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SYNTHESIS AND CHARACTERIZATION OF BIOLOGICALLY ACTIVE COMPOUND E-2-((2-AMINO PYRIDINE-3-YL) METHYLENE AMINO) ETHANE THIOL AND ITS METAL COMPLEXES
A new physiologically active compound E-2-((2-amino pyridine-3-yl) methylene amino)ethane thiol derived from the condensation of Cysteamine and 2-amino Pyridine 3-Carbaldehyde was synthesized and characterized by spectral techniques like IR, UV-Vis,1H- NMR, TG-DTA, ESR, CHN analyses. The complexes were further screened for their biological activity at Nishka labs and Nickel and Cobalt complexes we...
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INVESTIGATION ON THE IN VITRO ANTIOXIDANT, ANTIMUTAGENIC AND CYTOTOXIC POTENTIAL OF THYMUS VULGARIS L. HYDRO-ALCOHOLIC EXTRACT
Aim: To evaluate the in vitro antioxidant, antimutagenic and cytotoxic property of hydro-alcoholic extract of Thymus vulgaris L. by subjecting it to free radical scavenging, Ames and MTT assay respectively. Methods: Powdered Thyme leaves were extracted in a Soxhlet apparatus using 70% ethanol to obtain a dry extract. The extract was assessed for its total phenolic, tannin, flavonoid and flavono...
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EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF LEAVES OF ECLIPTA PROSTRATA LINN. (ASTERACEAE)
Eclipta prostrata Linn. (Asteraceae) popularly known as "Bhringaraj" is a very useful medicinal plant in India. The aim of the present study is to evaluate the anti-inflammatory activity of ethanolic extract of leaves of Eclipta prostrata. The anti-inflammatory effects were investigated by employing acute inflammatory model; Carrageenan induced paw edema and Sub-acute inflammatory model; formalin ...
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A COMPARATIVE STUDY TO EVALUATE EFFICACY, SAFETY AND COST EFFECTIVENESS BETWEEN ORAL BALOFLOXACIN VS. ORAL LEVOFLOXACIN IN PATIENTS OF ACUTE, UNCOMPLICATED URINARY TRACT INFECTION ATTENDING C. U. SHAH MEDICAL COLLEGE, SURENDRANAGAR
Objectives: To compare the efficacy, safety and cost effectiveness between oral Balofloxacin and oral Levofloxacin in acute uncomplicated urinary tract infections. Methods: Total 130 patients were enrolled for the study, out of them 119 patients completed the study. Patients were divided into two groups randomly; 63 patients received Balofloxacin 100 mg BID orally and 56 patients received Levoflox...
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SYNTHESIS AND CHARACTERIZATION OF PVA BASED SERICIN FILM FOR ANTIBACTERIAL WOUND DRESSING
Sericin is a globular protein obtained from degumming of silk cocoon in the silk reeling process. The sericin film was synthesized for the application of antibacterial wound dressing, but it has a low physical property, hence the synthetic polymer was used in the synthesis of highly stable biocompatible film. The PVA based sericin film was prepared by solvent casting method by the addition of synt...
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PROTECTIVE ROLE OF NANOCONJUGATED VANCOMYCIN AGAINST VANCOMYCIN SENSITIVE STAPHYLOCOCCUS AUREUS INDUCED OXIDATIVE STRESS AND DNA DAMAGE
Staphylococcus aureus causes a wide range of infection such as skin and soft tissue infection to life threatening disease like respiratory tract infection, musculoskeletal infection, endocarditis and urinary tract infection. The aim of the present study was to evaluate the possible protective effects of nanoconjugated vancomycin against VSSA infection on select makers of oxidative damage and antio...
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BIOMARKERS FOR THERAPEUTIC RESPONSE IN CERVICAL CANCER
Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Despite the tremendous progress that has been achieved in the screening and management of cervical cancer, there is still a need for clinically relevant prognostic biomarkers to monitor the response of patients to various therapies and to predict the chances of recurrence and recovery....
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THE ANTIMICROBIAL ACTIVITY OF n-C6H14 AND CH3CH2OH EXTRACT OF SOLANUM MELONGENA FRUIT AND LEAVES OF MORINGA OLEIFERA
As part of a research initiative to evaluate plants used for their nutritional and herbal values, the antimicrobial activity of Solanum Melongena’s fruit and Moringa oleifera’s leaveswere investigated. Each plant part was subjected to selective extraction using solvents of varying polarity: n-C6H14, CH2Cl2, EtOAc and CH3CH2OH. The n-C6H14 and CH3CH2OH extract of these two plants were tested fo...
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COMPARATIVE STUDY OF HYPOGLYCEMIC EFFECT OF ETHANOLIC AND HOT WATER EXTRACTS OF ANDROGRAPHIS PANICULATA IN ALLOXAN INDUCED RAT
The aim of present study was to investigate the potential roles of ethanolic and hot water extracts of Andrographis paniculata on reducing the blood sugar level (BSL) in alloxan- induced rats. Oral administration of ethanolic (2 g/kg b. w.) and hot water (0.8 g/kg b. w.) extracts of Andrographis paniculata showed the antidiabetic properties and decreased the blood glucose level by 33.71% (p<0.0...
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ANTIOXIDANT ANALYSIS AND ENZYME INHIBITION ASSAY OF PLANTS OF APOCYNACEAE FAMILY FOR ULCERS
Different plants of the Apocynaceae family viz. Alstonia scholaris, Calotropis procera, Rauvolfia serpentine, Hemidesmus indicus and Calotropis gigantean are traditionally being reported in ulcers treatments. The present study was aimed to validate the authenticity of correlationship of various phytoconstituents concentrations, antioxidant activity and urease inhibitory potential of the same. Vari...
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