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NEUROPATHIC PAIN SYMPTOMS OF POST HERPETIC NEURALGIA PATIENTS WITH CYP2D6 POLYMORPHISM UNDERGOING TRAMADOL TREATMENT
Main aim of this study was to find out relation of CYP2D6 polymorphism with tramadol action in post herpetic neuralgia (PHN) patients. This non- responders versus responders study mainly includes 246 patients (age group 20-80 years) of PHN, assigned into two groups depending upon their response to tramadol treatment at the end of 2nd week of drug therapy. On the basis of CYP2D6 polymorphism, an al...
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STUDY OF THE EFFECT OF MELATONIN ON RETENTION OF CONDITIONED AVOIDANCE RESPONSE AND ON ENHANCEMENT OF SEROTONIN MEDIATED BEHAVIOURAL RESPONSES AFTER ELECTROCONVULSIVE SHOCK (ECS) ADMINISTRATION IN RATS
Objectives: To obtain the data regarding the effects of melatonin on retention of conditioned avoidance response (CAR) and on enhancement of serotonin mediated behavioural responses after electroconvulsive shock (ECS) administration in rats. Methods: Forty rats after training for conditioned avoidance response by using Cook’s pole climbing apparatus were divided in four groups with ten rats in e...
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STANDADADIZATION AND STABILITY INDICATING STUDIES BY RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF CANDESARTAN CILEXETIL & HYDROCHLORTHIAZIDE IN TABLET DOSAGE FORM
A rapid, selective, precise, accurate, rugged and robust high performance liquid chrmatgraphic (HPLC) method for the simultaneous determination of Candesartan Cilexetil & Hydrochlorthiazide in tablet dosage form .The method was validated according to ICH and FDA guidelines. The chromatography is performed on a Kromasil C8, 150 x 4.6 mm, 5µm, in a gradient mode with a mobile phase of Water, ac...
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ANALYTICAL METHOD DEVELOPMENT AND ITS VALIDATION FOR THE ESTIMATIONOF THYMOL IN TACHYSPERMUM AMMI MILL FRUIT BY GAS LIQUID CHROMATOGRAPHY
Thymol is the main volatile compound extracted from dried fruits of Tachyspermum ammi Mill. The compound serves as a biological marker because of its interesting biological activities and is used in traditional medicine, as a bactericide, fungicide, Gastro-intestinal disorders, Bronchitis and asthma, and others. A GC method for the determination of thymol was developed. Chromatographic analysis wa...
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COMBINATION THERAPY AND ITS IMPLICATION ON CLINICAL EFFICACY OF ARTEMISININS- REVIEW
Artemisinin and its derivatives have successfully been used in treatment of falciparum malaria infections in various parts of the world. More importantly, they have proved effective against strains resistant to conventional antimalarials such as chloroquine and mefloquine in those parts of the world where malaria is endemic. Only one clinically relevant artemisinin-resistant human malaria has been...
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MICRODOSING: A NEW STRATEGY FOR DRUG DEVELOPMENT PROCESS
New drugs are a great need for clinical conditions but unfortunately development costs are rising and number of drugs receiving marketing approval has fallen. Microdosing is a new experimental approach that offers a faster and potentially less expensive approach for obtaining human in vivo pharmacokinetic (PK) data in early stages of drug development. The concept of microdosing involves the use of...
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A RAPID AND SENSITIVE METHOD FOR THE QUANTITATION OF MONTELUKAST IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY
A simple, precise and reproducible liquid chromatography–tandem mass spectrometry method has been developed and validated according to the United States - Food and Drug Administration (US-FDA) guidelines for the quantitation of Montelukat in human plasma using Neverapine as an internal standard. Montelukast is a fast acting and potent cysteinyl leukotriene receptor antagonist which is being used...
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BIOCHEMICAL ESTIMATION OF PRIMARY METABOLITES OF CASSIA NODOSA BUNCH.
Cassia nodosa Bunch.is an ornamental tree belonging to family Leguminosae, popularly known as Pink Shower is a perennial tree. Laboratory evaluations were made to asses the study of primary metabolites in different plant parts of Cassia nodosa Bunch. The highest amount of soluble sugars (10.27mg/ gdw), lipids (32.36mg/gdw), phenols (20.0mg/gdw), DNA (11.78mg/gdw) and Chlorophyll- a+b (0.94mg/gdw) ...
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SESAME OIL INCORPORATED MEDIUM FOR ISOLATION AND ENUMERATION OF LIPOPHILIC YEASTS
This communication reports on an easy and cost effective mycological medium, developed for primary isolation and culture of lipophilic yeasts. The medium has been modified and adjusted specifically to promote the growth of lipophilic yeasts and simultaneously suppress the growth of other fungi and bacteria. The traditional medium of Sabouraud’s dextrose agar (SDA) with olive oil overlay was modi...
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STUDYING OMEGA-3 AND OMEGA-6 CONTENT OF NATIVE WALNUT AND STORAGE EFFECT ON IT
Walnuts from Northwest region of Syria was collected to determine Omega-6 (linoleic acid (LA, 18:2n-6)) and Omega-3 (α-linolenic acid (ALA, 18:3n-3)) in their oils, also called essential fatty acids (EFAs). This work was carried out using two different portions of samples. First samples were collected at harvest and second samples stored for one year under normal conditions. The extraction of...
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