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DESIGN AND EVALUATION OF LOSARTAN POTASSIUM MATRIX TABLETS WITH NATURAL AND SYNTHETIC POLYMERS
The objective of the study was to formulate controlled release matrix tablets of losartan Potassium by using a combination of hydrophilic synthetic polymer like poly (ethylene oxides) and natural gums like xanthan gum, karaya gum and guar gum. A combination of synthetic hydrophobic polymers like methacrylates with synthetic hydrophilic polymer like poly (ethylene oxide) was also used in the prepar...
4239
1507
FORMULATION AND EVALUATION OF LORNOXICAM MOUTH DISSOLVING TABLET BY USING NATURAL SUPERDISINTEGRANTS
The concept of fast dissolving drug delivery system emerged from the desire to provide patients with more convenient means of taking their medication. It is difficult for many patients to swallow tablets and hard gelatin capsules. The main objective of the study is to develop a reproducible formulation of fast dissolving tablets of Lornoxicam already used the therapeutic molecule to enhance effect...
4239
1816
FORMULATION, CHARACTERIZATION AND EVALUATION OF ISOTRETINOIN GEL FOR TREATMENT OF ACNE VULGARIS
Acne vulgaris is a commonly diagnosed inflammatory skin condition that affects pediatric, young and adult patients. The object of the paper is formulation development and evaluation of isotretinoin gel for the treatment of Acne vulgaris. The isotretinoin based anti-acne gel was formulated using different polymers includes carbopol 940, carbopol 934 and carbopol 980. Disodium edetate is used as ch...
4239
1615
NEWER VACCINE INTRODUCTION (PNEUMOCOCCAL CONJUGATE VACCINE) FROM THE STATE’S OWN RESOURCES IN HARYANA, INDIA: AN EXAMPLE OF ADVOCACY TO POLICY AND ACCELERATED PUBLIC HEALTH ACTION
Introduction: Global pneumonia mortality (50%) caused by pneumococcus is responsible for invasive pneumococcal disease. Pneumococcal Conjugate Vaccine (PCV) has been introduced by the Government of India in a phased manner in selected states, but Haryana was not included. Objective: To draw key lessons learned from the process of newer vaccine introduction (PCV) in Haryana from the state’s resou...
4238
1345
PRELIMINARY ANTIMICROBIAL ACTIVITY AND CYTOTOXICITY OF PLANT EXTRACTS (ROOTS) OF COCCINIA GRANDIS (FAMILY: CUCURBITACEAE) h
In the present study, the in vitro antimicrobial and cytotoxic activity of root extract of Coccinia grandis were evaluated. Ethanolic crude extract with its various solvent soluble fractions of C. grandis showed significant antimicrobial activity by disc diffusion method on some gram positive and gram negative bacteria. The extracts exhibited 9-12 mm (approximately) of zone of inhibition comparing...
4237
1597
SALICYLIC ACID-INDUCED MODULATION OF GROWTH AND METABOLISM OF A MEDICINAL PLANT MENTHA SPICATA L.
Salicylic acid is a phenolic plant growth regulator found in plants with various important physiological roles. This investigation was aimed to study the effect of exogenous application of salicylic acid on the growth, metabolism and health status of Mentha spicata, an aromatic medicinal plant having several monoterpenes and antioxidants which show various kinds of medicinal properties. In the pre...
4237
1593
A STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR ANALYSIS OF VILDAGLIPTIN AS BULK DRUG AND FROM ITS PHARMACEUTICAL DOSAGE FORM
Vildagliptin chemically (S)-1-[N-(3-hydroxy-1- adamantyl) glycyl] pyrrolidine-2-carbonitrile, is a potent dipeptidyl peptidase IV (dip-IV) inhibitor, a drug for the treatment of diabetes. DPP-IV inhibitors represent a new class of oral antihyperglycemic agents to treat patients with type 2 diabetes. The Present work describes the development and validation of a new simple, accurate, precise and st...
4237
1957
SYNTHESIS AND BIOCIDAL ACTIVITY OF Co (II) AND Zn (II) COMPLEXES OF SULFA DRUG SCHIFF BASES
The novel Co (II) and Zn (II) complexes have been synthesized by reaction of CoCl2/ZnCl2 with Schiff bases of benzoyl derivative of 3-methyl-1-phenyl-2-pyrazoline-5-one and sulfa drugs in 1:2 ratio. The synthesized complexes were screened/tested for their antimicrobial activity against pathogenic bacterial strains i.e. E. coli, Staphylococcus aureus strain I, Staphylococcus aureus strain II, Staph...
4236
1585
CHARACTERISATION OF FLAVONOID GLYCOSIDES IN PHARMACOPOEIAL PREPARATION OF CISSUS VERTICILLATA (L) NICOLSON & C. E. JARVIS) USING HPLC-DAD AND HPLC-MS
According to Brazilian regulation, the registration of phytomedicines must inform the characterisation of, at least, one of their constituent. In order to contribute to this goal, a tincture of Cissus verticillata (L.) Nicolson & C.E. Jarvis prepared with ethanol 96oGL was investigated. This plant species is widely used due its hypoglycaemic properties, to control diabetes, and empirically to ...
4236
1965
SUPPRESSION OF ELEVATED REACTIVE OXYGEN SPECIES BY ACORUS CALAMUS (VACHA) A SWEET FLAG IN DROSOPHILA MELANOGASTER UNDER STRESS FULL CONDITIONS
Reactive Oxygen Species is a phrase used to describe a number of reactive molecules and free radicals derived from molecular Oxygen. The production of Oxygen based radicals is the bane to all aerobic species where its excessive levels intern induces oxidative stress. The present study is to evaluate the anti-stress property of Acorus calamus (vacha), where the fruit flies in different groups are a...
4236
1624