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ACUTE AND SUBACUTE TOXICITY STUDY ON SPERMATOGENIC SIDDHA DRUG ‘ISAPPUKOL CHOORANAM’ (IC)
Herbal medicines have been broadly used in developed countries hence they are natural and comparatively safe. They contain plant materials as their pharmacologically active components. Infertility is one of the most extremely tragic all over the world. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The male infertility is mainly due t...
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COMPARISON OF DIFFERENT SUPERDISINTEGRANTS IN DESIGNING OF FAST DISSOLVING TABLETS OF METOPROLOL TARTRATE
Metoprolol tartrate which is used in the present study is widely used as antianginal properties. Oral bioavailability of metoprolol tartrate is around 40%. In the present work fast dissolving tablets of metoprolol tartrate have been prepared by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and Hausner’s ratio. Th...
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FORMULATION DEVLOPMENT AND EVALUATION OF MUCOADHESIVE MICROSPHERE OF LOSARTAN POTASSIUM BY USING NATURAL POLYMER
The present work is regarding formulation, development and evaluation of losartan potassium microspheres using natural polymer. The mucoadhesive microspheres of losartan potassium were successfully developed by W/O emulsion solvent evaporation technique using two different natural polymers katira gum and babul gum. Total 12 batches were formulated. Six formulations were prepared by using each natu...
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DEVELOPMENT AND VALIDATION OF SECOND ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ATENOLOL AND NIFEDIPINE IN COMBINED DOSAGE FORM
A simple, precise, accurate and reproducible spectrophotometric method has been developed for Simultaneous estimation of Atenolol and Nifedipine by employing second order UV derivative Spectrophotometric method in Water: ACN (60:40). The Second order derivative absorption at 245.63 nm (zero cross point of Nifedipine) was used for quantification of Atenolol and 218.7 nm (zero cross point of Atenolo...
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A VALIDATED LC-MS/MS BIOANALYTICAL METHOD FOR THE SIMULTANEOUS DETERMINATION OF THREE ACE-INHIBITORS IN HUMAN PLASMA
A selective and rapid LC-MS/MS spectrophotometric method has been developed and validated for the simultaneous determination of three ACE-inhibitors used in anti-hypertensive therapy, namely enalapril maleate, perindopril, and ramipril in human plasma using high-performance liquid chromatography-tandem mass spectrophotometry (LC-MS/MS) with electrospray ionization (ESI). Separation of analytes and...
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SALINE WATER AS SOURCE OF CANCER DRUGS: ANTI- CANCER METABOLITES FROM MARINE SPONGES
Oceans and its ecosystem comprise an untapped source for many potential drugs. Marine sponges which inhabit mainly in the saline ocean water are considered as one of the oldest form of life. Due to intense concentration of various sponge species and other organisms co- existing in limited extent marine habitats, necessarily makes them highly competitive and complex. Hence most of the sponge specie...
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EVALUATION OF WOUND HEALING ACTIVITY OF LEAF EXTRACT OF DODONAEA VISCOSA JACQ INALLOXAN INDUCED DIABETIC WISTAR ALBINO RATS
The present study was undertaken to evaluate the wound healing activity of leaf extract of Dodonaea viscosa Jacq in diabetic wistar albino rats. Wound is defined as a loss or breaking of cellular and anatomic or functional continuity of living tissue. Normal wound healing response begins the moment the tissue is injured. Wound healing is the process of repair that follows injury to the skin and ot...
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ANTINOCICEPTIVE AND GASTRO PROTECTIVE EFFECTS OF INHALED AND ORALLY ADMINISTERED THEVETIA PERUVIANA PERS. K. SCHUM. ESSENTIAL OIL
In Present study the antinociceptive and the gastroprotective effects of orally administered or inhaled Thevetia peruviana Pers. K. (Schum) (Oleander) volatile oil, and its principal constituents linalool and 1,8-cineole were evaluated in mice. Either when orally administered (100µl/kg) or inhaled for 60 min Thevetia peruviana volatile oil significantly reduced the acetic acid-writhing response i...
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QSAR STUDIES OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS
A QSAR studies on pyrazole derivatives as specific anticancer agents was performed with 37 (32 training + 5 test) compounds. QSAR studies were performed using chemOffice 6.0 software supplied by Cambridge soft. The sketched structures were subjected to energy minimization and then used to calculate the physiochemical properties. The regression analysis was carried out using a computer program call...
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DEVELOPMENT, EVALUATION AND TARGETING OF IMATINIB MESYLATE LOADED SOLID LIPID NANOPARTICLES TO THE LYMPHATIC SYSTEM
For a formulation scientist, the delivery of therapeutic agents to the diseased organ has been a challenging problem. It is expected to improve the therapeutic index and reduce side effects of a drug by good delivery strategy to diseased organ. The objective of this investigation is to evaluate the targeting potential of solid lipid nanoparticle (SLN) formulation of imatinib mesylate to the lympha...
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