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PREVALENCE AND FACTORS ASSOCIATED WITH HIV AND HEPATITIS B VIRUS INFECTIONS AMONG FEMALE COMMERCIAL SEX WORKERS IN MEKELLE, ETHIOPIA: CROSS SECTIONAL STUDY
Background: Sexually Transmitted Infections remain major public health problems among the most at risk population groups such as female commercial sex workers. Objective: To assess the magnitude of Hepatitis B Virus and HIV/AIDS and identify the associated factors among female commercial sex workers. Methodology: A Community Based Cross Sectional Study was conducted in Mekelle city. A total of 319...
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DEVELOPMENT AND VALIDATION OF BIO-ANALYTICAL RP-ULTRA FAST LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF CLOPIDOGREL AND ROSUVASTATIN IN HUMAN PLASMA
ABSTRACT: This manuscript describes a simple, sensitive, rapid and precise Ultra fast liquid chromatographic (UFLC) method was developed and validated for the simultaneous determination Clopidogrel and Rosuvastatin in human plasma according to USFDA draft guidelines. In the current study, the analysis was performed on phenomenex C8 (250 × 4.6mm, 5μm) column using phosphate buffer (pH-2.5) and ac...
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PHARMACOLOGICAL AND PHYTOCHEMICAL EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF SOLANUM NIGRUM
Anti-ulcer activity of the Solanum nigrum L. extracts was studied in rats by using pylorus ligated ulcer model. Rantidine was used as the standard drug for comparison. The animals were sacrificed after 19 hrs after the ligation. Stomach was dissected out and contents were drained into tubes and were centrifuged at 1000 rpm for 10min and volume was noted. The PH of gastric juice was recorde...
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SENSITIVE AND SELECTIVE SPECTROPHOTOMETRIC DETERMINATION OF SPIRAMYCIN IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS
Three simple and sensitive and reproducible spectrophotometric methods were developed for the determination of spiramycin (SPM) in pure form and in pharmaceutical formulations (tablets). The first and second methods, A and B, are based on the formation of charge transfer complex between drug and the chromogenic reagents quinalizarin (method A) and alizarin red S (method B) producing charge transfe...
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SYNTHESIS AND ANALYTICAL METHOD DEVELOPMENT OF A NEW PRODRUG OF ACECLOFENAC
In the present work, a prodrug (2) of aceclofenac was synthesized using N-hydroxymethylisatin (1) as promoiety. Its structure was established on the basis of modern analytical techniques. An analytical, rapid, cost-effective and accurate method using UV-spectroscopy has been developed for the synthesized prodrug. The results and calibration curves obtained with different solvents for the prodrug r...
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EFFICACY OF SODIUM HYPOCHLORITE IN CONTROLLING BACTERIAL INFECTIONS IN FIFTH INSTAR LARVAE OF ANTHEREAE MYLITTA DRURY (DABA TV)
Bacterial diseases are highly virulent and cause significant crop loss in Anthereae mylittadrury (Daba TV).Therefore an attempt has been made to evaluate the efficient concentration of sodium hypochlorite in controlling bacterial infection through studies on mortality, Total haemocytes, Protein carbonyl content, Alanine transaminase, Aspartate transaminase in the fifth in star larvae. Results reve...
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ANTI-INFLAMMATORY AND ANTIBACTERIAL POTENTIAL OF CARISSA CARANDAS AND CARISSA SPINARUM NANOEMULSIONS
The studies in the present article aims at developing an optimal oral polyherbal nanoemulsions from Carissa carandas (CC) and Carissa spinarum (CS) which are noticed in ethnobotanical herbarium for their pharmacological relevance. Nanoemulsions were developed in different proportions of oil and surfactant systems in order to enhance its oral bioavailability. Solubility studies were carried out for...
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PREPARATION, STANDARDIZATION AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ARKA LAVANA
The liver is a vital organ of the human body. It is responsible for protecting the body from harmful substances and the maintenance of good health. In last few years, various types of liver disorders, such as drug-induced liver disease, hepatomegaly, fatty liver disease, liver cirrhosis, autoimmune hepatitis, chronic viral hepatitis, autoimmune hepatitis, etc. are become a people’s health proble...
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EVALUATION OF ANALGESIC ACTIVITY OF MOMORDICA DIOICA ROXB. WILLD FRUIT PULP
In the present study Momordica dioica Roxb willd (Cucurbitaceae) fruit pulp was successively extracted with petroleum ether, ethyl acetate and methanol. All extracts were vacuum dried to yield the respective extracts. All extracts were evaluated by non-narcotic models like acetic acid induced writhing syndrome test and narcotic models like hot plate for its analgesic activity in doses of 50 mg/kg ...
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CONTEMPORARY APPROACHES FOR BI-LAYER TECHNOLOGY OF DRUGS THROUGH ORAL ROUTE: AN OVERVIEW
Bi-layer tablet technology for bimodal release of drug and co-administration of drugs via oral route has been engaged a significant place in the field of drug delivery technology. At present, several pharmaceutical companies are developing bilayer tablet for co-administration of drugs to improve the therapeutic efficacy as well as to reduce the chances of drug-drug interaction. This review indicat...
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