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SYNERGISTIC EFFECT OF (S)-CIS-VERBENOL WITH THE ANTIBIOTICS AMOXICILLIN AND GENTAMICIN AGAINST SENSITIVE AND RESISTANT STAPHYLOCOCCUS AUREUS STRAINS
The synergistic activity among the monoterpene (S)-cis-Verbenol and the antibiotics Amoxicillin and Gentamicin were evaluated against a sensitive and a resistant strain of Staphylococcus aureus, is the last one also resistant to methicillin (MRSA). The combinations were evaluated by the checkerboard method. The combinations of both antibiotics with the terpene showed synergic effects for the MRSA ...
4252
1821
ISOLATION OF PRELIMINARY PHYTOCONSTITUENTS AND ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF CALOTROPIS GIGANTEA LINN. LEAVES EXTRACTS
The present studies that Isolation of preliminary phytoconstituents and anti-inflammatory and antipyretic activity of Calotropis gigantea Linn. Leaves Extracts. Therapeutic use of plants for the treatment of human illnesses dates back over man millennia. Evidence of their effectiveness in the diagnosis, cure and prevention of disease states exists in every culture throughout the world. Today “...
4251
2434
EVALUATION OF ANTIANAPHYLACTIC ACTIVITY OF VARIOUS EXTRACTS OF WITHANIA SOMNIFERA IN RATS
Antianaphylactic activity of Withania somnifera was investigated by using rat peritoneal mast cells. The investigation was carried out by presensitization of the rat by using sheep serum and tripple antigen. Sensitization induces mast cell degranulation. The rats which were pretreated with standard drug, prednisolone (10 mg) and different extracts (petroleum ether, methanol and aqueous extract) of...
4251
1626
ANTI MRSA AND ANTITUBERCULAR ACTIVITY OF PHENOXAZINONE CONTAINING MOLECULE FROM BORRA CAVES STREPTOMYCES SP. BCA1
An attempt was made to study the anti MRSA and antitubercularactivity of Streptomyces sp. BCA1 isolated from Borra Caves soil. In agar plug method, strain BCA1 showed 12-17 mm inhibition against Gram positive and Gram negative bacteria, including MRSA. Crude pigment produced from strain BCA1 by agar surface fermentation showed 15 – 17 mm inhibition in disc diffusion method against bacterial path...
4250
1976
STUDY OF PREVALENCE AND SENSITIVITY PATTERN OF DENTAL PLAQUE BACTERIA AGAINST ANTIBIOTICS AND POMEGRANATE
Dental plaque, biofilms of microorganisms on tooth surface, plays an important role in the development of caries and periodontal disease. Our aim was to check the prevalence of bacteria in dental plaque and to test in vitro antibacterial activity of antibiotics and pomrgranate extracts against dental plaque bacteria. Doxycycline and clindamycin showed highest range of antibacterial activity agains...
4250
1805
DESIGN AND EVALUATION OF LOSARTAN POTASSIUM MATRIX TABLETS WITH NATURAL AND SYNTHETIC POLYMERS
The objective of the study was to formulate controlled release matrix tablets of losartan Potassium by using a combination of hydrophilic synthetic polymer like poly (ethylene oxides) and natural gums like xanthan gum, karaya gum and guar gum. A combination of synthetic hydrophobic polymers like methacrylates with synthetic hydrophilic polymer like poly (ethylene oxide) was also used in the prepar...
4248
1509
EVALUATION OF DIURETIC ACTIVITY FROM TEUCRIUM POLIUM L. CAPITATUM EXTRACTS (LAMIACEAE) IN RATS
The present study was carried out to investigate the diuretic activity of the ethanolic extract of Teucrium polium L. Capitatum (Lamiaceae)in normal albino rats. The diuretic activity of extract was evaluated by determining the urine volume and electrolyte concentration in albino rats (n=4). Furosemide (20 mg/kg) was used as the reference diuretic drug while normal saline (0.9%) was used as contro...
4247
1609
INVESTIGATION OF IN-VIVO PENETRATION AND DISTRIBUTION OF NANOMETRIC TiO2 IN TROPICAL ALBINISTIC SKIN BY SEQUENTIAL ADHESIVE TAPE STRIPPING
The non-invasive adhesive tape stripping technique was used to evaluate dermato-pharmacokinetics of nanometric titanium dioxide in tropical albinistic skin. Ten sequential strippings were conducted on exposure sites on the forehead, inner and upper forearms of three oculocutaneous albinism individuals 26+/- 4 years old, 15 minutes post dosing of 6.75mg/cm2 of a 5% titanium dioxide cream specifical...
4247
2142
ABERRANT EXPRESSION OF WNT/BETA-CATENIN SIGNALING PATHWAY AND IN -VITRO CYTOTOXIC ACTIVITY OF TRADESCANTIA SPATHACEA MEDICINAL PLANT USED TO TREAT HUMAN BREAST ADENOCARCINOMA (MCF-7 CELL LINES)
Cancer plays crucial role in human life and critical disease to cure. Signaling pathways involved in stem cells development process. Especially, Wnt/β-catenin signaling pathway plays important role in stem cells self-renewal, differentiation and proliferation. Despite, over expression and mutation of Wnt/β-catenin signaling pathway induced variety of cancer development. Anticancer activities of ...
4246
1965
FORMULATION AND EVALUATION OF LORNOXICAM MOUTH DISSOLVING TABLET BY USING NATURAL SUPERDISINTEGRANTS
The concept of fast dissolving drug delivery system emerged from the desire to provide patients with more convenient means of taking their medication. It is difficult for many patients to swallow tablets and hard gelatin capsules. The main objective of the study is to develop a reproducible formulation of fast dissolving tablets of Lornoxicam already used the therapeutic molecule to enhance effect...
4246
1822