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COMPARATIVE QUALITY EVALUATION OF SOME METRONIDAZOLE TABLETS AND METRONIDAZOLE BENZOATE ORAL SUSPENSIONS AVAILABLE IN RETAIL OUTLETS OF ADDIS ABABA, ETHIOPIA
In this study, five different products of each metronidazole tablets and benzoate salt oral suspensions were purchased from the different retail outlets in the local market of Addis Ababa and analyzed using official methods (Pharmacopoeial methods of USP/BP/IP) by employing HPLC for the tablet dosage forms and non-aqueous titration with potentiometric end point for the suspensions. The assay resul...
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IONTOPHORESIS: CONTROLLED TRANSDERMAL DRUG DELIVERY SYSTEM
Currently there has been an increased interest in using iontophoretic technique for the controlled transdermal drug delivery of medicines, especially in the delivery of proteins & peptides through skin membranes. The delivery of ionic drug molecules and peptide/protein molecules through transdermal delivery to attain a systemic therapeutic effect, chemical or physical methods are needed to imp...
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FORMULATION AND DEVELOPMENT OF LIPOSOMAL GEL FOR TOPICAL DRUG DELIVERY SYSTEM
Aim: The aims of this study were to develop liposome enriched Dexibuprofen liposomal hydrogels for topical delivery, perform in vitro release studies and in vivo permeation studies through mice/rat skin, and evaluate the efficacy of liposomal gels against inflammation induced rats. The purpose was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavai...
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DEVELOPMENT OF ORALLY ADMINISTERED FIXED DOSE COMBINATION (FDC) PRODUCTS: PHARMACOKINETIC AND BIOPHARMACEUTICAL CONSIDERATIONS
Combination drug therapy has been shown to be beneficial in chronic multifactorial diseases, infectious diseases and in the treatment of comorbid conditions. Some drug combinations have also been developed to improve the bioavailability of the active components by combining with drug metabolizing enzyme inhibitors. Fixed dose combinations (FDC) offer advantages of better efficacy, ease of administ...
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STANDARDIZATION OF YAKRIT PLIHANTAK CHURNA: AN AYURVEDIC POLYHERBAL FORMULATION
Most of the traditional systems of medicine are effective but they lack of standardization. So there is need to develop standardization technique. Central Council for Research in Ayurveda has given preliminary guidelines for standardization the conventionally used formulations. Standardization of herbal formulations is essential in order to assess the quality of drugs, based on the concentration o...
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UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TELMISARTAN IN BULK AND TABLET DOSAGE FORM
A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The spectra of Telmisartan in 0.1 N NaOH and distilled water (20:80) shows λmax at 234 nm and estimation was carried out by A (1% 1cm) and by comparison with standard. Calibration graph was found to be linear (r2= 0.999) over the concentrat...
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APPROACHES TO PULMONARY DRUG DELIVERY SYSTEMS
Pulmonary route have been used to treat various respiratory diseases for centuries. Ancient inhalation therapies included the use of leaves from plants, vapors from aromatic plants, balsams, and myrrh. The pulmonary route has gained increasing importance in the recent times due to its unique properties such as a large absorptive area of up to 100m2; extremely thin 0.1 μm – 0.2 μm absorptive mu...
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AN IDENTIFICATION OF CROP DISEASE USING IMAGE SEGMENTATION
Agriculture forms a vital part of India’s economy. More than 50% of India’s population is dependent on agriculture for their livelihood. In India, many crops are cultivated, out of which wheat is one of the most important food grains that this country cultivates and exports. Thus it can be seen that wheat forms a major part of the Indian agricultural system and India’s economy. Hence, the ma...
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IN-VITRO ANTIFUNGAL ACTIVITY OF LEAF EXTRACTS OF LEUCAS ASPERA AND LEUCAS ZEYLANICA
The aim of the present study is to probe the antimicrobial activities of methanol leaf extract of Leucas sp. Antifungal susceptibilities of certain clinically isolated dermatophytes to methanol extracts of Leucas aspera and Leucas zeylanica leaves were performed using agar well diffusion method. The result obtained shows that all the extracts expressed remarkable antifungal activity with zone of i...
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FORMULATION AND PHYSICOCHEMICAL CHARACTERIZATION OF SODIUM CARBOXY METHYL CELLULOSE AND β CYCLODEXTRIN MEDIATED TERNARY INCLUSION COMPLEXES OF SILYMARIN
The objective of the present investigation was to study the complexation of silymarin, a poorly water soluble herbal drug, with β-cyclodextrin alone and in the presence of sodium carboxymethyl cellulose to evaluate the feasibility of enhancing the solubility and dissolution rate of silymarine. Phase solubility study and kneading method was employed to develop and formulate solid inclusion complex...
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