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ASSOCIATION OF THE APOLIPOPROTEIN B/APOLIPOPROTEIN A-1 RATIO WITH THE SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Although many studies have demonstrated the importance of the apoB/apoA-1 ratio as a risk marker of atherogenicity, less is known about apoB/apoA-1 ratio in predicting and the severity of coronary artery disease (CAD) in T2DM. Our study aimed to assess possible associations between apoB/apoA-1 ratio levels and the severity of coronary artery diseases in patients with type 2 diabetes mellitus (T2DM...
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HEPARIN IN HIT: EFFECTIVENESS AS AN ANTICOAGULANT
Heparin-induced thrombocytopenia (HIT), a devastating immune mediated adverse drug reaction, is triggered by the development of antibodies that stimulates the platelet activation in presence of heparin. Bleeding is infrequent in HIT patients regardless of thrombocytopenia; however, HIT is strongly associated with thromboembolic complications involving both venous and arterial systems. Numerous nov...
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ANTIMICROBIAL ACTIVITY OF PRICKLY CHAFF (ACHYRANTHES ASPERA) SEED TRYPSIN INHIBITOR
Trypsin inhibitor (AATI) was purified from the seeds of Achyranthes aspera to homogeneity by conventional methods and its antimicrobial activity was tested on selected pathogenic microbes. The inhibitor significantly affected the growth of Proteus vulgaris followed by Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia with zones of inhibition recorded as 28mm, 26mm...
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MODULATION OF mTOR RECEPTOR IN DIABETIC NEPHROPATHY BY SANTALIN A OF LAL CHANDAN (PTEROCARPUS SANTALINUS): AN IN-SILICO ASSESSMENT BY MOLECULAR DOCKING
Background: Diabetic nephropathy (DN) is a primary cause of end-stage renal disease globally. Activation of mTOR and reduced autophagy has been identified as one of the pathogenic pathways. The presently available drugs have been successful in inhibiting the mTOR signaling, but show low oral bioavailability and suboptimal solubility. Rapamycin is a selective inhibitor of mTOR, shown significant pr...
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ANTIBIOTIC RESISTANCE ISSUES IN CLINICAL PATHOGENS: A REVIEW
Antibiotic resistance in pathogens is on the increase but in the past few decades this problem raised a deepening concern among scientific community in terms of the clinical management of infectious diseases. In this review, the common gram negative clinically significant pathogenic bacteria who have acquired resistance with passage of time like Shigella dysenteriae, Sh. Boydii, Sh. Flexneri, List...
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FORMULATION AND IN-VITRO EVALUATION OF ZIDOVUDINE LOADED ETHYL CELLULOSE MICROCAPSULES
Microencapsulation is a well-known method that is used to modify and retard drug release. In this study, the preparation of Zidovudine loaded microcapsule was accomplished in order to assess the suitability of them for production of oral/vaginal sustained release multiparticulate dosage form of Zidovudine.Microcapsules were prepared using the solvent evaporation method. The effect of formulation v...
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ANTIBACTERIAL ACTIVITY FROM BARK EXTRACTS OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD.
Although there are many studies on antimicrobial activities of different plants, there is no report on antibacterial activity of Pterospermum acerifolium (Sterculiaceae). Therefore, a microbiological study was conducted to detect antibacterial activity of P. acerifolium. Successive ethanolic extract of bark of P. acerifolium were fractionated with hexane, butanol, methanol and water. In vitro anti...
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DEVELOPMENT, EVALUATION AND TARGETING OF IMATINIB MESYLATE LOADED SOLID LIPID NANOPARTICLES TO THE LYMPHATIC SYSTEM
For a formulation scientist, the delivery of therapeutic agents to the diseased organ has been a challenging problem. It is expected to improve the therapeutic index and reduce side effects of a drug by good delivery strategy to diseased organ. The objective of this investigation is to evaluate the targeting potential of solid lipid nanoparticle (SLN) formulation of imatinib mesylate to the lympha...
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STUDIES ON PHENOTYPIC CHARACTERIZATION AND SELECTIVE VIRULENCE FACTORS OF CANDIDA SPP. AND CRYPTOCOCCUS NEOFORMANS AND IN VITRO SUSCEPTIBILITY OF THESE ORGANISMS TO THE CONVENTIONAL AMPHOTERICIN B AND FUNGISOMETM
The human fungal infections have increased tremendously in our country, especially candidal infections. Cryptococcus neoformans is encapsulated yeast, causes life-threatening infections in immuno-compromised individuals such as AIDS. Meningoencephalitis is the serious consequence of C. neoformans infection. Studies are therefore, required for identification of these fungal...
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PHARMACOKINETIC STUDY OF ANDROGRAPHIS PANICULATA ETHANOLIC EXTRACT TABLET
Andrographis paniculata (Burm. F) Nees, commonly known as the “king of bitters,” is an herbaceous plant belonging to the Acanthaceae and is found throughout tropical and subtropical Asia, Southeast Asia, and India. Andrographolide, a bitter diterpenoid, is the major active principle present in the plant. Authors have already worked on the phytochemical investigation, analgesic and antipyretic ...
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2027