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PHYTOCHEMICAL SCREENING AND ANTINOCICEPTIVE ACTIVITY OF MIMOSA DIPLOTRICHA LEAVES
Though possessing a lot of ethnopharmacological use, Mimosa diplotricha did not explore thoroughly for its bioactivity & the phytoconstituents responsible for its bioactivity. The purpose of the current work was to conduct phytochemical screening and antinociceptive activity of methanolic extract and its different fractions of Mimosa diplotricha leaves. Phytochemical screening of methanolic ex...
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1761
DEVELOPMENT AND IN VITRO EVALUATION OF MICRONIZED SUSTAINED RELEASE MATRIX TABLET OF CARVEDILOL
Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dis...
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1700
BIOMIMETIC SYNTHESIS OF CdSe NANOPARTICLES WITH POTENTIAL BIOIMAGING APPLICATIONS
This study presents in vitro biomimetic synthesis of CdSe nanoparticles using the enzyme, NADPH dependent-Nitrate reductase purified from fungus, Fusarium oxysporum. The synthesis of CdSe nanoparticles was accomplished in the presence of a synthetic peptide having amino acid sequence (γ-Glu-Cys-Glu-Cys)-Gly, which acted as binding molecule. The nanoparticles were synthesized in the size range of ...
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1579
RISK ASSESSMENT OF SOME HERBAL POWDERS AND HERBAL FORMULATIONS CONTAMINATED WITH HEAVY METALS
Ten herbal medicines, Four herb choornam (Trikatu, Hingwashtak, Triphala and sitopladi) and five herbal compounds - Kutajghan Vati, Gandhak Rasayan, Sarivadi Vati, Chanderprabha Vati, Shankh Vati were tested for levels of heavy metals (Lead, copper, cadmium, iron, chromium, manganese, nickel and zinc). Both herbal extracts and herbal formulations showed the presence of heavy metals. Concentrations...
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1841
PHYTOCHEMICAL PROFILING AND ANTICANCER ACTIVITY OF DRAGON FRUIT HYLOCEREUS UNDATUS EXTRACTS AGAINST HUMAN HEPATOCELLULAR CARCINOMA CANCER (HEPG-2) CELLS
To investigate the phytoconstituents and anticancer potential followed by apoptotic studies of H. undatus fruit extracts on HepG-2 cells. Qualitative phytochemical profiling and anti-proliferation activity of Aqueous, Chloroform, Ethyl acetate, Hexane, and Methanol extracts of dragon fruit pulp was carried out. Based on the results of anti-proliferation studies, methanol extract was taken further ...
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1557
PREVALENCE AND FACTORS ASSOCIATED WITH HIV AND HEPATITIS B VIRUS INFECTIONS AMONG FEMALE COMMERCIAL SEX WORKERS IN MEKELLE, ETHIOPIA: CROSS SECTIONAL STUDY
Background: Sexually Transmitted Infections remain major public health problems among the most at risk population groups such as female commercial sex workers. Objective: To assess the magnitude of Hepatitis B Virus and HIV/AIDS and identify the associated factors among female commercial sex workers. Methodology: A Community Based Cross Sectional Study was conducted in Mekelle city. A total of 319...
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1879
EVALUATION OF ANALGESIC ACTIVITY OF MOMORDICA DIOICA ROXB. WILLD FRUIT PULP
In the present study Momordica dioica Roxb willd (Cucurbitaceae) fruit pulp was successively extracted with petroleum ether, ethyl acetate and methanol. All extracts were vacuum dried to yield the respective extracts. All extracts were evaluated by non-narcotic models like acetic acid induced writhing syndrome test and narcotic models like hot plate for its analgesic activity in doses of 50 mg/kg ...
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1558
DETERMINATION OF QUERCETIN BY HPTLC METHOD PRESENT IN ZYMODYNE SYRUP- A POLY HERBAL FORMULATION
Zymodyne Syrup is poly herbal formulation made by Ayrulab Herbals Pvt. Ltd., as an appetite enhancer. This formulation contains various 17 plant extract from these 6 plants namely Cyperus rotundus, Bacopa monnieri, Glycyrrhiza glabra, Phyllanthus amarus, Asparagus racemosus, and Tribulus terrestris contains Quercetin flavonoid as a chemical constitute and it can be determined by HPTLC method. Th...
4236
1915
RENOPROTECTIVE EFFECT OF OCIMUM SANCTUM IN COMPARISON WITH OLMESARTAN MEDOXOMIL AND PITAVASTATIN IN METFORMIN TREATED DIABETIC RATS
Nephropathy is an important comorbidity associated with diabetes leading to chronic kidney disease. We studied the effect of Ocimum sanctum in comparison to Olmesartanmedoxomil, Pitavastatin and their combination in prevention of this comorbidity. Male Wistar rats were given streptozotocin to induce diabetes and randomly divided into groups. Group 1 (Control group) received Metformin (94.5mg/kg/da...
4236
1801
SELF-MEDICATION WITH ANTIBIOTICS: GENERAL PERSPECTIVE AMONG PEOPLE IN PESHAWAR AND MARDAN (TWO MOST POPULATED CITIES OF KHYBER PUKHTOONKHWA-PAKISTAN)
Self-medication is global problem but in developing regions, where drugs are available to customers easily it arises greater risks and challenges. Peshawar and Mardan are two big and heavily inhibited cities of a developing country, Pakistan hence in this study we aim to find the level of self-medication and general knowledge about antibiotics of the people in these two cities. We conducted our st...
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