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PHYTOCHEMICAL SCREENING AND ANTINOCICEPTIVE ACTIVITY OF MIMOSA DIPLOTRICHA LEAVES
Though possessing a lot of ethnopharmacological use, Mimosa diplotricha did not explore thoroughly for its bioactivity & the phytoconstituents responsible for its bioactivity. The purpose of the current work was to conduct phytochemical screening and antinociceptive activity of methanolic extract and its different fractions of Mimosa diplotricha leaves. Phytochemical screening of methanolic ex...
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1758
SELF-MEDICATION WITH ANTIBIOTICS: GENERAL PERSPECTIVE AMONG PEOPLE IN PESHAWAR AND MARDAN (TWO MOST POPULATED CITIES OF KHYBER PUKHTOONKHWA-PAKISTAN)
Self-medication is global problem but in developing regions, where drugs are available to customers easily it arises greater risks and challenges. Peshawar and Mardan are two big and heavily inhibited cities of a developing country, Pakistan hence in this study we aim to find the level of self-medication and general knowledge about antibiotics of the people in these two cities. We conducted our st...
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2169
DEVELOPMENT OF UV SPECTROPHOTOMETRIC FIRST ORDER DERIVATIVE METHOD FOR THE SIMULTANEOUS ESTIMATION OF RITONAVIR AND LOPINAVIR IN COMBINED TABLET DOSAGE FORM
A simple, accurate, precise analytical method has been developed for the simultaneous estimation of ritonavir and lopinavir in pure bulk drug and in combined tablet dosage form by UV spectrophotometry by first order derivative method. The standard solutions of ritonavir and lopinavir were prepared in acetonitrile followed by further required with the same solvent. The solution containing ritonav...
4224
1917
RISK ASSESSMENT OF SOME HERBAL POWDERS AND HERBAL FORMULATIONS CONTAMINATED WITH HEAVY METALS
Ten herbal medicines, Four herb choornam (Trikatu, Hingwashtak, Triphala and sitopladi) and five herbal compounds - Kutajghan Vati, Gandhak Rasayan, Sarivadi Vati, Chanderprabha Vati, Shankh Vati were tested for levels of heavy metals (Lead, copper, cadmium, iron, chromium, manganese, nickel and zinc). Both herbal extracts and herbal formulations showed the presence of heavy metals. Concentrations...
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1832
SALICYLIC ACID AND CHITOSAN MEDIATED ABIOTIC STRESS IN CELL SUSPENSION CULTURE OF ANDROGRAPHIS PANICULATA (BURM.F.) NEES. FOR ANDRO-GRAPHOLIDE SYNTHESIS
Quantitative and qualitative improvement of rare and valuable bioactive plant products is promisingly possible using In-vitro cell culture techniques. The present investigation was conducted with the aim to elicit the synthesis ofandrographolide by subjecting cultured cells of Andrographis paniculata to Salicylic acid (SA) and Chitosan mediated abiotic stressCell suspension culture of Andrographis...
4223
1928
ASSESSMENT OF MEMBRANE STABILIZATION, ANTIOXIDANT AND THROMBOLYTIC POTENTIAL OF LUTEIN- AN IN-VITRO STUDY
Lutein; an orange-red colored powder, insoluble in water; is a member of the carotenoid family, a xanthophyll pigment. Lutein was evaluated for its antioxidant property when dissolved in different solvents. Solvents used in the study were chloroform, ethanol, methanol and dimethyl sulfoxide (DMSO). The antioxidant potential of lutein was evaluated by total antioxidant capacity, 2, 2’-diphenyl-1-...
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1661
STABILITY INDICATING HPLC METHOD FOR DETERMINATION OF MYRSINOIC ACIDS A AND B IN RAPANEA FERRUGINEA EXTRACTS AND NANOEMULSIONS
Rapanea ferruginea Mez. stem barks and fruits extracts have demonstrated anticholinesterasic and antimicrobial activities assigned to myrsinoic acids A and B (MAA and MAB), compounds that have also proven anti-inflammatory and antinociceptive activities. To stablish the quality control of nanotechnology-based herbal medicines, the aim of this study was develop and validate a stability indicating H...
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2157
ASSOCIATION OF THE APOLIPOPROTEIN B/APOLIPOPROTEIN A-1 RATIO WITH THE SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Although many studies have demonstrated the importance of the apoB/apoA-1 ratio as a risk marker of atherogenicity, less is known about apoB/apoA-1 ratio in predicting and the severity of coronary artery disease (CAD) in T2DM. Our study aimed to assess possible associations between apoB/apoA-1 ratio levels and the severity of coronary artery diseases in patients with type 2 diabetes mellitus (T2DM...
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HEPARIN IN HIT: EFFECTIVENESS AS AN ANTICOAGULANT
Heparin-induced thrombocytopenia (HIT), a devastating immune mediated adverse drug reaction, is triggered by the development of antibodies that stimulates the platelet activation in presence of heparin. Bleeding is infrequent in HIT patients regardless of thrombocytopenia; however, HIT is strongly associated with thromboembolic complications involving both venous and arterial systems. Numerous nov...
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ANTIMICROBIAL ACTIVITY OF PRICKLY CHAFF (ACHYRANTHES ASPERA) SEED TRYPSIN INHIBITOR
Trypsin inhibitor (AATI) was purified from the seeds of Achyranthes aspera to homogeneity by conventional methods and its antimicrobial activity was tested on selected pathogenic microbes. The inhibitor significantly affected the growth of Proteus vulgaris followed by Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia with zones of inhibition recorded as 28mm, 26mm...
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1707