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FORMULATION OF REGIOSELECTIVE FLOATING MATRIX TABLETS OF DEXTRO-METHORPHAN USING GAS FORMING TECHNIQUE AND EVALUATION
The present study deals with the formulation and evaluation of gastroretentive floating tablets of dextromethorphan. Dextromethorphan is a highly potent and commonly used antitussive agent. It has no narcotic, analgesic or addictive properties and its potency as an antitussive agent is almost equal to that of codeine. The purpose of this research is to increase the gastric residence time by prepar...
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A CLINICAL STUDY ON THE IMPACT OF DIFFERENT TREATMENT MODALITIES ON IMPROVING THE CLINICAL OUTCOMES IN CHRONIC PERIODONTITIS PATIENTS
Background: Periodontal disease is one of the two main and most prevalent oral diseases all over the world. Treatment strategies are diverse. To date, scaling and root planing (SRP) is still the gold standard non-surgical therapy for periodontitis. Systemically administered antibiotics can be used as an adjunct to SRP to improve the treatment outcome of periodontitis. Purpose: To compare clinical ...
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1927
STABILITY INDICATING HPLC METHOD FOR DETERMINATION OF MYRSINOIC ACIDS A AND B IN RAPANEA FERRUGINEA EXTRACTS AND NANOEMULSIONS
Rapanea ferruginea Mez. stem barks and fruits extracts have demonstrated anticholinesterasic and antimicrobial activities assigned to myrsinoic acids A and B (MAA and MAB), compounds that have also proven anti-inflammatory and antinociceptive activities. To stablish the quality control of nanotechnology-based herbal medicines, the aim of this study was develop and validate a stability indicating H...
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2194
ANTIBIOTIC RESISTANCE ISSUES IN CLINICAL PATHOGENS: A REVIEW
Antibiotic resistance in pathogens is on the increase but in the past few decades this problem raised a deepening concern among scientific community in terms of the clinical management of infectious diseases. In this review, the common gram negative clinically significant pathogenic bacteria who have acquired resistance with passage of time like Shigella dysenteriae, Sh. Boydii, Sh. Flexneri, List...
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1523
STUDIES ON PHENOTYPIC CHARACTERIZATION AND SELECTIVE VIRULENCE FACTORS OF CANDIDA SPP. AND CRYPTOCOCCUS NEOFORMANS AND IN VITRO SUSCEPTIBILITY OF THESE ORGANISMS TO THE CONVENTIONAL AMPHOTERICIN B AND FUNGISOMETM
The human fungal infections have increased tremendously in our country, especially candidal infections. Cryptococcus neoformans is encapsulated yeast, causes life-threatening infections in immuno-compromised individuals such as AIDS. Meningoencephalitis is the serious consequence of C. neoformans infection. Studies are therefore, required for identification of these fungal...
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DEVELOPMENT, EVALUATION AND TARGETING OF IMATINIB MESYLATE LOADED SOLID LIPID NANOPARTICLES TO THE LYMPHATIC SYSTEM
For a formulation scientist, the delivery of therapeutic agents to the diseased organ has been a challenging problem. It is expected to improve the therapeutic index and reduce side effects of a drug by good delivery strategy to diseased organ. The objective of this investigation is to evaluate the targeting potential of solid lipid nanoparticle (SLN) formulation of imatinib mesylate to the lympha...
4268
1937
ANTIOXIDANT ACTIVITY OF TAXIFOLIN OBTAINED FROM METHANOLIC EXTRACTS OF CORDIA DICHOTOMA LINN. SEEDS
Cordia dichotoma L. family Boraginaceae is a medium sized tree, is taken as food. The immature fruits are pickled and are also used as vegetable. The various extracts and fractions of Cordia dichotoma were screened for their free radical scavenging properties using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and comparing it with butylated hydroxyl toluene (BHT) as standard antioxidant...
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EFFICACY OF SODIUM HYPOCHLORITE IN CONTROLLING BACTERIAL INFECTIONS IN FIFTH INSTAR LARVAE OF ANTHEREAE MYLITTA DRURY (DABA TV)
Bacterial diseases are highly virulent and cause significant crop loss in Anthereae mylittadrury (Daba TV).Therefore an attempt has been made to evaluate the efficient concentration of sodium hypochlorite in controlling bacterial infection through studies on mortality, Total haemocytes, Protein carbonyl content, Alanine transaminase, Aspartate transaminase in the fifth in star larvae. Results reve...
4267
1911
THE EFFECT OF SUBCHRONIC ADMINISTRATION OF ROSELLA (HIBISCUS SABDARIFFA L.) EXTRACT ON LEVELS OF UREUM, CREATININE, AND RENAL HISTOPATHOLOGY
Rosella (Hibiscus sabdariffa L.) calyx traditionally used to treat various diseases. There is limited evidence based could be found including the efficacy and safety. The present study was aimed to investigate the effects of subchronic administration of Rosella calyx extract on the renal function of female Sprague Dawley (SD) rats. The rosella calyx was extracted by 70% ethanol and evaporated with...
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1472
ANTIMICROBIAL ACTIVITY OF PRICKLY CHAFF (ACHYRANTHES ASPERA) SEED TRYPSIN INHIBITOR
Trypsin inhibitor (AATI) was purified from the seeds of Achyranthes aspera to homogeneity by conventional methods and its antimicrobial activity was tested on selected pathogenic microbes. The inhibitor significantly affected the growth of Proteus vulgaris followed by Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia with zones of inhibition recorded as 28mm, 26mm...
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