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ANTI-ULCER PROPERTIES OF ALKALOIDS ISOLATED FROM THE FRUIT PULP OF CUCUMIS METULIFEROUS (CURCURBITACEAE)
Anti-ulcer properties of the alkaloids isolated from the fruit of Cucumis metuliferous was investigated in mice. Ethanol-induced gastric lesion was used to assess the anti-ulcer activity. In this study, there was a significant (p<0.05) decrease in haemorrhages and ulcerations of the gastric mucosa at 500 and 1000 mg/kg of the alkaloid compared with control. The activity of the extract is compar...
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SYNTHESIS OF NOVEL 1, 3-INDANEDIONE DERIVATIVES AND PHARMACOLOGICAL EVALUATION AS ANTI-MICROBIAL, ANTI-OXIDATIVE AGENTS
1,3-Indanedione derivatives, which are of wide interest because of their diverse biological and chemical applications. A series of novel 1,3-Indanedione derivatives are synthesized via KNOEVENAGEL condensing reaction mechanism by condensing 1,3-Indanedione with the 1-(4-aminophenyl) ethanone to form a styrylated indanedione leading to the formation of different Schiff base (imine) preparation by u...
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ZYGOPHYLLUM GAETULUM AQUEOUS EXTRACT PROTECTS AGAINST DIABETIC DYSLIPIDEMIA AND ATTENUATES LIVER AND KIDNEY OXIDATIVE DAMAGE IN STREPTOZOTOCIN INDUCED-DIABETIC RATS
Zygophyllum gaetulum is one of several traditional remedies used for diabetes treatment in Algeria. The purpose of this study is to investigate the effects of this plant on hyperglycemia, insulin sensitivity indexes, lipid profiles, lecithin: cholesterol acyltransferase (LCAT) and paraoxonase (PON1) activities and liver and kidney antioxidant status, in streptozotocin-induced diabetic rat. Diabete...
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PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIMICROBIAL ACTIVITY OF POGOSTEMON QUADRIFOLIUS (BENTH) OF LAMIACEAE
Pogostemon quadrifolius (Benth.) is a medicinal aromatic shrub in family Lamiaceae which is used as folk medicine in India. This present study deals with the preliminary screening of Pogostemon quadrifolius antimicrobial activity and TLC profiling of the crude plant extract. Cold extraction technique was carried out to prepare the crude plant extract, which was further screened for the presence of...
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SCREENING OF NOVEL INHIBITOR FOR HER2 INDUCED BREAST CANCER-AN INSILICO APPROACH
HER2 stands for Human Epidermal growth factor Receptor 2. Each normal breast cell contains copies of the HER2 gene coding for HER2 protein found on the cell surface, which helps normal cells grow.HER2+ breast cancer is characterized by over expression of this gene in breast cells which fosters the cell growth giving rise to breast tumors. Studies show that 20-25% of breast cancer patients have...
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IN VITRO ANTIOXIDANT AND FREE RADICAL SCAVENGING POTENTIAL OF HOLOSTEMMA ADA – KODIEN K. SCHUM., AN IMPORTANT RARE MEDICINAL PLANT
The present study was undertaken to evaluate the in vitro antioxidant activities of hexane, ethyl acetate and methanolic extracts of Holostemma ada kodien root tubers. The above extracts exhibited a dose dependent scavenging activity against DPPH radicals, Superoxide radicals, and Nitric oxide radicals. Further, the MeOH, EtOAC extracts showed relatively higher reducing power compare to that of BH...
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MYCOCHEMICAL PROFILING OF LENTINUS SQUARROSULUS MONT., A WILD EDIBLE MACROFUNGI USING GC-MS
Studies to exploit wild mushrooms as a source of biologically active compounds are gaining importance in the recent years. In that view, the present study was carried out to evaluate the bioactives of wild edible macrofungi, Lentinus squarrosulus Mont. The specimen was subjected to various biochemical tests with the view to establish standards for their identity and chemical composition. To identi...
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NUCLEAR MAGNETIC RESONANCE AND HYPHENATIONS – A REVIEW
Nuclear magnetic resonance spectroscopy is an absorption spectroscopic technique that helps in structural elucidation and has a wide range of applications in various fields like drug discovery and development, metabolomics, combinatorial chemistry, and food sciences. This paper gives information about nuclear magnetic resonance spectroscopy, and clear description of LC-NMR-MS, and a brief descript...
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THE EFFECT OF ELICITORS ON THE PRODUCTION OF VASICINE FROM JUSTICIA ADHATODA L. CELL SUSPENSION CULTURES
In this study, α-naphthyl acetic acid and mannitol were used as elicitors to improve the productivity of useful metabolite, vasicine for archiving high concentration in Justicia adhatoda L. cell suspension cultures. When the cells were treated with 3mg 100 ml-1 suspension of α-naphthyl acetic acid, the vasicine concentration was increased by 1.65 mg ml-1 in 15 days culture compared to untrea...
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BACOPAMONNIERA, A NOOTROPIC HERB ALLEVIATES ABNORMAL MOLECULAR AND IMMUNOHISTOCHEMICAL CHANGES EVOKED BY CHRONIC EXPOSURE OF METHYLMERCURY IN RAT CEREBELLUM
Methylmercury (MeHg), a highly toxic environmental pollutant, induces oxidative stress and dysfunction in many cell types. Bacopa monniera is a perennial herb, and is used as a nerve tonic in ayurveda, a traditional medicinal system in India. This study was aimed to evaluate the effect of Bacopa monniera extract (BME) on MeHg-induced toxicity in rat cerebellum. Male Wistar rats were administered w...
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