Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
CYTOTOXIC ACTIVITY AND PHYTOCHEMICAL INVESTIGATION OF PHYLLANTHUS EMBLICA L. LEAVES
The aim of this study is to investigate the cytotoxic effect of various extracts from Phyllanthus emblica L. According to Ayurveda this plant has potent anticancer activity and hence, this study is targeted at screening potential cytotoxic extracts using a yeast system. Yeast has been used as a model organism for many preclinical drug screens. In this study phytochemical extraction has been done b...
5491
1886
ISOLATION AND CHARACTERIZATION OF A TRITERPENOID FROM THE LEAVES OF AZIMA TETRACANTHA LAM.
Azima tetracantha Lam. (Salvadoraceae) is a traditional medicinal plant primarily used for mother care treatments after delivery. Based on literature survey, it was noticed that the evaluation of the biopotential of A. tetracantha, and its phytoconstituents are scarcely reported from plant materials growing in the state of Kerala, India. An attempt was made to reveal the phytochemical profile of...
6548
2507
COMPARATIVE HISTOLOGICAL, HISTOCHEMICAL AND PHYTOCHEMICAL STUDIES OF THE RAW DRUG JIVANTI FROM DIFFERENT RAW DRUG MARKETS OF KERALA
Jivanti is considered a stimulant and tonic in Ayurvedic literature. Its medicinal use dates back to about 4500 to 1600 BC, as mentioned in classical texts. Holostemma ada- kodien and Leptadenia reticulata are the two plants used in Ayurveda as source plants of the drug Jivanti. Roots of these plants are used in several Ayurvedic preparations. Though Ayurvedic Formulary of India mentions Leptadeni...
4704
2258
ASSESSMENT OF RATIONAL USE OF FIXED DOSE COMBINATION IN COMMUNITY PHARMACIES OF RESOURCE LIMITED SETTINGS OF ANDHRA PRADESH
Fixed dose combination (FDC’s) is the term, which generically used to mean a particular combination of active ingredient irrespective of the formulation or brand. Now a day’s irrational FDCs are more rapidly being marketed, which results in serious ADRs and reduction of patient quality of life. The study aims at assessing the rational usage of fixed dose combinations in community pharmacies by...
5185
2016
DESIGN AND OPTIMIZATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM OF SITAGLIPTIN
In the present study, Gastro retentive floating drug delivery systems (GFDDS) of sitagliptin, an anti diabetic drug, have been designed to increase the therapeutic efficacy & gastric residence time and to reduce frequency of administration. Therefore a sustained release medication was advantageous so as to achieve the prolonged therapeutic effect and to reduce peak and valley effect in plasma ...
4944
1801
HIGH PRESSURE LIQUID CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF ACYCLOVIR IN BULK AND MARKETED FORMULATION
A simple, selective, rapid and economical High Performance Liquid Chromatography (HPLC) method was developed for estimation of Acyclovir in bulk and marketed formulation. Chromatographic separation and estimation was achieved in a run time of 6.482 minutes on Hemsil C18- 5U (250 × 4.6 mm, 5μm) using Acetonitrile and pH adjusted water (6.74) in the ratio of 10:90 v/v at flow rate of 0.5ml/min. ...
6341
2001
PRE-FORMULATION CHARACTERIZATION OF CHELATED AMINO ACID COMPLEXES
Amino acid chelated complexes were synthesized and characterized to determine their purity. The purity of the complexes was found to be ranging from 42-75%. The HPLC method for determination of free amino acid content in the complexes was developed and validated and found to be linear, precise and accurate within concentration range of 0.157 mg/mL to 20.14 mg/mL. The method was used to estimate ...
8461
2539
A DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF METHYLXANTHINES AND TANNINS IN GUARANA BULK (PAULLINIA CUPANA)
A method using derivative UV spectrophotometry was developed and validated for the determination of methylxanthines and tannins in guarana bulk, using caffeine and catechin as markers. The spectra were obtained using first order derivatization, Δλ=20.000, and scale factor of 10. The quantification of actives was performed using wavelengths of 244 and 277 nm for catechin and caffeine, respectivel...
6306
2542
RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING METHOD A FOR ESTIMATION OF LOSARTAN POTASSIUM UNDER STRESS CONDITION AND TABLET DOSAGE FORM
Losartan potassium, a highly effective blood pressure lowering agent, has widely used for treatment of hypertension. Simple, economic, selective, and precise and stability indicating HPLC method has been developed and validated for analysis of losartan potassium in bulk drug and formulation dosage form. In order to optimize more one response at time, the chemo metric approach which includes 23...
5230
2180
DESIGN AND SYNTHESIS OF NOVEL MYCOBACTERIUM TUBERCULOSIS DHFR INHIBITORS
A series of 2,4-diaminotriazines were synthesized as Mycobacterium tuberculosis(Mtb) dihydrofolatereductase (DHFR) inhibitors. These derivatives were evaluated in whole cells by employing resazurinmicrotitre plate assay (REMA) against MtbH37Rv. Further, these were tested against other gram positive and gram negative bacterial strains to check specificity for Mtb. Cytotoxicity assessment was perfor...
5655
2155