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ANALYSIS OF THE STRUCTURAL AND ULTRASTRUCTURAL ANATOMY OF SYMPHONIA GLOBULIFERA L. F. (CLUSIACEAE) LEAVES.
Symphonia globulifera L.f. (Anani) is an arboreal species, which occurs in the Amazon with antimalarial and antimicrobial properties, especially in the treatment of skin inflammations. It is also used as a general tonic and laxative for pregnant women and its sap/latex is used against rheumatism and tumors. The utilization of natural products from plant origin implies in pharmacobotanical quality ...
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1832
MODULATION OF mTOR RECEPTOR IN DIABETIC NEPHROPATHY BY SANTALIN A OF LAL CHANDAN (PTEROCARPUS SANTALINUS): AN IN-SILICO ASSESSMENT BY MOLECULAR DOCKING
Background: Diabetic nephropathy (DN) is a primary cause of end-stage renal disease globally. Activation of mTOR and reduced autophagy has been identified as one of the pathogenic pathways. The presently available drugs have been successful in inhibiting the mTOR signaling, but show low oral bioavailability and suboptimal solubility. Rapamycin is a selective inhibitor of mTOR, shown significant pr...
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1919
SYNTHESIS, CHARACTERIZATION OF SOME 2-AZETIDINONE DERIVATIVES FROM 4- NITRO ETHYL BENZOATE BY MICROWAVE METHOD AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY
Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2-azetidinones is developed. This method has been assessed as greener methodology. In our present study, series of five novel azetidinones are synthesi...
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PHARMACOLOGICAL AND PHYTOCHEMICAL EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF SOLANUM NIGRUM
Anti-ulcer activity of the Solanum nigrum L. extracts was studied in rats by using pylorus ligated ulcer model. Rantidine was used as the standard drug for comparison. The animals were sacrificed after 19 hrs after the ligation. Stomach was dissected out and contents were drained into tubes and were centrifuged at 1000 rpm for 10min and volume was noted. The PH of gastric juice was recorde...
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COMBINATION THERAPY AND ITS IMPLICATION ON CLINICAL EFFICACY OF ARTEMISININS- REVIEW
Artemisinin and its derivatives have successfully been used in treatment of falciparum malaria infections in various parts of the world. More importantly, they have proved effective against strains resistant to conventional antimalarials such as chloroquine and mefloquine in those parts of the world where malaria is endemic. Only one clinically relevant artemisinin-resistant human malaria has been...
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INVESTIGATION OF IN-VIVO PENETRATION AND DISTRIBUTION OF NANOMETRIC TiO2 IN TROPICAL ALBINISTIC SKIN BY SEQUENTIAL ADHESIVE TAPE STRIPPING
The non-invasive adhesive tape stripping technique was used to evaluate dermato-pharmacokinetics of nanometric titanium dioxide in tropical albinistic skin. Ten sequential strippings were conducted on exposure sites on the forehead, inner and upper forearms of three oculocutaneous albinism individuals 26+/- 4 years old, 15 minutes post dosing of 6.75mg/cm2 of a 5% titanium dioxide cream specifical...
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2159
ANTI-INFLAMMATORY AND ANTIBACTERIAL POTENTIAL OF CARISSA CARANDAS AND CARISSA SPINARUM NANOEMULSIONS
The studies in the present article aims at developing an optimal oral polyherbal nanoemulsions from Carissa carandas (CC) and Carissa spinarum (CS) which are noticed in ethnobotanical herbarium for their pharmacological relevance. Nanoemulsions were developed in different proportions of oil and surfactant systems in order to enhance its oral bioavailability. Solubility studies were carried out for...
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1635
PRODUCTION AND PURIFICATION STRATEGIES FOR LACCASE
Laccase belongs to polyphenol oxidases, which is a very wide family of copper-containing atoms in the center, which serves as the catalytic site. It is biochemically a glycoprotein with molecular mass being between 50kda to 130kda and 30% carbohydrate content, in addition to this it has three types of copper atoms. It is one of the most important enzymes due to its role in the food industry. It ac...
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1846
CYTOLOGICAL STUDIES OF TWO SPECIES OF GENUS DELONIX
Many cytological characteristics were studied in two species of Genus Delonix i.e., D. regia and D. elata . Delonix regia possessed 2n = 28 chromosome number. Both univalent as well as bivalents occurred invariably in this plant species, the former type being predominant over latter type. The chiasma frequency per PMc varied from 8-12 with average being 15.82. The chiasma frequency per chromosom...
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1574
DEVELOPMENT OF UV SPECTROPHOTOMETRIC FIRST ORDER DERIVATIVE METHOD FOR THE SIMULTANEOUS ESTIMATION OF RITONAVIR AND LOPINAVIR IN COMBINED TABLET DOSAGE FORM
A simple, accurate, precise analytical method has been developed for the simultaneous estimation of ritonavir and lopinavir in pure bulk drug and in combined tablet dosage form by UV spectrophotometry by first order derivative method. The standard solutions of ritonavir and lopinavir were prepared in acetonitrile followed by further required with the same solvent. The solution containing ritonav...
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1940