. AND SILIBUM MARIANUM L. GAERTN DISPLAY SIGNIFICANT IRON-CHELATING ACTIVITY
In some disease like thalassemia major long-term transfusion alone inexorably produces the clinical problem of iron overload. Danshen and Milk thistle has been widely prescribed in traditional folk medicine for treatment of liver diseases. In this study we selected eight medicinal plants whose efficiencies had been previously demonstrated in treatment of liver diseases in ancient medicine were stu...
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1810
ISOLATION OF PRELIMINARY PHYTOCONSTITUENTS AND ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF CALOTROPIS GIGANTEA LINN. LEAVES EXTRACTS
The present studies that Isolation of preliminary phytoconstituents and anti-inflammatory and antipyretic activity of Calotropis gigantea Linn. Leaves Extracts. Therapeutic use of plants for the treatment of human illnesses dates back over man millennia. Evidence of their effectiveness in the diagnosis, cure and prevention of disease states exists in every culture throughout the world. Today “...
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VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF DICLOFENAC DIETYLAMINE
Simple, sensitive and convenient spectrophotometric methods (method A and method B) are developed for the determination of diclofenac diethylamine (DDEA) in pure form and in formulations. Method A is based on the oxidation of drug by Fe(III) followed by the complex formation between reduced form of Fe(III) with 1,10-phenantroline. The resulting red colored chromogen is measured at 510 nm. Method B...
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EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC LEAVES EXTRACT OF LASIA SPINOSA AND ITS ROLE IN PREVENTION OF HYPERLIPIDEMIA INDUCED PANCREATITIS IN RATS
Leaves, rootstock, fruit and decoction of Lasia spinosa (Araceae) are used in folklore medicine for Gastrointestinal, Respiratory and Skin diseases. The intent of the present study was to evaluate the Antihyperlipidemic activity of methanolic leaves extract of Lasia spinosa and for its role in the prevention of hyperlipidemia induced pancreatitis in rats. The evaluation of the Antihyperlipidemic a...
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PHARMACOPHORE MAPPING AND VIRTUAL SCREENING ON HUMAN ALPHA AMYLASE INHIBITORS
Diabetes is a non communicable chronic metabolic disease characterized by high blood glucose level in the body. Targeting alpha amylase to control diabetes has long been studied. This study focused on developing pharmacophore model for set of inhibitor that possess anti amylase activity based on previous studies. Developing a pharmacophore model for these compound yields a hypothesis of ADDRR. F...
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ANTIMICROBIAL, CYTOTOXICITY, FREE RADICAL SCAVENGING ACTIVITIES AND COMPOUNDS ISOLATED FROM THE ROOTS OF HEMIDESMUS INDICUS (LINN.) R. BR.
Hemidesmus indicus Linn. R. Br. is a twining shrub traditionally used for the treatment of various diseases and ailments in the rural area of Bangladesh. Different extracts (methanol, hexane, ethyl acetate, n-butanol and water) from the roots of this shrub tested for their antimicrobial, cytotoxicity and free radical scavenging activities. All extracts showed moderate free radical scavenging act...
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NOCTURNAL ENURESIS, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF PANDANUS ODORATISSIMUS L. PEDUNCLE
Nocturnal Enuresis treatment activity in rabbits by measuring the changes in urine volume and concentrations of electrolytes as well as bladder capacities. In addition, antioxidant activity was measured using free radical scavenging (DPPH method) and antimicrobial activity against human bacterial pathogens using agar diffusion technique. Pandanus Odoratissimus L. peduncle showed no toxic effect wi...
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