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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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8.

HEPARIN IN HIT: EFFECTIVENESS AS AN ANTICOAGULANT

Heparin-induced thrombocytopenia (HIT), a devastating immune mediated adverse drug reaction, is triggered by the development of antibodies that stimulates the platelet activation in presence of heparin. Bleeding is infrequent in HIT patients regardless of thrombocytopenia; however, HIT is strongly associated with thromboembolic complications involving both venous and arterial systems. Numerous nov...

Salma M. Aldallal*

Haematology Laboratory Specialist, Amiri Hospital, Sharq, Kuwait

DOI: 10.13040/IJPSR.0975-8232.8(8).3261-64

3261-3264

4230

1456

9.

ANTIBIOTIC RESISTANCE ISSUES IN CLINICAL PATHOGENS: A REVIEW

Antibiotic resistance in pathogens is on the increase but in the past few decades this problem raised a deepening concern among scientific community in terms of the clinical management of infectious diseases. In this review, the common gram negative clinically significant pathogenic bacteria who have acquired resistance with passage of time like Shigella dysenteriae, Sh. Boydii, Sh. Flexneri, List...

Sikandar Khan Sherwani*1 Aisha Irshad , Muhammad Ajmal Shah , Munazza Ajaz and Haroon Ahmad

Lecturer at Department of Microbiology, Federal Urdu University of Arts, Science and Technology, Gulshan Iqbal, Karachi-75300, Pakistan.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(5).1725-29

1725-1729

4229

1502

11.

PHYTOTHERAPY AS NEW APPROACH TO TREAT SCORPION ENVENOMATION: EXPERIMENTAL STUDY

Citrullus colocynthis is a wild common plant in arid and semi arid areas of Algeria which are characterized by high incidence of scorpion envenomation. It is used in Algeria to treat many diseases. In order to optimize and develop new therapeutic strategies for scorpion envenoming, a phytotherapeutic approach has been investigated. Pharmacological properties of Citrullus colocynthis were evaluated...

Laraba-Djebari Fatima* and Kabrine Mohamed

USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32 El Alia, Bab Ezzouar, Algiers, Algeria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1682-92

1682-1692

4229

2111

16.

MODULATION OF mTOR RECEPTOR IN DIABETIC NEPHROPATHY BY SANTALIN A OF LAL CHANDAN (PTEROCARPUS SANTALINUS): AN IN-SILICO ASSESSMENT BY MOLECULAR DOCKING

Background: Diabetic nephropathy (DN) is a primary cause of end-stage renal disease globally. Activation of mTOR and reduced autophagy has been identified as one of the pathogenic pathways. The presently available drugs have been successful in inhibiting the mTOR signaling, but show low oral bioavailability and suboptimal solubility. Rapamycin is a selective inhibitor of mTOR, shown significant pr...

P. Shree, D. Yadav, V. K. Singh, R. Chaube and Y. B. Tripathi *

Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(3).1103-09

1115-1121

4228

1900

45.

ANTIMICROBIAL ACTIVITY OF PRICKLY CHAFF (ACHYRANTHES ASPERA) SEED TRYPSIN INHIBITOR

Trypsin inhibitor (AATI) was purified from the seeds of Achyranthes aspera to homogeneity by conventional methods and its antimicrobial activity was tested on selected pathogenic microbes. The inhibitor significantly affected the growth of Proteus vulgaris followed by Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia with zones of inhibition recorded as 28mm, 26mm...

Geetha Konala, Lavanya Seva and Siva Prasad Davuluri*

Department of Biochemistry, Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3241-48

3241-3248

4227

1713

31.

STUDIES ON PHENOTYPIC CHARACTERIZATION AND SELECTIVE VIRULENCE FACTORS OF CANDIDA SPP. AND CRYPTOCOCCUS NEOFORMANS AND IN VITRO SUSCEPTIBILITY OF THESE ORGANISMS TO THE CONVENTIONAL AMPHOTERICIN B AND FUNGISOMETM

The human fungal infections have increased tremendously in our country, especially candidal infections. Cryptococcus neoformans is encapsulated   yeast,   causes   life-threatening   infections   in   immuno-compromised individuals such as AIDS. Meningoencephalitis is the serious consequence of C. neoformans infection. Studies are therefore, required for identification of these fungal...

Kanchan Kumari, Amit Kumar and P.C. Sharma*

Department of Microbiology, School of Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan-173 212, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(2).532-47

532-547

4227

2268

13.

ANTIBACTERIAL ACTIVITY FROM BARK EXTRACTS OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD.

Although there are many studies on antimicrobial activities of different plants, there is no report on antibacterial activity of Pterospermum acerifolium (Sterculiaceae). Therefore, a microbiological study was conducted to detect antibacterial activity of P. acerifolium. Successive ethanolic extract of bark of P. acerifolium were fractionated with hexane, butanol, methanol and water. In vitro anti...

S K Panda* and S K Dutta

P G Department of Zoology, North Orissa University, Baripada, Orissa, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(3).584-95

584-595

4227

1556

10.

FORMULATION AND IN-VITRO EVALUATION OF ZIDOVUDINE LOADED ETHYL CELLULOSE MICROCAPSULES

Microencapsulation is a well-known method that is used to modify and retard drug release. In this study, the preparation of Zidovudine loaded microcapsule was accomplished in order to assess the suitability of them for production of oral/vaginal sustained release multiparticulate dosage form of Zidovudine.Microcapsules were prepared using the solvent evaporation method. The effect of formulation v...

Amitava Ghosh , Abhradeep Saha , Sujit Das and Tanmoy Ghosh

Himachal Institute of Pharmacy, Rampur Ghat Road, Ponta Sahib, Distt. Sirmour Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.2(2).289-97

289-297

4226

1571

25.

DEVELOPMENT, EVALUATION AND TARGETING OF IMATINIB MESYLATE LOADED SOLID LIPID NANOPARTICLES TO THE LYMPHATIC SYSTEM

For a formulation scientist, the delivery of therapeutic agents to the diseased organ has been a challenging problem. It is expected to improve the therapeutic index and reduce side effects of a drug by good delivery strategy to diseased organ. The objective of this investigation is to evaluate the targeting potential of solid lipid nanoparticle (SLN) formulation of imatinib mesylate to the lympha...

R. Vivek * and S. Jose

KVM College of Pharmacy, Kokkothamangalam, Cherthala, Aleppey, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(6).2359-68

2359-2368

4226

1920

27.

IN VIVO ANTIINFLAMMATORY EFFECT OF EMU OIL (DROMAIS NOVAEHOLLANDIAE) AND VIRGIN COCONUT OIL (COCOS NUCIFERA) ON PHORBOL ESTER INDUCED ACUTE INFLAMMATORY MODEL

Inflammation is a cellular reaction to injury and plays a central role in pathophysiology of a variety of diseases.Oil derived from Emu (Dromais novaehollandiae) fat, is reported to have healing property. The present investigation was performed to demonstrate in vivo anti-inflammatory effect of Emu oil using phorbol ester induced acute inflammatory ear edema model. Also, the efficacy of Emu oil wa...

P. Logeswari*, V. Dinesh Kumar , P.T.A. Usha and Prathap Kumar

Research Scholar, Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Mannuthy, Thrissur, Kerala-680651, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.5(3).896-99

896-899

4225

1861