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PRODUCTION AND PURIFICATION STRATEGIES FOR LACCASE
Laccase belongs to polyphenol oxidases, which is a very wide family of copper-containing atoms in the center, which serves as the catalytic site. It is biochemically a glycoprotein with molecular mass being between 50kda to 130kda and 30% carbohydrate content, in addition to this it has three types of copper atoms. It is one of the most important enzymes due to its role in the food industry. It ac...
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PHYTOTHERAPY AS NEW APPROACH TO TREAT SCORPION ENVENOMATION: EXPERIMENTAL STUDY
Citrullus colocynthis is a wild common plant in arid and semi arid areas of Algeria which are characterized by high incidence of scorpion envenomation. It is used in Algeria to treat many diseases. In order to optimize and develop new therapeutic strategies for scorpion envenoming, a phytotherapeutic approach has been investigated. Pharmacological properties of Citrullus colocynthis were evaluated...
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ANTIBACTERIAL ACTIVITY FROM BARK EXTRACTS OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD.
Although there are many studies on antimicrobial activities of different plants, there is no report on antibacterial activity of Pterospermum acerifolium (Sterculiaceae). Therefore, a microbiological study was conducted to detect antibacterial activity of P. acerifolium. Successive ethanolic extract of bark of P. acerifolium were fractionated with hexane, butanol, methanol and water. In vitro anti...
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EVALUATION OF BONE MARROW FOR HEMATOLOGICAL ANOMALIES IN INDIAN PEDIATRIC AND ADULT PATIENTS: A SINGLE TERTIARY CARE CENTER STUDY
Bone marrow aspiration can determine the metastatic deposits, degree of cellularity and fibrosis readily. A retrospective analysis of bone marrow aspiration and biopsy, in children and adult patients with hematological anomalies, were performed in 674 cases for different indication of hematological abnormalities from January 2013 to March 2014. Cases were analyzed in detail regarding clinical, hem...
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FORMULATION AND EVALUATION OF LORNOXICAM MOUTH DISSOLVING TABLET BY USING NATURAL SUPERDISINTEGRANTS
The concept of fast dissolving drug delivery system emerged from the desire to provide patients with more convenient means of taking their medication. It is difficult for many patients to swallow tablets and hard gelatin capsules. The main objective of the study is to develop a reproducible formulation of fast dissolving tablets of Lornoxicam already used the therapeutic molecule to enhance effect...
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1836
PROTECTIVE EFFECT OF “RAPHANUS SATIVUS” EXTRACT AGAINST COPPER SULPHATE TOXICITY IN “CTENOPHARYNGODON IDELLA” FISH
The living organisms of the aquatic ecosystem have been directly affected by the accumulation of the heavy metals in the aquatic environment 1. Fishes are very good biosensors of aquatic contaminants and as bio-indicator species respond with great sensitivity to changes in the aquatic environment. Copper will accumulate in many different organs in fish and mollusks. In the present study the acute ...
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1804
CHARACTERIZATION OF ANTIOXIDANT AND CYTOTOXIC POTENTIAL OF METHANOLIC EXTRACTS OF DIFFERENT PARTS OF AEGLE MARMELOS (L.)
Aegle marmelos(L.), family rutaceae is highly reputed medicinal tree commonly known as the bael. All parts of the plant have medicinal properties and extensively used by the traditional medicine practitioners of Bangladesh in different health ailments like Diabetes, Diarrhea, Jaundice, typhoid. The present study was dedicated to investigate phytochemical and pharmacological properties of ripe frui...
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DEVELOPMENT AND VALIDATION OF BIO-ANALYTICAL RP-ULTRA FAST LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS ESTIMATION OF CLOPIDOGREL AND ROSUVASTATIN IN HUMAN PLASMA
ABSTRACT: This manuscript describes a simple, sensitive, rapid and precise Ultra fast liquid chromatographic (UFLC) method was developed and validated for the simultaneous determination Clopidogrel and Rosuvastatin in human plasma according to USFDA draft guidelines. In the current study, the analysis was performed on phenomenex C8 (250 × 4.6mm, 5μm) column using phosphate buffer (pH-2.5) and ac...
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DETERMINATION OF QUERCETIN BY HPTLC METHOD PRESENT IN ZYMODYNE SYRUP- A POLY HERBAL FORMULATION
Zymodyne Syrup is poly herbal formulation made by Ayrulab Herbals Pvt. Ltd., as an appetite enhancer. This formulation contains various 17 plant extract from these 6 plants namely Cyperus rotundus, Bacopa monnieri, Glycyrrhiza glabra, Phyllanthus amarus, Asparagus racemosus, and Tribulus terrestris contains Quercetin flavonoid as a chemical constitute and it can be determined by HPTLC method. Th...
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1932
IN VIVO ANTIINFLAMMATORY EFFECT OF EMU OIL (DROMAIS NOVAEHOLLANDIAE) AND VIRGIN COCONUT OIL (COCOS NUCIFERA) ON PHORBOL ESTER INDUCED ACUTE INFLAMMATORY MODEL
Inflammation is a cellular reaction to injury and plays a central role in pathophysiology of a variety of diseases.Oil derived from Emu (Dromais novaehollandiae) fat, is reported to have healing property. The present investigation was performed to demonstrate in vivo anti-inflammatory effect of Emu oil using phorbol ester induced acute inflammatory ear edema model. Also, the efficacy of Emu oil wa...
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