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COMPARATIVE STUDY OF OVERLAPPING GENES IN THE GENOMES OF MYCOPLASMA HOMINIS AND MYCOPLASMA PENETRANS
Overlapping genes are pairs of adjacent genes whose coding regions are partially or entirely overlapping. Overlapping genes in prokaryotes are a means to minimize genome size and increase the density of genetic information. Overlapping genes play an important role in genome reduction of Mycoplasmas during the course of their degenerative evolution. In this study overlapping genes in the genomes of...
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ANTINOCICEPTIVE AND GASTRO PROTECTIVE EFFECTS OF INHALED AND ORALLY ADMINISTERED THEVETIA PERUVIANA PERS. K. SCHUM. ESSENTIAL OIL
In Present study the antinociceptive and the gastroprotective effects of orally administered or inhaled Thevetia peruviana Pers. K. (Schum) (Oleander) volatile oil, and its principal constituents linalool and 1,8-cineole were evaluated in mice. Either when orally administered (100µl/kg) or inhaled for 60 min Thevetia peruviana volatile oil significantly reduced the acetic acid-writhing response i...
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OPTIMIZATION AND IN-VIVO EVALUATION OF OCULAR FILMS OF AN ANTI-INFLAMMATORY AGENT
The present study focuses on the treatment of ocular inflammation with objectives of reducing the frequency of administration, obtaining controlled release and greater therapeutic efficacy of drug (Keterolac tromethamine) using ocular films. Various combinations were designed for different batches of ocular films as per factorial design study with 0.5 % w/v concentration by solvent evaporation met...
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IN VIVO AND IN VITRO DETERMINATION OF TOTAL PHENOLS, ASCORBIC ACID CONTENT AND ANTIOXIDANT ACTIVITY IN PLUCHEA LANCEOLATA OLIVER & HIERN.
The present investigation deals with the determination of in vitro antioxidant activity as well as the phenols and ascorbic acid content in in vivo (leaf, stem, root) and in vitro (unorganised static callus cultures) plant parts of Pluchea lanceolata. Unorganised static callus cultures (eighteen months old) were grown on MS medium supplemented with NAA (1.0 mg/l) and BAP (0.5 mg/l) using leaf expl...
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ANALYTICAL CHARACTERIZATION OF A CONTROLLED RELEASE POLYMERIC SUSPENSION
Aims: Qualitative analysis of a mucoadhesive polymeric (Carbopol940) suspension of Norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. Methods: The characterization of ultrasonicated formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, X-ray powder diffraction (XRD) and Scanning electron micr...
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ANTIBACTERIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITY OF BACTERIAL CAROTENOIDS ISOLATED FROM RHODOPSEUDOMONAS PALUSTRIS KRPR01 AND KRPR02
The microbial pigments have more applications than synthetic pigments and are easily biodegradable and safe to use. Among all bacteria, the anoxygenic phototrophic purple non-sulfur bacteria have more applications and can synthesize different pigments. In this present study, bacterial carotenoids were isolated from the two novel strains of Rhodopseudomonas palustris and evaluated its applications....
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ANGIOGENESIS IN CARDIOVASCULAR DISEASE: A REVIEW
Angiogenesis is process of new blood vessel formation that occurs under both normal and pathological conditions. In the normal state, two distinct processes can be seen. One utilizes endothelial progenitor cells (EPC) and the second utilizes existing vasculature to generate new vessels. The healthy body controls angiogenesis through a series of "on" (angiogenesis-stimulating growth factors) and "o...
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EFFECTS OF STREPTOZOTOCIN- INDUCED TYPE I DIABETES MELLITUS ON CATION CONTENTS IN URINARY BLADDER TISSUES OF THE RAT
Diabetes mellitus is known to induce microvascular changes and alterations to neuronal functions. Diabetic neuropathy and diabetic nephropathy are two of the major long-term complications of diabetic mellitus (DM). The main aim of the comparative study is to investigate the role of cations contents compared to the age matched control.Adult rats were humanely killed and detrusor muscles of urinary ...
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CONSUMER PROPERTIES OF TRANSDERMAL PATCHES AND THEIR USE IN MODERN PHARMACOTHERAPY
In today's hectic lifestyle, such dosage form as plaster, attracts more attention of scientists and gives new opportunities to use it in medicine. The purpose of our study was to investigate consumer properties of transdermal patches, hold the commodity analysis of the dosage form and determine the prospectiveness of their use in modern pharmacotherapy. Market review has been conducted. Analyzed t...
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AN IN-VITRO STUDY FOR MUCOADHESION AND CONTROL RELEASE PROPERTIES OF GUAR GUM AND CHITOSAN IN ITRACONAZOLE MUCOADHESIVE TABLETS
This study describes the effect of Guar gum and chitosan on formulation of mucoadhesive drug delivery system of itraconazole. Mucoadhesive strength, Drug content, Hardness, Friability, Weight variation, Moisture content and accelerated stability studies were performed to study the effect of polymers on prepared mucoadhesive tablets. Results of the present study clarified the potential of guar gum ...
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